{"id":"https://openalex.org/W4297201638","doi":"https://doi.org/10.3390/jcm11195632","title":"Efficacy and Safety of Tinzaparin in Prophylactic, Intermediate and Therapeutic Doses in Non-Critically Ill Patients Hospitalized with COVID-19: The PROTHROMCOVID Randomized Controlled Trial","display_name":"Efficacy and Safety of Tinzaparin in Prophylactic, Intermediate and Therapeutic Doses in Non-Critically Ill Patients Hospitalized with COVID-19: The PROTHROMCOVID Randomized Controlled Trial","publication_year":2022,"publication_date":"2022-09-24","ids":{"openalex":"https://openalex.org/W4297201638","doi":"https://doi.org/10.3390/jcm11195632","pmid":"https://pubmed.ncbi.nlm.nih.gov/36233500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9571371"},"language":"en","primary_location":{"id":"doi:10.3390/jcm11195632","doi":"https://doi.org/10.3390/jcm11195632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11195632","pdf_url":"https://www.mdpi.com/2077-0383/11/19/5632/pdf?version=1664195405","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/11/19/5632/pdf?version=1664195405","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061652725","display_name":"Nuria Mu\u00f1oz\u2010Rivas","orcid":"https://orcid.org/0000-0001-9774-963X","observed_orcids":["https://orcid.org/0000-0001-9774-963X"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210165557","display_name":"Hospital Universitario Infanta Leonor","ror":"https://ror.org/05nfzf209","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165557"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Nuria Mu\u00f1oz-Rivas","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario Infanta Leonor. Madrid. Spain","Department of Internal Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","Universidad Complutense, 28040 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9774-963X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario Infanta Leonor. Madrid. Spain","institution_ids":["https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","institution_ids":["https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Universidad Complutense, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067956151","display_name":"Jes\u00fas Aibar","orcid":"https://orcid.org/0000-0001-5415-3449","observed_orcids":["https://orcid.org/0000-0001-5415-3449"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Aibar","raw_affiliation_strings":["Department of Internal Medicine. Hospital Cl\u00ednic. IDIBAPS, University of Barcelona, Barcelona. Spain","Department of Internal Medicine, Hospital Cl\u00ednic, IDIBAPS, 08036 Barcelona, Spain","University of Barcelona, 08007 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Cl\u00ednic. IDIBAPS, University of Barcelona, Barcelona. Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Cl\u00ednic, IDIBAPS, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"University of Barcelona, 08007 Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085790095","display_name":"Cristina Gabara-Xanc\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Gabara-Xanc\u00f3","raw_affiliation_strings":["Department of Internal Medicine. Hospital Cl\u00ednic. IDIBAPS, University of Barcelona, Barcelona. Spain","Department of Internal Medicine, Hospital Cl\u00ednic, IDIBAPS, 08036 Barcelona, Spain","University of Barcelona, 08007 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Cl\u00ednic. IDIBAPS, University of Barcelona, Barcelona. Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Cl\u00ednic, IDIBAPS, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"University of Barcelona, 08007 Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077668745","display_name":"\u00c1ngela Trueba-Vicente","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c1ngela Trueba-Vicente","raw_affiliation_strings":["Department of Internal Medicine. Hospital de Emergencias Enfermera Isabel Zendal. Madrid. Spain","Department of Internal Medicine, Hospital de Emergencias Enfermera Isabel Zendal, 28055 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital de Emergencias Enfermera Isabel Zendal. Madrid. Spain","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Emergencias Enfermera Isabel Zendal, 28055 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025412586","display_name":"Ana Urbelz-P\u00e9rez","orcid":"https://orcid.org/0000-0001-7468-7077","observed_orcids":["https://orcid.org/0000-0001-7468-7077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Urbelz-P\u00e9rez","raw_affiliation_strings":["Department of Internal Medicine. Hospital de Emergencias Enfermera Isabel Zendal. Madrid. Spain","Department of Internal Medicine, Hospital de Emergencias Enfermera Isabel Zendal, 28055 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7468-7077","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital de Emergencias Enfermera Isabel Zendal. Madrid. Spain","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital de Emergencias Enfermera Isabel Zendal, 28055 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025659158","display_name":"Vicente G\u00f3mez del