{"id":"https://openalex.org/W4296545153","doi":"https://doi.org/10.1016/j.tiv.2022.105479","title":"Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis","display_name":"Exenatide increases CTRP3 gene expression in adipose cells by inhibiting adipogenesis and induces apoptosis","publication_year":2022,"publication_date":"2022-09-21","ids":{"openalex":"https://openalex.org/W4296545153","doi":"https://doi.org/10.1016/j.tiv.2022.105479","pmid":"https://pubmed.ncbi.nlm.nih.gov/36152787"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2022.105479","doi":"https://doi.org/10.1016/j.tiv.2022.105479","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2022.105479","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032914277","display_name":"Meliha Koldemir G\u00fcnd\u00fcz","orcid":"https://orcid.org/0000-0003-0969-6377","observed_orcids":["https://orcid.org/0000-0003-0969-6377"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Meliha Koldemir G\u00fcnd\u00fcz","raw_affiliation_strings":["Kutahya Health Sciences University, Faculty of Engineering and Natural Sciences, Department of Basic Sciences of Engineering, K\u00fctahya, Turkey. Electronic address: meliha.koldemirgunduz@ksbu.edu.tr","Kutahya Health Sciences University, Faculty of Engineering and Natural Sciences, Department of Basic Sciences of Engineering, K\u00fctahya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kutahya Health Sciences University, Faculty of Engineering and Natural Sciences, Department of Basic Sciences of Engineering, K\u00fctahya, Turkey. Electronic address: meliha.koldemirgunduz@ksbu.edu.tr","institution_ids":["https://openalex.org/I4387156457"]},{"raw_affiliation_string":"Kutahya Health Sciences University, Faculty of Engineering and Natural Sciences, Department of Basic Sciences of Engineering, K\u00fctahya, Turkey","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002240124","display_name":"G\u00fcll\u00fc Kaymak","orcid":"https://orcid.org/0000-0001-6309-0208","observed_orcids":["https://orcid.org/0000-0001-6309-0208"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcll\u00fc Kaymak","raw_affiliation_strings":["Kutahya Health Sciences University, Training and Research Center, K\u00fctahya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kutahya Health Sciences University, Training and Research Center, K\u00fctahya, Turkey","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040578933","display_name":"Ertan Kanbur","orcid":"https://orcid.org/0000-0001-8399-8942","observed_orcids":["https://orcid.org/0000-0001-8399-8942"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ertan Kanbur","raw_affiliation_strings":["Bursa Uluda\u011f University, Faculty of Medicine, Department of Immunology, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bursa Uluda\u011f University, Faculty of Medicine, Department of Immunology, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045292488","display_name":"Derya Berikten","orcid":"https://orcid.org/0000-0002-8672-4813","observed_orcids":["https://orcid.org/0000-0002-8672-4813"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Derya Berikten","raw_affiliation_strings":["Kutahya Health Sciences University, Training and Research Center, K\u00fctahya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kutahya Health Sciences University, Training and Research Center, K\u00fctahya, Turkey","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085556382","display_name":"Harun \u015eener","orcid":"https://orcid.org/0000-0003-3521-0684","observed_orcids":["https://orcid.org/0000-0003-3521-0684"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Harun \u015eener","raw_affiliation_strings":["Kutahya Health Sciences University, Department of Forensic Sciences, Faculty of Engineering and Natural Sciences, K\u00fctahya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kutahya Health Sciences University, Department of Forensic Sciences, Faculty of Engineering and Natural Sciences, K\u00fctahya, Turkey","institution_ids":["https://openalex.org/I4387156457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032914277"],"corresponding_institution_ids":["https://openalex.org/I4387156457"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":0.6598,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.64083405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"85","issue":null,"first_page":"105479","last_page":"105479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exenatide","display_name":"exenatide","score":1.0},{"id":"https://openalex.org/keywords/ctrp3","display_name":"CTRP3","score":0.8930000066757202},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8220000267028809},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.902999997138977},{"id":"https://openalex.org/keywords/obesity-pharmacotherapy","display_name":"obesity pharmacotherapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6029999852180481},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2780533449","wikidata":"https://www.wikidata.org/wiki/Q417762","display_name":"Exenatide","level":4,"score":0.9512435793876648},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.8717743158340454},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.8125303983688354},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.65696781873703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5868384838104248},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5810860395431519},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4721263349056244},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.45728155970573425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35739997029304504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34491974115371704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27544140815734863},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.12809595465660095},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.09734687209129333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09260326623916626}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077270","descriptor_name":"Exenatide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015922","descriptor_name":"Complement C1q","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015922","descriptor_name":"Complement C1q","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015922","descriptor_name":"Complement C1q","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041721","descriptor_name":"3T3-L1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tiv.2022.105479","doi":"https://doi.org/10.1016/j.tiv.2022.105479","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2022.105479","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:36152787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36152787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"},{"id":"pmh:899c9809-480f-44cf-adb6-73a5dbd28a39","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/899c9809-480f-44cf-adb6-73a5dbd28a39/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1878985566","https://openalex.org/W1965072462","https://openalex.org/W1966511832","https://openalex.org/W1967442749","https://openalex.org/W1973074169","https://openalex.org/W1981606087","https://openalex.org/W1982191008","https://openalex.org/W1984740259","https://openalex.org/W1994369811","https://openalex.org/W2007127356","https://openalex.org/W2017810555","https://openalex.org/W2022271042","https://openalex.org/W2025327530","https://openalex.org/W2040496679","https://openalex.org/W2043889992","https://openalex.org/W2051051060","https://openalex.org/W2054584654","https://openalex.org/W2063792225","https://openalex.org/W2070532232","https://openalex.org/W2072860264","https://openalex.org/W2073525091","https://openalex.org/W2076939762","https://openalex.org/W2084948079","https://openalex.org/W2086125606","https://openalex.org/W2102038522","https://openalex.org/W2104085328","https://openalex.org/W2107863336","https://openalex.org/W2115047538","https://openalex.org/W2119670027","https://openalex.org/W2152835319","https://openalex.org/W2170874580","https://openalex.org/W2174354874","https://openalex.org/W2249523439","https://openalex.org/W2252465393","https://openalex.org/W2288966387","https://openalex.org/W2303037955","https://openalex.org/W2414527615","https://openalex.org/W2475233216","https://openalex.org/W2560711395","https://openalex.org/W2571040143","https://openalex.org/W2587680743","https://openalex.org/W2607038632","https://openalex.org/W2738187814","https://openalex.org/W2763434667","https://openalex.org/W2782232423","https://openalex.org/W2791017844","https://openalex.org/W3029874317","https://openalex.org/W3119669585","https://openalex.org/W3191097563","https://openalex.org/W6677595303","https://openalex.org/W6691471849"],"related_works":["https://openalex.org/W1981606087","https://openalex.org/W2510808832","https://openalex.org/W2088845323","https://openalex.org/W2050360984","https://openalex.org/W2345270412","https://openalex.org/W2139118130","https://openalex.org/W3113624064","https://openalex.org/W1993137708","https://openalex.org/W2755430399","https://openalex.org/W3095103662"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-21T00:00:00"}
