{"id":"https://openalex.org/W4297091190","doi":"https://doi.org/10.1101/2022.09.20.508562","title":"The Long Noncoding RNA Playrr Regulates Pitx2 Dosage and Protects Against Cardiac Arrhythmias","display_name":"The Long Noncoding RNA Playrr Regulates Pitx2 Dosage and Protects Against Cardiac Arrhythmias","publication_year":2022,"publication_date":"2022-09-20","ids":{"openalex":"https://openalex.org/W4297091190","doi":"https://doi.org/10.1101/2022.09.20.508562"},"language":"en","primary_location":{"id":"doi:10.1101/2022.09.20.508562","doi":"https://doi.org/10.1101/2022.09.20.508562","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.20.508562","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/20/2022.09.20.508562.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/20/2022.09.20.508562.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061358636","display_name":"Frances L. Chen","orcid":"https://orcid.org/0000-0001-6441-9677","observed_orcids":["https://orcid.org/0000-0001-6441-9677"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances L. Chen","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":"https://orcid.org/0000-0001-6441-9677","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028111733","display_name":"Eva M. Oxford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva M. Oxford","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061047722","display_name":"Shao\u2010Pei Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shao-Pei Chou","raw_affiliation_strings":["Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368012","display_name":"Na Li","orcid":"https://orcid.org/0000-0001-6163-1648","observed_orcids":["https://orcid.org/0000-0001-6163-1648"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["Department of Medicine- Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA","Department of Medicine- Cardiovascular Research, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine- Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Medicine- Cardiovascular Research, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009598248","display_name":"John P. Leach","orcid":"https://orcid.org/0000-0002-0779-8583","observed_orcids":["https://orcid.org/0000-0002-0779-8583"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Leach","raw_affiliation_strings":["Department of Medicine- Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA","Department of Medicine- Cardiovascular Research, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine- Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Medicine- Cardiovascular Research, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101351043","display_name":"Sienna K. Perry","orcid":"https://orcid.org/0000-0003-2964-9842","observed_orcids":["https://orcid.org/0000-0003-2964-9842"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sienna K. Perry","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082249148","display_name":"Bhargav D. Sanketi","orcid":"https://orcid.org/0000-0002-0581-7509","observed_orcids":["https://orcid.org/0000-0002-0581-7509"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhargav D. Sanketi","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":"https://orcid.org/0000-0002-0581-7509","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032986580","display_name":"Christina Cong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Cong","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003251746","display_name":"Sophie Ann Kupiec-Weglinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophie A. Kupiec-Weglinski","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086596690","display_name":"Rebecca Dubowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Dubowitz","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031332190","display_name":"Erin K. Daugherity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Daugherity","raw_affiliation_strings":["Center for Animal Resources and Education, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Center for Animal Resources and Education, College of Veterinary Medicine, Cornell University","Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Animal Resources and Education, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Center for Animal Resources and Education, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080982128","display_name":"James F. Martin","orcid":"https://orcid.org/0000-0002-7842-9857","observed_orcids":["https://orcid.org/0000-0002-7842-9857"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Martin","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA","Texas Heart Institute, Houston, TX 77030, USA","Department of Molecular Physiology and Biophysics, Baylor College of Medicine","Texas Heart Institute"],"raw_orcid":"https://orcid.org/0000-0002-7842-9857","affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Heart Institute, Houston, TX 77030, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Heart Institute","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024923108","display_name":"Charles G. Danko","orcid":"https://orcid.org/0000-0002-1999-7125","observed_orcids":["https://orcid.org/0000-0002-1999-7125"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles G. Danko","raw_affiliation_strings":["Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University"],"raw_orcid":"https://orcid.org/0000-0002-1999-7125","affiliations":[{"raw_affiliation_string":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051812491","display_name":"Natasza