Olmo","orcid":"https://orcid.org/0000-0002-7992-3769","observed_orcids":["https://orcid.org/0000-0002-7992-3769"]},"institutions":[{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente G\u00f3mez-Del Olmo","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario Ram\u00f3n y Cajal. Madrid. Spain","Department of Internal Medicine, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario Ram\u00f3n y Cajal. Madrid. Spain","institution_ids":["https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain","institution_ids":["https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008363748","display_name":"Pablo Demelo Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-3096-4711","observed_orcids":["https://orcid.org/0000-0002-3096-4711"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Demelo-Rodriguez","raw_affiliation_strings":["Department of Internal Medicine. Hospital General Universitario Gregorio Mara\u00f1\u00f3n. Madrid. Spain","Department of Internal Medicine, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3096-4711","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital General Universitario Gregorio Mara\u00f1\u00f3n. Madrid. Spain","institution_ids":["https://openalex.org/I2960094004"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain","institution_ids":["https://openalex.org/I2960094004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026893987","display_name":"Alberto Rivera-Gallego","orcid":"https://orcid.org/0000-0001-8600-1183","observed_orcids":["https://orcid.org/0000-0001-8600-1183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Rivera-Gallego","raw_affiliation_strings":["Department of Internal Medicine. Hospital \u00c1lvaro Cunqueiro. Vigo, Pontevedra. Spain","Department of Internal Medicine, Hospital \u00c1lvaro Cunqueiro, 36312 Vigo, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8600-1183","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital \u00c1lvaro Cunqueiro. Vigo, Pontevedra. Spain","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital \u00c1lvaro Cunqueiro, 36312 Vigo, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012692341","display_name":"Pau Bosch\u2010Nicolau","orcid":"https://orcid.org/0000-0002-7435-1829","observed_orcids":["https://orcid.org/0000-0002-7435-1829"]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pau Bosch-Nicolau","raw_affiliation_strings":["Department of Infectious Diseases. Hospital Universitario Vall d\u2019Hebron. Barcelona. Spain","Department of Infectious Diseases, Hospital Universitario Vall d'Hebron, 08035 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7435-1829","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases. Hospital Universitario Vall d\u2019Hebron. Barcelona. Spain","institution_ids":["https://openalex.org/I4210127641"]},{"raw_affiliation_string":"Department of Infectious Diseases, Hospital Universitario Vall d'Hebron, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051811107","display_name":"Montserrat P\u00e9rez\u2010Pinar","orcid":"https://orcid.org/0000-0002-3683-5478","observed_orcids":["https://orcid.org/0000-0002-3683-5478"]},"institutions":[{"id":"https://openalex.org/I4210092665","display_name":"Hospital Virgen de la Luz","ror":"https://ror.org/00k49k182","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210092665","https://openalex.org/I4210141158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Perez-Pinar","raw_affiliation_strings":["Department of Internal Medicine. Hospital Virgen de la Luz. Cuenca. Spain","Department of Internal Medicine, Hospital Virgen de la Luz, 16002 Cuenca, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3683-5478","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Virgen de la Luz. Cuenca. Spain","institution_ids":["https://openalex.org/I4210092665"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Virgen de la Luz, 16002 Cuenca, Spain","institution_ids":["https://openalex.org/I4210092665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046290334","display_name":"M\u00f3nica R\u00edos-Prego","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158603","display_name":"Complejo Hospitalario de Pontevedra","ror":"https://ror.org/016cxc226","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158603"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Rios-Prego","raw_affiliation_strings":["Department of Internal Medicine. Complexo Hospitalario Universitario de Pontevedra. Pontevedra. Spain","Department of Internal Medicine, Complexo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Complexo Hospitalario Universitario de Pontevedra. Pontevedra. Spain","institution_ids":["https://openalex.org/I4210158603"]},{"raw_affiliation_string":"Department of Internal Medicine, Complexo Hospitalario Universitario de Pontevedra, 36071 Pontevedra, Spain","institution_ids":["https://openalex.org/I4210158603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043092318","display_name":"Olga Madridano-Cobo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Madridano-Cobo","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario Infanta Sof\u00eda. San Sebasti\u00e1n de los