{"id":"https://openalex.org/W4296252941","doi":"https://doi.org/10.3390/biom12091315","title":"Plasma Kallikrein-Activated TGF-\u03b2 Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis","display_name":"Plasma Kallikrein-Activated TGF-\u03b2 Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis","publication_year":2022,"publication_date":"2022-09-17","ids":{"openalex":"https://openalex.org/W4296252941","doi":"https://doi.org/10.3390/biom12091315","pmid":"https://pubmed.ncbi.nlm.nih.gov/36139154","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9496221"},"language":"en","primary_location":{"id":"doi:10.3390/biom12091315","doi":"https://doi.org/10.3390/biom12091315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091315","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1315/pdf?version=1663640013","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/12/9/1315/pdf?version=1663640013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012651970","display_name":"Rasmus S. Pedersen","orcid":"https://orcid.org/0000-0003-2965-166X","observed_orcids":["https://orcid.org/0000-0003-2965-166X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Rasmus S. Pedersen","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark","Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2965-166X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037705156","display_name":"Neel Ingemann Nissen","orcid":"https://orcid.org/0000-0002-8970-8798","observed_orcids":["https://orcid.org/0000-0002-8970-8798"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Neel I. Nissen","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8970-8798","affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083099939","display_name":"Christina Jensen","orcid":"https://orcid.org/0000-0002-3485-7307","observed_orcids":["https://orcid.org/0000-0002-3485-7307"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christina Jensen","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-3485-7307","affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059994714","display_name":"Jeppe Thorlacius\u2010Ussing","orcid":"https://orcid.org/0000-0002-3340-0786","observed_orcids":["https://orcid.org/0000-0002-3340-0786"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jeppe Thorlacius-Ussing","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-3340-0786","affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054710115","display_name":"Tina Manon\u2010Jensen","orcid":"https://orcid.org/0000-0002-2271-4405","observed_orcids":["https://orcid.org/0000-0002-2271-4405"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tina Manon-Jensen","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Majken L. Olesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Majken L. Olesen","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084107761","display_name":"Lasse L\u00f8cke Langholm","orcid":"https://orcid.org/0000-0003-0549-5797","observed_orcids":["https://orcid.org/0000-0003-0549-5797"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lasse L. Langholm","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082513177","display_name":"Hadi M. H. Diab","orcid":"https://orcid.org/0000-0002-1469-1899","observed_orcids":["https://orcid.org/0000-0002-1469-1899"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801150652","display_name":"Frederiksberg Hospital","ror":"https://ror.org/00d264c35","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801150652","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hadi M. H. Diab","raw_affiliation_strings":["Digestive Disease Center, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Disease Center, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801150652","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020717767","display_name":"Lars Nannestad J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-7465-5374","observed_orcids":["https://orcid.org/0000-0001-7465-5374"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801150652","display_name":"Frederiksberg Hospital","ror":"https://ror.org/00d264c35","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801150652","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars N. Jorgensen","raw_affiliation_strings":["Digestive Disease Center, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-7465-5374","affiliations":[{"raw_affiliation_string":"Digestive Disease Center, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801150652","https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038457626","display_name":"Carsten Paln\u00e6s Hansen","orcid":"https://orcid.org/0000-0002-9256-2240","observed_orcids":["https://orcid.org/0000-0002-9256-2240"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Carsten P. Hansen","raw_affiliation_strings":["Department of Surgery, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-9256-2240","affiliations":[{"raw_affiliation_string":"Department of Surgery, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071985590","display_name":"Inna  