{"id":"https://openalex.org/W4296327438","doi":null,"title":"Adult-type granulosa cell tumor of the ovary.","display_name":"Adult-type granulosa cell tumor of the ovary.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4296327438","pmid":"https://pubmed.ncbi.nlm.nih.gov/36119817","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9442026"},"language":"en","primary_location":{"id":"pmid:36119817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36119817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9442026/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102755271","display_name":"Xiuwen Li","orcid":"https://orcid.org/0000-0003-0316-0184","observed_orcids":["https://orcid.org/0000-0003-0316-0184"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuwen Li","raw_affiliation_strings":["School of Basic Medical Sciences, Weifang Medical University Weifang 261053, Shandong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Weifang Medical University Weifang 261053, Shandong, P. R. China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067556791","display_name":"Bo Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Tian","raw_affiliation_strings":["Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000508636","display_name":"Mengyan Liu","orcid":"https://orcid.org/0000-0003-0882-1498","observed_orcids":["https://orcid.org/0000-0003-0882-1498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengyan Liu","raw_affiliation_strings":["Taoyuan People's Hospital Changde 425700, Hunan, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taoyuan People's Hospital Changde 425700, Hunan, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041025847","display_name":"Chunlei Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlei Miao","raw_affiliation_strings":["Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China","institution_ids":["https://openalex.org/I117331123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101519956","display_name":"Di Wang","orcid":"https://orcid.org/0000-0002-4711-8159","observed_orcids":["https://orcid.org/0000-0002-4711-8159"]},"institutions":[{"id":"https://openalex.org/I117331123","display_name":"Weifang Medical University","ror":"https://ror.org/03tmp6662","country_code":"CN","type":"education","lineage":["https://openalex.org/I117331123"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wang","raw_affiliation_strings":["School of Basic Medical Sciences, Weifang Medical University Weifang 261053, Shandong, P. R. China","Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Weifang Medical University Weifang 261053, Shandong, P. R. China","institution_ids":["https://openalex.org/I117331123"]},{"raw_affiliation_string":"Plastic Surgery Institute, Weifang Medical University Weifang 261053, Shandong, P. R. China","institution_ids":["https://openalex.org/I117331123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2072,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80592928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"8","first_page":"3495","last_page":"3511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-granulosa-cell-tumor","display_name":"adult granulosa cell tumor","score":0.953000009059906},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/foxl2-mutation","display_name":"FOXL2 mutation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/somatic-missense-mutations","display_name":"somatic missense mutations","score":0.7139999866485596},{"id":"https://openalex.org/keywords/molecular-pathogenesis","display_name":"molecular pathogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7250000238418579},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.925000011920929},{"id":"https://openalex.org/keywords/postoperative-recurrence","display_name":"postoperative recurrence","score":0.7049999833106995},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ovarian-cancer-screening","display_name":"ovarian cancer screening","score":0.7009999752044678},{"id":"https://openalex.org/keywords/multidisciplinary-management","display_name":"multidisciplinary