{"id":"https://openalex.org/W4296063679","doi":"https://doi.org/10.1038/s41598-022-19551-4","title":"Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury","display_name":"Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury","publication_year":2022,"publication_date":"2022-09-16","ids":{"openalex":"https://openalex.org/W4296063679","doi":"https://doi.org/10.1038/s41598-022-19551-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/36114250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9481644"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-19551-4","doi":"https://doi.org/10.1038/s41598-022-19551-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19551-4","pdf_url":"https://www.nature.com/articles/s41598-022-19551-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-19551-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047147000","display_name":"Cheng Chen","orcid":"https://orcid.org/0000-0002-3240-8153","observed_orcids":["https://orcid.org/0000-0002-3240-8153","https://orcid.org/0009-0005-9367-8447"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Chen","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012370449","display_name":"Sean Hennessy","orcid":"https://orcid.org/0000-0003-4726-9413","observed_orcids":["https://orcid.org/0000-0003-4726-9413"]},"institutions":[{"id":"https://openalex.org/I4405271814","display_name":"Leonard Davis Institute of Health Economics","ror":"https://ror.org/033gy9j95","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271814"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Hennessy","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031453430","display_name":"Colleen M Brensinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen M. Brensinger","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063038301","display_name":"Emily K. Acton","orcid":"https://orcid.org/0000-0002-5150-5995","observed_orcids":["https://orcid.org/0000-0002-5150-5995"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K. Acton","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024575747","display_name":"Warren B. Bilker","orcid":"https://orcid.org/0000-0002-2704-7525","observed_orcids":["https://orcid.org/0000-0002-2704-7525"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren B. Bilker","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057382952","display_name":"Sophie P. Chung","orcid":"https://orcid.org/0000-0003-1520-2898","observed_orcids":["https://orcid.org/0000-0003-1520-2898"]},"institutions":[{"id":"https://openalex.org/I4210141706","display_name":"athenahealth","ror":"https://ror.org/0448wcz36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210141706"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophie P. Chung","raw_affiliation_strings":["AthenaHealth, Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AthenaHealth, Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210141706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032557614","display_name":"Ghadeer K. Dawwas","orcid":"https://orcid.org/0000-0002-7982-7419","observed_orcids":["https://orcid.org/0000-0002-7982-7419","https://orcid.org/0000-0001-8232-8840"]},"institutions":[{"id":"https://openalex.org/I4405271814","display_name":"Leonard Davis Institute of Health Economics","ror":"https://ror.org/033gy9j95","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271814"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghadeer K. Dawwas","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023024177","display_name":"John R. Horn","orcid":"https://orcid.org/0000-0003-4525-4250","observed_orcids":["https://orcid.org/0000-0003-4525-4250"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Horn","raw_affiliation_strings":["Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037598335","display_name":"Todd A. Miano","orcid":"https://orcid.org/0000-0002-3832-6212","observed_orcids":["https://orcid.org/0000-0002-3832-6212"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd A. Miano","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037261680","display_name":"Thanh Phuong Pham Nguyen","orcid":"https://orcid.org/0000-0003-3589-764X","observed_orcids":["https://orcid.org/0000-0003-3589-764X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh Phuong Pham Nguyen","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043526096","display_name":"Charles E. Leonard","orcid":"https://orcid.org/0000-0002-5092-9657","observed_orcids":["https://orcid.org/0000-0002-5092-9657"]},"institutions":[{"id":"https://openalex.org/I4405271814","display_name":"Leonard Davis Institute of Health Economics","ror":"https://ror.org/033gy9j95","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271814"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles E. Leonard","raw_affiliation_strings":["Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. celeonar@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043526096"],"corresponding_institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.6921,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62321336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"15569","last_page":"15569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.3515999913215637,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9940000176429749},{"id":"https://openalex.org/keywords/injury-risk","display_name":"injury risk","score":0.4659999907016754},{"id":"https://openalex.org/keywords/clonazepam","display_name":"clonazepam","score":0.8849999904632568},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cefuroxime","display_name":"cefuroxime","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alprazolam","display_name":"alprazolam","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hydrocodone","display_name":"hydrocodone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tizanidine","display_name":"tizanidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacoepidemiology","display_name":"pharmacoepidemiology","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7607376575469971},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.574836254119873},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.5231917500495911},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5082342028617859},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.41567718982696533},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3558223247528076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3508148491382599},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