Markovna Chen","orcid":"https://orcid.org/0000-0003-2891-0762","observed_orcids":["https://orcid.org/0000-0003-2891-0762"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Inna M. Chen","raw_affiliation_strings":["Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2891-0762","affiliations":[{"raw_affiliation_string":"Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063670944","display_name":"Julia Sidenius Johansen","orcid":"https://orcid.org/0000-0002-4217-6560","observed_orcids":["https://orcid.org/0000-0002-4217-6560"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Julia S. Johansen","raw_affiliation_strings":["Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark","Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark","Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564","https://openalex.org/I2802582725"]},{"raw_affiliation_string":"Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063475809","display_name":"M.A. Karsdal","orcid":"https://orcid.org/0000-0001-5026-8740","observed_orcids":["https://orcid.org/0000-0001-5026-8740"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten A. Karsdal","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049099295","display_name":"Nicholas Willumsen","orcid":"https://orcid.org/0000-0002-5207-5173","observed_orcids":["https://orcid.org/0000-0002-5207-5173"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nicholas Willumsen","raw_affiliation_strings":["Nordic Bioscience, 2730 Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, 2730 Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012651970"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4210142214"],"apc_list":{"value":2100,"currency":"CHF","value_usd":2199},"apc_paid":{"value":2100,"currency":"CHF","value_usd":2199},"fwci":1.1281,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.78870997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"9","first_page":"1315","last_page":"1315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.13269999623298645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tgf-beta-activation","display_name":"TGF-beta activation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/latency-associated-protein","display_name":"latency-associated protein","score":0.8429999947547913},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.753000020980835},{"id":"https://openalex.org/keywords/tumor-fibrosis","display_name":"tumor fibrosis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6660000085830688},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.7020957469940186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5487717390060425},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5434766411781311},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5005857944488525},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.48506441712379456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4816545248031616},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4711947441101074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4053565561771393},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.3395878076553345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27149704098701477},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18623724579811096},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020842","descriptor_name":"Plasma Kallikrein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024061","descriptor_name":"Collagen Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024142","descriptor_name":"Collagen Type VI","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom12091315","doi":"https://doi.org/10.3390/biom12091315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091315","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1315/pdf?version=1663640013","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9496221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9496221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:36139154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36139154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/7b4d9b77-cb89-4d48-beaa-8156d47b0455","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/7b4d9b77-cb89-4d48-beaa-8156d47b0455","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pedersen, R S, Nissen, N, Jensen, C, Thorlacius-Ussing, J, Manon-Jensen, T, Olesen, M L, Langholm, L L, Diab, H M H, Jorgensen, L N, Hansen, C P, Chen, I M, Johansen, J S, Karsdal, M A & Willumsen, N 2022, 'Plasma Kallikrein-Activated TGF-beta Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis', Biomolecules, vol. 12, no. 9, 1315. https://doi.org/10.3390/biom12091315","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:090d7e20b41848078ab5b37623004dd1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/090d7e20b41848078ab5b37623004dd1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 12, Iss 9, p 1315 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom12091315","doi":"https://doi.org/10.3390/biom12091315","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091315","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1315/pdf?version=1663640013","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321590","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296252941.pdf","grobid_xml":"https://content.openalex.org/works/W4296252941.