{"id":"https://openalex.org/W4296101591","doi":"https://doi.org/10.3389/fphys.2022.969000","title":"Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation","display_name":"Inhibition of Ca2+ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation","publication_year":2022,"publication_date":"2022-09-15","ids":{"openalex":"https://openalex.org/W4296101591","doi":"https://doi.org/10.3389/fphys.2022.969000","pmid":"https://pubmed.ncbi.nlm.nih.gov/36187775","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9521718"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2022.969000","doi":"https://doi.org/10.3389/fphys.2022.969000","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.969000","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066748216","display_name":"Yuyang Sun","orcid":"https://orcid.org/0000-0002-2256-0581","observed_orcids":["https://orcid.org/0000-0002-2256-0581","https://orcid.org/0000-0001-5750-7855"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuyang Sun","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054533847","display_name":"Emily Kate Zboril","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K. Zboril","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073130548","display_name":"Jorge J. De La Chapa","orcid":"https://orcid.org/0000-0001-7610-1252","observed_orcids":["https://orcid.org/0000-0001-7610-1252"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge J. De La Chapa","raw_affiliation_strings":["Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052223447","display_name":"Xiufang Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiufang Chai","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081736734","display_name":"Viviane Nascimento Da Conceicao","orcid":"https://orcid.org/0000-0002-0589-1493","observed_orcids":["https://orcid.org/0000-0002-0589-1493"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viviane Nascimento Da Conceicao","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089005385","display_name":"Matthew C. Valdez","orcid":"https://orcid.org/0000-0002-5612-0007","observed_orcids":["https://orcid.org/0000-0002-5612-0007"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew C. Valdez","raw_affiliation_strings":["Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010689843","display_name":"Stanton F. McHardy","orcid":"https://orcid.org/0000-0003-0070-4924","observed_orcids":["https://orcid.org/0000-0003-0070-4924"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanton F. McHardy","raw_affiliation_strings":["Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063077669","display_name":"Cara B. Gonzales","orcid":"https://orcid.org/0000-0002-1739-4574","observed_orcids":["https://orcid.org/0000-0002-1739-4574"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cara B. Gonzales","raw_affiliation_strings":["Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082568887","display_name":"Brij Bhan Singh","orcid":"https://orcid.org/0000-0003-0535-5997","observed_orcids":["https://orcid.org/0000-0003-0535-5997"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brij B. Singh","raw_affiliation_strings":["Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063077669","https://openalex.org/A5082568887"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.4525,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5434489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"969000","last_page":"969000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/calcium-entry-inhibition","display_name":"calcium entry inhibition","score":0.6909999847412109},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.953000009059906},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.5600000023841858},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.754311740398407},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6916689872741699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5880193710327148},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.5304008722305298},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5099512338638306},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.4809255301952362},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4621070325374603},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4328688383102417},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42739999294281006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4229016602039337},{"id":"https://openalex.org/C167007842","wikidata":"https://www.wikidata.org/wiki/Q15322678","display_name":"TRPC1","level":4,"score":0.4204511046409607},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3777603507041931},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.37771886587142944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35143646597862244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3228549063205719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23179474472999573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17747145891189575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09536632895469666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphys.2022.969000","doi":"https://doi.org/10.3389/fphys.2022.969000","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.969000","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9521718","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9521718","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:36187775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36187775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c7f11cbee0e24145a6b0354762e7fe89","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c7f11cbee0e24145a6b0354762e7fe89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2022.969000","doi":"https://doi.org/10.3389/fphys.2022.969000","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2022.969000","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2022.969000/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1143455775","display_name":null,"funder_award_id":"CA-054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888885","display_name":"TRPC1, Calcium, and