{"id":"https://openalex.org/W4296794534","doi":"https://doi.org/10.3390/ijms231810497","title":"Lysophosphatidic Acid Promotes Epithelial\u2013Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy","display_name":"Lysophosphatidic Acid Promotes Epithelial\u2013Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy","publication_year":2022,"publication_date":"2022-09-10","ids":{"openalex":"https://openalex.org/W4296794534","doi":"https://doi.org/10.3390/ijms231810497","pmid":"https://pubmed.ncbi.nlm.nih.gov/36142408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500642"},"language":"en","primary_location":{"id":"doi:10.3390/ijms231810497","doi":"https://doi.org/10.3390/ijms231810497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810497","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10497/pdf?version=1663121557","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/18/10497/pdf?version=1663121557","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038768164","display_name":"Geon-Ho Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Geon-Ho Lee","raw_affiliation_strings":["College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076216075","display_name":"Jayeon Cheon","orcid":"https://orcid.org/0000-0002-6314-5747","observed_orcids":["https://orcid.org/0000-0002-6314-5747"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jayeon Cheon","raw_affiliation_strings":["College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414798","display_name":"Donghee Kim","orcid":"https://orcid.org/0000-0001-8773-6528","observed_orcids":["https://orcid.org/0000-0001-8773-6528"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Donghee Kim","raw_affiliation_strings":["Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea"],"raw_orcid":"https://orcid.org/0000-0001-8773-6528","affiliations":[{"raw_affiliation_string":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083258493","display_name":"Hee\u2010Sook Jun","orcid":"https://orcid.org/0000-0002-1166-4932","observed_orcids":["https://orcid.org/0000-0002-1166-4932"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]},{"id":"https://openalex.org/I4210088426","display_name":"Gachon University Gil Medical Center","ror":"https://ror.org/005nteb15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I12832649","https://openalex.org/I4210088426"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hee-Sook Jun","raw_affiliation_strings":["College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea","Gachon Medical Research Institute, Gil Hospital, Incheon 21565, Korea","Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea"],"raw_orcid":"https://orcid.org/0000-0002-1166-4932","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon 21936, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Gachon Medical Research Institute, Gil Hospital, Incheon 21565, Korea","institution_ids":["https://openalex.org/I4210088426"]},{"raw_affiliation_string":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea","institution_ids":["https://openalex.org/I12832649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083258493"],"corresponding_institution_ids":["https://openalex.org/I12832649","https://openalex.org/I4210088426"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.5376,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80472103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"23","issue":"18","first_page":"10497","last_page":"10497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6226000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lpar1","display_name":"LPAR1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mapk-akt-signaling","display_name":"MAPK/AKT signaling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/klf5","display_name":"KLF5","score":0.968999981880188},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6069999933242798},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9819999933242798},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7459999918937683},{"id":"https://openalex.org/keywords/renal-epithelial-cells","display_name":"renal epithelial cells","score":0.6710000038146973},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.8832170963287354},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6560432314872742},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6192747950553894},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5982010364532471},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5728667378425598},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5225655436515808},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4929225444793701},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46863722801208496},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4546012580394745},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44458621740341187},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39431828260421753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2609432339668274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22781828045845032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21838974952697754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21374589204788208},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.16405972838401794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08479246497154236},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020404","descriptor_name":"Glycerophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms231810497","doi":"https://doi.org/10.3390/ijms231810497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810497","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10497/pdf?version=1663121557","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36142408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36142408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9500642","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9500642/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms231810497","doi":"https://doi.org/10.3390/ijms231810497","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810497","