{"id":"https://openalex.org/W4296499396","doi":"https://doi.org/10.56499/jppres21.1047_9.4.484","title":"Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins","display_name":"Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins","publication_year":2021,"publication_date":"2021-07-01","ids":{"openalex":"https://openalex.org/W4296499396","doi":"https://doi.org/10.56499/jppres21.1047_9.4.484"},"language":"en","primary_location":{"id":"doi:10.56499/jppres21.1047_9.4.484","doi":"https://doi.org/10.56499/jppres21.1047_9.4.484","is_oa":true,"landing_page_url":"https://doi.org/10.56499/jppres21.1047_9.4.484","pdf_url":"https://jppres.com/jppres/pdf/vol9/jppres21.1047_9.4.484.pdf","source":{"id":"https://openalex.org/S4387282690","display_name":"Journal of Pharmacy & Pharmacognosy Research","issn_l":"0719-4250","issn":["0719-4250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy & Pharmacognosy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://jppres.com/jppres/pdf/vol9/jppres21.1047_9.4.484.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080382695","display_name":"Muhammad Hermawan Widyananda","orcid":"https://orcid.org/0000-0002-1167-3177","observed_orcids":["https://orcid.org/0000-0002-1167-3177","https://orcid.org/0000-0002-0064-8865"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhammad Hermawan Widyananda","raw_affiliation_strings":["Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia","Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041670090","display_name":"Setyaki Kevin Pratama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Setyaki Kevin Pratama","raw_affiliation_strings":["Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084839276","display_name":"Rizky Senna Samoedra","orcid":"https://orcid.org/0000-0003-3789-8099","observed_orcids":["https://orcid.org/0000-0003-3789-8099"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rizky Senna Samoedra","raw_affiliation_strings":["Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011569806","display_name":"Fikriya Novita Sari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fikriya Novita Sari","raw_affiliation_strings":["Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Physiology, Structure, and Growth, Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044810587","display_name":"Viol Dhea Kharisma","orcid":"https://orcid.org/0000-0001-9060-0429","observed_orcids":["https://orcid.org/0000-0001-9060-0429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viol Dhea Kharisma","raw_affiliation_strings":["Division of Molecular Biology and Genetics , Generasi Biologi Indonesia Foundation , Gresik , Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biology and Genetics , Generasi Biologi Indonesia Foundation , Gresik , Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042650965","display_name":"Arif Nur Muhammad Ansori","orcid":"https://orcid.org/0000-0002-1279-3904","observed_orcids":["https://orcid.org/0000-0002-1279-3904"]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Arif Nur Muhammad Ansori","raw_affiliation_strings":["Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia","institution_ids":["https://openalex.org/I205133468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052134011","display_name":"Yulanda Antonius","orcid":"https://orcid.org/0000-0002-4950-8134","observed_orcids":["https://orcid.org/0000-0002-4950-8134"]},"institutions":[{"id":"https://openalex.org/I16413167","display_name":"University of Surabaya","ror":"https://ror.org/013314927","country_code":"ID","type":"education","lineage":["https://openalex.org/I16413167"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yulanda Antonius","raw_affiliation_strings":["Faculty of Biotechnology, University of Surabaya, Surabaya, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology, University of Surabaya, Surabaya, Indonesia","institution_ids":["https://openalex.org/I16413167"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0694,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.97460671,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"484","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12841","display_name":"Echinoderm