{"id":"https://openalex.org/W4297090317","doi":"https://doi.org/10.1021/acsmedchemlett.2c00216","title":"Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1","display_name":"Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1","publication_year":2022,"publication_date":"2022-09-23","ids":{"openalex":"https://openalex.org/W4297090317","doi":"https://doi.org/10.1021/acsmedchemlett.2c00216","pmid":"https://pubmed.ncbi.nlm.nih.gov/36262391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9575160"},"language":"en","primary_location":{"id":"doi:10.1021/acsmedchemlett.2c00216","doi":"https://doi.org/10.1021/acsmedchemlett.2c00216","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.2c00216","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9575160","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052998813","display_name":"Melanie M. Domenech Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-6610-6890","observed_orcids":["https://orcid.org/0000-0002-6610-6890"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Rodriguez","raw_affiliation_strings":["Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061121815","display_name":"Ashari Rashmi Kannangara","orcid":"https://orcid.org/0000-0003-3100-9676","observed_orcids":["https://orcid.org/0000-0003-3100-9676"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashari Kannangara","raw_affiliation_strings":["Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063575403","display_name":"Julita Chlebowicz","orcid":"https://orcid.org/0000-0002-0437-0338","observed_orcids":["https://orcid.org/0000-0002-0437-0338"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julita Chlebowicz","raw_affiliation_strings":["Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States"],"raw_orcid":"https://orcid.org/0000-0002-0437-0338","affiliations":[{"raw_affiliation_string":"Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021430416","display_name":"Radha Akella","orcid":"https://orcid.org/0000-0003-1488-1091","observed_orcids":["https://orcid.org/0000-0003-1488-1091"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Radha Akella","raw_affiliation_strings":["Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829470","display_name":"Haixia He","orcid":"https://orcid.org/0000-0002-9237-3474","observed_orcids":["https://orcid.org/0000-0002-9237-3474"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haixia He","raw_affiliation_strings":["Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054143843","display_name":"Uttam K. Tambar","orcid":"https://orcid.org/0000-0001-5659-5355","observed_orcids":["https://orcid.org/0000-0001-5659-5355"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Uttam K. Tambar","raw_affiliation_strings":["Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States"],"raw_orcid":"https://orcid.org/0000-0001-5659-5355","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086387871","display_name":"Elizabeth J. Goldsmith","orcid":"https://orcid.org/0000-0001-8102-5012","observed_orcids":["https://orcid.org/0000-0001-8102-5012"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth J. Goldsmith","raw_affiliation_strings":["Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States"],"raw_orcid":"https://orcid.org/0000-0001-8102-5012","affiliations":[{"raw_affiliation_string":"Department of Biophysics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, United States","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054143843","https://openalex.org/A5086387871"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.2854,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.38241133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"10","first_page":"1678","last_page":"1684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.24660000205039978,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.1543000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnk1","display_name":"WNK1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/wnk-kinases","display_name":"WNK kinases","score":0.8040000200271606},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/protein-kinase-inhibition","display_name":"protein kinase inhibition","score":0.5680000185966492},{"id":"https://openalex.org/keywords/inhibitor-binding-site","display_name":"inhibitor binding site","score":0.6909999847412109},{"id":"https://openalex.org/keywords/active-site-binding","display_name":"active site binding","score":0.6570000052452087},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5270000100135803},{"id":"https://openalex.org/keywords/high-throughput-screening-hits","display_name":"high-throughput screening hits","score":0.7599999904632568},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2778806918","wikidata":"https://www.wikidata.org/wiki/Q411193","display_name":"Sulfone","level":2,"score":0.9452165365219116},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6584653258323669},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.6308823823928833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5293760299682617},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.49061480164527893},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4839332699775696},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46725910902023315},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4136786162853241},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35928863286972046},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3449695110321045},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32689395546913147},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.30554696917533875},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09022191166877747}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1021/acsmedchemlett.2c00216","doi":"https://doi.org/10.1021/acsmedchemlett.2c00216","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsmedchemlett.2c00216","pdf_url":null,"source":{"id":"https://openalex.org/S191852912","display_name":"ACS