{"id":"https://openalex.org/W4296468306","doi":"https://doi.org/10.1016/s2152-2650(22)01194-6","title":"ALL-269 Safety and Pharmacokinetics of Calaspargase Pegol in Adults With Newly Diagnosed Philadelphia-Negative Acute Lymphoblastic Leukemia: A Phase 2/3 Study","display_name":"ALL-269 Safety and Pharmacokinetics of Calaspargase Pegol in Adults With Newly Diagnosed Philadelphia-Negative Acute Lymphoblastic Leukemia: A Phase 2/3 Study","publication_year":2022,"publication_date":"2022-09-20","ids":{"openalex":"https://openalex.org/W4296468306","doi":"https://doi.org/10.1016/s2152-2650(22)01194-6"},"language":"en","primary_location":{"id":"doi:10.1016/s2152-2650(22)01194-6","doi":"https://doi.org/10.1016/s2152-2650(22)01194-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)01194-6","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005939966","display_name":"Wendy Stock","orcid":"https://orcid.org/0000-0002-8349-9200","observed_orcids":["https://orcid.org/0000-0002-8349-9200"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Stock","raw_affiliation_strings":["University of Chicago, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101838284","display_name":"Jae H. Park","orcid":"https://orcid.org/0000-0002-2903-5130","observed_orcids":["https://orcid.org/0000-0002-2903-5130","https://orcid.org/0009-0003-2678-9513"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae H. Park","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018403340","display_name":"Ashkan Emadi","orcid":"https://orcid.org/0000-0003-3769-3210","observed_orcids":["https://orcid.org/0000-0003-3769-3210"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashkan Emadi","raw_affiliation_strings":["Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069511421","display_name":"Maher Abdul\u2010Hay","orcid":"https://orcid.org/0000-0003-1041-7689","observed_orcids":["https://orcid.org/0000-0003-1041-7689"]},"institutions":[{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maher Abdul-Hay","raw_affiliation_strings":["New York University Perlmutter Cancer Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Perlmutter Cancer Center, New York, USA","institution_ids":["https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844603","display_name":"Ryan Daniel Cassaday","orcid":"https://orcid.org/0000-0002-3424-2425","observed_orcids":["https://orcid.org/0000-0002-3424-2425"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Cassaday","raw_affiliation_strings":["University of Washington School of Medicine and Fred Hutchinson Cancer Center, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington School of Medicine and Fred Hutchinson Cancer Center, Seattle, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024492683","display_name":"Vinod A. Pullarkat","orcid":"https://orcid.org/0000-0001-9129-3424","observed_orcids":["https://orcid.org/0000-0001-9129-3424"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinod Pullarkat","raw_affiliation_strings":["Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068544225","display_name":"Jonathan Allen Webster","orcid":"https://orcid.org/0000-0003-3647-6345","observed_orcids":["https://orcid.org/0000-0003-3647-6345"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Webster","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086009314","display_name":"Susan S. Pandya","orcid":"https://orcid.org/0009-0006-7669-0652","observed_orcids":["https://orcid.org/0009-0006-7669-0652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Pandya","raw_affiliation_strings":["Servier Pharmaceuticals, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Pharmaceuticals, Boston, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049817425","display_name":"Mark Jeffrey Mogul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Mogul","raw_affiliation_strings":["Servier Pharmaceuticals, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Pharmaceuticals, Boston, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042008692","display_name":"Yelena Shvenke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yelena Shvenke","raw_affiliation_strings":["Servier Pharmaceuticals, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Pharmaceuticals, Boston, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101902343","display_name":"Jian Zhu","orcid":"https://orcid.org/0000-0002-4744-0703","observed_orcids":["https://orcid.org/0000-0002-4744-0703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Zhu","raw_affiliation_strings":["Servier Pharmaceuticals, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servier Pharmaceuticals, Boston, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021687248","display_name":"Adrien Tessier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adrien Tessier","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082924494","display_name":"Daniel J. DeAngelo","orcid":"https://orcid.org/0000-0001-7865-2306","observed_orcids":["https://orcid.org/0000-0001-7865-2306"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. DeAngelo","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":null,"first_page":"S199","last_page":"S200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/philadelphia-negative-acute-lymphoblastic-leukemia","display_name":"Philadelphia-negative acute lymphoblastic leukemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.5680000185966492},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.6729999780654907},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.4490000009536743},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.38199999928474426},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.718999981880188},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.597000002861023},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.3889999985694885},{"id":"https://openalex.org/keywords/antileukemic-activity","display_name":"antileukemic activity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.5730000138282776},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.6589999794960022},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7039999961853027},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8571107387542725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5917769074440002},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43432140350341797},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.43175920844078064},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.42843353748321533},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42776528000831604},{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.4106219708919525},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3223543167114258}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s2152-2650(22)01194-6","doi":"https://doi.org/10.1016/s2152-2650(22)01194-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2152-2650(22)01194-6","pdf_url":null,"source":{"id":"https://openalex.org/S186546955","display_name":"Clinical Lymphoma Myeloma & Leukemia","issn_l":"2152-2650","issn":["2152-2650","2152-2669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Lymphoma Myeloma and Leukemia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162519659","https://openalex.org/W3217097929","https://openalex.org/W2969653769","https://openalex.org/W2113477288","https://openalex.org/W4405041589","https://openalex.org/W2947706358","https://openalex.org/W2608464015","https://openalex.org/W2981719747","https://openalex.org/W2056667876","https://openalex.org/W4413767041"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-21T00:00:00"}