A. Kurpios","orcid":"https://orcid.org/0000-0002-1251-7395","observed_orcids":["https://orcid.org/0000-0002-1251-7395"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natasza A. Kurpios","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","Department of Molecular Medicine, College of Veterinary Medicine, Cornell University"],"raw_orcid":"https://orcid.org/0000-0002-1251-7395","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]},{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051812491"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pitx2","display_name":"PITX2","score":0.921999990940094},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/sinus-node-dysfunction","display_name":"sick sinus syndrome","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.7940000295639038},{"id":"https://openalex.org/keywords/left-right-asymmetry","display_name":"left-right asymmetry","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pitx2c","display_name":"Pitx2c","score":0.734000027179718},{"id":"https://openalex.org/keywords/atrial-fibrosis","display_name":"atrial fibrosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.8939999938011169},{"id":"https://openalex.org/keywords/atrial-substrate","display_name":"atrial substrate","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tbx5","display_name":"TBX5","score":0.7059999704360962},{"id":"https://openalex.org/keywords/hcn1","display_name":"HCN1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sinoatrial-node","display_name":"sinoatrial node","score":0.7770000100135803},{"id":"https://openalex.org/keywords/atrial-myocytes","display_name":"atrial myocytes","score":0.5479999780654907},{"id":"https://openalex.org/keywords/left-right-patterning","display_name":"left-right patterning","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C90620890","wikidata":"https://www.wikidata.org/wiki/Q18030562","display_name":"PITX2","level":5,"score":0.8268008232116699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.703626811504364},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.520095705986023},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.49538862705230713},{"id":"https://openalex.org/C83482732","wikidata":"https://www.wikidata.org/wiki/Q18029742","display_name":"MYH6","level":5,"score":0.44772109389305115},{"id":"https://openalex.org/C105130999","wikidata":"https://www.wikidata.org/wiki/Q414976","display_name":"Pseudoknot","level":4,"score":0.43020883202552795},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40201056003570557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39052122831344604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3840222656726837},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.334206759929657},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.30072712898254395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27633586525917053},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.15382826328277588},{"id":"https://openalex.org/C74581901","wikidata":"https://www.wikidata.org/wiki/Q14876107","display_name":"MYH7","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2022.09.20.508562","doi":"https://doi.org/10.1101/2022.09.20.508562","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.20.508562","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/20/2022.09.20.508562.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2022.09.20.508562","doi":"https://doi.org/10.1101/2022.09.20.508562","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.20.508562","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/20/2022.09.20.508562.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297091190.pdf","grobid_xml":"https://content.openalex.org/works/W4297091190.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1494964562","https://openalex.org/W1518173022","https://openalex.org/W1911722375","https://openalex.org/W1926307205","https://openalex.org/W1963916703","https://openalex.org/W1970214265","https://openalex.org/W1970707135","https://openalex.org/W1988891936","https://openalex.org/W1992917791","https://openalex.org/W2037988353","https://openalex.org/W2039809281","https://openalex.org/W2045807397","https://openalex.org/W2050440230","https://openalex.org/W2051514127","https://openalex.org/W2051577225","https://openalex.org/W2052223883","https://openalex.org/W2054421446","https://openalex.org/W2060338081","https://openalex.org/W2071466017","https://openalex.org/W2081452498","https://openalex.org/W2084584963","https://openalex.org/W2087818666","https://openalex.org/W2097312037","https://openalex.org/W2099788803","https://openalex.org/W2100186867","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2117529010","https://openalex.org/W2121902325","https://openalex.org/W2124668407","https://openalex.org/W2124719424","https://openalex.org/W2125890475","https://openalex.org/W2129742479","https://openalex.org/W2132522861","https://openalex.org/W2132872450","https://openalex.org/W2141219610","https://openalex.org/W2143909584","https://openalex.org/W2149665587","https://openalex.org/W2150288232","https://openalex.org/W2154148336","https://openalex.org/W2161734038","https://openalex.org/W2167931463","https://openalex.org/W2168005921","https://openalex.org/W2168881898","https://openalex.org/W2174459583","https://openalex.