{"id":"https://openalex.org/W4296772253","doi":"https://doi.org/10.1038/s41419-022-05248-z","title":"Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation","display_name":"Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation","publication_year":2022,"publication_date":"2022-09-20","ids":{"openalex":"https://openalex.org/W4296772253","doi":"https://doi.org/10.1038/s41419-022-05248-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/36127346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489770"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-022-05248-z","doi":"https://doi.org/10.1038/s41419-022-05248-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05248-z","pdf_url":"https://www.nature.com/articles/s41419-022-05248-z.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-022-05248-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Lin","orcid":"https://orcid.org/0000-0002-9183-9324","observed_orcids":["https://orcid.org/0000-0002-9183-9324"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Lin","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China"],"raw_orcid":"https://orcid.org/0000-0002-9183-9324","affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460577","display_name":"Jianan Zhang","orcid":"https://orcid.org/0000-0001-9801-2779","observed_orcids":["https://orcid.org/0000-0001-9801-2779","https://orcid.org/0009-0004-0046-0530"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianan Zhang","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088464876","display_name":"Hakim Bouamar","orcid":"https://orcid.org/0009-0006-9627-1877","observed_orcids":["https://orcid.org/0009-0006-9627-1877"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hakim Bouamar","raw_affiliation_strings":["Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449964","display_name":"Zhiwei Peter Wang","orcid":"https://orcid.org/0000-0002-6465-7779","observed_orcids":["https://orcid.org/0000-0002-6465-7779"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiwei Wang","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. zhiweichina@126.com","Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China"],"raw_orcid":"https://orcid.org/0000-0002-6465-7779","affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. zhiweichina@126.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056931880","display_name":"Lu\u2010Zhe Sun","orcid":"https://orcid.org/0000-0001-7117-4559","observed_orcids":["https://orcid.org/0000-0001-7117-4559"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu-Zhe Sun","raw_affiliation_strings":["Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. sunl@uthscsa.edu","Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-7117-4559","affiliations":[{"raw_affiliation_string":"Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. sunl@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems & Anatomy, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003159043","display_name":"Xueqiong Zhu","orcid":"https://orcid.org/0000-0002-8389-928X","observed_orcids":["https://orcid.org/0000-0002-8389-928X"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xueqiong Zhu","raw_affiliation_strings":["Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. zjwzzxq@163.com","Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China"],"raw_orcid":"https://orcid.org/0000-0002-8389-928X","affiliations":[{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. zjwzzxq@163.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003159043","https://openalex.org/A5056931880","https://openalex.org/A5100449964"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I27781120"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":{"value":4290,"currency":"USD","value_usd":4290},"fwci":2.4445,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.91160085,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"805","last_page":"805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fbxo22","display_name":"FBXO22","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/p57kip2","display_name":"p57KIP2","score":1.0},{"id":"https://openalex.org/keywords/scf-ubiquitin-ligase","display_name":"SCF ubiquitin ligase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9010000228881836},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.984000027179718},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-progression","display_name":"G1/S cell cycle progression","score":0.8149999976158142},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6760396957397461},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6327649354934692},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5523769855499268},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5206683874130249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49863743782043457},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4949125647544861},{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.47095757722854614},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.46752405166625977},{"id":"https://openalex.org/C131312102","wikidata":"https://www.wikidata.org/wiki/Q5423632","display_name":"F-box protein","level":5,"score":0.45224982500076294},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.419096440076828},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37418776750564575},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3348255753517151},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2497042715549469},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24859851598739624},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.14117082953453064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07743129134178162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050761","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p57","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41419-022-05248-z","doi":"https://doi.org/10.1038/s41419-022-05248-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05248-z","pdf_url":"https://www.nature.com/articles/s41419-022-05248-z.