{"id":"https://openalex.org/W4296387635","doi":"https://doi.org/10.1097/01.tp.0000888976.86487.32","title":"P8.148: HLA Desensitization in Kidney Transplantation","display_name":"P8.148: HLA Desensitization in Kidney Transplantation","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4296387635","doi":"https://doi.org/10.1097/01.tp.0000888976.86487.32"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0000888976.86487.32","doi":"https://doi.org/10.1097/01.tp.0000888976.86487.32","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000888976.86487.32","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069417570","display_name":"Aida Turganbekova","orcid":"https://orcid.org/0000-0002-4764-5258","observed_orcids":["https://orcid.org/0000-0002-4764-5258"]},"institutions":[{"id":"https://openalex.org/I10232997","display_name":"L. N. Gumilyov Eurasian National University","ror":"https://ror.org/0242cby63","country_code":"KZ","type":"education","lineage":["https://openalex.org/I10232997"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Aida Turganbekova","raw_affiliation_strings":["L.N.Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan","Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L.N.Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan","institution_ids":["https://openalex.org/I10232997"]},{"raw_affiliation_string":"Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111386915","display_name":"Saniya A. Abdrakhmanova","orcid":"https://orcid.org/0000-0003-0782-1795","observed_orcids":["https://orcid.org/0000-0003-0782-1795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saniya Abdrakhmanova","raw_affiliation_strings":["Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049073173","display_name":"Gulnara Kulkayeva","orcid":"https://orcid.org/0000-0002-7883-211X","observed_orcids":["https://orcid.org/0000-0002-7883-211X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gulnara Kulkayeva","raw_affiliation_strings":["National Research Oncology Center, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Oncology Center, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017639154","display_name":"Zhuldyz Zhanzakova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhuldyz Zhanzakova","raw_affiliation_strings":["Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048368997","display_name":"Jamilya Saparbay","orcid":"https://orcid.org/0000-0002-8478-5452","observed_orcids":["https://orcid.org/0000-0002-8478-5452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamilya Saparbay","raw_affiliation_strings":["National Research Oncology Center, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Oncology Center, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089587329","display_name":"Mels Assykbayev","orcid":"https://orcid.org/0000-0003-2386-0997","observed_orcids":["https://orcid.org/0000-0003-2386-0997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mels Assykbayev","raw_affiliation_strings":["National Research Oncology Center, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Oncology Center, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056886832","display_name":"Gulnur Zhakhina","orcid":"https://orcid.org/0000-0002-1001-1374","observed_orcids":["https://orcid.org/0000-0002-1001-1374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gulnur Zhakhina","raw_affiliation_strings":["National Research Oncology Center, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Oncology Center, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047926368","display_name":"Kuralay Zhangaziyeva","orcid":"https://orcid.org/0000-0002-8879-3206","observed_orcids":["https://orcid.org/0000-0002-8879-3206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuralay Zhangaziyeva","raw_affiliation_strings":["Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041175816","display_name":"Saniya Saussakova","orcid":"https://orcid.org/0000-0003-0394-5117","observed_orcids":["https://orcid.org/0000-0003-0394-5117"]},"institutions":[{"id":"https://openalex.org/I4210141757","display_name":"Astana Medical University","ror":"https://ror.org/038mavt60","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210141757"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Saniya Saussakova","raw_affiliation_strings":["Astana Medical University, Nur-Sultan, Kazakhstan","Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astana Medical University, Nur-Sultan, Kazakhstan","institution_ids":["https://openalex.org/I4210141757"]},{"raw_affiliation_string":"Scientific and Production Center of Transfusiology, Nur-Sultan, Kazakhstan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"9S","first_page":"S629","last_page":"S629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-alloimmunization","display_name":"HLA sensitization","score":0.9100000262260437},{"id":"https://openalex.org/keywords/desensitization-therapy","display_name":"desensitization therapy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anti-hla-antibodies","display_name":"HLA antibodies","score":0.9300000071525574},{"id":"https://openalex.org/keywords/end-stage-chronic-kidney-disease","display_name":"end-stage chronic kidney disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/crossmatching","display_name":"crossmatch","score":0.5860000252723694},{"id":"https://openalex.org/keywords/living-donor-transplantation","display_name":"living donor transplantation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/transplant-waiting-list","display_name":"transplant waiting list","score":0.4869999885559082},{"id":"https://openalex.org/keywords/donor-recipient-hla-matching","display_name":"donor-recipient HLA matching","score":0.43799999356269836},{"id":"https://openalex.org/keywords/hla-dqa1","display_name":"HLA-DQA1","score":0.3400000035762787},{"id":"https://openalex.org/keywords/hla-dqb1","display_name":"HLA-DQB1","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8619681596755981},{"id":"https://openalex.org/C2778842783","wikidata":"https://www.wikidata.org/wiki/Q603502","display_name":"Plasmapheresis","level":3,"score":0.729239284992218},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.7046626806259155},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6438846588134766},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.5790526866912842},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5699912309646606},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5306386351585388},{"id":"https://openalex.org/C64518967","wikidata":"https://www.wikidata.org/wiki/Q7130831","display_name":"Panel