management","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5364509224891663},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5281938314437866},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5147707462310791},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.4827655851840973},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.46982908248901367},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.43130791187286377},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4117574989795685},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38657981157302856},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3790714740753174},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3770701289176941},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3615952432155609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30118095874786377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23439037799835205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1896885633468628}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:36119817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36119817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9442026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9442026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9442026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9442026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W1515288906","https://openalex.org/W1555534494","https://openalex.org/W1584870901","https://openalex.org/W1619256199","https://openalex.org/W1832839964","https://openalex.org/W1917900907","https://openalex.org/W1954207676","https://openalex.org/W1963896755","https://openalex.org/W1965772308","https://openalex.org/W1970078959","https://openalex.org/W1970279487","https://openalex.org/W1971453556","https://openalex.org/W1971546287","https://openalex.org/W1972712348","https://openalex.org/W1976048583","https://openalex.org/W1976722903","https://openalex.org/W1977836596","https://openalex.org/W1978078849","https://openalex.org/W1979045512","https://openalex.org/W1981437208","https://openalex.org/W1982090628","https://openalex.org/W1982828599","https://openalex.org/W1983102462","https://openalex.org/W1983528787","https://openalex.org/W1984466312","https://openalex.org/W1986127810","https://openalex.org/W1987705769","https://openalex.org/W1987880828","https://openalex.org/W1993222497","https://openalex.org/W1997863391","https://openalex.org/W1998234777","https://openalex.org/W2000775791","https://openalex.org/W2000971601","https://openalex.org/W2001703201","https://openalex.org/W2005211911","https://openalex.org/W2009616259","https://openalex.org/W2012406527","https://openalex.org/W2013881488","https://openalex.org/W2015463509","https://openalex.org/W2019884068","https://openalex.org/W2020721351","https://openalex.org/W2020875165","https://openalex.org/W2025451148","https://openalex.org/W2029872286","https://openalex.org/W2030209169","https://openalex.org/W2031850977","https://openalex.org/W2032457040","https://openalex.org/W2034427531","https://openalex.org/W2035066075","https://openalex.org/W2039965654","https://openalex.org/W2041688636","https://openalex.org/W2043990322","https://openalex.org/W2043999231","https://openalex.org/W2045265592","https://openalex.org/W2046201999","https://openalex.org/W2046717184","https://openalex.org/W2048063355","https://openalex.org/W2052492794","https://openalex.org/W2061564388","https://openalex.org/W2061596207","https://openalex.org/W2062070190","https://openalex.org/W2062626814","https://openalex.org/W2065747627","https://openalex.org/W2066603248","https://openalex.org/W2066801022","https://openalex.org/W2069177191","https://openalex.org/W2069991737","https://openalex.org/W2077588167","https://openalex.org/W2084726969","https://openalex.org/W2085254107","https://openalex.org/W2087099484","https://openalex.org/W2089893679","https://openalex.org/W2090396315","https://openalex.org/W2091965888","https://openalex.org/W2095908694","https://openalex.org/W2098159000","https://openalex.org/W2098718574","https://openalex.org/W2098777148","https://openalex.org/W2100522747","https://openalex.org/W2101957987","https://openalex.org/W2103388007","https://openalex.org/W2104500293","https://openalex.org/W2104602638","https://openalex.org/W2106381149","https://openalex.org/W2106883887","https://openalex.org/W2110969580","https://openalex.org/W2113122060","https://openalex.org/W2117692326","https://openalex.org/W2117805512","https://openalex.org/W2123624440","https://openalex.org/W2125522014","https://openalex.org/W2126900445","https://openalex.org/W2127244878","https://openalex.org/W2132231496","https://openalex.org/W2133386664","https://openalex.org/W2134989837","https://openalex.org/W2135153712","https://openalex.org/W2135399640