{"id":"https://openalex.org/W4296129809","doi":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","title":"Influence of clinical and molecular genetic characteristics on the first relapse-free period in patients with glioblastoma in the era of modern chemoradiotherapy","display_name":"Influence of clinical and molecular genetic characteristics on the first relapse-free period in patients with glioblastoma in the era of modern chemoradiotherapy","publication_year":2022,"publication_date":"2022-09-16","ids":{"openalex":"https://openalex.org/W4296129809","doi":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34"},"language":"en","primary_location":{"id":"doi:10.18705/2782-3806-2022-2-4-23-34","doi":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","is_oa":true,"landing_page_url":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","pdf_url":"https://persmed.elpub.ru/jour/article/download/66/69","source":{"id":"https://openalex.org/S4387282190","display_name":"Russian Journal for Personalized Medicine","issn_l":"2782-3806","issn":["2782-3806","2782-3814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal for Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://persmed.elpub.ru/jour/article/download/66/69","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039610517","display_name":"Sofia S. Sklyar","orcid":"https://orcid.org/0000-0002-3284-9688","observed_orcids":["https://orcid.org/0000-0002-3284-9688"]},"institutions":[{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. S. Sklyar","raw_affiliation_strings":["Polenov Neurosurgical Research Institute, branch of the Almazov National Medical Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polenov Neurosurgical Research Institute, branch of the Almazov National Medical Research Centre","institution_ids":["https://openalex.org/I3018698992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036437921","display_name":"\u041c\u0430\u0440\u0438\u043d\u0430 \u0412\u0438\u0442\u0430\u043b\u044c\u0435\u0432\u043d\u0430 \u041c\u0430\u0446\u043a\u043e","orcid":"https://orcid.org/0000-0003-1564-0943","observed_orcids":["https://orcid.org/0000-0003-1564-0943"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]},{"id":"https://openalex.org/I4210101202","display_name":"Saint-Petersburg Medico-Social Institute","ror":"https://ror.org/015q7hw55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210101202"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. V. Matsko","raw_affiliation_strings":["Clinical scientific-practical center of oncology;\r\nSaint Petersburg State University;\r\nSaint Petersburg Medico-Social Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical scientific-practical center of oncology;\r\nSaint Petersburg State University;\r\nSaint Petersburg Medico-Social Institute","institution_ids":["https://openalex.org/I172901346","https://openalex.org/I4210101202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2244,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44948263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"4","first_page":"23","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9629999995231628},{"id":"https://openalex.org/keywords/relapse-free-period","display_name":"relapse-free period","score":0.753000020980835},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/subtotal-resection","display_name":"subtotal resection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.47200000286102295},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ercc1","display_name":"ERCC1","score":0.699999988079071},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.9750000238418579},{"id":"https://openalex.org/keywords/beta-iii-tubulin","display_name":"TUBB3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.8354141712188721},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6318474411964417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6134353280067444},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5942305326461792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5467974543571472},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5263403654098511},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4939756989479065},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.47418317198753357},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28726011514663696}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18705/2782-3806-2022-2-4-23-34","doi":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","is_oa":true,"landing_page_url":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","pdf_url":"https://persmed.elpub.ru/jour/article/download/66/69","source":{"id":"https://openalex.org/S4387282190","display_name":"Russian Journal for Personalized Medicine","issn_l":"2782-3806","issn":["2782-3806","2782-3814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal for Personalized Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18705/2782-3806-2022-2-4-23-34","doi":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","is_oa":true,"landing_page_url":"https://doi.org/10.18705/2782-3806-2022-2-4-23-34","pdf_url":"https://persmed.elpub.ru/jour/article/download/66/69","source":{"id":"https://openalex.org/S4387282190","display_name":"Russian Journal for Personalized Medicine","issn_l":"2782-3806","issn":["2782-3806","2782-3814"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal for Personalized Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296129809.pdf","grobid_xml":"https://content.openalex.org/works/W4296129809.