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9489770","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9489770","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:36127346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36127346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:864f297e5270460286a2dcde81b42c05","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/864f297e5270460286a2dcde81b42c05","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 13, Iss 9, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-022-05248-z","doi":"https://doi.org/10.1038/s41419-022-05248-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-022-05248-z","pdf_url":"https://www.nature.com/articles/s41419-022-05248-z.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1143455775","display_name":null,"funder_award_id":"CA-054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1221135887","display_name":"Mays Cancer Center at UT Health SA","funder_award_id":"P30CA054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4612875222","display_name":"FBXO22 \u5bf9\u5bab\u9888\u764c\u987a\u94c2\u5316\u7597\u654f\u611f\u6027\u7684\u5f71\u54cd\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"LY22H160033","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G9000324485","display_name":null,"funder_award_id":"CA054174","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310111","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333683","display_name":"Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296772253.pdf","grobid_xml":"https://content.openalex.org/works/W4296772253.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1927394523","https://openalex.org/W1965205650","https://openalex.org/W2133405234","https://openalex.org/W2145689869","https://openalex.org/W2154602568","https://openalex.org/W2161657796","https://openalex.org/W2171582083","https://openalex.org/W2264761648","https://openalex.org/W2578502482","https://openalex.org/W2607190720","https://openalex.org/W2775382512","https://openalex.org/W2785184148","https://openalex.org/W2806864054","https://openalex.org/W2810775312","https://openalex.org/W2892222262","https://openalex.org/W2911243287","https://openalex.org/W2922216360","https://openalex.org/W2938582775","https://openalex.org/W2941605147","https://openalex.org/W2947379059","https://openalex.org/W2949071566","https://openalex.org/W2955964880","https://openalex.org/W2974231343","https://openalex.org/W2992033969","https://openalex.org/W2995590704","https://openalex.org/W3013937146","https://openalex.org/W3014418349","https://openalex.org/W3015248457","https://openalex.org/W3025917813","https://openalex.org/W3045150485","https://openalex.org/W3128646645","https://openalex.org/W4220809718","https://openalex.org/W4283072036"],"related_works":["https://openalex.org/W4384067377","https://openalex.org/W2941605147","https://openalex.org/W3045150485","https://openalex.org/W2911243287","https://openalex.org/W4413406325","https://openalex.org/W3081635863","https://openalex.org/W4289782324","https://openalex.org/W4296026288","https://openalex.org/W4412154666","https://openalex.org/W3035648002"],"abstract_inverted_index":{"Abstract":[0],"F-box":[1],"only":[2],"protein":[3,14,75,104,199],"22":[4],"(FBXO22)":[5],"is":[6,21],"a":[7,233],"key":[8],"subunit":[9],"of":[10,48,60,88,94,102,120,142,157,165,224],"the":[11,44,86,182,219],"Skp1-Cullin":[12],"1-F-box":[13],"(SCF)":[15],"E3":[16],"ubiquitin":[17],"ligase":[18],"complex.":[19],"Little":[20],"known":[22],"regarding":[23],"its":[24,189],"biological":[25],"function":[26],"and":[27,46,57,79,90,133,149,171,191,221,237],"underlying":[28],"molecular":[29,92],"mechanisms":[30,93],"in":[31,50,98,105,112,136,147,153,174,208],"regulating":[32,218],"cervical":[33,115],"cancer":[34],"(CC)":[35],"progression.":[36,52,197],"In":[37,162],"this":[38],"study,":[39],"we":[40],"aim":[41],"to":[42,84,195],"explore":[43],"role":[45],"mechanism":[47],"FBXO22":[49,56,89,103,121,143,158,166,178,198,212,230],"CC":[51,61,106,137,175,210,214],"The":[53,100],"correlation":[54],"between":[55],"clinicopathological":[58],"characteristics":[59],"was":[62,108,122,201],"analyzed":[63],"by":[64],"tissue":[65],"microarray.":[66],"MTT,":[67],"colony":[68],"formation,":[69],"flow":[70],"cytometry,":[71],"Western":[72],"blotting,":[73],"qRT-PCR,":[74],"half-life,":[76],"co-immunoprecipitation,":[77],"ubiquitination,":[78],"xenograft":[80],"experiments":[81],"were":[82],"performed":[83],"assess":[85],"functions":[87],"potential":[91],"FBXO22-mediated":[95],"malignant":[96],"progression":[97,170,215],"CC.":[99,241],"expression":[101,119,141],"tissues":[107],"higher":[109],"than":[110],"that":[111,229],"adjacent":[113],"non-tumor":[114],"tissues.":[116],"Notably,":[117],"high":[118,126],"significantly":[123],"associated":[124,204],"with":[125,181,205],"histology":[127],"grades,":[128],"positive":[129],"lymph":[130],"node":[131],"metastasis,":[132],"poor":[134],"outcomes":[135],"patients.":[138],"Functionally,":[139],"ectopic":[140],"promoted":[144,167],"cell":[145],"viability":[146],"vitro":[148],"induced":[150],"tumor":[151,196],"growth":[152],"vivo,":[154],"while":[155],"knockdown":[156],"exhibited":[159],"opposite":[160],"effects.":[161],"addition,":[163],"overexpression":[164],"G1/S":[168],"phase":[169],"inhibited":[172],"apoptosis":[173],"cells.":[176],"Mechanistically,":[177],"physically":[179],"interacted":[180],"cyclin-dependent":[183],"kinase":[184],"inhibitor":[185],"p57Kip2and":[186],"subsequently":[187],"mediated":[188],"ubiquitination":[190,220],"proteasomal":[192,222],"degradation":[193,223],"leading":[194],"level":[200],"found":[202],"negatively":[203],"p57Kip2protein":[206],"levels":[207],"patient":[209],"samples.":[211],"promotes":[213],"partly":[216],"through":[217],"p57Kip2.":[225],"Our":[226],"study":[227],"indicates":[228],"might":[231],"be":[232],"novel":[234],"prognostic":[235],"biomarker":[236],"therapeutic":[238],"target":[239],"for":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-23T00:00:00"}