{"id":"https://openalex.org/W4296284302","doi":"https://doi.org/10.3390/ijms231810756","title":"Stemazole Promotes Oligodendrocyte Precursor Cell Survival In Vitro and Remyelination In Vivo","display_name":"Stemazole Promotes Oligodendrocyte Precursor Cell Survival In Vitro and Remyelination In Vivo","publication_year":2022,"publication_date":"2022-09-15","ids":{"openalex":"https://openalex.org/W4296284302","doi":"https://doi.org/10.3390/ijms231810756","pmid":"https://pubmed.ncbi.nlm.nih.gov/36142668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500784"},"language":"en","primary_location":{"id":"doi:10.3390/ijms231810756","doi":"https://doi.org/10.3390/ijms231810756","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810756","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10756/pdf?version=1663235284","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4296284302"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/18/10756/pdf?version=1663235284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078573674","display_name":"Yizi Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizi Zhu","raw_affiliation_strings":["Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075586363","display_name":"Mingzhu Chen","orcid":"https://orcid.org/0000-0002-6774-9599","observed_orcids":["https://orcid.org/0000-0002-6774-9599"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhu Chen","raw_affiliation_strings":["Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100695905","display_name":"Yubo Zhang","orcid":"https://orcid.org/0000-0002-4232-5407","observed_orcids":["https://orcid.org/0000-0002-4232-5407"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubo Zhang","raw_affiliation_strings":["Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101912253","display_name":"Mei Han","orcid":"https://orcid.org/0000-0003-3834-6667","observed_orcids":["https://orcid.org/0000-0003-3834-6667"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mei Han","raw_affiliation_strings":["Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101912253"],"corresponding_institution_ids":["https://openalex.org/I25254941"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.4096,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54337683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"18","first_page":"10756","last_page":"10756"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.9660000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cuprizone-induced-demyelination","display_name":"cuprizone-induced demyelination","score":0.8389999866485596},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.7799999713897705},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/olig2","display_name":"Olig2","score":0.7829999923706055},{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.9700720310211182},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7984505891799927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6476941704750061},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6056306958198547},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.561455249786377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4846954643726349},{"id":"https://openalex.org/C124964019","wikidata":"https://www.wikidata.org/wiki/Q11616062","display_name":"Precursor cell","level":3,"score":0.48461636900901794},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44134122133255005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40068089962005615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3160315155982971},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1677444577217102},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.15400496125221252},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14475607872009277},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09852716326713562}],"mesh":[{"descriptor_ui":"D000073637","descriptor_name":"Oligodendrocyte Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074586","descriptor_name":"Remyelination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003471","descriptor_name":"Cuprizone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms231810756","doi":"https://doi.org/10.3390/ijms231810756","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810756","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10756/pdf?version=1663235284","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36142668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36142668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9500784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9500784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms231810756","doi":"https://doi.org/10.3390/ijms231810756","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810756","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10756/pdf?version=1663235284","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2430917788","display_name":null,"funder_award_id":"81173139","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7089844272","display_name":null,"funder_award_id":"30672491","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321432","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296284302.pdf","grobid_xml":"https://content.openalex.org/works/W4296284302.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1980230515","https://openalex.org/W1988317772","https://openalex.org/W1989398840","https://openalex.org/W2010812346","https://openalex.org/W2012666288","https://openalex.org/W2017042997","https://openalex.org/W2025477103","https://openalex.org/W2048082433","https://openalex.org/W2062159906","https://openalex.org/W2063656803","https://openalex.org/W2083424028","https://openalex.org/W2083551906","https://openalex.org/W2089597510","https://openalex.org/W2152100400","https://openalex.org/W2277941724","https://openalex.org/W2336862132","https://openalex.org/W2771148500","https://openalex.org/W2909270098","https://openalex.org/W2913351110","https://openalex.org/W2928739568","https://openalex.org/W2967983128","https://openalex.org/W2971362820","https://openalex.org/W2999444733","https://openalex.org/W3006059050","https://openalex.org/W3099273656","https://openalex.org/W3119010010","https://openalex.org/W4211090999","https://openalex.org/W4281562766"],"related_works":["https://openalex.org/W2056677926","https://openalex.org/W6912943097","https://openalex.org/W350330409","https://openalex.org/W2322717930","https://openalex.org/W3037534488","https://openalex.org/W2906424100","https://openalex.org/W4220942817","https://openalex.org/W2947852304","https://openalex.org/W2030126638","https://openalex.org/W7023782166"],"abstract_inverted_index":{"Maintaining":[0],"the":[1,15,29,38,53,57,68,75,89,94,101,107,122,128,135,138,146,178],"normal":[2],"function":[3],"of":[4,17,31,40,59,70,77,103,124,130],"oligodendrocyte":[5,41],"precursor":[6,42],"cells":[7],"(OPCs)":[8],"and":[9,45,56,66,110,127,161,190],"protecting":[10],"OPCs":[11],"from":[12],"damage":[13],"is":[14],"basis":[16],"myelin":[18,131,147],"regeneration":[19],"in":[20,62,88,145,155,165,188,192],"multiple":[21],"sclerosis":[22],"(MS).":[23],"In":[24,73,97,182],"this":[25,196],"paper,":[26],"we":[27,99],"investigated":[28],"effect":[30,102,176],"stemazole,":[32],"a":[33,63,142,152,162,174,202],"novel":[34],"small":[35],"molecule,":[36],"on":[37,105],"promotion":[39],"cell":[43,71,78],"survival":[44,54,187],"remyelination.":[46],"The":[47,116],"results":[48,117],"show":[49,118],"that":[50,119,195],"stemazole":[51,90,104,120,139,172,184],"enhanced":[52],"rate":[55],"number":[58,76],"clone":[60],"formation":[61],"dose-dependent":[64],"manner":[65],"decreased":[67],"percentage":[69],"apoptosis.":[72],"particular,":[74],"clones":[79],"was":[80],"increased":[81],"up":[82],"to":[83],"6-fold":[84],"(p":[85,149,158,168],"<":[86,150,159,169],"0.001)":[87],"group":[91,140],"compared":[92],"with":[93,134],"control":[95,180],"group.":[96],"vivo,":[98,193],"assessed":[100],"recovering":[106],"motor":[108,125],"dysfunction":[109,126],"demyelination":[111],"induced":[112],"by":[113],"cuprizone":[114],"(CPZ).":[115],"promoted":[121,185],"recovery":[123],"repair":[129],"sheaths.":[132],"Compared":[133],"CPZ":[136],"group,":[137],"showed":[141],"30.46%":[143],"increase":[144,154,164],"area":[148],"0.001),":[151],"37.08%":[153],"MBP":[156],"expression":[157,167],"0.01),":[160],"1.66-fold":[163],"Olig2":[166],"0.001).":[170],"Histologically,":[171],"had":[173],"better":[175],"than":[177],"positive":[179],"drugs.":[181],"conclusion,":[183],"OPC":[186],"vitro":[189],"remyelination":[191],"suggesting":[194],"compound":[197],"may":[198],"be":[199],"used":[200],"as":[201],"therapeutic":[203],"agent":[204],"against":[205],"demyelinating":[206],"disease.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-09-19T00:00:00"}