{"id":"https://openalex.org/W4296793607","doi":"https://doi.org/10.1371/journal.pone.0275175","title":"Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle","display_name":"Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle","publication_year":2022,"publication_date":"2022-09-23","ids":{"openalex":"https://openalex.org/W4296793607","doi":"https://doi.org/10.1371/journal.pone.0275175","pmid":"https://pubmed.ncbi.nlm.nih.gov/36149919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9506634"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0275175","doi":"https://doi.org/10.1371/journal.pone.0275175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0275175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275175&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027870370","display_name":"Yuichiro Honda","orcid":"https://orcid.org/0000-0002-8664-475X","observed_orcids":["https://orcid.org/0000-0002-8664-475X"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichiro Honda","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8664-475X","affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027447459","display_name":"Ayumi Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayumi Takahashi","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071739128","display_name":"Natsumi Tanaka","orcid":"https://orcid.org/0000-0002-7019-7748","observed_orcids":["https://orcid.org/0000-0002-7019-7748"]},"institutions":[{"id":"https://openalex.org/I149737473","display_name":"Seirei Christopher University","ror":"https://ror.org/02cd6sx47","country_code":"JP","type":"education","lineage":["https://openalex.org/I149737473"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsumi Tanaka","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Hamamatsu, Shizuoka, Japan","institution_ids":["https://openalex.org/I149737473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066638173","display_name":"Yasuhiro Kajiwara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165237","display_name":"Nagasaki University Hospital","ror":"https://ror.org/05kd3f793","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165237"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kajiwara","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Department of Rehabilitation, Nagasaki University Hospital, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Rehabilitation, Nagasaki University Hospital, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I4210165237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073305181","display_name":"Ryo Sasaki","orcid":"https://orcid.org/0000-0002-3943-2973","observed_orcids":["https://orcid.org/0000-0002-3943-2973"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Sasaki","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Department of Rehabilitation, Jyuzenkai Hospital, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Rehabilitation, Jyuzenkai Hospital, Nagasaki, Nagasaki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088295904","display_name":"Seima Okita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]},{"id":"https://openalex.org/I4405284692","display_name":"Japanese Red Cross Nagasaki Genbaku Hospital","ror":"https://ror.org/041r2wa07","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seima Okita","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Department of Rehabilitation, The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Rehabilitation, The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I4405284692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052979626","display_name":"Junya Sakamoto","orcid":"https://orcid.org/0000-0001-5621-2756","observed_orcids":["https://orcid.org/0000-0001-5621-2756"]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junya Sakamoto","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044847835","display_name":"Minoru Okita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Minoru Okita","raw_affiliation_strings":["Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044847835"],"corresponding_institution_ids":["https://openalex.org/I43777268"],"apc_list":{"value":1805,"currency":"USD","value_usd":1805},"apc_paid":{"value":1805,"currency":"USD","value_usd":1805},"fwci":0.9491,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69679403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"9","first_page":"e0275175","last_page":"e0275175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/muscle-contracture","display_name":"muscle contracture","score":0.8500000238418579},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.671999990940094},{"id":"https://openalex.org/keywords/immobilization","display_name":"immobilization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8149999976158142},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/macrophage-accumulation","display_name":"macrophage accumulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/murf1","display_name":"MuRF1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pressure-pain-threshold","display_name":"pressure pain threshold","score":0.8769999742507935},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7574200630187988},{"id":"https://openalex.org/C127607297","wikidata":"https://www.wikidata.org/wiki/Q11602751","display_name":"Muscle contracture","level":2,"score":0.6892769932746887},{"id":"https://openalex.org/C2776937108","wikidata":"https://www.wikidata.org/wiki/Q1480291","display_name":"Contracture","level":2,"score":0.6043663024902344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5620124340057373},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.5569860935211182},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5457413196563721},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.4510280191898346},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.42242738604545593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3433266878128052},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.3302425146102905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22415614128112793},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15297698974609375}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003286","descriptor_name":"Contracture","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003286","descriptor_name":"Contracture","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006909","descriptor_name":"Hydroxyproline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007103","descriptor_name":"Immobilization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063806","descriptor_name":"Myalgia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D063806","descriptor_name":"Myalgia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0275175","doi":"https://doi.org/10.1371/journal.pone.0275175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0275175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:36149919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36149919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01160:0005592815","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/27652","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9506634","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9506634/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e679625ac5cc4f27b6fc4953c8321ae9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e679625ac5cc4f27b6fc4953c8321ae9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 