org/W2188832683","https://openalex.org/W2192260820","https://openalex.org/W2342972477","https://openalex.org/W2390663394","https://openalex.org/W2509059566","https://openalex.org/W2585827199","https://openalex.org/W2589025451","https://openalex.org/W2601961147","https://openalex.org/W2607238069","https://openalex.org/W2612635084","https://openalex.org/W2729948611","https://openalex.org/W2771501127","https://openalex.org/W2789933752","https://openalex.org/W2804559696","https://openalex.org/W2896399042","https://openalex.org/W2913772219","https://openalex.org/W2950354537","https://openalex.org/W2952444044","https://openalex.org/W2981634880","https://openalex.org/W3036547154","https://openalex.org/W3130065846","https://openalex.org/W3147559586","https://openalex.org/W3206689450"],"related_works":["https://openalex.org/W3216351860","https://openalex.org/W4281697445","https://openalex.org/W2980479267","https://openalex.org/W2018718768","https://openalex.org/W2040840643","https://openalex.org/W2087818666","https://openalex.org/W2081060939","https://openalex.org/W2099788803","https://openalex.org/W2304893248","https://openalex.org/W2118405128"],"abstract_inverted_index":{"Abstract":[0],"Rationale":[1],"The":[2,104],"most":[3,54],"significantly":[4],"associated":[5],"atrial":[6,269,276],"fibrillation":[7],"(AF)":[8],"risk":[9],"loci":[10],"in":[11,95,116,134,142,157,162,173,204,226,239,268,278,292,310,351],"humans":[12],"map":[13],"to":[14,43,88,110,152,175,300,341,348,371],"a":[15,30,70,112,362],"noncoding":[16,73],"gene":[17],"desert":[18],"upstream":[19],"of":[20,33,46,106,114,125,194,224,233,246,259,265,294,307,318],"the":[21,44,53,61,83,91,123,135,150,155,195,243,319],"evolutionarily":[22],"conserved":[23,71],"left-right":[24],"(LR)":[25],"transcription":[26,119],"factor":[27],"Pitx2":[28,38,89,101,118,153,352,357,367],",":[29,77,178,199],"master":[31],"regulator":[32],"LR":[34],"asymmetric":[35],"organ":[36,202],"development.":[37],"dosage":[39,368],"is":[40,79],"fundamentally":[41],"linked":[42],"development":[45,124],"sinus":[47],"node":[48,166],"dysfunction":[49],"(SND)":[50],"and":[51,120,130,212,218,261,289,313,316,324,338,358,369,373],"AF,":[52],"common":[55],"cardiac":[56,126,196,321,344],"arrhythmia":[57],"affecting":[58],"adults,":[59],"but":[60],"mechanistic":[62],"basis":[63],"for":[64,365],"this":[65,107],"remains":[66],"obscure.":[67],"We":[68,168],"identified":[69],"long":[72],"RNA":[74,141,183],"(lncRNA),":[75],"Playrr":[76,115,132,145,177,182,186,205,227,234,247,279,295,332,359],"which":[78],"exclusively":[80],"transcribed":[81],"on":[82,90],"embryo\u2019s":[84],"right":[85,244],"side,":[86],"opposite":[87],"left,":[92],"that":[93],"participates":[94],"mutually":[96],"antagonistic":[97],"transcriptional":[98],"regulation":[99],"with":[100,140],".":[102,326],"Objective":[103],"objective":[105],"study":[108],"was":[109,138,146],"investigate":[111],"role":[113],"regulating":[117],"protecting":[121],"against":[122],"rhythm":[127],"disturbances.":[128],"Methods":[129],"Results":[131],"expression":[133,306],"developing":[136,158],"heart":[137],"analyzed":[139],"situ":[143],"hybridization.":[144],"expressed":[147],"asymmetrically":[148],"(on":[149,154],"right)":[151],"left)":[156],"mouse":[159,163],"embryos,":[160],"including":[161],"embryonic":[164],"sinoatrial":[165],"cells.":[167],"utilized":[169],"CRISPR/Cas9":[170],"genome":[171],"editing":[172],"mice":[174,180,298,329],"target":[176],"generating":[179],"lacking":[181,330],"transcript":[184,334],"(":[185],"Ex1sj":[187,206,228,235,248,280,296],"allele).":[188],"Using":[189],"qRT-PCR":[190],"we":[191],"detected":[192,216],"upregulation":[193],"isoform,":[197],"Pitx2c":[198],"during":[200],"visceral":[201],"morphogenesis":[203],"mutant":[207,229,236,249,297],"embryos.":[208],"Surface":[209],"ECG":[210,215],"(AliveCor\u00ae)":[211],"24-hour":[213],"telemetry":[214],"bradycardia":[217],"irregular":[219],"interbeat":[220],"(R-R)":[221],"intervals":[222],"suggestive":[223],"SND":[225,372],"adults.":[230],"Programmed":[231],"stimulation":[232],"adults":[237],"resulted":[238],"pacing-induced":[240],"AF.":[241,342,374],"Within":[242],"atrium":[245],"hearts,":[250],"Masson\u2019s":[251],"trichrome":[252],"stain":[253],"revealed":[254,304],"increased":[255,339],"collagen":[256],"deposition":[257],"indicative":[258],"fibrosis,":[260,315],"immunofluorescence":[262],"demonstrated":[263],"mis-localization":[264],"Connexin":[266],"43":[267],"cardiomyocytes.":[270],"These":[271,343],"findings":[272],"suggested":[273],"an":[274],"altered":[275],"substrate":[277],"adult":[281],"mice.":[282,354],"Finally,":[283],"transcriptomic":[284],"analysis":[285],"by":[286],"chromatin":[287],"run-on":[288],"sequencing":[290],"(ChRO-seq)":[291],"atria":[293],"compared":[299],"wild":[301],"type":[302],"controls":[303],"differential":[305],"genes":[308,322],"involved":[309],"cell-cell":[311],"adhesion":[312],"motility,":[314],"dysregulation":[317],"key":[320],"Tbx5":[323],"Hcn1":[325],"Conclusions":[327],"Adult":[328],"functional":[331],"lncRNA":[333],"have":[335],"baseline":[336],"bradyarrhythmia":[337],"susceptibility":[340,370],"phenotypes":[345],"are":[346],"similar":[347],"those":[349],"observed":[350],"heterozygous":[353],"Interactions":[355],"between":[356],"may":[360],"provide":[361],"genetic":[363],"mechanism":[364],"modulating":[366]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-09-27T00:00:00"}