{"id":"https://openalex.org/W4296784809","doi":"https://doi.org/10.1155/2022/8385456","title":"Cefazolin/BMP\u20102\u2010Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects","display_name":"Cefazolin/BMP\u20102\u2010Loaded Mesoporous Silica Nanoparticles for the Repair of Open Fractures with Bone Defects","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4296784809","doi":"https://doi.org/10.1155/2022/8385456","pmid":"https://pubmed.ncbi.nlm.nih.gov/36193077","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9526639"},"language":"en","primary_location":{"id":"doi:10.1155/2022/8385456","doi":"https://doi.org/10.1155/2022/8385456","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8385456","pdf_url":"https://downloads.hindawi.com/journals/omcl/2022/8385456.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4296784809"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/omcl/2022/8385456.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008510580","display_name":"Mingkui Shen","orcid":"https://orcid.org/0000-0001-7684-1226","observed_orcids":["https://orcid.org/0000-0001-7684-1226"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingkui Shen","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444623","display_name":"Lulu Wang","orcid":"https://orcid.org/0000-0001-7466-9522","observed_orcids":["https://orcid.org/0000-0001-7466-9522","https://orcid.org/0009-0008-0104-970X"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Wang","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Feng","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110917812","display_name":"Chuangye Xu","orcid":"https://orcid.org/0000-0002-9554-4611","observed_orcids":["https://orcid.org/0000-0002-9554-4611"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuangye Xu","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072501746","display_name":"Yi Gao","orcid":"https://orcid.org/0000-0003-3525-0133","observed_orcids":["https://orcid.org/0000-0003-3525-0133"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Gao","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sijing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijing Li","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104085286","display_name":"Yulan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulan Wu","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042108511","display_name":"Guoxian Pei","orcid":"https://orcid.org/0000-0002-5089-5012","observed_orcids":["https://orcid.org/0000-0002-5089-5012"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoxian Pei","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-5089-5012","affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, 518055 Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042108511"],"corresponding_institution_ids":["https://openalex.org/I3045169105"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":0.7782,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.62034024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"2022","issue":"1","first_page":"8385456","last_page":"8385456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefazolin","display_name":"cefazolin","score":0.984000027179718},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/open-fractures","display_name":"open fractures","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6854004859924316},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.642237663269043},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.5838997960090637},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5626341700553894},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5261228680610657},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4620726704597473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33013367652893066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19137609004974365},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12133592367172241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09184041619300842},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07459962368011475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.058831363916397095},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002437","descriptor_name":"Cefazolin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005597","descriptor_name":"Fractures, Open","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1155/2022/8385456","doi":"https://doi.org/10.1155/2022/8385456","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8385456","pdf_url":"https://downloads.hindawi.com/journals/omcl/2022/8385456.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmid:36193077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36193077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9526639","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9526639/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2022/8385456","doi":"https://doi.org/10.1155/2022/8385456","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8385456","pdf_url":"https://downloads.hindawi.com/journals/omcl/2022/8385456.