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10497/pdf?version=1663121557","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1702413344","display_name":null,"funder_award_id":"HR14C0001","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2403942480","display_name":null,"funder_award_id":"2022R1A2C1006621","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G5057471333","display_name":null,"funder_award_id":"2019R1A2B5B02070355","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G7052237142","display_name":null,"funder_award_id":"HR14C0001","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G7421126669","display_name":null,"funder_award_id":"2022R1A2C1006621","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G946271847","display_name":null,"funder_award_id":"2019R1A2B5B02070355","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296794534.pdf","grobid_xml":"https://content.openalex.org/works/W4296794534.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W594344596","https://openalex.org/W833849825","https://openalex.org/W1204326888","https://openalex.org/W1835939522","https://openalex.org/W1964081206","https://openalex.org/W1964847767","https://openalex.org/W1972849081","https://openalex.org/W1987979328","https://openalex.org/W1989193425","https://openalex.org/W1997989669","https://openalex.org/W2005564970","https://openalex.org/W2010828866","https://openalex.org/W2011409573","https://openalex.org/W2013313780","https://openalex.org/W2016726176","https://openalex.org/W2028927090","https://openalex.org/W2031515819","https://openalex.org/W2032869210","https://openalex.org/W2054589040","https://openalex.org/W2056701883","https://openalex.org/W2056952939","https://openalex.org/W2063288300","https://openalex.org/W2098615703","https://openalex.org/W2100908727","https://openalex.org/W2108812575","https://openalex.org/W2130561540","https://openalex.org/W2148184356","https://openalex.org/W2154589460","https://openalex.org/W2162375246","https://openalex.org/W2170783508","https://openalex.org/W2266538168","https://openalex.org/W2340790095","https://openalex.org/W2470157805","https://openalex.org/W2558929801","https://openalex.org/W2560724952","https://openalex.org/W2577343906","https://openalex.org/W2582910361","https://openalex.org/W2588873696","https://openalex.org/W2612514553","https://openalex.org/W2739251986","https://openalex.org/W2886147354","https://openalex.org/W2891910239","https://openalex.org/W2903026494","https://openalex.org/W2912200865","https://openalex.org/W2913918016","https://openalex.org/W2915700009","https://openalex.org/W2943085601","https://openalex.org/W2950345003","https://openalex.org/W2950591949","https://openalex.org/W2971209630","https://openalex.org/W3023600430","https://openalex.org/W3036641704","https://openalex.org/W3042254299","https://openalex.org/W3112498053","https://openalex.org/W3116589830","https://openalex.org/W3118251246","https://openalex.org/W3128663446","https://openalex.org/W4229451861","https://openalex.org/W6754798940","https://openalex.org/W6756202791","https://openalex.org/W6758649289","https://openalex.org/W6762269767"],"related_works":["https://openalex.org/W2912200865","https://openalex.org/W2577343906","https://openalex.org/W2950345003","https://openalex.org/W4399637336","https://openalex.org/W4399849881","https://openalex.org/W4380086721","https://openalex.org/W1526831513","https://openalex.org/W2909378093","https://openalex.org/W2913918016","https://openalex.org/W3030548089"],"abstract_inverted_index":{"The":[0,182],"epithelial-mesenchymal":[1],"transition":[2],"(EMT)":[3],"is":[4,18],"a":[5,19,54],"differentiation":[6],"process":[7],"associated":[8],"with":[9,75,126,152],"fibrogenesis":[10],"in":[11,25,40,56,61,65,103,118,199],"diabetic":[12,70,238],"nephropathy":[13,239],"(DN).":[14],"Lysophosphatidic":[15],"acid":[16],"(LPA)":[17],"small,":[20],"naturally":[21],"occurring":[22],"glycerophospholipid":[23],"implicated":[24],"the":[26,35,41,49,66,80,90,94,134,163,166,204,235,252],"pathogenesis":[27,236],"of":[28,37,43,69,82,93,137,165,185,203,221,237,249],"DN.":[29],"In":[30,132,226],"this":[31,146],"study,":[32],"we":[33,107],"investigated":[34],"role":[36],"LPA/LPAR1":[38],"signaling":[39],"EMT":[42,84,186,224,242],"tubular":[44,245],"cells":[45],"as":[46,48],"well":[47],"underlying":[50],"mechanisms.":[51],"We":[52],"observed":[53],"decrease":[55],"E-cadherin":[57,112],"and":[58,73,98,114,139,145,154,188,213,223,243],"an":[59],"increase":[60],"vimentin":[62,116],"expression":[63,81,91,113,117,135,164,183,220],"levels":[64,92,136,184],"kidney":[67],"tubules":[68],"db/db":[71,104],"mice,":[72],"treatment":[74,87,125,151,178],"ki16425":[76,127,153],"(LPAR1/3":[77],"inhibitor)":[78],"inhibited":[79],"these":[83,228],"markers.":[85,225],"Ki16425":[86],"also":[88],"decreased":[89,111,175,195,218],"fibrotic":[95,189],"factors":[96,190],"fibronectin":[97,138],"alpha-smooth":[99],"muscle":[100],"actin":[101],"(\u03b1-SMA)":[102],"mice.":[105],"Similarly,":[106],"found":[108],"that":[109,231],"LPA":[110,161,193,232],"increased":[115,142],"HK-2":[119,200],"cells,":[120],"which":[121,173],"was":[122,148,174],"reversed":[123,149],"by":[124,143,150,157,176,192,240],"or":[128,156,179],"AM095":[129,155,177],"(LPAR1":[130],"inhibitor).":[131],"addition,":[133],"\u03b1-SMA":[140],"were":[141,194],"LPA,":[144],"effect":[147],"LPAR1":[158,180],"knockdown.":[159,181],"Moreover,":[160],"induced":[162,191],"transcription":[167],"factor,":[168],"Kr\u00fcppel-like":[169],"factor":[170],"5":[171],"(KLF5),":[172],"markers":[187],"upon":[196],"KLF5":[197,222,250],"knockdown":[198],"cells.":[201],"Inhibition":[202],"extracellular":[205],"signal-regulated":[206],"kinase":[207,211,215],"(ERK),":[208],"c-Jun":[209],"N-terminal":[210],"(JNK),":[212],"serine-threonine":[214],"(AKT)":[216],"pathways":[217],"LPA-induced":[219],"conclusion,":[227],"data":[229],"suggest":[230],"contributes":[233],"to":[234],"inducing":[241],"renal":[244],"fibrosis":[246],"via":[247],"regulation":[248],"through":[251],"LPAR1.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-09-24T00:00:00"}
