{"id":"https://openalex.org/W4296993203","doi":"https://doi.org/10.3390/biomedicines10102369","title":"Serum CCL2 Is a Prognostic Biomarker for Non-Metastatic Castration-Sensitive Prostate Cancer","display_name":"Serum CCL2 Is a Prognostic Biomarker for Non-Metastatic Castration-Sensitive Prostate Cancer","publication_year":2022,"publication_date":"2022-09-22","ids":{"openalex":"https://openalex.org/W4296993203","doi":"https://doi.org/10.3390/biomedicines10102369","pmid":"https://pubmed.ncbi.nlm.nih.gov/36289628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9598117"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines10102369","doi":"https://doi.org/10.3390/biomedicines10102369","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10102369","pdf_url":"https://www.mdpi.com/2227-9059/10/10/2369/pdf?version=1663845153","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/10/10/2369/pdf?version=1663845153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009445050","display_name":"Hiroaki Iwamoto","orcid":"https://orcid.org/0000-0003-3599-2217","observed_orcids":["https://orcid.org/0000-0003-3599-2217"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Iwamoto","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3599-2217","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056369807","display_name":"Kouji Izumi","orcid":"https://orcid.org/0000-0002-8480-9100","observed_orcids":["https://orcid.org/0000-0002-8480-9100"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kouji Izumi","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8480-9100","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052920889","display_name":"Ryunosuke Nakagawa","orcid":"https://orcid.org/0000-0002-2503-8908","observed_orcids":["https://orcid.org/0000-0002-2503-8908"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryunosuke Nakagawa","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2503-8908","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073570932","display_name":"Ren Toriumi","orcid":"https://orcid.org/0000-0002-6951-8524","observed_orcids":["https://orcid.org/0000-0002-6951-8524"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ren Toriumi","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073237061","display_name":"Shuhei Aoyama","orcid":"https://orcid.org/0009-0009-0537-8057","observed_orcids":["https://orcid.org/0009-0009-0537-8057"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhei Aoyama","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032171493","display_name":"Taiki Kamijima","orcid":"https://orcid.org/0009-0003-2553-0497","observed_orcids":["https://orcid.org/0009-0003-2553-0497"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taiki Kamijima","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101481949","display_name":"Takafumi Shimada","orcid":"https://orcid.org/0000-0001-8753-0802","observed_orcids":["https://orcid.org/0000-0001-8753-0802"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Shimada","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112558517","display_name":"Hiroshi Kano","orcid":"https://orcid.org/0000-0002-3543-1236","observed_orcids":["https://orcid.org/0000-0002-3543-1236"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kano","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomoyuki Makino","orcid":"https://orcid.org/0000-0003-2554-7048","observed_orcids":["https://orcid.org/0000-0003-2554-7048"]},"institutions":[{"id":"https://openalex.org/I4210119324","display_name":"Ishikawa Prefectural Central Hospital","ror":"https://ror.org/02cv4ah81","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Makino","raw_affiliation_strings":["Department of Urology, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2554-7048","affiliations":[{"raw_affiliation_string":"Department of Urology, Ishikawa Prefectural Central Hospital, Kanazawa 920-8530, Japan","institution_ids":["https://openalex.org/I4210119324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111154943","display_name":"Renato Naito","orcid":"https://orcid.org/0000-0002-3936-7235","observed_orcids":["https://orcid.org/0000-0002-3936-7235"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Renato Naito","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075703460","display_name":"Suguru Kadomoto","orcid":"https://orcid.org/0000-0003-4136-8998","observed_orcids":["https://orcid.org/0000-0003-4136-8998"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Suguru Kadomoto","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040788925","display_name":"Hiroshi Yaegashi","orcid":"https://orcid.org/0000-0003-3188-8834","observed_orcids":["https://orcid.org/0000-0003-3188-8834"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yaegashi","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3188-8834","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033402086","display_name":"Shohei