{"id":"https://openalex.org/W4296182425","doi":"https://doi.org/10.4012/dmj.2022-122","title":"Impact of surface pre-reacted glass ionomer filler eluate on lipase gene expression in Candida albicans: An in vitro study","display_name":"Impact of surface pre-reacted glass ionomer filler eluate on lipase gene expression in Candida albicans: An in vitro study","publication_year":2022,"publication_date":"2022-09-16","ids":{"openalex":"https://openalex.org/W4296182425","doi":"https://doi.org/10.4012/dmj.2022-122","pmid":"https://pubmed.ncbi.nlm.nih.gov/36123045"},"language":"en","primary_location":{"id":"doi:10.4012/dmj.2022-122","doi":"https://doi.org/10.4012/dmj.2022-122","is_oa":true,"landing_page_url":"https://doi.org/10.4012/dmj.2022-122","pdf_url":"https://www.jstage.jst.go.jp/article/dmj/42/1/42_2022-122/_pdf","source":{"id":"https://openalex.org/S202133162","display_name":"Dental Materials Journal","issn_l":"0287-4547","issn":["0287-4547","1881-1361"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4324004147","host_organization_name":"Japanese Society for Dental Materials and Devices","host_organization_lineage":["https://openalex.org/P4324004147"],"host_organization_lineage_names":["Japanese Society for Dental Materials and Devices"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental Materials Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/dmj/42/1/42_2022-122/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066613984","display_name":"Watcharapong Tonprasong","orcid":"https://orcid.org/0000-0002-6658-4243","observed_orcids":["https://orcid.org/0000-0002-6658-4243"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I66200439","display_name":"Naresuan University","ror":"https://ror.org/03e2qe334","country_code":"TH","type":"education","lineage":["https://openalex.org/I66200439"]}],"countries":["JP","TH"],"is_corresponding":false,"raw_author_name":"Watcharapong TONPRASONG","raw_affiliation_strings":["Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University","Department of Restorative Dentistry, Faculty of Dentistry, Naresuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Naresuan University","institution_ids":["https://openalex.org/I66200439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041100417","display_name":"Masanao Inokoshi","orcid":"https://orcid.org/0000-0001-8833-3907","observed_orcids":["https://orcid.org/0000-0001-8833-3907"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanao INOKOSHI","raw_affiliation_strings":["Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034951767","display_name":"Muneaki Tamura","orcid":"https://orcid.org/0000-0002-8637-1579","observed_orcids":["https://orcid.org/0000-0002-8637-1579"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Muneaki TAMURA","raw_affiliation_strings":["Department of Microbiology and Immunology, Nihon University School of Dentistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nihon University School of Dentistry","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035225174","display_name":"Keita Hatano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keita HATANO","raw_affiliation_strings":["Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033156378","display_name":"Shunsuke Minakuchi","orcid":"https://orcid.org/0000-0003-2217-7539","observed_orcids":["https://orcid.org/0000-0003-2217-7539"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke MINAKUCHI","raw_affiliation_strings":["Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9711,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70526474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"42","issue":"1","first_page":"49","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surface-pre-reacted-glass-ionomer","display_name":"S-PRG","score":0.9890000224113464},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipase-gene-expression","display_name":"lipase gene expression","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lipase-activity","display_name":"lipase activity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.46700000762939453},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8129822015762329},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.7159438729286194},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.495764821767807},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4588298499584198},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4342738389968872},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4018021821975708},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37275469303131104},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32072967290878296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2999125123023987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25358694791793823},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21397453546524048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14978015422821045}],"mesh":[{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005899","descriptor_name":"Glass Ionomer Cements","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4012/dmj.2022-122","doi":"https://doi.org/10.4012/dmj.2022-122","is_oa":true,"landing_page_url":"https://doi.org/10.4012/dmj.2022-122","pdf_url":"https://www.jstage.jst.go.jp/article/dmj/42/1/42_2022-122/_pdf","source":{"id":"https://openalex.org/S202133162","display_name":"Dental