{"id":"https://openalex.org/W4296120124","doi":"https://doi.org/10.1111/cas.15595","title":"ROS inhibits ROR\u03b1 degradation by decreasing its arginine methylation in liver cancer","display_name":"ROS inhibits ROR\u03b1 degradation by decreasing its arginine methylation in liver cancer","publication_year":2022,"publication_date":"2022-09-17","ids":{"openalex":"https://openalex.org/W4296120124","doi":"https://doi.org/10.1111/cas.15595","pmid":"https://pubmed.ncbi.nlm.nih.gov/36114756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9807526"},"language":"en","primary_location":{"id":"doi:10.1111/cas.15595","doi":"https://doi.org/10.1111/cas.15595","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15595","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15595","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054071377","display_name":"Hyuntae Im","orcid":"https://orcid.org/0000-0003-1454-2575","observed_orcids":["https://orcid.org/0000-0003-1454-2575"]},"institutions":[{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyuntae Im","raw_affiliation_strings":["Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1454-2575","affiliations":[{"raw_affiliation_string":"Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I165507594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030178025","display_name":"Hee\u2010ji Baek","orcid":"https://orcid.org/0000-0001-8060-4792","observed_orcids":["https://orcid.org/0000-0001-8060-4792"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee\u2010ji Baek","raw_affiliation_strings":["BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-8060-4792","affiliations":[{"raw_affiliation_string":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068488473","display_name":"Eunbi Yang","orcid":"https://orcid.org/0000-0002-5873-3413","observed_orcids":["https://orcid.org/0000-0002-5873-3413"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunbi Yang","raw_affiliation_strings":["BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5873-3413","affiliations":[{"raw_affiliation_string":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054616093","display_name":"Kyeongkyu Kim","orcid":"https://orcid.org/0000-0002-9533-6142","observed_orcids":["https://orcid.org/0000-0002-9533-6142"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyeongkyu Kim","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024129488","display_name":"Se Kyu Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se Kyu Oh","raw_affiliation_strings":["Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100599986","display_name":"Jung\u2010Shin Lee","orcid":"https://orcid.org/0000-0002-9126-5463","observed_orcids":["https://orcid.org/0000-0002-9126-5463"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung\u2010Shin Lee","raw_affiliation_strings":["Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon, Korea","Graduate School of Medical Science & Engineering Korea Advanced Institute of Science and Technology  Daejeon Korea"],"raw_orcid":"https://orcid.org/0000-0002-9126-5463","affiliations":[{"raw_affiliation_string":"Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon, Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Graduate School of Medical Science & Engineering Korea Advanced Institute of Science and Technology  Daejeon Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100710093","display_name":"Hyun-Kyung Kim","orcid":"https://orcid.org/0000-0001-7678-6087","observed_orcids":["https://orcid.org/0000-0001-7678-6087","https://orcid.org/0000-0002-3020-7040"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyunkyung Kim","raw_affiliation_strings":["BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7678-6087","affiliations":[{"raw_affiliation_string":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ji Min Lee","orcid":"https://orcid.org/0000-0003-2978-2440","observed_orcids":["https://orcid.org/0000-0003-2978-2440"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I165507594","display_name":"Kangwon National University","ror":"https://ror.org/01mh5ph17","country_code":"KR","type":"education","lineage":["https://openalex.org/I165507594"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji Min Lee","raw_affiliation_strings":["Department of Molecular Bioscience, College of Biomedical Sciences Kangwon National University  Chuncheon Korea","Graduate School of Medical Science & Engineering Korea Advanced Institute of Science and Technology Daejeon Korea"],"raw_orcid":"https://orcid.org/0000-0003-2978-2440","affiliations":[{"raw_affiliation_string":"Department of Molecular Bioscience, College of Biomedical Sciences Kangwon National University  Chuncheon Korea","institution_ids":["https://openalex.org/I165507594"]},{"raw_affiliation_string":"Graduate School of Medical Science & Engineering Korea Advanced Institute of Science and Technology Daejeon Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100710093"],"corresponding_institution_ids":["https://openalex.org/I157485424","https://openalex.org/I165507594","https://openalex.org/I197347611"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.7353,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.64002073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"1","first_page":"187","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/roralpha","display_name":"ROR\u03b1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-arginine-methylation","display_name":"arginine methylation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.9660000205039978},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.5889999866485596},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8090000152587891},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6980000138282776},{"id":"https://openalex.org/keywords/transcription-factor-regulation","display_name":"transcription factor regulation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.9163782596588135},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7286974191665649},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6188584566116333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46705663204193115},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.45320984721183777},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4228050708770752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4199659526348114},{"id":"https://openalex.org/C2778178838","wikidata":"https://www.wikidata.org/wiki/Q14876922","display_name":"Protein