{"id":"https://openalex.org/W4296325562","doi":"https://doi.org/10.1128/mbio.01086-22","title":"High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages","display_name":"High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages","publication_year":2022,"publication_date":"2022-09-19","ids":{"openalex":"https://openalex.org/W4296325562","doi":"https://doi.org/10.1128/mbio.01086-22","pmid":"https://pubmed.ncbi.nlm.nih.gov/36121152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9600926"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.01086-22","doi":"https://doi.org/10.1128/mbio.01086-22","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01086-22","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.01086-22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077465578","display_name":"Graciela Ter\u00e1n","orcid":"https://orcid.org/0000-0003-0151-8752","observed_orcids":["https://orcid.org/0000-0003-0151-8752"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Graciela Ter\u00e1n","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hanxiong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hanxiong Li","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053671560","display_name":"Sergiu\u2010Bogdan Catrina","orcid":"https://orcid.org/0000-0002-6914-3902","observed_orcids":["https://orcid.org/0000-0002-6914-3902"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sergiu-Bogdan Catrina","raw_affiliation_strings":["Center for Diabetes, Academic Specialist Center, Stockholm, Sweden","Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Diabetes, Academic Specialist Center, Stockholm, Sweden","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001366710","display_name":"Ruining Liu","orcid":"https://orcid.org/0000-0002-4182-9734","observed_orcids":["https://orcid.org/0000-0002-4182-9734","https://orcid.org/0009-0001-9758-588X","https://orcid.org/0009-0006-6167-4086"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ruining Liu","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069208310","display_name":"Susanna Brighenti","orcid":"https://orcid.org/0000-0001-8540-153X","observed_orcids":["https://orcid.org/0000-0001-8540-153X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanna Brighenti","raw_affiliation_strings":["Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069329974","display_name":"Xiaowei Zheng","orcid":"https://orcid.org/0000-0002-2648-1119","observed_orcids":["https://orcid.org/0000-0002-2648-1119"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xiaowei Zheng","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000142078","display_name":"Jacob Gr\u00fcnler","orcid":"https://orcid.org/0000-0001-8813-2558","observed_orcids":["https://orcid.org/0000-0001-8813-2558"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jakob Gr\u00fcnler","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084452838","display_name":"Susanne Nyl\u00e9n","orcid":"https://orcid.org/0000-0002-3875-3353","observed_orcids":["https://orcid.org/0000-0002-3875-3353"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne Nyl\u00e9n","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066265695","display_name":"Berit Carow","orcid":"https://orcid.org/0000-0002-8760-6253","observed_orcids":["https://orcid.org/0000-0002-8760-6253"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Berit Carow","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000231962","display_name":"Mart\u00edn E. Rottenberg","orcid":"https://orcid.org/0000-0003-0514-7434","observed_orcids":["https://orcid.org/0000-0003-0514-7434"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Martin E. Rottenberg","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0514-7434","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000231962"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3665,"currency":"EUR","value_usd":3952},"fwci":2.7933,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.9244672,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":"5","first_page":"e0108622","last_page":"e0108622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.8769999742507935},{"id":"https://openalex.org/keywords/carbonyl-stress","display_name":"carbonyl stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.800000011920929},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9480000138282776},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mycobacterial-persistence","display_name":"mycobacterial persistence","score":0.6570000052452087},{"id":"https://openalex.org/keywords/dfo","display_name":"DFO","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.8520313501358032},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7625981569290161},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6335315704345703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5829142332077026},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5390076041221619},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5319129824638367},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38633018732070923},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33573848009109497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2538922429084778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2181941270828247},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20490702986717224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1301652193069458}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008277","descriptor_name":"Magnesium Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011765","descriptor_name":"Pyruvaldehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mbio.01086-22","doi":"https://doi.org/10.1128/mbio.01086-22","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01086-22","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9600926","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9600926/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9600926/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmid:36121152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36121152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3c79e6a54a8b467baaa861f0f21a88de","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c79e6a54a8b467baaa861f0f21a88de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 