Reyes, Madrid. Spain","Department of Internal Medicine, Hospital Universitario Infanta Sof\u00eda, 28702 San Sebasti\u00e1n de los Reyes, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario Infanta Sof\u00eda. San Sebasti\u00e1n de los Reyes, Madrid. Spain","institution_ids":["https://openalex.org/I4210160736"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario Infanta Sof\u00eda, 28702 San Sebasti\u00e1n de los Reyes, Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072229568","display_name":"Laura Ramos-Alonso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140856","display_name":"Complexo Hospitalario Universitario A Coru\u00f1a","ror":"https://ror.org/044knj408","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210140856"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Ramos-Alonso","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario A Coru\u00f1a. A Coru\u00f1a. Spain","Department of Internal Medicine, Hospital Universitario A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario A Coru\u00f1a. A Coru\u00f1a. Spain","institution_ids":["https://openalex.org/I4210140856"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario A Coru\u00f1a, 15006 A Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I4210140856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040430464","display_name":"Jes\u00fas Alonso\u2010Carrillo","orcid":"https://orcid.org/0000-0003-4910-1497","observed_orcids":["https://orcid.org/0000-0003-4910-1497"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Alonso-Carrillo","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario 12 de Octubre. Madrid. Spain","Department of Internal Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario 12 de Octubre. Madrid. Spain","institution_ids":["https://openalex.org/I4210101691"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056987073","display_name":"Iria Francisco-Albelsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154933","display_name":"Hospital Universitari de Girona Doctor Josep Trueta","ror":"https://ror.org/04g27v387","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210153292","https://openalex.org/I4210154933"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Iria Francisco-Albelsa","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitari de Girona Dr. Josep Trueta. Girona. Spain","Department of Internal Medicine, Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitari de Girona Dr. Josep Trueta. Girona. Spain","institution_ids":["https://openalex.org/I4210154933"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain","institution_ids":["https://openalex.org/I4210154933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057907775","display_name":"Edelmira Mart\u00ed","orcid":"https://orcid.org/0000-0002-5678-2916","observed_orcids":["https://orcid.org/0000-0002-5678-2916"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Edelmira Mart\u00ed-Saez","raw_affiliation_strings":["Department of Haematology. Hospital Cl\u00ednico Universitario de Valencia. Valencia. Spain","Department of Haematology, Hospital Cl\u00ednico Universitario de Valencia, 46010 Valencia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5678-2916","affiliations":[{"raw_affiliation_string":"Department of Haematology. Hospital Cl\u00ednico Universitario de Valencia. Valencia. Spain","institution_ids":["https://openalex.org/I4210094406"]},{"raw_affiliation_string":"Department of Haematology, Hospital Cl\u00ednico Universitario de Valencia, 46010 Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104184787","display_name":"Ana Maestre Peir\u00f3","orcid":"https://orcid.org/0000-0001-7400-5400","observed_orcids":["https://orcid.org/0000-0001-7400-5400"]},"institutions":[{"id":"https://openalex.org/I4210137487","display_name":"Hospital Universitario del Vinalop\u00f3","ror":"https://ror.org/03gtg9w20","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137487"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Maestre-Peir\u00f3","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario de Vinalop\u00f3. Elche, Alicante. Spain","Department of Internal Medicine, Hospital Universitario de Vinalop\u00f3, 03293 Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario de Vinalop\u00f3. Elche, Alicante. Spain","institution_ids":["https://openalex.org/I4210137487"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario de Vinalop\u00f3, 03293 Elche, Spain","institution_ids":["https://openalex.org/I4210137487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011378189","display_name":"Manuel M\u00e9ndez\u2010Bail\u00f3n","orcid":"https://orcid.org/0000-0003-0830-8897","observed_orcids":["https://orcid.org/0000-0003-0830-8897"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel M\u00e9ndez-Bail\u00f3n","raw_affiliation_strings":["Department of Internal Medicine. Hospital Clinico San Carlos.UniversidadComplutense,Madrid.Spain","Department of Internal Medicine, Hospital Clinico San Carlos, 28040 Madrid, Spain","Universidad Complutense, 28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Clinico San