{"id":"https://openalex.org/W4296120701","doi":"https://doi.org/10.1016/s2215-0366(22)00264-4","title":"Maternal infection during pregnancy and likelihood of autism and intellectual disability in children in Sweden: a negative control and sibling comparison cohort study","display_name":"Maternal infection during pregnancy and likelihood of autism and intellectual disability in children in Sweden: a negative control and sibling comparison cohort study","publication_year":2022,"publication_date":"2022-09-07","ids":{"openalex":"https://openalex.org/W4296120701","doi":"https://doi.org/10.1016/s2215-0366(22)00264-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/36087610"},"language":"en","primary_location":{"id":"doi:10.1016/s2215-0366(22)00264-4","doi":"https://doi.org/10.1016/s2215-0366(22)00264-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2215-0366(22)00264-4","pdf_url":null,"source":{"id":"https://openalex.org/S2531556786","display_name":"The Lancet Psychiatry","issn_l":"2215-0366","issn":["2215-0366","2215-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045831978","display_name":"Martin Brynge","orcid":"https://orcid.org/0000-0001-7408-5674","observed_orcids":["https://orcid.org/0000-0001-7408-5674"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Martin Brynge","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: m.brynge@ki.se"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: m.brynge@ki.se","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063015618","display_name":"Hugo Sj\u00f6qvist","orcid":"https://orcid.org/0000-0003-4953-7725","observed_orcids":["https://orcid.org/0000-0003-4953-7725"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hugo Sj\u00f6qvist","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004286063","display_name":"Renee M. Gardner","orcid":"https://orcid.org/0000-0002-7011-798X","observed_orcids":["https://orcid.org/0000-0002-7011-798X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Renee M Gardner","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047653896","display_name":"Brian K. Lee","orcid":"https://orcid.org/0000-0002-3635-8034","observed_orcids":["https://orcid.org/0000-0002-3635-8034"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Brian K Lee","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA; A J Drexel Autism Institute, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA; A J Drexel Autism Institute, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I28166907","https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072336887","display_name":"Christina Dalman","orcid":"https://orcid.org/0000-0002-3579-2357","observed_orcids":["https://orcid.org/0000-0002-3579-2357"]},"institutions":[{"id":"https://openalex.org/I2801939835","display_name":"Region Stockholm","ror":"https://ror.org/02zrae794","country_code":"SE","type":"government","lineage":["https://openalex.org/I2801939835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christina Dalman","raw_affiliation_strings":["Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden","institution_ids":["https://openalex.org/I2801939835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":null,"display_name":"H\u00e5kan Karlsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H\u00e5kan Karlsson","raw_affiliation_strings":["Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045831978"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":6000,"currency":"USD","value_usd":6000},"apc_paid":null,"fwci":6.3167,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.97855138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"10","first_page":"782","last_page":"791"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.45019999146461487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.45019999146461487,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-infection","display_name":"maternal infection","score":0.9440000057220459},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":1.0},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.7400000095367432},{"id":"https://openalex.org/keywords/residual-confounding","display_name":"residual confounding","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sibling-discordance","display_name":"sibling discordance","score":0.7369999885559082},{"id":"https://openalex.org/keywords/family-factors","display_name":"family factors","score":0.41200000047683716},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.35600000619888306},{"id":"https://openalex.org/keywords/sweden","display_name":"Sweden","score":0.33899998664855957},{"id":"https://openalex.org/keywords/prevention-targets","display_name":"prevention targets","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7128662467002869},{"id":"https://openalex.org/C551499885","wikidata":"https://www.wikidata.org/wiki/Q183560","display_name":"Intellectual disability","level":2,"score":0.6710658669471741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6667826771736145},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6584123373031616},{"id":"https://openalex.org/C2776194465","wikidata":"https://www.wikidata.org/wiki/Q31184","display_name":"Sibling","level":2,"score":0.6216938495635986},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5465784072875977},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4850577414035797},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4273890256881714},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4177323281764984},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23523691296577454},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.1294318437576294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036801","descriptor_name":"Parturition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s2215-0366(22)00264-4","doi":"https://doi.org/10.1016/s2215-0366(22)00264-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2215-0366(22)00264-4","pdf_url":null,"source":{"id":"https://openalex.org/S2531556786","display_name":"The Lancet Psychiatry","issn_l":"2215-0366","issn":["2215-0366","2215-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Psychiatry","raw_type":"journal-article"},{"id":"pmid:36087610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36087610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The lancet. Psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G158726132","display_name":null,"funder_award_id":"523\u20102010\u20101052","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4451974425","display_name":"Early life inflammation and the risk of autism \u2013 a combined analysis of national registers and stored blood samples from matched pairs of mothers during pregnancy and their newborn children","funder_award_id":"2016-01477","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8137979467","display_name":"The role of early life inflammation in the aethiology of autism spectrum disorder: a longitudinal study based on a combination of register and bio-sample data.","funder_award_id":"2012-02264","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8646925878","display_name":"Maternal nutrition and offspring risk for autism, ADHD, and intellectual disability","funder_award_id":"2017-02900","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320306097","display_name":"Autism Speaks","ror":"https://ror.org/04bkad313"},{"id":"https://openalex.org/F4320309530","display_name":"Stanley Medical Research Institute","ror":"https://ror.org/01pj5nn22"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W93849095","https://openalex.org/W1979733376","https://openalex.org/W1982693223","https://openalex.org/W1982984257","https://openalex.org/W1985739089","https://openalex.org/W1998337942","https://openalex.org/W2009428399","https://openalex.org/W2050947021","https://openalex.org/W2069738007","https://openalex.org/W2069962212","https://openalex.org/W2081161499","https://openalex.org/W2084450750","https://openalex.org/W2092305484","https://openalex.org/W2107774719","https://openalex.org/W2122037893","https://openalex.org/W2163385548","https://openalex.org/W2215537341","https://openalex.org/W2227393071","https://openalex.org/W2337392459","https://openalex.org/W2466937105","https://openalex.org/W2470385410","https://openalex.org/W2515449383","https://openalex.org/W2765858400","https://openalex.org/W2919361526","https://openalex.org/W2924383394","https://openalex.org/W2939942554","https://openalex.org/W2941534306","https://openalex.org/W2952977999","https://openalex.org/W2958993741","https://openalex.org/W2985316494","https://openalex.org/W3006158900","https://openalex.org/W3093769196","https://openalex.org/W3136538098"],"related_works":["https://openalex.org/W3136538098","https://openalex.org/W2084450750","https://openalex.org/W2553628518","https://openalex.org/W2183812478","https://openalex.org/W2092305484","https://openalex.org/W2144947742","https://openalex.org/W2334193067","https://openalex.org/W4213084526","https://openalex.org/W2417157474","https://openalex.org/W4387363092"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-17T00:00:00"}