biology and ecology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arbacia-lixula","display_name":"Arbacia lixula","score":0.9340000152587891},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/multi-target-inhibitors","display_name":"multi-target inhibitors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7960000038146973},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.996999979019165},{"id":"https://openalex.org/keywords/jak3","display_name":"JAK3","score":1.0},{"id":"https://openalex.org/keywords/peptide-protein-binding-affinity","display_name":"peptide-protein binding affinity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anticancer-peptides","display_name":"anticancer peptides","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.7491053342819214},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.636761486530304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5427395105361938},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5246867537498474},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.4587107300758362},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4547322690486908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42239412665367126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4093930423259735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2922758460044861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1113162636756897},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08898144960403442},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.56499/jppres21.1047_9.4.484","doi":"https://doi.org/10.56499/jppres21.1047_9.4.484","is_oa":true,"landing_page_url":"https://doi.org/10.56499/jppres21.1047_9.4.484","pdf_url":"https://jppres.com/jppres/pdf/vol9/jppres21.1047_9.4.484.pdf","source":{"id":"https://openalex.org/S4387282690","display_name":"Journal of Pharmacy & Pharmacognosy Research","issn_l":"0719-4250","issn":["0719-4250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy & Pharmacognosy Research","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3201331a6ea84a4aa0ea25776b5b5ed6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3201331a6ea84a4aa0ea25776b5b5ed6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacy & Pharmacognosy Research, Vol 9, Iss 4, Pp 484-496 (2021)","raw_type":"article"},{"id":"pmh:oai:repository.ubaya.ac.id:41217","doi":null,"is_oa":false,"landing_page_url":"http://repository.ubaya.ac.id/41217/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402324","display_name":"Ubaya Repository (University of Surabaya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16413167","host_organization_name":"University of Surabaya","host_organization_lineage":["https://openalex.org/I16413167"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.56499/jppres21.1047_9.4.484","doi":"https://doi.org/10.56499/jppres21.1047_9.4.484","is_oa":true,"landing_page_url":"https://doi.org/10.56499/jppres21.1047_9.4.484","pdf_url":"https://jppres.com/jppres/pdf/vol9/jppres21.1047_9.4.484.pdf","source":{"id":"https://openalex.org/S4387282690","display_name":"Journal of Pharmacy & Pharmacognosy Research","issn_l":"0719-4250","issn":["0719-4250"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy & Pharmacognosy Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327743","display_name":"Universitas Surabaya","ror":"https://ror.org/013314927"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296499396.pdf","grobid_xml":"https://content.openalex.org/works/W4296499396.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W633839035","https://openalex.org/W1842992197","https://openalex.org/W1860382351","https://openalex.org/W1887624773","https://openalex.org/W1931438814","https://openalex.org/W1952507411","https://openalex.org/W1966669762","https://openalex.org/W1977332018","https://openalex.org/W1983358124","https://openalex.org/W1997117729","https://openalex.org/W2000019642","https://openalex.org/W2000231857","https://openalex.org/W2004748840","https://openalex.org/W2005640766","https://openalex.org/W2012558213","https://openalex.org/W2014881369","https://openalex.org/W2020428280","https://openalex.org/W2030374