17, Iss 9, p e0275175 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0275175","doi":"https://doi.org/10.1371/journal.pone.0275175","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0275175","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275175&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1716146081","display_name":null,"funder_award_id":"20K20668 and 21H03291","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2451413917","display_name":"Development of preventive intervention strategies for inactivity-induced locomotive syndromes to extend healthy life expectancy in elderly people","funder_award_id":"23K21586","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2647311984","display_name":"Exploring the developmental mechanism of muscle contracture from the control system of mitochondrial dynamics","funder_award_id":"22K11419","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4874206680","display_name":"Investigation of molecular mechanisms involved in the pathogenesis of muscular contracture and development of physical therapeutic strategies","funder_award_id":"19K19795","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296793607.pdf","grobid_xml":"https://content.openalex.org/works/W4296793607.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1240635074","https://openalex.org/W1542412277","https://openalex.org/W1543036842","https://openalex.org/W1805974092","https://openalex.org/W1964330275","https://openalex.org/W1970679074","https://openalex.org/W1986144986","https://openalex.org/W2007897586","https://openalex.org/W2029093872","https://openalex.org/W2041140907","https://openalex.org/W2051696368","https://openalex.org/W2053348218","https://openalex.org/W2062130801","https://openalex.org/W2071554097","https://openalex.org/W2073649616","https://openalex.org/W2077502665","https://openalex.org/W2113657338","https://openalex.org/W2116208682","https://openalex.org/W2133109641","https://openalex.org/W2140760739","https://openalex.org/W2144553387","https://openalex.org/W2153010576","https://openalex.org/W2154899074","https://openalex.org/W2160581548","https://openalex.org/W2162539094","https://openalex.org/W2167033587","https://openalex.org/W2168602192","https://openalex.org/W2178875473","https://openalex.org/W2338333451","https://openalex.org/W2407926544","https://openalex.org/W2515750618","https://openalex.org/W2548494651","https://openalex.org/W2610462629","https://openalex.org/W2767734603","https://openalex.org/W2783770880","https://openalex.org/W2901174793","https://openalex.org/W3007022935","https://openalex.org/W3127186891","https://openalex.org/W3163452103"],"related_works":["https://openalex.org/W3163452103","https://openalex.org/W4408026398","https://openalex.org/W2884760476","https://openalex.org/W2286202611","https://openalex.org/W7084752426","https://openalex.org/W4396581180","https://openalex.org/W4401315213","https://openalex.org/W2973081950","https://openalex.org/W4409082228","https://openalex.org/W2154005996"],"abstract_inverted_index":{"PURPOSE:":[0],"Immobilization":[1],"of":[2,15,67,167,197,212,214],"skeletal":[3],"muscles":[4,139,159],"causes":[5],"muscle":[6,8,11,23,47,88,107,130,289],"atrophy,":[7,46,288],"contracture,":[9,48,290],"and":[10,49,76,87,101,106,126,129,171,175,190,209,228,238,250,260,291],"pain,":[12],"the":[13,73,136,153,156,169,176,180,188,202,205,210,217,226,236,247,251,258,269,277,295],"mechanisms":[14],"which":[16],"are":[17],"related":[18],"to":[19,135],"macrophage":[20,33],"accumulation.":[21,34],"However,":[22],"contractile":[24,89,108,131,274],"exercise":[25,39,90,109,132,275],"through":[26,276],"a":[27,92,111],"belt":[28,278],"electrode":[29,279],"device":[30,280],"may":[31,281],"mitigate":[32],"We":[35],"hypothesized":[36],"that":[37,245,267],"such":[38],"would":[40],"be":[41,282],"effective":[42,283],"in":[43,57,179,187,201,216,225,235,246,257,268,284,294],"preventing":[44,285],"myofiber":[45,287],"muscular":[50,292],"pain.":[51],"This":[52],"study":[53],"tested":[54],"this":[55],"hypothesis":[56],"immobilized":[58,85,104,296],"rat":[59,297],"gastrocnemius":[60,158,298],"muscle.":[61,299],"MATERIALS":[62],"AND":[63],"METHODS:":[64],"A":[65],"total":[66],"32":[68],"rats":[69],"were":[70,160,183,220,241],"divided":[71],"into":[72],"following":[74],"control":[75],"experimental":[77],"groups:":[78],"immobilization":[79,189,227,248,270],"(immobilized":[80],"treatment":[81,86,105],"only),":[82],"low-frequency":[83],"(LF;":[84],"with":[91,110],"2":[93,112,148],"s":[94,97,113,115],"(do)":[95],"/6":[96],"(rest)":[98,116],"duty":[99,117],"cycle),":[100],"high-frequency":[102],"(HF;":[103],"(do)/2":[114],"cycle).":[118],"Electrical":[119],"stimulation":[120],"was":[121,133,263],"performed":[122],"at":[123],"50":[124],"Hz":[125],"4.7":[127],"mA,":[128],"applied":[134],"lower":[137,184,265],"limb":[138],"for":[140,147,162],"15":[141],"or":[142],"20":[143],"min/session":[144],"(once":[145],"daily)":[146],"weeks":[149],"(6":[150],"times/week).":[151],"After":[152],"behavioral":[154],"tests,":[155],"bilateral":[157],"collected":[161],"analysis.":[163],"RESULTS:":[164],"The":[165,193,231],"number":[166],"macrophages,":[168],"Atrogin-1":[170],"MuRF-1":[172],"mRNA":[173,207],"expression,":[174,208],"hydroxyproline":[177],"content":[178,256],"HF":[181,218,239,261],"group":[182,219],"than":[185,223,244,266],"those":[186,224],"LF":[191,229,237,259],"groups.":[192,230],"cross-sectional":[194],"area":[195],"(CSA)":[196],"type":[198],"IIb":[199],"myofibers":[200],"superficial":[203],"region,":[204],"PGC-1\u03b1":[206],"range":[211],"motion":[213],"dorsiflexion":[215],"significantly":[221,242,264],"higher":[222,243],"pressure":[232],"pain":[233,293],"thresholds":[234],"groups":[240,262],"group,":[249],"nerve":[252],"growth":[253],"factor":[254],"(NGF)":[255],"group.":[271],"CONCLUSION:":[272],"Muscle":[273],"immobilization-induced":[286]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-24T00:00:00"}