methylation","level":5,"score":0.41058826446533203},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3700075149536133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3547423481941223},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.28998473286628723},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1927013099193573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09384384751319885}],"mesh":[{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011484","descriptor_name":"Protein-Arginine N-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/cas.15595","doi":"https://doi.org/10.1111/cas.15595","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15595","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9807526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9807526","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},{"id":"pmid:36114756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36114756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cas.15595","doi":"https://doi.org/10.1111/cas.15595","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.15595","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.15595","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6872152469","display_name":null,"funder_award_id":"NRF-2020R1C1C1010489","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7891567542","display_name":null,"funder_award_id":"NRF\u2010 2021R1C1C1008780","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8403716776","display_name":null,"funder_award_id":"NRF-2020R1C1C1010489","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296120124.pdf","grobid_xml":"https://content.openalex.org/works/W4296120124.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W160853306","https://openalex.org/W1757407923","https://openalex.org/W1966692726","https://openalex.org/W1969343369","https://openalex.org/W1969571204","https://openalex.org/W1969839676","https://openalex.org/W1979760591","https://openalex.org/W1985003152","https://openalex.org/W1995754186","https://openalex.org/W2001305844","https://openalex.org/W2001628772","https://openalex.org/W2025277638","https://openalex.org/W2049748395","https://openalex.org/W2058452903","https://openalex.org/W2062274317","https://openalex.org/W2066050590","https://openalex.org/W2092809155","https://openalex.org/W2092979885","https://openalex.org/W2094566719","https://openalex.org/W2097859995","https://openalex.org/W2102018890","https://openalex.org/W2105481533","https://openalex.org/W2122976298","https://openalex.org/W2127844596","https://openalex.org/W2132198990","https://openalex.org/W2136850410","https://openalex.org/W2149966409","https://openalex.org/W2159202225","https://openalex.org/W2162449964","https://openalex.org/W2178248816","https://openalex.org/W2265354786","https://openalex.org/W2794084157","https://openalex.org/W2802881492","https://openalex.org/W2808913983","https://openalex.org/W2887370334","https://openalex.org/W2890311526","https://openalex.org/W2892295112","https://openalex.org/W2899707256","https://openalex.org/W2920257904","https://openalex.org/W2922854582","https://openalex.org/W2933430692","https://openalex.org/W2934230578","https://openalex.org/W2949815414","https://openalex.org/W2965551559","https://openalex.org/W2978586206","https://openalex.org/W2995708286","https://openalex.org/W3004974279","https://openalex.org/W3006940072","https://openalex.org/W3044762253","https://openalex.org/W3045278282","https://openalex.org/W3096317905","https://openalex.org/W3134078080","https://openalex.org/W3139352227","https://openalex.org/W3187268549","https://openalex.org/W3196896362","https://openalex.org/W3203019814","https://openalex.org/W3210764093"],"related_works":["https://openalex.org/W4362593576","https://openalex.org/W4397006782","https://openalex.org/W6939681752","https://openalex.org/W1963982440","https://openalex.org/W2572194133","https://openalex.org/W3005884400","https://openalex.org/W2092234804","https://openalex.org/W3190857161","https://openalex.org/W7097350270","https://openalex.org/W2232650922"],"abstract_inverted_index":{"Abstract":[0],"Retinoic":[1],"acid":[2,77],"receptor\u2013related":[3],"orphan":[4],"receptor":[5],"\u03b1":[6],"(ROR\u03b1)":[7],"is":[8,53,91,102],"a":[9,18,54],"transcription":[10],"factor":[11],"involved":[12],"in":[13,42,48,57,155,186,205],"nuclear":[14],"gene":[15,139],"expression":[16],"and":[17,62,65,70,125,174,189],"known":[19],"tumor":[20],"suppressor.":[21],"ROR\u03b1":[22,43,126,128,134,152,172],"was":[23],"the":[24,33,82,117,120,175],"first":[25],"identified":[26],"substrate":[27,67],"of":[28,35,60],"lysine":[29],"methylation\u2013dependent":[30,100,132],"degradation.":[31],"However,":[32],"mechanisms":[34],"other":[36],"post\u2010translational":[37],"modifications":[38],"(PTMs)":[39],"that":[40,98,114],"occur":[41],"remain":[44],"largely":[45],"unknown,":[46],"especially":[47],"liver":[49,157,164,206],"cancer.":[50,207],"Arginine":[51,131],"methylation":[52,173],"common":[55],"PTM":[56],"arginine":[58,92,107,129],"residues":[59],"nonhistone":[61],"histone":[63,87],"proteins":[64],"affects":[66],"protein":[68,106,148,153],"function":[69],"fate.":[71],"We":[72],"found":[73],"an":[74,183],"analogous":[75],"amino":[76],"disposition":[78],"containing":[79],"R37":[80,99],"at":[81],"ROR":[83],"N\u2010terminus":[84],"compared":[85],"to":[86],"H3":[88],"residue,":[89],"which":[90],"methylated.":[93],"Here,":[94],"we":[95,112],"provide":[96],"evidence":[97],"degradation":[101,135],"carried":[103],"out":[104],"by":[105,167],"methyltransferase":[108],"5":[109],"(PRMT5).":[110],"Further,":[111],"discovered":[113],"PRMT5":[115,147,181],"regulated":[116],"interaction":[118],"between":[119],"E3":[121],"ubiquitin":[122],"ligase":[123],"ITCH":[124,176],"through":[127],"methylation.":[130],"ubiquitination\u2010mediated":[133],"reduced":[136],"downstream":[137],"target":[138,185],"activation.":[140],"H2O2\u2010induced":[141],"reactive":[142],"oxygen":[143],"species":[144],"(ROS)":[145],"decreased":[146],"levels,":[149],"consequently":[150],"increasing":[151],"levels":[154],"HepG2":[156],"cancer":[158,165,187],"cells.":[159],"In":[160],"addition,":[161],"ROS":[162,195],"inhibited":[163],"progression":[166],"inducing":[168],"apoptosis":[169],"via":[170],"PRMT5\u2010mediated":[171],"axis.":[177],"Our":[178],"results":[179],"potentiate":[180],"as":[182],"elimination":[184],"therapy,":[188],"this":[190],"additional":[191],"regulatory":[192],"level":[193],"within":[194],"signaling":[196],"may":[197],"help":[198],"identify":[199],"new":[200],"targets":[201],"for":[202],"therapeutic":[203],"intervention":[204]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-09-17T00:00:00"}