{"id":"https://openalex.org/W4296468447","doi":"https://doi.org/10.1016/s2152-2650(22)01403-3","title":"MDS-278 Mixed-Methods Study Assessing the Impact of C3 Inhibition on the Emotional and Physical Burden of Living With Paroxysmal Nocturnal Hemoglobinuria","display_name":"MDS-278 Mixed-Methods Study Assessing the Impact of C3 Inhibition on the Emotional and Physical Burden of Living With Paroxysmal Nocturnal Hemoglobinuria","publication_year":2022,"publication_date":"2022-09-20","ids":{"openalex":"https://openalex.org/W4296468447","doi":"https://doi.org/10.1016/s2152-2650(22)01403-3"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(22)01403-3","doi":"https://doi.org/10.1016/s2152-2650(22)01403-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)01403-3","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080314729","display_name":"Dharmik Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120540","display_name":"Apellis Pharmaceuticals (United States)","ror":"https://ror.org/0231n7e68","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120540"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dharmik Desai","raw_affiliation_strings":["Apellis Pharmaceuticals, Inc., Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apellis Pharmaceuticals, Inc., Waltham, USA","institution_ids":["https://openalex.org/I4210120540"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lisa Bailey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Bailey","raw_affiliation_strings":["Trinity Life Sciences, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Life Sciences, Waltham, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077321428","display_name":"Nandini Hadker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nandini Hadker","raw_affiliation_strings":["Trinity Life Sciences, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Life Sciences, Waltham, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032496402","display_name":"Amanda Cassidy Torres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Cassidy Torres","raw_affiliation_strings":["Trinity Life Sciences, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Life Sciences, Waltham, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004","observed_orcids":["https://orcid.org/0000-0001-7477-3004"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dingli","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":null,"first_page":"S308","last_page":"S308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paroxysmal-nocturnal-hemoglobinuria","display_name":"paroxysmal nocturnal hemoglobinuria","score":1.0},{"id":"https://openalex.org/keywords/pegcetacoplan","display_name":"pegcetacoplan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5609999895095825},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.871999979019165},{"id":"https://openalex.org/keywords/emotional-burden","display_name":"emotional burden","score":0.8519999980926514},{"id":"https://openalex.org/keywords/physical-burden","display_name":"physical burden","score":0.9610000252723694},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.4480000138282776},{"id":"https://openalex.org/keywords/daily-functioning","display_name":"daily functioning","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7878177165985107},{"id":"https://openalex.org/C2777346216","wikidata":"https://www.wikidata.org/wiki/Q1479494","display_name":"Paroxysmal nocturnal hemoglobinuria","level":2,"score":0.699991762638092},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6312556266784668},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.50569748878479},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.4503921866416931},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39480602741241455},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3505488336086273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3024657368659973},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(22)01403-3","doi":"https://doi.org/10.1016/s2152-2650(22)01403-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)01403-3","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310103252","https://openalex.org/W4310102718","https://openalex.org/W4388952302","https://openalex.org/W4389248451","https://openalex.org/W3097000093","https://openalex.org/W4283377453","https://openalex.org/W4283371093","https://openalex.org/W4386282191","https://openalex.org/W4360946230","https://openalex.org/W4310105144"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2022-09-21T00:00:00"}