{"id":"https://openalex.org/W4296887231","doi":"https://doi.org/10.1016/j.bbr.2022.114119","title":"Therapeutic hypothermia demonstrates sex-dependent improvements in motor function in a rat model of neonatal hypoxic ischemic encephalopathy","display_name":"Therapeutic hypothermia demonstrates sex-dependent improvements in motor function in a rat model of neonatal hypoxic ischemic encephalopathy","publication_year":2022,"publication_date":"2022-09-23","ids":{"openalex":"https://openalex.org/W4296887231","doi":"https://doi.org/10.1016/j.bbr.2022.114119","pmid":"https://pubmed.ncbi.nlm.nih.gov/36162642"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2022.114119","doi":"https://doi.org/10.1016/j.bbr.2022.114119","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2022.114119","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064813211","display_name":"Angela Saadat","orcid":"https://orcid.org/0000-0002-4351-6387","observed_orcids":["https://orcid.org/0000-0002-4351-6387"]},"institutions":[{"id":"https://openalex.org/I4210126004","display_name":"Children's Specialty Group","ror":"https://ror.org/036tjv560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Angela Saadat","raw_affiliation_strings":["Neonatal Brain Institute, Children's Specialty Group, USA. Electronic address: saadatap@evms.edu","Neonatal Brain Institute, Children's Specialty Group, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA. Electronic address: saadatap@evms.edu","institution_ids":["https://openalex.org/I4210126004"]},{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA","institution_ids":["https://openalex.org/I4210126004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055159032","display_name":"Ashley A. Blackwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Blackwell","raw_affiliation_strings":["Center for Integrative Neuroinflammatory and Inflammatory Diseases, USA; Dept. Radiation Oncology, Eastern Virginia Medical School, USA","Center for Integrative Neuroinflammatory and Inflammatory Diseases, USA","Dept. Radiation Oncology, Eastern Virginia Medical School, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Neuroinflammatory and Inflammatory Diseases, USA; Dept. Radiation Oncology, Eastern Virginia Medical School, USA","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Center for Integrative Neuroinflammatory and Inflammatory Diseases, USA","institution_ids":[]},{"raw_affiliation_string":"Dept. Radiation Oncology, Eastern Virginia Medical School, USA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047853430","display_name":"Cortney L. Kaszowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126004","display_name":"Children's Specialty Group","ror":"https://ror.org/036tjv560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cortney Kaszowski","raw_affiliation_strings":["Neonatal Brain Institute, Children's Specialty Group, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA","institution_ids":["https://openalex.org/I4210126004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080688879","display_name":"Haree K. Pallera","orcid":"https://orcid.org/0000-0002-4576-1626","observed_orcids":["https://orcid.org/0000-0002-4576-1626"]},"institutions":[{"id":"https://openalex.org/I4210126004","display_name":"Children's Specialty Group","ror":"https://ror.org/036tjv560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haree Pallera","raw_affiliation_strings":["Neonatal Brain Institute, Children's Specialty Group, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA","institution_ids":["https://openalex.org/I4210126004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020353505","display_name":"Daley Owens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126004","display_name":"Children's Specialty Group","ror":"https://ror.org/036tjv560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daley Owens","raw_affiliation_strings":["Neonatal Brain Institute, Children's Specialty Group, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA","institution_ids":["https://openalex.org/I4210126004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019114414","display_name":"Frank A. Lattanzio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Lattanzio","raw_affiliation_strings":["Dept. Physiological Sciences, Eastern Virginia Medical School, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Physiological Sciences, Eastern Virginia Medical School, USA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069037327","display_name":"Tushar A. Shah","orcid":"https://orcid.org/0000-0001-5962-1838","observed_orcids":["https://orcid.org/0000-0001-5962-1838"]},"institutions":[{"id":"https://openalex.org/I4210126004","display_name":"Children's Specialty Group","ror":"https://ror.org/036tjv560","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tushar Shah","raw_affiliation_strings":["Neonatal Brain Institute, Children's Specialty Group, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatal Brain Institute, Children's Specialty