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W407665433","https://openalex.org/W1537699783","https://openalex.org/W1860764269","https://openalex.org/W1972911961","https://openalex.org/W1985603041","https://openalex.org/W2027572371","https://openalex.org/W2041296416","https://openalex.org/W2103987247","https://openalex.org/W2105100844","https://openalex.org/W2126809148","https://openalex.org/W2140165290","https://openalex.org/W2154974088","https://openalex.org/W2590216127","https://openalex.org/W2741270291","https://openalex.org/W2741627931","https://openalex.org/W2748542724","https://openalex.org/W2795365939","https://openalex.org/W2887387458","https://openalex.org/W2999983497","https://openalex.org/W3001610059","https://openalex.org/W3174246647","https://openalex.org/W4211132876"],"related_works":["https://openalex.org/W4393115884","https://openalex.org/W3173706377","https://openalex.org/W4402985048","https://openalex.org/W2758807368","https://openalex.org/W3201060421","https://openalex.org/W2127901599","https://openalex.org/W2115050263","https://openalex.org/W2511394252","https://openalex.org/W7134069010","https://openalex.org/W4388590714"],"abstract_inverted_index":{"Introduction.":[0],"Due":[1],"to":[2,93,378,386,472],"the":[3,7,14,17,29,33,42,46,50,53,56,62,71,74,105,114,140,146,156,161,179,193,211,216,221,228,235,251,254,260,263,268,271,278,281,289,298,306,316,322,328,336,340,350,390,407,411,415,424,433,439,444,447,453,457,462,482,492],"active":[4],"research":[5],"of":[6,12,16,35,45,49,55,64,73,108,122,155,160,169,181,183,189,192,197,230,234,247,250,262,270,280,288,300,305,315,324,339,358,376,406,417,423,443,449,459,470,478,484,490,494],"molecular":[8,67,186,440],"and":[9,66,79,127,151,178,185,277,335,456,488],"genetic":[10,47,68,187,441],"features":[11,154],"glioblastoma,":[13],"performance":[15],"biological":[18],"processes":[19],"occurring":[20],"in":[21,52,88,102,111,253,297,327,389,401,410,452,461],"tumor":[22,51,162,165,170,190,255,272,282,307,347],"cells":[23],"has":[24],"become":[25],"more":[26,395],"distinct.":[27],"In":[28,133,414],"modern":[30],"scientific":[31,36],"literature,":[32],"number":[34,180],"studies":[37],"is":[38],"growing,":[39],"which":[40],"emphasizes":[41],"priority":[43],"importance":[44],"status":[48,144,219],"prognosis":[54],"disease.":[57],"Purpose":[58],"statement.":[59],"To":[60],"study":[61],"influence":[63],"clinical":[65,136,213],"factors":[69,486],"on":[70,145,220,438],"median":[72,229,233,314],"first":[75,82,115,236,290,317,351,391,434,489],"relapse-free":[76,392],"period.":[77],"Materials":[78],"methods.":[80],"The":[81,98,232,286,313,374],"progression-free":[83],"survival":[84],"(PFS)":[85],"was":[86,100,238,295,319],"analyzed":[87],"30":[89],"patients":[90,118,301,402,465],"aged":[91],"28":[92],"81":[94],"years":[95],"with":[96,104,129,174,292,403,431,466],"glioblastoma.":[97],"diagnosis":[99],"established":[101],"accordance":[103],"WHO":[106],"classification":[107],"CNS":[109],"tumors":[110],"2021.":[112],"After":[113],"operation,":[116],"all":[117,210],"underwent":[119],"a":[120,325,355,450,475],"course":[121],"radiation":[123,172,379],"therapy":[124,173,380,420,430,473],"(LT)":[125],"(60Gr)":[126],"chemotherapy":[128],"temozolomide":[130,177,377],"(2\u201318":[131],"cycles).":[132],"each":[134],"case,":[135],"parameters":[137,188],"such":[138,242],"as":[139,245],"patient\u2019s":[141],"age,":[142],"functional":[143,218],"Karnovsky":[147,222],"scale":[148,223],"both":[149],"before":[150],"after":[152,302],"surgery,":[153],"neuroimaging":[157],"picture":[158],"(prevalence":[159],"process,":[163],"localization,":[164],"volume),":[166],"treatment":[167],"(degree":[168],"resection,":[171],"or":[175],"without":[176,363],"cycles":[182],"chemotherapy)":[184],"(determination":[191],"mRNA":[194],"expression":[195,337,405],"level":[196,338,357,458,477],"genes:":[198],"MGMT,":[199],"VEGF,":[200],"PDGFRA,":[201],"\u03b2-tubulin":[202],"III,":[203],"ERCC-1,":[204],"TOP2A)":[205],"were":[206],"studied.":[207],"Results.":[208],"Of":[209],"studied":[212],"parameters,":[214],"only":[215,353,400],"postoperative":[217],"(p":[224,257,265,274,283,343],"=":[225,258,266,275,284,344,372],"0.001)":[226],"influenced":[227,320],"PFS.":[231],"PFS":[237,291,318,435],"not":[239],"affected":[240],"by":[241,321,394,428],"radiological":[243],"characteristics":[244,442],"involvement":[246],"basal":[248],"structures":[249],"brain":[252],"process":[256,273],"0.9),":[259],"side":[261],"lesion":[264],"0.67),":[267],"prevalence":[269],"0.6)":[276],"volume":[279,493],"0.52).":[285],"duration":[287],"statistical":[293],"reliability":[294],"higher":[296],"group":[299],"subtotal":[303],"resection":[304,348],"(14.9":[308],"months;":[309,370],"p":[310,371],"\u00b3":[311],"0.05).":[312],"presence":[323,448],"mutation":[326,451],"IDH1":[329,454],"gene":[330,342,360,409,455,480],"(22.5":[331],"vs":[332,368],"11.5":[333],"months)":[334],"MGMT":[341,359,408,460,479],"0.036).":[345],"Total":[346],"increases":[349],"BRP":[352],"at":[354],"high":[356,476],"expression,":[361],"although":[362],"statistically":[364],"significant":[365],"differences":[366],"(7.6":[367],"2.7":[369],"0.6).":[373],"addition":[375],"(75":[381],"mg/m2,":[382],"orally,":[383],"daily)":[384],"led":[385],"an":[387,467],"increase":[388],"period":[393],"than":[396],"6.9":[397],"months,":[398],"but":[399],"low":[404],"tumor.":[412,463],"Conclusion.":[413],"conditions":[416],"standard":[418],"patient":[419],"(surgical":[421],"removal":[422],"tumor,":[425,445],"chemoradiotherapy":[426],"followed":[427],"adjuvant":[429],"temozolomide),":[432],"primarily":[436],"depends":[437],"namely,":[446],"For":[464],"expected":[468],"lack":[469],"response":[471],"(i.e.,":[474],"activity),":[481],"role":[483],"other":[485],"increases,":[487],"all,":[491],"cytoreduction.":[495]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-17T00:00:00"}