Kawaguchi","orcid":"https://orcid.org/0000-0001-6847-9861","observed_orcids":["https://orcid.org/0000-0001-6847-9861"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Kawaguchi","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024925008","display_name":"Takahiro Nohara","orcid":"https://orcid.org/0000-0001-9792-2068","observed_orcids":["https://orcid.org/0000-0001-9792-2068"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Nohara","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051605638","display_name":"Kazuyoshi Shigehara","orcid":"https://orcid.org/0000-0002-2118-9135","observed_orcids":["https://orcid.org/0000-0002-2118-9135"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Shigehara","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2118-9135","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039868774","display_name":"Yoshifumi Kadono","orcid":"https://orcid.org/0000-0001-5780-4032","observed_orcids":["https://orcid.org/0000-0001-5780-4032"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi Kadono","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5780-4032","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036460015","display_name":"Atsushi Mizokami","orcid":"https://orcid.org/0000-0002-5643-2182","observed_orcids":["https://orcid.org/0000-0002-5643-2182"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Mizokami","raw_affiliation_strings":["Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5643-2182","affiliations":[{"raw_affiliation_string":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan","institution_ids":["https://openalex.org/I10091056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056369807"],"corresponding_institution_ids":["https://openalex.org/I10091056"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":0.6975,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.59902649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"10","issue":"10","first_page":"2369","last_page":"2369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7459999918937683},{"id":"https://openalex.org/keywords/visceral-metastasis","display_name":"visceral metastases","score":0.7360000014305115},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.8799999952316284},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8586243391036987},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8274365067481995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7940810322761536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6134762763977051},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6130551099777222},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4737328290939331},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.44081833958625793},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.42968106269836426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4232603907585144},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.414799302816391},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.4130641520023346},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4106655716896057},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.38331979513168335},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.32673951983451843},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1249367892742157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06131628155708313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines10102369","doi":"https://doi.org/10.3390/biomedicines10102369","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10102369","pdf_url":"https://www.mdpi.com/2227-9059/10/10/2369/pdf?version=1663845153","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:36289628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36289628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9598117","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9598117/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3613733106ca4940a5b5491b9ec4c496","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3613733106ca4940a5b5491b9ec4c496","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 10, Iss 10, p 2369 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines10102369","doi":"https://doi.org/10.3390/biomedicines10102369","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines10102369","pdf_url":"https://www.mdpi.com/2227-9059/10/10/2369/pdf?version=1663845153","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6258372554","display_name":"KRAS Activation in Double-Negative Prostate Cancer","funder_award_id":"22K09495","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7531065908","display_name":"Elucidation of the mechanism of action of chemokines and immune mechanisms in the acquisition of cabazitaxel resistance","funder_award_id":"21K16728","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296993203.pdf","grobid_xml":"https://content.openalex.org/works/W4296993203.