reactive antibody","level":4,"score":0.5008373260498047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47992071509361267},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.45998021960258484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44674408435821533},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4361322820186615},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4203528165817261},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.41207146644592285},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3513026237487793},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.31888440251350403},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0000888976.86487.32","doi":"https://doi.org/10.1097/01.tp.0000888976.86487.32","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0000888976.86487.32","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200279934","https://openalex.org/W2966067406","https://openalex.org/W4406861037","https://openalex.org/W3128978314","https://openalex.org/W2560580270","https://openalex.org/W3107045791","https://openalex.org/W4296385710","https://openalex.org/W2768104751","https://openalex.org/W7135175739","https://openalex.org/W4200141394"],"abstract_inverted_index":{"Introduction:":[0],"In":[1,221,259,419],"the":[2,51,88,105,136,147,163,188,207,226,235,254,273,298,303,318,322,341,361,378,391,402,425],"last":[3],"decade,":[4],"organ":[5],"transplantation":[6,277],"has":[7,373],"been":[8,16],"developing":[9],"fast":[10],"in":[11,162,206,234,242,284,289,302,345,360,377],"Kazakhstan.":[12],"1892":[13],"transplants":[14],"have":[15],"performed":[17,44],"since":[18],"2012.":[19],"Patients":[20],"often":[21],"need":[22],"kidney":[23,32,92,120,276,417],"(91.5%),":[24],"heart":[25],"(4.4%),":[26],"liver":[27],"(4%)":[28],"transplantations.":[29],"Nearly":[30],"100":[31],"transplantations":[33],"from":[34,40,194,278],"living":[35,279],"donors":[36,42],"and":[37,145,168,175,180,215,311,326,355,367,406,416],"30":[38],"ones":[39],"deceased":[41],"are":[43,79,251],"annually.":[45],"The":[46,59,123,171,184],"most":[47],"important":[48],"factor":[49],"hindering":[50],"long-term":[52],"survival":[53],"of":[54,61,71,101,107,138,165,173,187,201,209,218,224,228,237,245,249,257,262,275,300,305,309,317,332,349,363,380,386,394,404,427],"recipients":[55],"is":[56,268,435],"HLA":[57,65],"sensitization.":[58],"formation":[60],"specific":[62],"antibodies":[63,139,211,239,286,306,364,382],"to":[64,97,134,140,154,196,272,399,410,430],"may":[66],"develop":[67],"as":[68],"a":[69,126,130,204,264,358,374,412],"result":[70],"previous":[72],"transplantation,":[73],"blood":[74],"transfusion":[75],"or":[76,336],"pregnancy.":[77],"There":[78],"3.5%":[80],"highly":[81],"sensitized":[82],"patients":[83,86,108,116,202,250,292],"among":[84],"3012":[85],"on":[87],"waiting":[89],"list":[90],"for":[91,109],"transplantation.":[93,110,418],"This":[94,112,433],"study":[95,113,133,434],"aimed":[96],"review":[98],"an":[99],"effectiveness":[100],"desensitizing":[102,395,431],"therapy":[103],"during":[104],"preparation":[106],"Methods:":[111],"included":[114],"13":[115],"with":[117],"end-stage":[118],"chronic":[119],"disease":[121],"(CKD).":[122],"participants":[124,189,319],"underwent":[125,320],"general":[127],"clinical":[128],"examination,":[129],"specialized":[131],"immunological":[132,343],"determine":[135],"level":[137,208,227,236,304,362,379],"leukocyte":[141,210,238,285,381],"antigens":[142],"(anti-HLA)":[143],"before":[144],"after":[146,212,293,307,365,383],"desensitization":[148],"stages.":[149],"Microsoft":[150],"Excel":[151],"was":[152,177,190,240,287,408],"used":[153],"perform":[155],"statistical":[156],"analyses.":[157],"Qualitative":[158],"variables":[159],"were":[160],"summarized":[161],"form":[164],"absolute":[166],"frequency":[167],"percentages.":[169],"Results:":[170],"proportion":[172],"male":[174],"female":[176,333],"38.5%":[178],"(5)":[179,348],"61.5%":[181],"(8),":[182],"respectively.":[183],"average":[185],"age":[186],"44.8":[191],"years,":[192],"ranging":[193],"25":[195],"58":[197],"years.":[198],"30.8%":[199],"(4)":[200],"had":[203,334,351,357],"decrease":[205,283,359,376],"rituximab":[213,310,366,407],"administration":[214,308],"three":[216],"sessions":[217,385],"citrate":[219],"plasmapheresis.":[220,387],"23.1%":[222],"(3)":[223,331],"patients,":[225,263],"sensitization":[229],"remained":[230],"same.":[231],"An":[232],"increase":[233],"observed":[241],"15.4%":[243,247],"(2)":[244,248,389],"participants.":[246],"currently":[252],"at":[253],"second":[255],"stage":[256,324,393],"desensitization.":[258],"53.8%":[260,290],"(7)":[261,291],"positive":[265],"cross-match":[266,414],"test":[267,415],"observed,":[269],"which":[270,339],"leads":[271],"impossibility":[274],"donor.":[280],"A":[281],"significant":[282,375],"revealed":[288],"repeated":[294],"plasmapheresis":[295,313,328,369,405],"sessions,":[296],"despite":[297],"absence":[299],"differences":[301],"one":[312,327,352,368],"session.":[314,329,370],"46.2%":[315],"(6)":[316],"only":[321],"first":[323,392],"(rituximab)":[325],"37.5%":[330],"5":[335],"more":[337],"pregnancies,":[338],"affects":[340],"increased":[342],"risk":[344],"CKD.":[346],"62.5%":[347],"women":[350],"pregnancy":[353],"each":[354],"they":[356],"One":[371],"patient":[372],"several":[384],"25%":[388],"undergo":[390],"therapy.":[396,432],"Conclusion:":[397],"According":[398],"preliminary":[400],"data,":[401],"combination":[403],"insufficient":[409],"achieve":[411],"negative":[413],"this":[420],"regard,":[421],"we":[422],"recommend":[423],"adding":[424],"introduction":[426],"human":[428],"immunoglobulin":[429],"ongoing.":[436]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-09-20T00:00:00"}