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7517626496","display_name":null,"funder_award_id":"Y01416214","funder_id":"https://openalex.org/F4320327605","funder_display_name":"Southern University of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320327605","display_name":"Southern University of Science and Technology","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296784809.pdf","grobid_xml":"https://content.openalex.org/works/W4296784809.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1517735842","https://openalex.org/W1598338190","https://openalex.org/W1964267129","https://openalex.org/W1967418591","https://openalex.org/W2041191822","https://openalex.org/W2048056641","https://openalex.org/W2069016923","https://openalex.org/W2076534710","https://openalex.org/W2090808401","https://openalex.org/W2124042548","https://openalex.org/W2132491361","https://openalex.org/W2165433466","https://openalex.org/W2170485626","https://openalex.org/W2194581180","https://openalex.org/W2396526078","https://openalex.org/W2518155806","https://openalex.org/W2551096367","https://openalex.org/W2607451500","https://openalex.org/W2612831414","https://openalex.org/W2770688707","https://openalex.org/W2778575740","https://openalex.org/W2782398916","https://openalex.org/W2795330436","https://openalex.org/W2801182474","https://openalex.org/W2803200986","https://openalex.org/W2803721053","https://openalex.org/W2804460675","https://openalex.org/W2811218362","https://openalex.org/W2845197751","https://openalex.org/W2892116115","https://openalex.org/W2901691612","https://openalex.org/W2978280775","https://openalex.org/W3046715402","https://openalex.org/W3127206044","https://openalex.org/W3164542753","https://openalex.org/W4239609946"],"related_works":["https://openalex.org/W4289133568","https://openalex.org/W2797396730","https://openalex.org/W2132219715","https://openalex.org/W3213224509","https://openalex.org/W4281765726","https://openalex.org/W4400594689","https://openalex.org/W2314858419","https://openalex.org/W3046715402","https://openalex.org/W2070346219","https://openalex.org/W2911585454"],"abstract_inverted_index":{"The":[0],"study":[1],"aimed":[2],"to":[3,12,72,133,158,183],"explore":[4],"the":[5,44,48,54,100,114,122,139,165,185,213,227],"feasibility":[6],"of":[7,46,53,187,201,215,241],"a":[8,21,67],"nanodrug":[9],"delivery":[10,31,116,141,167],"system":[11,142,168],"treat":[13],"open":[14,250],"fractures":[15,251],"with":[16,113,235,252],"bone":[17,59,68,123,135,173,218,242,253],"defects.":[18,243,254],"We":[19],"developed":[20,40],"cefazolin":[22],"(Cef)/bone":[23],"morphogenetic":[24],"protein":[25],"2":[26],"(BMP\u20102)@mesoporous":[27],"silica":[28],"nanoparticle":[29],"(MSN)":[30],"system;":[32],"meanwhile,":[33],"Cef/MBP\u20102@":[34],"poly(lactic\u2010co\u2010glycolic":[35],"acid)":[36],"(PLGA)":[37],"was":[38,177],"also":[39,197],"as":[41],"control.":[42],"For":[43],"purpose":[45],"determining":[47],"osteogenic":[49,162],"and":[50,65,88,95,130,153,189,191,203,223],"anti\u2010inflammatory":[51],"actions":[52],"nanodelivery":[55],"system,":[56,117],"we":[57,81,109],"cultured":[58],"marrow":[60],"mesenchymal":[61],"stem":[62],"cells":[63],"(BMSCs)":[64],"constructed":[66],"defect":[69,136,174],"mouse":[70],"model":[71],"evaluate":[73],"its":[74,161,181],"clinical":[75],"efficacy.":[76],"After":[77],"physicochemical":[78],"property":[79],"testing,":[80],"determined":[82],"that":[83,111],"MSN":[84,140,166],"had":[85],"good":[86],"stability":[87],"did":[89],"not":[90],"easily":[91],"accumulate":[92],"or":[93],"precipitate":[94],"it":[96,195],"could":[97,143,169,196],"effectively":[98,126,159,198],"prolong":[99],"Cef\u2019s":[101],"half\u2010life":[102],"by":[103],"nearly":[104],"eight":[105],"times.":[106],"In":[107],"BMSCs,":[108],"found":[110],"compared":[112],"PLGA":[115],"MSNs":[118],"better":[119,239],"penetrated":[120],"into":[121],"tissue,":[124],"thus":[125,207],"increasing":[127],"BMSCs\u2019":[128,145],"proliferation":[129],"migration":[131],"ability":[132,182],"facilitate":[134],"repair.":[137],"Furthermore,":[138,212],"improve":[144,160],"mineralization":[146],"indexes":[147],"(alkaline":[148],"phosphatase":[149],"[ALP],":[150],"osteocalcin":[151],"[OCN],":[152],"collagen":[154],"I":[155],"[Col":[156],"I])":[157],"ability.":[163],"Moreover,":[164],"inhibit":[170],"inflammation":[171],"in":[172,180,226,232],"mice,":[175],"which":[176,237],"mainly":[178],"reflected":[179],"reduce":[184,199],"release":[186],"IL\u20101\u03b2":[188],"IL\u20104":[190],"increase":[192],"IL\u201010":[193],"levels;":[194],"apoptosis":[200],"CD4+":[202],"CD8+":[204],"T":[205],"cells,":[206],"improving":[208],"their":[209],"immune":[210],"function.":[211],"percentage":[214],"new":[216],"bones,":[217],"mineral":[219],"density,":[220],"trabecular":[221,224],"volume,":[222],"numbers":[225],"fracture":[228],"region":[229],"were":[230],"improved":[231],"mice":[233],"treated":[234],"MSN,":[236],"allowed":[238],"repair":[240],"Hence,":[244],"Cef/BMP\u20102@MSN":[245],"may":[246],"be":[247],"feasible":[248],"for":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-09-23T00:00:00"}
