{"id":"https://openalex.org/W4296964928","doi":"https://doi.org/10.1016/s2152-2650(22)00978-8","title":"Poster: MPN-469 Rusfertide (PTG-300) Treatment Interruption Reverses Hematological Gains and Upon Reinitiation, Restoration of Clinical Benefit Observed in Patients With Polycythemia Vera","display_name":"Poster: MPN-469 Rusfertide (PTG-300) Treatment Interruption Reverses Hematological Gains and Upon Reinitiation, Restoration of Clinical Benefit Observed in Patients With Polycythemia Vera","publication_year":2022,"publication_date":"2022-09-20","ids":{"openalex":"https://openalex.org/W4296964928","doi":"https://doi.org/10.1016/s2152-2650(22)00978-8"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(22)00978-8","doi":"https://doi.org/10.1016/s2152-2650(22)00978-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)00978-8","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088307376","display_name":"Naveen Pemmaraju","orcid":"https://orcid.org/0000-0002-1670-6513","observed_orcids":["https://orcid.org/0000-0002-1670-6513"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Pemmaraju","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047764826","display_name":"Andrew Tucker Kuykendall","orcid":"https://orcid.org/0000-0002-9040-7415","observed_orcids":["https://orcid.org/0000-0002-9040-7415"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Kuykendall","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065098368","display_name":"Marina Kremyanskaya","orcid":"https://orcid.org/0000-0002-8912-3757","observed_orcids":["https://orcid.org/0000-0002-8912-3757"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Kremyanskaya","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai Hospital, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018349748","display_name":"Yelena Z. Ginzburg","orcid":"https://orcid.org/0000-0002-3496-3783","observed_orcids":["https://orcid.org/0000-0002-3496-3783"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yelena Ginzburg","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai Hospital, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078887304","display_name":"Ellen Kelly Ritchie","orcid":"https://orcid.org/0000-0001-8150-5542","observed_orcids":["https://orcid.org/0000-0001-8150-5542"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Ritchie","raw_affiliation_strings":["New York Presbyterian Hospital - Weill Cornell Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Presbyterian Hospital - Weill Cornell Medical Center, New York, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Gotlib","raw_affiliation_strings":["Stanford Hospital, Palo Alto, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital, Palo Alto, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023728016","display_name":"Aaron Thomas Gerds","orcid":"https://orcid.org/0000-0002-3422-1309","observed_orcids":["https://orcid.org/0000-0002-3422-1309"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Gerds","raw_affiliation_strings":["Cleveland Clinic Taussig Cancer Center, Cleveland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Taussig Cancer Center, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057941081","display_name":"Jeanne M. Palmer","orcid":"https://orcid.org/0000-0002-2185-1504","observed_orcids":["https://orcid.org/0000-0002-2185-1504"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanne Palmer","raw_affiliation_strings":["Mayo Clinic Hospital, Phoenix, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Hospital, Phoenix, USA","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059414971","display_name":"Frank H. Valone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091875","display_name":"Protagonist Therapeutics (United States)","ror":"https://ror.org/00bp7kt89","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Valone","raw_affiliation_strings":["Protagonist Therapeutics, Inc, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protagonist Therapeutics, Inc, Newark, USA","institution_ids":["https://openalex.org/I4210091875"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paula O'Connor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091875","display_name":"Protagonist Therapeutics (United States)","ror":"https://ror.org/00bp7kt89","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula O'Connor","raw_affiliation_strings":["Protagonist Therapeutics, Inc, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protagonist Therapeutics, Inc, Newark, USA","institution_ids":["https://openalex.org/I4210091875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105184029","display_name":"Nishit B. Modi","orcid":"https://orcid.org/0000-0002-5111-867X","observed_orcids":["https://orcid.org/0000-0002-5111-867X"]},"institutions":[{"id":"https://openalex.org/I4210091875","display_name":"Protagonist Therapeutics (United States)","ror":"https://ror.org/00bp7kt89","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishit Modi","raw_affiliation_strings":["Protagonist Therapeutics, Inc, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protagonist Therapeutics, Inc, Newark, USA","institution_ids":["https://openalex.org/I4210091875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101767697","display_name":"Suneel Gupta","orcid":"https://orcid.org/0000-0001-7813-9940","observed_orcids":["https://orcid.org/0000-0001-7813-9940"]},"institutions":[{"id":"https://openalex.org/I4210091875","display_name":"Protagonist Therapeutics (United States)","ror":"https://ror.org/00bp7kt89","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suneel Gupta","raw_affiliation_strings":["Protagonist Therapeutics, Inc, Newark, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protagonist Therapeutics, Inc, Newark, USA","institution_ids":["https://openalex.org/I4210091875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006372952","display_name":"Ronald Hoffman","orcid":"https://orcid.org/0000-0001-6564-6732","observed_orcids":["https://orcid.org/0000-0001-6564-6732"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Hoffman","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai Hospital, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai Hospital, New York, USA","institution_ids":["https://openalex.org/I1324220072","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085521139","display_name":"Sr\u0111an Verstov\u0161ek","orcid":"https://orcid.org/0000-0002-6912-8569","observed_orcids":["https://orcid.org/0000-0002-6912-8569"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srdan Verstovsek","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15740253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":null,"first_page":"S159","last_page":"S159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.9049999713897705},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hematological-response","display_name":"hematologic response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/reinitiation","display_name":"reinitiation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.44600000977516174},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.9255645275115967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5756497383117676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37104272842407227}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(22)00978-8","doi":"https://doi.org/10.1016/s2152-2650(22)00978-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)00978-8","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296963604","https://openalex.org/W4386270852","https://openalex.org/W7204684062","https://openalex.org/W7204686762","https://openalex.org/W4296531433","https://openalex.org/W4386277469","https://openalex.org/W4283390908","https://openalex.org/W7222818590","https://openalex.org/W7204719377","https://openalex.org/W3214048855"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-09-25T00:00:00"}