792","https://openalex.org/W2049076566","https://openalex.org/W2054022416","https://openalex.org/W2095450456","https://openalex.org/W2099861795","https://openalex.org/W2105341103","https://openalex.org/W2107614388","https://openalex.org/W2128344699","https://openalex.org/W2129000787","https://openalex.org/W2134967712","https://openalex.org/W2142995543","https://openalex.org/W2144052431","https://openalex.org/W2157745198","https://openalex.org/W2159013299","https://openalex.org/W2304153433","https://openalex.org/W2340293510","https://openalex.org/W2345942152","https://openalex.org/W2603411876","https://openalex.org/W2662350717","https://openalex.org/W2783897572","https://openalex.org/W2800446703","https://openalex.org/W2800809626","https://openalex.org/W2884323962","https://openalex.org/W2889646458","https://openalex.org/W2894746403","https://openalex.org/W2895926103","https://openalex.org/W2904609077","https://openalex.org/W2921784091","https://openalex.org/W2927578120","https://openalex.org/W2951160992","https://openalex.org/W2970830956","https://openalex.org/W2989605045","https://openalex.org/W3015259629","https://openalex.org/W3026234138"],"related_works":["https://openalex.org/W7218980870","https://openalex.org/W4392545502","https://openalex.org/W4417259972","https://openalex.org/W6958256859","https://openalex.org/W3178798393","https://openalex.org/W3200774162","https://openalex.org/W3094162653","https://openalex.org/W4415715559","https://openalex.org/W4287012478","https://openalex.org/W7221055449"],"abstract_inverted_index":{"Context:":[0],"Lung":[1],"cancer":[2,7,20,25],"is":[3,21],"a":[4,71,142,179],"type":[5,17],"of":[6,18,44,55,138,145,155,163,176,182,186,235,245],"that":[8,69,237],"causes":[9],"the":[10,41,53,64,97,124,135,139,152,173,196,233,243,255],"most":[11,15],"deaths":[12],"worldwide.":[13],"The":[14],"common":[16],"lung":[19,24],"non-small":[22],"cell":[23],"(NSCLC).":[26],"Sea":[27],"urchin":[28],"(Arbacia":[29],"lixula)":[30],"has":[31],"high":[32,224],"potential":[33,225],"as":[34,87,195,226],"an":[35,239],"anti-NSCLC":[36,227],"agent.":[37],"Aims:":[38],"To":[39],"analyze":[40],"anticancer":[42],"activity":[43,54,234],"peptides":[45,121,188,201],"from":[46,96],"A.":[47],"lixula":[48],"coelomic":[49],"fluid":[50],"in":[51,74,242],"inhibiting":[52],"NSCLC-related":[56],"proteins.":[57],"Methods:":[58],"Peptide":[59,131,148,169],"modeling":[60],"was":[61,102,111],"performed":[62,103],"using":[63,79,104,114],"PEP-FOLD3":[65],"web":[66],"server.":[67],"Proteins":[68],"have":[70,189,223],"crucial":[72],"role":[73,241],"NSCLC":[75],"progression":[76],"were":[77,94],"determined":[78],"KEGG":[80],"pathway":[81],"database.":[82,100],"3D":[83],"protein":[84],"structures":[85],"such":[86],"EGFR,":[88,248],"PI3K,":[89,249],"BRAF":[90,158,250],"V600E,":[91,251],"and":[92,157,165,221,252],"JAK3":[93,177,253],"taken":[95],"RCSB":[98],"PDB":[99],"Docking":[101,108],"Autodock":[105],"Vina":[106],"software.":[107,118],"results":[109],"analysis":[110],"carried":[112],"out":[113],"Discovery":[115],"Studio":[116],"2019":[117],"Results:":[119],"Some":[120],"bind":[122],"to":[123,134,151,172,213],"active":[125,136,153,174],"sites":[126,154],"with":[127,141,160,178],"low":[128],"binding":[129,143,161,180,191],"affinity.":[130],"10":[132],"binds":[133,150,171],"site":[137,175],"EGFR":[140],"affinity":[144,162,181,192],"-9":[146],"kcal/mol.":[147,184],"5":[149],"PI3K":[156],"V600E":[159],"-8.2":[164],"-8.1":[166,183],"kcal/mol,":[167],"respectively.":[168],"11":[170,222],"All":[185],"these":[187,200],"lower":[190],"than":[193,207],"ATP":[194,257],"native":[197],"ligand.":[198],"Besides,":[199],"also":[202],"produce":[203],"more":[204,215],"hydrogen":[205],"bonds":[206],"ATP,":[208],"so":[209],"they":[210,230],"are":[211],"predicted":[212],"be":[214],"stable.":[216],"Conclusions:":[217],"Peptides":[218],"10,":[219],"5,":[220],"agents":[228],"because":[229],"can":[231],"inhibit":[232],"proteins":[236],"play":[238],"essential":[240],"growth":[244],"NSCLC,":[246],"namely":[247],"through":[254],"competitive":[256],"inhibitor":[258],"mechanism.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-09-21T00:00:00"}