Saliva Secretion","funder_award_id":"R01DE017102","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000896569","display_name":"Glycolytic metabolites, Calcium entry and Sjogren\u2019s syndrome","funder_award_id":"R01DE031716","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296101591.pdf","grobid_xml":"https://content.openalex.org/works/W4296101591.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1606755714","https://openalex.org/W1737797468","https://openalex.org/W1981592463","https://openalex.org/W1985800268","https://openalex.org/W2002401551","https://openalex.org/W2011281363","https://openalex.org/W2013180604","https://openalex.org/W2014028731","https://openalex.org/W2015128691","https://openalex.org/W2034175020","https://openalex.org/W2040767197","https://openalex.org/W2052985285","https://openalex.org/W2063092503","https://openalex.org/W2068836639","https://openalex.org/W2069099956","https://openalex.org/W2069917288","https://openalex.org/W2071577234","https://openalex.org/W2104587256","https://openalex.org/W2126853108","https://openalex.org/W2136033624","https://openalex.org/W2150294958","https://openalex.org/W2294419491","https://openalex.org/W2338835625","https://openalex.org/W2401857520","https://openalex.org/W2537848262","https://openalex.org/W2561631604","https://openalex.org/W2568957872","https://openalex.org/W2792199596","https://openalex.org/W2894771446","https://openalex.org/W2902485728","https://openalex.org/W2911188335","https://openalex.org/W2919965417","https://openalex.org/W2921914126","https://openalex.org/W2945683847","https://openalex.org/W2949967728","https://openalex.org/W2989132394","https://openalex.org/W3005452535","https://openalex.org/W3025741824","https://openalex.org/W3094650086","https://openalex.org/W3116541429","https://openalex.org/W3119005666","https://openalex.org/W3152256037","https://openalex.org/W3154381759","https://openalex.org/W3204495534","https://openalex.org/W6636266067","https://openalex.org/W6680252335"],"related_works":["https://openalex.org/W2919965417","https://openalex.org/W3175047730","https://openalex.org/W3082781661","https://openalex.org/W2885577184","https://openalex.org/W2559821614","https://openalex.org/W4417507450","https://openalex.org/W3047163853","https://openalex.org/W6889721793","https://openalex.org/W3204923622","https://openalex.org/W3217676823"],"abstract_inverted_index":{"Oral":[0],"cancer":[1,19],"patients":[2,11],"have":[3,23],"a":[4,113,204],"poor":[5],"prognosis,":[6],"with":[7,87,106],"approximately":[8],"66%":[9],"of":[10,77,80,91,99,121,143,169,193,197,206],"surviving":[12],"5-years":[13],"after":[14],"diagnosis.":[15],"Treatments":[16],"for":[17],"oral":[18,53],"are":[20,31,37],"limited":[21],"and":[22,68,93,97,115,160,177,182,200],"many":[24],"adverse":[25],"side":[26],"effects;":[27],"thus,":[28],"further":[29,149],"studies":[30],"needed":[32],"to":[33,174,210],"develop":[34],"drugs":[35],"that":[36,63,83,119,128,151,191],"more":[38],"efficacious.":[39],"To":[40],"achieve":[41],"this":[42],"objective,":[43],"we":[44,61],"developed":[45],"CIDD-99,":[46],"which":[47],"produces":[48],"cytotoxic":[49],"effects":[50,137],"in":[51,70,112,132,184,212],"multiple":[52],"squamous":[54],"cell":[55,58,130],"carcinoma":[56],"(OSCC)":[57],"lines.":[59],"While":[60],"demonstrated":[62],"CIDD-99":[64,88,107,135,162,167,211],"induces":[65,129],"ER":[66,175,198],"stress":[67,176,199],"apoptosis":[69],"OSCC,":[71],"the":[72,78,125,141,156,207],"mechanism":[73,127],"was":[74,154],"unclear.":[75],"Investigation":[76],"Bcl-family":[79],"proteins":[81,96],"showed":[82],"OSCC":[84,103],"cells":[85,104],"treated":[86,105],"undergo":[89],"downregulation":[90],"Bcl-XL":[92],"Bcl-2":[94],"anti-apoptotic":[95],"upregulation":[98],"Bax":[100],"(pro-apoptotic).":[101],"Importantly,":[102],"displayed":[108],"decreased":[109],"calcium":[110,122,152,170],"signaling":[111,123,171],"dose":[114],"time-dependent":[116],"manner,":[117],"suggesting":[118],"blockage":[120],"is":[124],"key":[126],"death":[131],"OSCC.":[133,213],"Indeed,":[134],"anti-proliferative":[136],"were":[138],"reversed":[139],"by":[140],"addition":[142],"exogenous":[144],"calcium.":[145],"Moreover,":[146],"electrophysiological":[147],"properties":[148],"established":[150],"entry":[153],"via":[155],"non-selective":[157],"TRPC1":[158],"channel":[159],"prolonged":[161],"incubation":[163],"inhibited":[164,178],"STIM1":[165],"expression.":[166],"inhibition":[168,192],"also":[172],"led":[173],"mitochondrial":[179,201],"complexes":[180],"II":[181],"V":[183],"vitro.":[185],"Taken":[186],"together,":[187],"these":[188],"findings":[189],"suggest":[190],"TRPC":[194],"mediates":[195],"induction":[196],"dysfunction":[202],"as":[203],"part":[205],"cellular":[208],"response":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-09-17T00:00:00"}