Group, USA","institution_ids":["https://openalex.org/I4210126004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064813211"],"corresponding_institution_ids":["https://openalex.org/I4210126004"],"apc_list":{"value":3120,"currency":"USD","value_usd":3120},"apc_paid":null,"fwci":2.3493,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.87130757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"437","issue":null,"first_page":"114119","last_page":"114119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neonatal-hypoxic-ischemic-encephalopathy","display_name":"neonatal hypoxic-ischemic encephalopathy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8669999837875366},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fine-motor-deficits","display_name":"fine motor deficits","score":0.6140000224113464},{"id":"https://openalex.org/keywords/beam-walking-test","display_name":"beam walking test","score":0.7440000176429749},{"id":"https://openalex.org/keywords/food-handling","display_name":"food handling","score":0.6209999918937683},{"id":"https://openalex.org/keywords/brain-lesions","display_name":"brain lesions","score":0.6000000238418579},{"id":"https://openalex.org/keywords/glial-scar","display_name":"glial scar","score":0.75}],"concepts":[{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.7166123390197754},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6919490098953247},{"id":"https://openalex.org/C2909832856","wikidata":"https://www.wikidata.org/wiki/Q2249526","display_name":"Hypoxic Ischemic Encephalopathy","level":3,"score":0.6726511716842651},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.538655698299408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.523885190486908},{"id":"https://openalex.org/C2778646069","wikidata":"https://www.wikidata.org/wiki/Q5468632","display_name":"Forelimb","level":2,"score":0.5159695744514465},{"id":"https://openalex.org/C105083479","wikidata":"https://www.wikidata.org/wiki/Q181497","display_name":"Sexual dimorphism","level":2,"score":0.5008630752563477},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.47209805250167847},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.43307745456695557},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.41867533326148987},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3508882522583008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30535638332366943},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12107694149017334}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbr.2022.114119","doi":"https://doi.org/10.1016/j.bbr.2022.114119","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2022.114119","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:36162642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36162642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W13425038","https://openalex.org/W1503832746","https://openalex.org/W1830337612","https://openalex.org/W1979510957","https://openalex.org/W1985230697","https://openalex.org/W1985626627","https://openalex.org/W1992171726","https://openalex.org/W1993467197","https://openalex.org/W1996133445","https://openalex.org/W2005779668","https://openalex.org/W2021935429","https://openalex.org/W2031634095","https://openalex.org/W2033381681","https://openalex.org/W2034975436","https://openalex.org/W2043677565","https://openalex.org/W2063564641","https://openalex.org/W2071973307","https://openalex.org/W2075296781","https://openalex.org/W2078889033","https://openalex.org/W2079012288","https://openalex.org/W2099540110","https://openalex.org/W2112357770","https://openalex.org/W2112963538","https://openalex.org/W2128592628","https://openalex.org/W2136967026","https://openalex.org/W2137052344","https://openalex.org/W2156900094","https://openalex.org/W2158239158","https://openalex.org/W2164664134","https://openalex.org/W2173823500","https://openalex.org/W2255165019","https://openalex.org/W2290170587","https://openalex.org/W2318430412","https://openalex.org/W2508584674","https://openalex.org/W2565195647","https://openalex.org/W2609462571","https://openalex.org/W2732500064","https://openalex.org/W2763586928","https://openalex.org/W2802749768","https://openalex.org/W2809180743","https://openalex.org/W2887114371","https://openalex.org/W2893082834","https://openalex.org/W2949246003","https://openalex.org/W2953848025","https://openalex.org/W2954723826","https://openalex.org/W3003488675","https://openalex.org/W3005474003","https://openalex.org/W3036478383","https://openalex.org/W3102718518","https://openalex.org/W3120044069","https://openalex.org/W3129666432","https://openalex.org/W3130047710","https://openalex.org/W3170983582","https://openalex.org/W3177095944","https://openalex.org/W4220820480","https://openalex.org/W4225412261","https://openalex.org/W4249331818","https://openalex.org/W4281261175"],"related_works":["https://openalex.org/W4310525414","https://openalex.org/W2255165019","https://openalex.org/W7204653093","https://openalex.org/W4283779216","https://openalex.org/W7115725830","https://openalex.org/W2587901628","https://openalex.org/W2461801998","https://openalex.org/W2081193490","https://openalex.org/W4388038599","https://openalex.org/W4414710156"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-24T00:00:00"}