","https://openalex.org/W2135633917","https://openalex.org/W2138493972","https://openalex.org/W2143338249","https://openalex.org/W2148084822","https://openalex.org/W2153050474","https://openalex.org/W2155834935","https://openalex.org/W2155842106","https://openalex.org/W2156382003","https://openalex.org/W2158701974","https://openalex.org/W2169327129","https://openalex.org/W2195040438","https://openalex.org/W2206969062","https://openalex.org/W2238796990","https://openalex.org/W2278717858","https://openalex.org/W2287974244","https://openalex.org/W2320544123","https://openalex.org/W2327137296","https://openalex.org/W2333131025","https://openalex.org/W2337993177","https://openalex.org/W2347084630","https://openalex.org/W2405236359","https://openalex.org/W2423304561","https://openalex.org/W2442721851","https://openalex.org/W2530769105","https://openalex.org/W2587618250","https://openalex.org/W2588971962","https://openalex.org/W2595257548","https://openalex.org/W2615946525","https://openalex.org/W2796061519","https://openalex.org/W2797702016","https://openalex.org/W2800019239","https://openalex.org/W2889213740","https://openalex.org/W2914968800","https://openalex.org/W2962043899","https://openalex.org/W2965447408","https://openalex.org/W2990779915","https://openalex.org/W3012402315","https://openalex.org/W3042070952","https://openalex.org/W3092371828","https://openalex.org/W3164341641","https://openalex.org/W4248292785"],"related_works":["https://openalex.org/W3120699816","https://openalex.org/W6904730957","https://openalex.org/W2588971962","https://openalex.org/W7124998829","https://openalex.org/W2784562096","https://openalex.org/W2561451097","https://openalex.org/W2423304561","https://openalex.org/W2110969580","https://openalex.org/W2031764657","https://openalex.org/W2622683216"],"abstract_inverted_index":{"Adult-type":[0],"Granulosa":[1],"Cell":[2],"Tumor":[3],"of":[4,13,19,36,42,58,81,113,136,148,161,183,203,220],"the":[5,45,59,99,120,126,139,146,158,165,218],"Ovary":[6],"(AGCT)":[7],"is":[8,85,96,129,152,186,189,206],"a":[9,73,104,133,175,192],"relatively":[10],"rare":[11],"subtype":[12],"ovarian":[14,21,82,184],"cancer,":[15],"accounting":[16],"for":[17,52,87,178],"2-4%":[18],"all":[20],"cancer.":[22,83],"AGCT":[23,43,62,114,162,185],"originates":[24],"from":[25,217],"proliferating":[26],"normal":[27],"preovulatory":[28],"granulosa":[29],"cells":[30],"(GCs)":[31],"and":[32,48,55,70,90,125,169,173,188,222],"retains":[33],"several":[34],"features":[35,41],"those":[37],"GCs.":[38],"The":[39,200],"hormonal":[40],"explain":[44,145],"clinical":[46],"manifestations":[47],"provide":[49,174],"reliable":[50],"markers":[51],"early":[53,68],"diagnosis":[54],"recurrence":[56,182,215],"prediction":[57],"disease.":[60],"Most":[61],"patients":[63,77,205,221],"are":[64],"diagnosed":[65],"at":[66],"an":[67,108],"stage":[69],"usually":[71],"demonstrate":[72],"better":[74],"prognosis":[75],"than":[76],"with":[78,191],"other":[79],"types":[80],"Surgery":[84],"crucial":[86],"both":[88],"initial":[89],"post-relapse":[91],"treatments,":[92],"whereas":[93],"adjuvant":[94],"therapy":[95],"still":[97],"in":[98,119,157],"exploratory":[100],"stage.":[101],"In":[102],"2009,":[103],"population-based":[105],"screening":[106],"makes":[107],"exciting":[109],"step,":[110],"about":[111],"97%":[112],"has":[115],"somatic":[116],"missense":[117],"mutations":[118],"transcription":[121],"factor":[122],"FOXL2":[123,127,140],"gene":[124],"mutation":[128,141],"considered":[130],"to":[131,163,213],"be":[132],"molecular":[134,159],"characteristic":[135],"AGCT.":[137,149],"Unfortunately,":[138],"does":[142],"not":[143],"fully":[144],"development":[147],"Ongoing":[150],"research":[151],"focusing":[153],"on":[154],"signalling":[155],"pathways":[156,172],"pathogenesis":[160],"identify":[164],"possible":[166],"pathogenetic":[167],"factors":[168],"signal":[170],"transduction":[171],"theoretical":[176],"basis":[177],"targeted":[179],"treatment.":[180],"Postoperative":[181],"common":[187],"associated":[190],"high":[193],"mortality":[194],"rate,":[195],"which":[196,209],"necessitates":[197],"regular":[198],"follow-up.":[199],"life":[201],"management":[202],"postoperative":[204],"also":[207],"crucial,":[208],"requires":[210],"multidisciplinary":[211],"experts":[212],"design":[214],"treatment":[216,225],"perspective":[219],"implement":[223],"meaningful":[224],"measures.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-20T00:00:00"}