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1770846351","https://openalex.org/W1984285433","https://openalex.org/W1988176837","https://openalex.org/W1992164020","https://openalex.org/W1995181448","https://openalex.org/W1997691329","https://openalex.org/W2002535198","https://openalex.org/W2012475333","https://openalex.org/W2014229457","https://openalex.org/W2015260142","https://openalex.org/W2018183502","https://openalex.org/W2024338865","https://openalex.org/W2036610808","https://openalex.org/W2046208657","https://openalex.org/W2066255007","https://openalex.org/W2077380927","https://openalex.org/W2105860930","https://openalex.org/W2106058419","https://openalex.org/W2107151134","https://openalex.org/W2117792530","https://openalex.org/W2122794487","https://openalex.org/W2123635819","https://openalex.org/W2127877679","https://openalex.org/W2148987788","https://openalex.org/W2160217483","https://openalex.org/W2161784528","https://openalex.org/W2166693531","https://openalex.org/W2292939892","https://openalex.org/W2624639454","https://openalex.org/W2786357651","https://openalex.org/W2901246164","https://openalex.org/W2922155217","https://openalex.org/W2923649249","https://openalex.org/W2974532703","https://openalex.org/W2979477227","https://openalex.org/W3023412268","https://openalex.org/W3041326846","https://openalex.org/W3091897481","https://openalex.org/W3097158220","https://openalex.org/W3110821598","https://openalex.org/W3132590495","https://openalex.org/W3189664645","https://openalex.org/W3191534679","https://openalex.org/W3209273929","https://openalex.org/W4206841660","https://openalex.org/W4220806363","https://openalex.org/W4249522930","https://openalex.org/W4283204206"],"related_works":["https://openalex.org/W4283204206","https://openalex.org/W2292939892","https://openalex.org/W1995181448","https://openalex.org/W7098433222","https://openalex.org/W4211071621","https://openalex.org/W7097584322","https://openalex.org/W4401419737","https://openalex.org/W7133235817","https://openalex.org/W3091889156","https://openalex.org/W1975005489"],"abstract_inverted_index":{"Purpose:":[0],"Prostate-specific":[1],"antigen":[2],"(PSA)":[3],"is":[4,204],"a":[5,36,68,121,173,213],"useful":[6],"prostate":[7,53,85,114],"cancer":[8,54],"(PC)":[9],"biomarker,":[10,40],"but":[11,41],"some":[12],"cases":[13],"reported":[14,33],"that":[15],"PSA":[16,39],"does":[17],"not":[18],"correlate":[19],"with":[20,100,111,196],"the":[21,60,108,205],"Gleason":[22,149],"score.":[23],"Serum":[24,62,76,170],"chemokine":[25],"(CC":[26],"motif)":[27],"ligand":[28],"2":[29],"(CCL2)":[30],"has":[31],"been":[32],"to":[34,50,93,207,215],"be":[35,48],"potential":[37],"complementary":[38],"it":[42,46],"remains":[43],"unclear":[44],"whether":[45],"can":[47],"applied":[49],"non-metastatic":[51],"castration-sensitive":[52],"(nmCSPC)":[55],"or":[56],"each":[57],"section":[58],"of":[59,97,107,133,162],"stages.":[61],"CCL2\u2032s":[63],"usefulness":[64],"was":[65,125,136,172],"investigated":[66,126],"as":[67,120,212],"prognostic":[69,122],"nmCSPC":[70,101,123],"biomarker":[71,124,175,214],"in":[72,104,146,167,180,220],"this":[73,105],"study.":[74],"Methods:":[75],"samples":[77],"were":[78,102,158],"collected":[79],"from":[80,91],"379":[81],"patients":[82,99,110,187],"who":[83],"underwent":[84],"biopsy":[86],"at":[87],"Kanazawa":[88],"University":[89],"Hospital":[90],"2007":[92],"2013.":[94],"A":[95],"total":[96],"230":[98],"included":[103],"study":[106,203],"255":[109],"histologically":[112],"diagnosed":[113],"cancer.":[115],"The":[116],"serum":[117,209],"CCL2":[118,137,154,171,183,197,210],"efficacy":[119],"retrospectively.":[127],"Results:":[128],"An":[129],"independent":[130,159],"significant":[131,160],"predictor":[132],"worse":[134,190],"OS":[135,177,217],"\u2265":[138,143,151,155,184],"280":[139,156,185,199],"pg/dL":[140,157],"and":[141,153,178,218],"CRP":[142],"0.5":[144],"mg/dL":[145],"multivariate":[147,168],"analysis.":[148,169],"score":[150],"8":[152],"predictors":[161],"CRPC-free":[163],"survival":[164,193],"(CFS)":[165],"worsening":[166],"predictive":[174],"for":[176],"CFS":[179,219],"nmCSPC.":[181,221],"Furthermore,":[182],"pg/mL":[186],"had":[188],"significantly":[189],"visceral":[191],"metastasis-free":[192],"than":[194],"those":[195],"<":[198],"pg/mL.":[200],"Conclusion:":[201],"This":[202],"first":[206],"demonstrate":[208],"utility":[211],"predict":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-25T00:00:00"}