Materials Journal","issn_l":"0287-4547","issn":["0287-4547","1881-1361"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4324004147","host_organization_name":"Japanese Society for Dental Materials and Devices","host_organization_lineage":["https://openalex.org/P4324004147"],"host_organization_lineage_names":["Japanese Society for Dental Materials and Devices"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental Materials Journal","raw_type":"journal-article"},{"id":"pmid:36123045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36123045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental materials journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4012/dmj.2022-122","doi":"https://doi.org/10.4012/dmj.2022-122","is_oa":true,"landing_page_url":"https://doi.org/10.4012/dmj.2022-122","pdf_url":"https://www.jstage.jst.go.jp/article/dmj/42/1/42_2022-122/_pdf","source":{"id":"https://openalex.org/S202133162","display_name":"Dental Materials Journal","issn_l":"0287-4547","issn":["0287-4547","1881-1361"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4324004147","host_organization_name":"Japanese Society for Dental Materials and Devices","host_organization_lineage":["https://openalex.org/P4324004147"],"host_organization_lineage_names":["Japanese Society for Dental Materials and Devices"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dental Materials Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4799181672","display_name":"Development of new antibacterial oral care agent for the elderly: Attempt from basic experiment to clinical practical use","funder_award_id":"21K10219","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000215077","display_name":"S-PRG\u30d5\u30a3\u30e9\u30fc\u542b\u6709\u7fa9\u6b6f\u5b89\u5b9a\u6750\u306e\u6297\u83cc\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u5b89\u5168\u6027\u306e\u89e3\u660e","funder_award_id":"22K17129","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296182425.pdf","grobid_xml":"https://content.openalex.org/works/W4296182425.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W178076803","https://openalex.org/W1964900779","https://openalex.org/W1969393720","https://openalex.org/W2041308751","https://openalex.org/W2051944507","https://openalex.org/W2063282574","https://openalex.org/W2066870814","https://openalex.org/W2092398848","https://openalex.org/W2111686574","https://openalex.org/W2113628061","https://openalex.org/W2127002115","https://openalex.org/W2137428110","https://openalex.org/W2144035662","https://openalex.org/W2148085432","https://openalex.org/W2165113482","https://openalex.org/W2168615162","https://openalex.org/W2196273966","https://openalex.org/W2330374799","https://openalex.org/W2338462821","https://openalex.org/W2346918950","https://openalex.org/W2473074332","https://openalex.org/W2586186420","https://openalex.org/W2752951686","https://openalex.org/W2788154033","https://openalex.org/W2805307936","https://openalex.org/W2805527156","https://openalex.org/W2984679221","https://openalex.org/W3081684620","https://openalex.org/W3179272901","https://openalex.org/W3201569885","https://openalex.org/W3209883841"],"related_works":["https://openalex.org/W7152438780","https://openalex.org/W2984679221","https://openalex.org/W2805527156","https://openalex.org/W2788154033","https://openalex.org/W4402187941","https://openalex.org/W2805307936","https://openalex.org/W2196273966","https://openalex.org/W2089007428","https://openalex.org/W7096669691","https://openalex.org/W4414057643"],"abstract_inverted_index":{"Although":[0],"a":[1,8,122],"surface":[2],"pre-reacted":[3],"glass":[4],"ionomer":[5],"(S-PRG)":[6],"exerts":[7],"suppressive":[9],"effect":[10,49],"on":[11,21,54],"Candida":[12,66],"albicans":[13,59,67,97],"(C.":[14],"albicans)":[15],"activity":[16,94,145],"and":[17,79,108],"growth,":[18],"its":[19],"influence":[20],"the":[22,25,48,106,136],"expression":[23,56,111],"of":[24,34,50,77,105,125],"lipase":[26,93,119],"gene":[27],"(LIP)":[28],"family":[29],"including":[30],"LIP1-LIP10,":[31],"an":[32,71],"indicator":[33],"clinical":[35],"infection,":[36],"has":[37,140],"not":[38],"yet":[39],"been":[40],"investigated.":[41],"Therefore,":[42],"in":[43,57,95,132],"this":[44],"study,":[45],"we":[46],"evaluated":[47],"S-PRG":[51,72,88,137],"filler":[52,73,89,138],"eluates":[53,90],"LIP":[55,133,148],"C.":[58,96],"using":[60],"real-time":[61],"reverse-transcription":[62],"polymerase":[63],"chain":[64],"reaction.":[65],"was":[68,128],"treated":[69],"with":[70,117],"diluted":[74,87],"at":[75,84],"ratios":[76],"1:32":[78],"1:64":[80],"for":[81],"24":[82,113],"h":[83],"37\u00b0C.":[85],"The":[86],"(1:32)":[91],"suppressed":[92],"by":[98,146],"downregulating":[99,147],"LIP5":[100],"(0.54\u00b10.25":[101],"relative":[102],"to":[103,142],"that":[104],"control)":[107],"LIP8":[109],"(0.35\u00b10.074)":[110],"after":[112],"h,":[114],"which":[115],"corresponded":[116],"decreased":[118],"activity.":[120],"At":[121],"dilution":[123],"factor":[124],"1:64,":[126],"there":[127],"no":[129],"significant":[130],"difference":[131],"expression.":[134,149],"Thus,":[135],"eluate":[139],"potential":[141],"suppress":[143],"fungal":[144]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-18T00:00:00"}