Carlos.UniversidadComplutense,Madrid.Spain","institution_ids":["https://openalex.org/I2961216182"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Clinico San Carlos, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I2961216182"]},{"raw_affiliation_string":"Universidad Complutense, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041612097","display_name":"Jos\u00e9\u2010\u00c1ngel Hern\u00e1ndez\u2010Rivas","orcid":"https://orcid.org/0000-0003-4550-757X","observed_orcids":["https://orcid.org/0000-0003-4550-757X"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210165557","display_name":"Hospital Universitario Infanta Leonor","ror":"https://ror.org/05nfzf209","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165557"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 \u00c1ngel Hern\u00e1ndez-Rivas","raw_affiliation_strings":["Department of Hematology. Hospital Universitario Infanta Leonor. Universidad Complutense. Madrid. Spain","Department of Hematology, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","Universidad Complutense, 28040 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4550-757X","affiliations":[{"raw_affiliation_string":"Department of Hematology. Hospital Universitario Infanta Leonor. Universidad Complutense. Madrid. Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","institution_ids":["https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Universidad Complutense, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089730894","display_name":"Juan Torres\u2010Macho","orcid":"https://orcid.org/0000-0002-8860-6837","observed_orcids":["https://orcid.org/0000-0002-8860-6837"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210165557","display_name":"Hospital Universitario Infanta Leonor","ror":"https://ror.org/05nfzf209","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210165557"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Torres-Macho","raw_affiliation_strings":["Department of Internal Medicine. Hospital Universitario Infanta Leonor. Madrid. Spain","Department of Internal Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","Universidad Complutense, 28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine. Hospital Universitario Infanta Leonor. Madrid. Spain","institution_ids":["https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Department of Internal Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain","institution_ids":["https://openalex.org/I4210165557"]},{"raw_affiliation_string":"Universidad Complutense, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"last","author":{"id":null,"display_name":"The PROTHROMCOVID Trial investigators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"The PROTHROMCOVID Trial investigators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5041612097","https://openalex.org/A5061652725"],"corresponding_institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210165557"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":5.7181,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.96780157,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":"19","first_page":"5632","last_page":"5632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.6255000233650208,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tinzaparin","display_name":"tinzaparin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8790000081062317},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.5249999761581421},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/non-invasive-ventilation","display_name":"non-invasive ventilation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.6690000295639038},{"id":"https://openalex.org/keywords/futility-analysis","display_name":"futility analysis","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9818100929260254},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.7339277267456055},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7103157639503479},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6960267424583435},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5388263463973999},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4856949746608734},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.45485663414001465},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.41899266839027405},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3322875499725342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17625901103019714},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jcm11195632","doi":"https://doi.org/10.3390/jcm11195632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11195632","pdf_url":"https://www.mdpi.com/2077-0383/11/19/5632/pdf?version=1664195405","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"doi:10.1101/2022.05.03.22274594","doi":"https://doi.org/10.1101/2022.05.03.22274594","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.05.03.22274594","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/05/05/2022.05.03.22274594.