13, Iss 5 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.01086-22","doi":"https://doi.org/10.1128/mbio.01086-22","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01086-22","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3482781783","display_name":null,"funder_award_id":"643558","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4586975594","display_name":"Mapping of human immune protective responses in the lung of individuals with latent or active Tuberculosis infection","funder_award_id":"2019-04725","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6307402069","display_name":"Eliciting Mucosal Immunity to Tuberculosis","funder_award_id":"643558","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G666572002","display_name":null,"funder_award_id":"4-1796/2014","funder_id":"https://openalex.org/F4320320939","funder_display_name":"Swedish Foundation for International Cooperation in Research and Higher Education"},{"id":"https://openalex.org/G7700065991","display_name":"Regulation and topography of pulmonary cellular immune responses in clinical and experimental Tuberculosis","funder_award_id":"2019-01691","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320939","display_name":"Swedish Foundation for International Cooperation in Research and Higher Education","ror":"https://ror.org/0561xc723"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296325562.pdf","grobid_xml":"https://content.openalex.org/works/W4296325562.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1513429447","https://openalex.org/W1580865462","https://openalex.org/W1595293335","https://openalex.org/W1749022239","https://openalex.org/W1937479869","https://openalex.org/W1967165953","https://openalex.org/W1972011552","https://openalex.org/W1975500135","https://openalex.org/W1976756088","https://openalex.org/W1981253971","https://openalex.org/W1991346678","https://openalex.org/W1999705679","https://openalex.org/W2005868568","https://openalex.org/W2006016787","https://openalex.org/W2020823643","https://openalex.org/W2024680254","https://openalex.org/W2025974453","https://openalex.org/W2037675339","https://openalex.org/W2042216712","https://openalex.org/W2046006673","https://openalex.org/W2060104085","https://openalex.org/W2064437259","https://openalex.org/W2080274549","https://openalex.org/W2083096330","https://openalex.org/W2089532303","https://openalex.org/W2098379861","https://openalex.org/W2100219680","https://openalex.org/W2104101804","https://openalex.org/W2107679943","https://openalex.org/W2108811173","https://openalex.org/W2109484445","https://openalex.org/W2110895800","https://openalex.org/W2111850449","https://openalex.org/W2117777873","https://openalex.org/W2124287509","https://openalex.org/W2128728706","https://openalex.org/W2131698535","https://openalex.org/W2136285679","https://openalex.org/W2136564653","https://openalex.org/W2144625075","https://openalex.org/W2148270074","https://openalex.org/W2149472502","https://openalex.org/W2163809998","https://openalex.org/W2169533924","https://openalex.org/W2170525767","https://openalex.org/W2171382646","https://openalex.org/W2191059068","https://openalex.org/W2331625487","https://openalex.org/W2409670633","https://openalex.org/W2417535567","https://openalex.org/W2471605942","https://openalex.org/W2478985445","https://openalex.org/W2494191041","https://openalex.org/W2566090297","https://openalex.org/W2598212562","https://openalex.org/W2888406753","https://openalex.org/W2922526669","https://openalex.org/W2951972329","https://openalex.org/W2952929850","https://openalex.org/W2973932371","https://openalex.org/W3001963980","https://openalex.org/W3003395581","https://openalex.org/W3009705041","https://openalex.org/W3025417578","https://openalex.org/W3119281466","https://openalex.org/W3125563499","https://openalex.org/W3136565328","https://openalex.org/W3169055842","https://openalex.org/W4221097369"],"related_works":["https://openalex.org/W4391757023","https://openalex.org/W7165613921","https://openalex.org/W3158861811","https://openalex.org/W7172414589","https://openalex.org/W7163643285","https://openalex.org/W2985891896","https://openalex.org/W2038758302","https://openalex.org/W4294804803","https://openalex.org/W4318065494","https://openalex.org/W123954592"],"abstract_inverted_index":{"People":[0],"living":[1],"with":[2,8,75,146],"diabetes":[3,63],"who":[4],"are":[5,11],"also":[6],"infected":[7],"M.":[9,38,70,76],"tuberculosis":[10,16,71,77],"more":[12],"likely":[13],"to":[14,47,95,137],"develop":[15],"disease":[17],"(TB).":[18],"Why":[19],"diabetic":[20],"patients":[21],"have":[22],"an":[23],"increased":[24],"risk":[25,140],"for":[26,37],"developing":[27,142],"TB":[28,143],"is":[29],"not":[30],"well":[31],"understood.":[32],"Macrophages,":[33],"the":[34,66,79,85,93,114,139],"cell":[35],"niche":[36],"tuberculosis,":[39],"can":[40,134],"express":[41],"microbicidal":[42],"mechanisms":[43],"or":[44,118],"be":[45,135],"permissive":[46],"mycobacterial":[48],"persistence":[49],"and":[50,58,103],"growth.":[51],"Here,":[52],"we":[53],"showed":[54],"that":[55,127,132],"high":[56],"glucose":[57,102,117],"carbonyl":[59,104,119],"stress,":[60],"which":[61],"mediate":[62],"pathogenesis,":[64],"impair":[65],"control":[67,112],"of":[68,81,92,116,141],"intracellular":[69],"in":[72,98,113,144],"macrophages.":[73,110],"Infection":[74],"stimulated":[78],"expression":[80],"genes":[82],"regulated":[83],"by":[84,109,123],"transcription":[86],"factor":[87],"HIF-1,":[88],"a":[89,125],"major":[90],"controller":[91],"responses":[94,108],"hypoxia,":[96],"resulting":[97],"macrophage":[99],"activation.":[100],"High":[101],"compounds":[105],"inhibited":[106],"HIF-1":[107,133],"Mycobacterial":[111],"presence":[115],"stress":[120],"was":[121],"restored":[122],"DFO,":[124],"compound":[126],"stabilizes":[128],"HIF-1.":[129],"We":[130],"propose":[131],"targeted":[136],"reduce":[138],"people":[145],"diabetes.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-09-20T00:00:00"}