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W15077488","https://openalex.org/W1524114372","https://openalex.org/W1771685561","https://openalex.org/W1890402826","https://openalex.org/W1969565221","https://openalex.org/W1974719543","https://openalex.org/W1986676191","https://openalex.org/W1990605319","https://openalex.org/W1995539429","https://openalex.org/W2012008369","https://openalex.org/W2030163851","https://openalex.org/W2038313328","https://openalex.org/W2055998280","https://openalex.org/W2104072969","https://openalex.org/W2111895881","https://openalex.org/W2132997519","https://openalex.org/W2150472477","https://openalex.org/W2152066366","https://openalex.org/W2155049325","https://openalex.org/W2161518005","https://openalex.org/W2172114097","https://openalex.org/W2195607455","https://openalex.org/W2211008635","https://openalex.org/W2342679639","https://openalex.org/W2499189569","https://openalex.org/W2586848166","https://openalex.org/W2592339836","https://openalex.org/W2765192645","https://openalex.org/W2901515128","https://openalex.org/W2913817815","https://openalex.org/W2920999109","https://openalex.org/W2942286148","https://openalex.org/W2956910394","https://openalex.org/W2981569660","https://openalex.org/W2983881502","https://openalex.org/W2987225757","https://openalex.org/W2989313910","https://openalex.org/W3005214954","https://openalex.org/W3023632796","https://openalex.org/W3040737854","https://openalex.org/W3043387159","https://openalex.org/W3044762644","https://openalex.org/W3097893749","https://openalex.org/W3135273346","https://openalex.org/W3149714833","https://openalex.org/W3198421791","https://openalex.org/W3207231649","https://openalex.org/W3207484823","https://openalex.org/W4206841660","https://openalex.org/W4210351446","https://openalex.org/W4221047401","https://openalex.org/W4294352168","https://openalex.org/W4323241890","https://openalex.org/W4412273324","https://openalex.org/W6600617801"],"related_works":["https://openalex.org/W4282960980","https://openalex.org/W2499189569","https://openalex.org/W4210351446","https://openalex.org/W4283582077","https://openalex.org/W7122861438","https://openalex.org/W4404064273","https://openalex.org/W4410532916","https://openalex.org/W6976829508","https://openalex.org/W2948979599","https://openalex.org/W4223475543"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"is":[4,22,29],"a":[5,36,65,175,198],"hard-to-treat":[6],"cancer":[7],"due":[8],"to":[9,58,107,128],"the":[10,78,84,178],"collagen-rich":[11],"(fibrotic)":[12],"and":[13,70,93,105,113,152,172,184],"immune-suppressed":[14],"microenvironment.":[15],"A":[16],"major":[17],"driver":[18],"of":[19,54,80,86,137,150,164],"this":[20,55],"phenomenon":[21],"transforming":[23],"growth":[24],"factor":[25],"beta":[26],"(TGF-\u03b2).":[27],"TGF-\u03b2":[28,182],"produced":[30],"in":[31,83,123,145],"an":[32],"inactive":[33],"complex":[34],"with":[35,89,101,125,142,147,169],"latency-associated":[37],"protein":[38],"(LAP)":[39],"that":[40],"can":[41],"be":[42,197],"cleaved":[43,61],"by":[44,62],"plasma":[45],"kallikrein":[46],"(PLK),":[47],"hereby":[48],"releasing":[49],"active":[50],"TGF-\u03b2.":[51],"The":[52],"aim":[53],"study":[56],"was":[57,75,121],"evaluate":[59],"LAP":[60],"PLK":[63],"as":[64],"non-invasive":[66],"biomarker":[67,199],"for":[68,77,200],"PDAC":[69,90,126,148],"tumor":[71,185],"fibrosis.":[72,186],"An":[73],"ELISA":[74],"developed":[76],"quantification":[79],"PLK-cleaved":[81,119,138,165,179,194],"LAP-TGF-\u03b2":[82,120,139,166,180,195],"serum":[85,108],"34":[87],"patients":[88,124,146],"(stage":[91],"1\u22124)":[92],"20":[94],"healthy":[95,129],"individuals.":[96],"Biomarker":[97],"levels":[98,135,163],"were":[99,140,167],"correlated":[100],"overall":[102],"survival":[103],"(OS)":[104],"compared":[106,127],"type":[109,114],"III":[110],"collagen":[111,116],"(PRO-C3)":[112],"VI":[115],"(PRO-C6)":[117],"pro-peptides.":[118],"higher":[122],"individuals":[130],"(p":[131],"<":[132],"0.0001).":[133],"High":[134,162],"(>median)":[136],"associated":[141,168],"poor":[143],"OS":[144],"independent":[149],"age":[151],"stage":[153],"(HR":[154],"2.57,":[155],"95%":[156],"CI:":[157],"1.22\u22125.44,":[158],"p":[159],"=":[160],"0.0135).":[161],"high":[170],"PRO-C3":[171],"PRO-C6,":[173],"indicating":[174],"relationship":[176],"between":[177],"fragment,":[181],"activity,":[183],"If":[187],"these":[188],"preliminary":[189],"results":[190],"are":[191],"validated,":[192],"circulating":[193],"may":[196],"future":[201],"clinical":[202],"trials.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-19T00:00:00"}