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:36233500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36233500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9571371","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9571371/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aabebeeae43b4fe2a6575cfe077a9abf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aabebeeae43b4fe2a6575cfe077a9abf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Medicine, Vol 11, Iss 5632, p 5632 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcm11195632","doi":"https://doi.org/10.3390/jcm11195632","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm11195632","pdf_url":"https://www.mdpi.com/2077-0383/11/19/5632/pdf?version=1664195405","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332071","display_name":"LEO Pharma","ror":"https://ror.org/05tzrdd39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297201638.pdf","grobid_xml":"https://content.openalex.org/works/W4297201638.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2162499932","https://openalex.org/W3028745449","https://openalex.org/W3029523302","https://openalex.org/W3042584574","https://openalex.org/W3046768896","https://openalex.org/W3081515108","https://openalex.org/W3083924429","https://openalex.org/W3108572624","https://openalex.org/W3118886549","https://openalex.org/W3124817318","https://openalex.org/W3128604271","https://openalex.org/W3134959801","https://openalex.org/W3136016654","https://openalex.org/W3153304864","https://openalex.org/W3172155398","https://openalex.org/W3174040578","https://openalex.org/W3180828297","https://openalex.org/W3189793200","https://openalex.org/W3197892791","https://openalex.org/W3202637221","https://openalex.org/W3205091111","https://openalex.org/W3215329344","https://openalex.org/W4205922819","https://openalex.org/W4220867566","https://openalex.org/W4231969161"],"related_works":["https://openalex.org/W4306320471","https://openalex.org/W4224325279","https://openalex.org/W3216921189","https://openalex.org/W3155392701","https://openalex.org/W3165362861","https://openalex.org/W3096248644","https://openalex.org/W4393281600","https://openalex.org/W4385620226","https://openalex.org/W3205091111","https://openalex.org/W6966950742"],"abstract_inverted_index":{"Hospitalized":[0],"patients":[1,42,59,164],"with":[2,60,208],"COVID-19":[3,45,61,227],"are":[4],"at":[5,94,128,156],"increased":[6],"risk":[7,244],"of":[8,19,32,91,104,166,206,245],"thrombosis,":[9],"acute":[10],"respiratory":[11],"distress":[12],"syndrome":[13],"and":[14,30,37,183,216],"death.":[15,254],"The":[16,23,96,121,153],"optimal":[17],"dosage":[18],"thromboprophylaxis":[20],"is":[21,48],"unknown.":[22],"aim":[24],"was":[25,100,125,198,202,222],"to":[26,66,213,234,241],"evaluate":[27],"the":[28,132,140,167,174,180,187,217,220,243],"efficacy":[29,98],"safety":[31,123],"tinzaparin":[33,79,93,232],"in":[34,40,139,162,173,179,186,204],"prophylactic,":[35],"intermediate,":[36],"therapeutic":[38,74,188],"doses":[39,80,237],"non-critical":[41],"admitted":[43],"for":[44,110],"pneumonia.":[46,62],"PROTHROMCOVID":[47],"a":[49,101],"randomized,":[50,135],"unblinded,":[51],"controlled,":[52],"multicenter":[53],"trial":[54,221],"enrolling":[55],"non-critical,":[56],"hospitalized":[57],"adult":[58],"Patients":[63],"were":[64,81,137],"randomized":[65],"prophylactic":[67,92,175,236],"(4500":[68],"IU),":[69],"intermediate":[70,181,229],"(100":[71],"IU/kg),":[72],"or":[73,112,116,230,250,253],"(175":[75],"IU/kg)":[76],"groups.":[77],"All":[78],"administered":[82],"once":[83],"daily":[84],"during":[85],"hospitalization,":[86],"followed":[87],"by":[88],"7":[89],"days":[90,158],"discharge.":[95],"primary":[97],"outcome":[99,124],"composite":[102,154],"endpoint":[103,155],"symptomatic":[105],"systemic":[106],"thrombotic":[107,246],"events,":[108],"need":[109],"invasive":[111],"non-invasive":[113,248],"mechanical":[114,251],"ventilation,":[115,249],"death":[117],"within":[118],"30":[119,129,157],"days.":[120,130],"main":[122],"major":[126,195],"bleeding":[127,196,201],"Of":[131],"311":[133],"subjects":[134],"300":[136],"included":[138],"prespecified":[141],"interim":[142],"analysis":[143],"(mean":[144],"[SD]":[145],"age,":[146],"56.7":[147],"[14.6]":[148],"years;":[149],"males,":[150],"182":[151],"[60.7%]).":[152],"from":[159],"randomization":[160],"occurred":[161],"58":[163],"(19.3%)":[165],"total":[168],"population;":[169],"19":[170,184],"(17.1":[171],"%)":[172],"group,":[176,182],"20":[177],"(22.1%)":[178],"(18.5%)":[185],"dose":[189],"group":[190],"(p":[191],"=":[192],"0.72).":[193],"No":[194],"event":[197],"reported;":[199],"non-major":[200],"observed":[203],"3.7%":[205],"patients,":[207,228],"no":[209],"intergroup":[210],"differences.":[211],"Due":[212],"these":[214],"results":[215],"futility":[218],"analysis,":[219],"stopped.":[223],"In":[224],"non-critically":[225],"ill":[226],"full-dose":[231],"compared":[233],"standard":[235],"did":[238],"not":[239],"appear":[240],"affect":[242],"event,":[247],"ventilation":[252],"Trial":[255],"RegistrationClinicalTrials.gov":[256],"Identifier":[257],"(NCT04730856).":[258],"Edura-CT":[259],"registration":[260],"number:":[261],"2020-004279-42.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-09-27T00:00:00"}