{"id":"https://openalex.org/W4296137440","doi":"https://doi.org/10.3390/ijms231810392","title":"An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation","display_name":"An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation","publication_year":2022,"publication_date":"2022-09-08","ids":{"openalex":"https://openalex.org/W4296137440","doi":"https://doi.org/10.3390/ijms231810392","pmid":"https://pubmed.ncbi.nlm.nih.gov/36142298"},"language":"en","primary_location":{"id":"doi:10.3390/ijms231810392","doi":"https://doi.org/10.3390/ijms231810392","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810392","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10392/pdf?version=1662634917","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/18/10392/pdf?version=1662634917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071003960","display_name":"Tzu-Yin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Yin Huang","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100729262","display_name":"Feng\u2010Ling Yang","orcid":"https://orcid.org/0000-0003-2392-8381","observed_orcids":["https://orcid.org/0000-0003-2392-8381"]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Feng-Ling Yang","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084421723","display_name":"Hsiao\u2010Wen Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75430998","display_name":"National Ilan University","ror":"https://ror.org/01npf0s58","country_code":"TW","type":"education","lineage":["https://openalex.org/I75430998"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiao-Wen Chiu","raw_affiliation_strings":["Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan","institution_ids":["https://openalex.org/I75430998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065475004","display_name":"Hong-Chu Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hong-Chu Chao","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072838575","display_name":"Yen-Ju Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Ju Yang","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070284562","display_name":"Jyh\u2010Horng Sheu","orcid":"https://orcid.org/0000-0002-1216-5991","observed_orcids":["https://orcid.org/0000-0002-1216-5991"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jyh-Horng Sheu","raw_affiliation_strings":["Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan","institution_ids":["https://openalex.org/I142974352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072624731","display_name":"Kuo\u2010Feng Hua","orcid":"https://orcid.org/0000-0001-8436-8299","observed_orcids":["https://orcid.org/0000-0001-8436-8299"]},"institutions":[{"id":"https://openalex.org/I75430998","display_name":"National Ilan University","ror":"https://ror.org/01npf0s58","country_code":"TW","type":"education","lineage":["https://openalex.org/I75430998"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Feng Hua","raw_affiliation_strings":["Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Animal Science, National Ilan University, Ilan 260, Taiwan","institution_ids":["https://openalex.org/I75430998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001947000","display_name":"Shih\u2010Hsiung Wu","orcid":"https://orcid.org/0000-0002-1490-1227","observed_orcids":["https://orcid.org/0000-0002-1490-1227"]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Hsiung Wu","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001947000"],"corresponding_institution_ids":["https://openalex.org/I4210092384"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":3.7716,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.94678595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"23","issue":"18","first_page":"10392","last_page":"10392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tremella-fuciformis","display_name":"Tremella fuciformis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fungal-polysaccharides","display_name":"fungal polysaccharides","score":0.859000027179718},{"id":"https://openalex.org/keywords/o-acetylation","display_name":"O-acetylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7300000190734863},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9240000247955322},{"id":"https://openalex.org/keywords/polysaccharide-structure-elucidation","display_name":"polysaccharide structure elucidation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/monosaccharide-composition","display_name":"monosaccharide composition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/glucuronic-acid","display_name":"glucuronic acid","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fucose","display_name":"fucose","score":0.6620000004768372},{"id":"https://openalex.org/keywords/xylose","display_name":"xylose","score":0.621999979019165},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.7453241348266602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.678474485874176},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.6746490001678467},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6519134044647217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5394144654273987},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.5281426906585693},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5183582901954651},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.5078223347663879},{"id":"https://openalex.org/C118859902","wikidata":"https://www.wikidata.org/wiki/Q133516","display_name":"Monosaccharide","level":2,"score":0.4964662194252014},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.453920841217041},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.39525043964385986},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.2495308220386505},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.09988585114479065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06886059045791626}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