Medicinal Chemistry Letters","issn_l":"1948-5875","issn":["1948-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9575160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9575160","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},{"id":"pmid:36262391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36262391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9575160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9575160","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Med Chem Lett","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1350236299","display_name":null,"funder_award_id":"16SA285300002","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G1590088021","display_name":null,"funder_award_id":"DK110358","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2641225326","display_name":null,"funder_award_id":"I-2100-20220331","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G466936045","display_name":null,"funder_award_id":"I-1748","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G6017890110","display_name":"Cancer Biology Training Grant","funder_award_id":"T32CA124334","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7229083455","display_name":"Structure-based Drug Design of Inhibitors for a Breast Cancer Signature Kinase","funder_award_id":"RP190421","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G7621392404","display_name":null,"funder_award_id":"14GRNT20500035","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G9000865029","display_name":"Regulation of WNK signaling by potassium and Mo25: structure, function and physiology","funder_award_id":"R01DK110358","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320314871","display_name":"W. W. Caruth, Jr. Foundation","ror":"https://ror.org/01p15ax39"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1822076535","https://openalex.org/W1937853139","https://openalex.org/W1994685053","https://openalex.org/W2012282709","https://openalex.org/W2075464225","https://openalex.org/W2076114632","https://openalex.org/W2077804275","https://openalex.org/W2079156404","https://openalex.org/W2092544528","https://openalex.org/W2097066538","https://openalex.org/W2104847547","https://openalex.org/W2104993130","https://openalex.org/W2131510524","https://openalex.org/W2131589269","https://openalex.org/W2146920291","https://openalex.org/W2159082261","https://openalex.org/W2341542918","https://openalex.org/W2516723064","https://openalex.org/W2527765961","https://openalex.org/W2594294602","https://openalex.org/W2742945088","https://openalex.org/W2754972833","https://openalex.org/W2897075077","https://openalex.org/W3019266968","https://openalex.org/W3183120444"],"related_works":["https://openalex.org/W6982321934","https://openalex.org/W4417356660","https://openalex.org/W2792511144","https://openalex.org/W2605074328","https://openalex.org/W2940769527","https://openalex.org/W2527765961","https://openalex.org/W2599827720","https://openalex.org/W7162438735","https://openalex.org/W2742945088","https://openalex.org/W2133185088"],"abstract_inverted_index":{"With":[0],"No":[1],"lysine":[2],"(K)":[3],"[WNK]":[4],"kinases":[5,11],"are":[6],"structurally":[7],"unique":[8],"serine/threonine":[9],"protein":[10],"that":[12,67],"have":[13],"therapeutic":[14],"potential":[15],"for":[16,56,116,129],"blood":[17],"pressure":[18],"regulation":[19],"and":[20,63,86,137],"cancer.":[21],"A":[22],"novel":[23,113,124],"class":[24],"of":[25,40,47,58,71,83,100,122,133],"trihalo-sulfone":[26,84,89,118],"compounds":[27],"was":[28],"identified":[29],"by":[30],"high-throughput":[31],"screening.":[32],"Trihalo-sulfone":[33],"1":[34,85],"emerged":[35],"as":[36,109,111],"an":[37,43],"effective":[38],"inhibitor":[39,106],"WNK1":[41,59,93],"with":[42],"IC":[44],"50":[45],"value":[46],"1.6":[48],"\u03bcM.":[49],"Herein,":[50],"we":[51],"define":[52],"chemical":[53,61],"features":[54],"necessary":[55],"inhibition":[57],"using":[60],"synthesis":[62],"X-ray":[64,81],"crystallography.":[65],"Analogues":[66],"probed":[68],"the":[69,76,101,117,130],"role":[70],"specific":[72],"functional":[73],"groups":[74],"to":[75,92,98],"inhibitory":[77],"activity":[78],"were":[79],"synthesized.":[80],"structures":[82],"a":[87,112],"second":[88],"23":[90],"bound":[91],"revealed":[94],"active":[95],"site":[96,115],"binding":[97,107,114],"two":[99],"three":[102],"previously":[103],"defined":[104],"canonical":[105],"pockets":[108],"well":[110],"moiety.":[119],"The":[120],"elucidation":[121],"these":[123],"interaction":[125],"sites":[126],"may":[127],"allow":[128],"strategic":[131],"design":[132],"even":[134],"more":[135],"selective":[136],"potent":[138],"WNK":[139],"inhibitors.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-09-27T00:00:00"}
