{"id":"https://openalex.org/W4296252930","doi":"https://doi.org/10.3390/biom12091309","title":"6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist","display_name":"6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist","publication_year":2022,"publication_date":"2022-09-16","ids":{"openalex":"https://openalex.org/W4296252930","doi":"https://doi.org/10.3390/biom12091309","pmid":"https://pubmed.ncbi.nlm.nih.gov/36139148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9496321"},"language":"en","primary_location":{"id":"doi:10.3390/biom12091309","doi":"https://doi.org/10.3390/biom12091309","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091309","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1309/pdf?version=1663665557","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/12/9/1309/pdf?version=1663665557","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089275093","display_name":"Peter Cuthbertson","orcid":"https://orcid.org/0000-0003-2903-2586","observed_orcids":["https://orcid.org/0000-0003-2903-2586"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Cuthbertson","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2903-2586","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031586983","display_name":"Amal Elhage","orcid":"https://orcid.org/0000-0003-0625-3183","observed_orcids":["https://orcid.org/0000-0003-0625-3183"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amal Elhage","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085486370","display_name":"Dena Al-Rifai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Dena Al-Rifai","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052350687","display_name":"Reece Andrew Sophocleous","orcid":"https://orcid.org/0000-0002-8339-9090","observed_orcids":["https://orcid.org/0000-0002-8339-9090"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Reece A. Sophocleous","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8339-9090","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058412111","display_name":"Ross J. Turner","orcid":"https://orcid.org/0000-0003-3762-6296","observed_orcids":["https://orcid.org/0000-0003-3762-6296"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ross J. Turner","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021862858","display_name":"Ashraf Aboelela","orcid":"https://orcid.org/0000-0002-8988-6252","observed_orcids":["https://orcid.org/0000-0002-8988-6252"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]},{"id":"https://openalex.org/I4399598398","display_name":"Sphinx University","ror":"https://ror.org/0568jvs10","country_code":"EG","type":"education","lineage":["https://openalex.org/I4399598398"]}],"countries":["AU","EG"],"is_corresponding":false,"raw_author_name":"Ashraf Aboelela","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, Assiut 71515, Egypt","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, Assiut 71515, Egypt; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, Assiut 71515, Egypt","institution_ids":["https://openalex.org/I4399598398"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, Assiut 71515, Egypt; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629","https://openalex.org/I4399598398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084063526","display_name":"Hiwa Majed","orcid":"https://orcid.org/0000-0003-1810-9445","observed_orcids":["https://orcid.org/0000-0003-1810-9445"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hiwa Majed","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021322013","display_name":"Richard S. Bujaroski","orcid":"https://orcid.org/0000-0002-8459-527X","observed_orcids":["https://orcid.org/0000-0002-8459-527X"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard S. Bujaroski","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Monash Institute of Pharmaceutical Science (ATMCF), Monash University, Parkville, VIC 3052, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia; Monash Institute of Pharmaceutical Science (ATMCF), Monash University, Parkville, VIC 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8459-527X","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Monash Institute of Pharmaceutical Science (ATMCF), Monash University, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia; Monash Institute of Pharmaceutical Science (ATMCF), Monash University, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031751030","display_name":"Iman Jalilian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Iman Jalilian","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052000729","display_name":"Michael J. Kelso","orcid":"https://orcid.org/0000-0001-7809-6637","observed_orcids":["https://orcid.org/0000-0001-7809-6637"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael J. Kelso","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":"https://orcid.org/0000-0001-7809-6637","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004438424","display_name":"Debbie Watson","orcid":"https://orcid.org/0000-0002-6242-3944","observed_orcids":["https://orcid.org/0000-0002-6242-3944"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Debbie Watson","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032460117","display_name":"Benjamin J. Buckley","orcid":"https://orcid.org/0000-0002-8346-3371","observed_orcids":["https://orcid.org/0000-0002-8346-3371"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Benjamin J. Buckley","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8346-3371","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041363133","display_name":"Ronald Sluyter","orcid":"https://orcid.org/0000-0003-4909-686X","observed_orcids":["https://orcid.org/0000-0003-4909-686X"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ronald Sluyter","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4909-686X","affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I4210091629"]},{"raw_affiliation_string":"Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041363133"],"corresponding_institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"],"apc_list":{"value":2100,"currency":"CHF","value_usd":2199},"apc_paid":{"value":2100,"currency":"CHF","value_usd":2199},"fwci":1.2438,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71518325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"9","first_page":"1309","last_page":"1309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/amiloride-derivatives","display_name":"amiloride derivatives","score":0.9700000286102295},{"id":"https://openalex.org/keywords/p2x7-antagonists","display_name":"P2X7 antagonists","score":0.7480000257492065},{"id":"https://openalex.org/keywords/atp-gated-cation-channels","display_name":"ATP-gated cation channels","score":0.8870000243186951},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.7879999876022339},{"id":"https://openalex.org/keywords/interleukin-1beta-release","display_name":"interleukin-1\u03b2 release","score":0.8830000162124634},{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.7549999952316284},{"id":"https://openalex.org/keywords/myeloma-cells","display_name":"myeloma cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/leukocyte-activation","display_name":"leukocyte activation","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.8763295412063599},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.8461645841598511},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6116423010826111},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5822303295135498},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5203647017478943},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.501777172088623},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48477333784103394},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.44844749569892883},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4258003830909729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36774423718452454},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33335191011428833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20047235488891602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18907049298286438},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.12276673316955566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058920","descriptor_name":"Purinergic P2X Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom12091309","doi":"https://doi.org/10.3390/biom12091309","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091309","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1309/pdf?version=1663665557","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmid:36139148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36139148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9496321","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9496321/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmh:oai:ro.uow.edu.au:test2021-11610","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/test2021/6063","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus Harvesting Series","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ec5409f7111249ca998740badc225245","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ec5409f7111249ca998740badc225245","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 12, Iss 9, p 1309 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom12091309","doi":"https://doi.org/10.3390/biom12091309","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom12091309","pdf_url":"https://www.mdpi.com/2218-273X/12/9/1309/pdf?version=1663665557","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296252930.pdf","grobid_xml":"https://content.openalex.org/works/W4296252930.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1608870321","https://openalex.org/W1831482945","https://openalex.org/W1978714719","https://openalex.org/W1998594826","https://openalex.org/W2006216368","https://openalex.org/W2015495495","https://openalex.org/W2022128427","https://openalex.org/W2029069980","https://openalex.org/W2040278093","https://openalex.org/W2049146381","https://openalex.org/W2059391185","https://openalex.org/W2062112365","https://openalex.org/W2066573557","https://openalex.org/W2092710350","https://openalex.org/W2098964711","https://openalex.org/W2127237840","https://openalex.org/W2152806530","https://openalex.org/W2252428378","https://openalex.org/W2307224898","https://openalex.org/W2379320148","https://openalex.org/W2559826741","https://openalex.org/W2597076579","https://openalex.org/W2729475301","https://openalex.org/W2737555531","https://openalex.org/W2765781349","https://openalex.org/W2771471373","https://openalex.org/W2793367826","https://openalex.org/W2886489703","https://openalex.org/W2888001388","https://openalex.org/W2901801276","https://openalex.org/W2905070817","https://openalex.org/W2936582881","https://openalex.org/W2938159790","https://openalex.org/W2954247725","https://openalex.org/W2981980119","https://openalex.org/W3004700754","https://openalex.org/W3011592910","https://openalex.org/W3042566941","https://openalex.org/W3042775141","https://openalex.org/W3047569335","https://openalex.org/W3089815098","https://openalex.org/W3094013802","https://openalex.org/W3107292109","https://openalex.org/W3124386657","https://openalex.org/W3139515002","https://openalex.org/W3145257564","https://openalex.org/W4280561212","https://openalex.org/W4285232526","https://openalex.org/W6691020469"],"related_works":["https://openalex.org/W2088918268","https://openalex.org/W1970469389","https://openalex.org/W2058352883","https://openalex.org/W2903402838","https://openalex.org/W3091375123","https://openalex.org/W2009070511","https://openalex.org/W2184027171","https://openalex.org/W1990393354","https://openalex.org/W2059391185","https://openalex.org/W2095083846"],"abstract_inverted_index":{"P2X7":[0,27,62,72,172,185],"is":[1,197],"an":[2],"extracellular":[3],"adenosine":[4],"5\u2032-triphopshate":[5],"(ATP)-gated":[6],"cation":[7],"channel":[8],"present":[9],"on":[10],"leukocytes,":[11],"where":[12],"its":[13,35,53,180],"activation":[14],"induces":[15],"pro-inflammatory":[16],"cytokine":[17],"release":[18,124],"and":[19,34,74,89,122,128,143,157,166],"ectodomain":[20],"shedding":[21,130],"of":[22,47,190],"cell":[23],"surface":[24],"molecules.":[25],"Human":[26],"can":[28],"be":[29],"partially":[30],"inhibited":[31,114],"by":[32],"amiloride":[33,51,56,191],"derivatives":[36,192],"at":[37],"micromolar":[38],"concentrations.":[39],"This":[40],"study":[41,189],"aimed":[42],"to":[43,58],"screen":[44],"a":[45,60,70,94,109,183],"library":[46],"compounds":[48],"derived":[49],"from":[50,131,173],"or":[52],"derivative":[54],"5-(N,N-hexamethylene)":[55],"(HMA)":[57],"identify":[59],"potential":[61],"antagonist.":[63],"6-Furopyridine":[64],"HMA":[65],"(6-FPHMA)":[66],"was":[67,75],"identified":[68],"as":[69,182,193],"novel":[71],"antagonist":[73],"characterized":[76],"further.":[77],"6-FPHMA":[78,99,113,134,148,170],"impaired":[79,136,149],"ATP-induced":[80,101,115,137,150],"dye":[81,116,138],"uptake":[82,117,139],"into":[83,118,140],"human":[84,90,105,119,126,154],"RPMI8226":[85,132],"multiple":[86,174],"myeloma":[87],"cells":[88,107,156],"P2X7-HEK293":[91,106,145],"cells,":[92,121,160],"in":[93,104,108,153],"concentration-dependent,":[95,110],"non-competitive":[96,111],"manner.":[97,112],"Likewise,":[98],"blocked":[100],"Ca2+":[102,151],"fluxes":[103,152],"T":[120],"interleukin-1\u03b2":[123],"within":[125],"blood":[127],"CD23":[129],"cells.":[133,146],"also":[135],"murine":[141],"P2X7-":[142],"canine":[144],"However,":[147],"P2X4-HEK293":[155],"non-transfected":[158],"HEK293":[159],"which":[161],"express":[162],"native":[163],"P2Y1,":[164],"P2Y2":[165],"P2Y4.":[167],"In":[168],"conclusion,":[169],"inhibits":[171],"species.":[175],"Its":[176],"poor":[177],"selectivity":[178],"excludes":[179],"use":[181],"specific":[184],"antagonist,":[186],"but":[187],"further":[188],"P2":[194],"receptor":[195],"antagonists":[196],"warranted.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-19T00:00:00"}