001487","descriptor_name":"Basidiomycota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005643","descriptor_name":"Fucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005643","descriptor_name":"Fucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005643","descriptor_name":"Fucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014994","descriptor_name":"Xylose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014994","descriptor_name":"Xylose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014994","descriptor_name":"Xylose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms231810392","doi":"https://doi.org/10.3390/ijms231810392","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810392","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10392/pdf?version=1662634917","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:36142298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36142298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9499394","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9499394","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aa060af720974457bd981387fe36f1a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aa060af720974457bd981387fe36f1a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 10392, p 10392 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms231810392","doi":"https://doi.org/10.3390/ijms231810392","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms231810392","pdf_url":"https://www.mdpi.com/1422-0067/23/18/10392/pdf?version=1662634917","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323900","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296137440.pdf","grobid_xml":"https://content.openalex.org/works/W4296137440.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1552524973","https://openalex.org/W1584765117","https://openalex.org/W1939504737","https://openalex.org/W1965857850","https://openalex.org/W1967434989","https://openalex.org/W1968834637","https://openalex.org/W1969310594","https://openalex.org/W1969350938","https://openalex.org/W1971614627","https://openalex.org/W1980308411","https://openalex.org/W1983220630","https://openalex.org/W1988279204","https://openalex.org/W1996120614","https://openalex.org/W2014988363","https://openalex.org/W2031280553","https://openalex.org/W2033329147","https://openalex.org/W2042826105","https://openalex.org/W2053861467","https://openalex.org/W2055810486","https://openalex.org/W2057007315","https://openalex.org/W2066318573","https://openalex.org/W2066517914","https://openalex.org/W2068419165","https://openalex.org/W2072163165","https://openalex.org/W2079003739","https://openalex.org/W2085095860","https://openalex.org/W2085835822","https://openalex.org/W2101363646","https://openalex.org/W2108597511","https://openalex.org/W2111502907","https://openalex.org/W2121878520","https://openalex.org/W2164353391","https://openalex.org/W2166674155","https://openalex.org/W2167137376","https://openalex.org/W2301195256","https://openalex.org/W2330783314","https://openalex.org/W2344107174","https://openalex.org/W2354039201","https://openalex.org/W2625602643","https://openalex.org/W2626978705","https://openalex.org/W2803042692","https://openalex.org/W2804926125","https://openalex.org/W2887945948","https://openalex.org/W2897487585","https://openalex.org/W2970034116","https://openalex.org/W2971351262","https://openalex.org/W3011852136","https://openalex.org/W3025522240","https://openalex.org/W3090585473","https://openalex.org/W3128966910","https://openalex.org/W3212171935","https://openalex.org/W3217335069","https://openalex.org/W4253779579","https://openalex.org/W6675461968"],"related_works":["https://openalex.org/W2138584415","https://openalex.org/W102657340","https://openalex.org/W2051929873","https://openalex.org/W170626015","https://openalex.org/W2324788270","https://openalex.org/W2064190052","https://openalex.org/W2170980916","https://openalex.org/W2010164265","https://openalex.org/W2084684705","https://openalex.org/W1965515663"],"abstract_inverted_index":{"The":[0,104],"edible":[1],"fungus":[2],"Tremella":[3],"fuciformis":[4],"was":[5,62,81],"shown":[6],"to":[7,83,110],"have":[8],"a":[9,47,75],"high":[10],"molecular":[11],"weight":[12],"(1.87":[13],"\u00d7":[14],"103":[15],"kDa)":[16],"bioactive":[17],"polysaccharide,":[18],"denoted":[19],"as":[20,64],"TFP-F1.":[21],"Monosaccharide":[22],"composition":[23],"and":[24,30,42,54,89],"NMR":[25],"analysis":[26],"of":[27,49,60,69,77,87,106,113,128],"the":[28,58,85,111,126],"polysaccharide":[29],"its":[31],"derivatives":[32],"indicated":[33],"it":[34],"contained":[35],"fucose":[36],"(Fucp),":[37],"xylose":[38],"(Xylp),":[39],"mannose":[40],"(Manp),":[41],"glucuronic":[43],"acid":[44],"(GlcAp)":[45],"in":[46,71,91,95,124],"ratio":[48],"0.9:1.0:3.2:1.2.":[50],"Using":[51],"IR,":[52],"NMR,":[53],"GC-MS":[55],"spectroscopic":[56],"data,":[57],"structure":[59],"TFP-F1":[61,80],"elucidated":[63],"{\u21923)-[\u03b2-D-GlcAp-(1\u21922)]-\u03b1-D-Manp-(1\u21923)-\u03b1-D-Manp-(1\u21923)-[\u03b1-L-Fucp-(1\u21922)-\u03b2-D-Xylp-(1\u21922)]-\u03b1-D-Manp-(1\u2192}n,":[65],"with":[66,99],"partial":[67],"acetylation":[68],"C6-OH":[70],"mannoses.":[72],"Furthermore,":[73],"at":[74],"concentration":[76],"1":[78],"\u03bcg/mL,":[79],"found":[82],"stimulate":[84],"secretion":[86],"TNF-\u03b1":[88],"IL-6":[90],"J774A.1":[92],"macrophage":[93],"cells":[94],"vitro":[96],"via":[97],"interaction":[98],"toll-like":[100],"receptor":[101],"4":[102],"(TLR4).":[103],"removal":[105],"O-acetyl":[107,118],"groups":[108,119],"led":[109],"loss":[112],"immunomodulatory":[114],"activities,":[115],"demonstrating":[116],"that":[117],"play":[120],"an":[121],"essential":[122],"role":[123],"enhancing":[125],"production":[127],"pro-inflammatory":[129],"cytokines.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-23T09:35:12.469056","created_date":"2022-09-17T00:00:00"}