{"id":"https://openalex.org/W4296691520","doi":"https://doi.org/10.1039/d2re00183g","title":"Rapid optimisation of API crystallisation in a segmented flow reactor with a continuous, variable temperature gradient","display_name":"Rapid optimisation of API crystallisation in a segmented flow reactor with a continuous, variable temperature gradient","publication_year":2022,"publication_date":"2022-09-21","ids":{"openalex":"https://openalex.org/W4296691520","doi":"https://doi.org/10.1039/d2re00183g"},"language":"en","primary_location":{"id":"doi:10.1039/d2re00183g","doi":"https://doi.org/10.1039/d2re00183g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d2re00183g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/re/d2re00183g","source":{"id":"https://openalex.org/S2764466794","display_name":"Reaction Chemistry & Engineering","issn_l":"2058-9883","issn":["2058-9883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reaction Chemistry &amp; Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2023/re/d2re00183g","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067373358","display_name":"Karen Robertson","orcid":"https://orcid.org/0000-0002-0719-5854","observed_orcids":["https://orcid.org/0000-0002-0719-5854"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Karen Robertson","raw_affiliation_strings":["Faculty of Engineering, University of Nottingham, Nottingham, UK","Max-Planck-Institute, Potsdam-Golm, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0719-5854","affiliations":[{"raw_affiliation_string":"Faculty of Engineering, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Max-Planck-Institute, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008512379","display_name":"Peter H. Seeberger","orcid":"https://orcid.org/0000-0003-3394-8466","observed_orcids":["https://orcid.org/0000-0003-3394-8466"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Peter H. Seeberger","raw_affiliation_strings":["Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, Connecticut, USA","Max-Planck-Institute, Potsdam-Golm, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3394-8466","affiliations":[{"raw_affiliation_string":"Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, Connecticut, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Max-Planck-Institute, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005050488","display_name":"Kerry M. Gilmore","orcid":"https://orcid.org/0000-0001-9897-6017","observed_orcids":["https://orcid.org/0000-0001-9897-6017"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Kerry Gilmore","raw_affiliation_strings":["Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, Connecticut, USA","Max-Planck-Institute, Potsdam-Golm, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9897-6017","affiliations":[{"raw_affiliation_string":"Chemistry, University of Connecticut, 55 N. Eagleville Rd, Storrs, Connecticut, USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"Max-Planck-Institute, Potsdam-Golm, Germany","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005050488","https://openalex.org/A5067373358"],"corresponding_institution_ids":["https://openalex.org/I140172145","https://openalex.org/I142263535","https://openalex.org/I149899117"],"apc_list":null,"apc_paid":null,"fwci":0.4673,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.49187314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"1","first_page":"77","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1506","display_name":"Filtration and Separation"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crystal-growth-control","display_name":"crystal growth control","score":0.7450000047683716},{"id":"https://openalex.org/keywords/process-optimization","display_name":"process optimization","score":0.5199999809265137},{"id":"https://openalex.org/keywords/small-organic-molecules","display_name":"small organic molecules","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.5638989210128784},{"id":"https://openalex.org/C137109543","wikidata":"https://www.wikidata.org/wiki/Q554388","display_name":"Temperature gradient","level":2,"score":0.5468723773956299},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5068739056587219},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.47210732102394104},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.46655982732772827},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4443323612213135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4173767566680908},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36453697085380554},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.32035911083221436},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15765133500099182},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1543618142604828},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.11057555675506592},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.05916699767112732}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d2re00183g","doi":"https://doi.org/10.1039/d2re00183g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d2re00183g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/re/d2re00183g","source":{"id":"https://openalex.org/S2764466794","display_name":"Reaction Chemistry & Engineering","issn_l":"2058-9883","issn":["2058-9883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reaction Chemistry &amp; Engineering","raw_type":"journal-article"},{"id":"pmh:oai:nottingham-repository.worktribe.com:12036109","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1039/d2re00183g","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:12036109","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/12036109","pdf_url":"https://nottingham-repository.worktribe.com/file/12036109/1/D2RE00183G","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d2re00183g","doi":"https://doi.org/10.1039/d2re00183g","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d2re00183g","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2023/re/d2re00183g","source":{"id":"https://openalex.org/S2764466794","display_name":"Reaction Chemistry & Engineering","issn_l":"2058-9883","issn":["2058-9883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reaction Chemistry &amp; Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318144","display_name":"Max-Planck-F\u00f6rderstiftung","ror":"https://ror.org/05tc5g775"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296691520.pdf","grobid_xml":"https://content.openalex.org/works/W4296691520.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1894736934","https://openalex.org/W1964593962","https://openalex.org/W1985196300","https://openalex.org/W2001032983","https://openalex.org/W2001854285","https://openalex.org/W2058856398","https://openalex.org/W2062653270","https://openalex.org/W2081244403","https://openalex.org/W2081932492","https://openalex.org/W2141192321","https://openalex.org/W2200568331","https://openalex.org/W2316099892","https://openalex.org/W2322631124","https://openalex.org/W2327370278","https://openalex.org/W2395992080","https://openalex.org/W2465466849","https://openalex.org/W2511953455","https://openalex.org/W2529555760","https://openalex.org/W2605009533","https://openalex.org/W2621108245","https://openalex.org/W2733737284","https://openalex.org/W2783378800","https://openalex.org/W2786473804","https://openalex.org/W2790739526","https://openalex.org/W2791282328","https://openalex.org/W2799756261","https://openalex.org/W2822230786","https://openalex.org/W2873461984","https://openalex.org/W2898336385","https://openalex.org/W2921347540","https://openalex.org/W2946157353","https://openalex.org/W2980634932","https://openalex.org/W2988178705","https://openalex.org/W2989232554","https://openalex.org/W3001497989","https://openalex.org/W3013722778","https://openalex.org/W3020325151","https://openalex.org/W3021544909","https://openalex.org/W3043857001","https://openalex.org/W3086273190","https://openalex.org/W3108715844","https://openalex.org/W3120927588","https://openalex.org/W4291901620"],"related_works":["https://openalex.org/W3150872260","https://openalex.org/W3136335294","https://openalex.org/W6964753659","https://openalex.org/W1544740599","https://openalex.org/W3089695876","https://openalex.org/W2969928271","https://openalex.org/W3140932681","https://openalex.org/W7077074909","https://openalex.org/W4399772586","https://openalex.org/W2013623485"],"abstract_inverted_index":{"A":[0],"continuous":[1],"flow":[2],"reactor":[3],"capable":[4],"of":[5,16,22,25],"a":[6],"continuous,":[7],"variable":[8],"temperature":[9],"gradient":[10],"allows":[11],"for":[12],"the":[13],"rapid":[14],"optimization":[15],"reproducible":[17],"crystallization":[18],"conditions":[19],"and":[20],"control":[21],"crystal":[23],"growth":[24],"small":[26],"organic":[27],"molecules.":[28]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-09-23T00:00:00"}