07768523693084717},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081084","descriptor_name":"Accidental Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000525","descriptor_name":"Alprazolam","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002998","descriptor_name":"Clonazepam","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006853","descriptor_name":"Hydrocodone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-022-19551-4","doi":"https://doi.org/10.1038/s41598-022-19551-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19551-4","pdf_url":"https://www.nature.com/articles/s41598-022-19551-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9481644","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9481644","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:36114250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36114250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:863d6552694c41f8a3429b96706fcd46","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/863d6552694c41f8a3429b96706fcd46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-19551-4","doi":"https://doi.org/10.1038/s41598-022-19551-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-19551-4","pdf_url":"https://www.nature.com/articles/s41598-022-19551-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1713231481","display_name":"Clinical Importance of Drug-Drug Interactions","funder_award_id":"R01AG025152","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2856156529","display_name":"Drug-Drug Interactions Involving Methadone and Buprenorphine","funder_award_id":"R01DA048001","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3885111787","display_name":"Enhancing the Utility of the Trend-in-Trend Research Design","funder_award_id":"R01AG064589","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4076807932","display_name":"STIMULANT OVERDOSE IN THE MEDICAID POPULATION: WHO IS AT RISK, AND WHEN ARE THEY AT RISK","funder_award_id":"R01CE003347","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G4804632312","display_name":null,"funder_award_id":"R01CE003347","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880533","display_name":"Drug interactions involving psychoactive drugs","funder_award_id":"R01AG060975","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296063679.pdf","grobid_xml":"https://content.openalex.org/works/W4296063679.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1560600210","https://openalex.org/W1971704279","https://openalex.org/W1977350710","https://openalex.org/W1991958065","https://openalex.org/W1992166682","https://openalex.org/W2015667356","https://openalex.org/W2035610264","https://openalex.org/W2059859839","https://openalex.org/W2060132702","https://openalex.org/W2076202846","https://openalex.org/W2113234081","https://openalex.org/W2119449914","https://openalex.org/W2156804930","https://openalex.org/W2158328803","https://openalex.org/W2166358066","https://openalex.org/W2221016424","https://openalex.org/W2224797978","https://openalex.org/W2261019420","https://openalex.org/W2290906583","https://openalex.org/W2314214487","https://openalex.org/W2586142598","https://openalex.org/W2600488841","https://openalex.org/W2729584713","https://openalex.org/W2751648725","https://openalex.org/W2767159911","https://openalex.org/W2771331752","https://openalex.org/W2805684986","https://openalex.org/W2894932872","https://openalex.org/W2904755589","https://openalex.org/W2912520537","https://openalex.org/W2990327598","https://openalex.org/W2996395595","https://openalex.org/W3014997028","https://openalex.org/W3016017223","https://openalex.org/W3021489965","https://openalex.org/W3046594382","https://openalex.org/W3126685348","https://openalex.org/W3152981090","https://openalex.org/W3185058623"],"related_works":["https://openalex.org/W4225257954","https://openalex.org/W4309707645","https://openalex.org/W7221992020","https://openalex.org/W3126685348","https://openalex.org/W2060132702","https://openalex.org/W7171648072","https://openalex.org/W2044175188","https://openalex.org/W2057159105","https://openalex.org/W3199940835","https://openalex.org/W2130768606"],"abstract_inverted_index":{"Drug":[0],"interactions":[1],"involving":[2],"benzodiazepines":[3],"and":[4,136,158],"related":[5],"drugs":[6],"(BZDs)":[7],"are":[8],"increasingly":[9],"recognized":[10],"as":[11,94],"a":[12,76],"contributor":[13],"to":[14,25,108,113,179,203],"increased":[15,45,155],"risk":[16],"of":[17,53],"unintentional":[18],"traumatic":[19],"injury.":[20],"Yet,":[21],"it":[22],"remains":[23],"unknown":[24],"what":[26],"extent":[27],"drug":[28,110],"interaction":[29],"triads":[30,148],"(3DIs)":[31],"may":[32,196],"amplify":[33],"BZDs'":[34],"inherent":[35],"injury":[36,46,73,103,156],"risk.":[37],"We":[38,126],"identified":[39,90],"BZD":[40,77,147,206],"3DI":[41,160],"signals":[42,165,195],"associated":[43,153],"with":[44,71,131,154,177,192],"rates":[47,104,157],"by":[48],"conducting":[49],"high-throughput":[50],"pharmacoepidemiologic":[51],"screening":[52],"2000-2019":[54],"Optum's":[55],"health":[56],"insurance":[57],"data.":[58],"Using":[59],"self-controlled":[60],"case":[61],"series":[62],"design,":[63],"we":[64,89,101],"included":[65],"patients":[66],"aged":[67],"\u2265":[68],"16":[69],"years":[70],"an":[72],"while":[74],"using":[75,118],"+":[78,175,190],"co-dispensed":[79,92],"medication":[80],"(i.e.,":[81],"base":[82,85,115],"pair).":[83],"During":[84],"pair-exposed":[86],"observation":[87],"time,":[88],"other":[91],"medications":[93],"candidate":[95],"interacting":[96],"precipitants.":[97],"Within":[98],"each":[99],"patient,":[100],"compared":[102],"during":[105],"time":[106],"exposed":[107],"the":[109,114,145],"triad":[111],"versus":[112],"pair":[116],"only":[117],"conditional":[119],"Poisson":[120],"regression,":[121],"adjusting":[122],"for":[123,138,164,173,188],"time-varying":[124],"covariates.":[125],"calculated":[127],"rate":[128],"ratios":[129],"(RRs)":[130],"95%":[132],"confidence":[133],"intervals":[134],"(CIs)":[135],"accounted":[137],"multiple":[139],"estimation":[140],"via":[141],"semi-Bayes":[142],"shrinkage.":[143],"Among":[144],"65,123":[146],"examined,":[149],"79":[150],"(0.1%)":[151],"were":[152],"considered":[159],"signals.":[161],"Adjusted":[162],"RRs":[163],"ranged":[166],"from":[167],"3.01":[168],"(95%":[169,181],"CI":[170,182],"=":[171,183,186],"1.53-5.94)":[172],"clonazepam":[174],"atorvastatin":[176],"cefuroxime":[178],"1.42":[180],"1.00-2.02,":[184],"p":[185],"0.049)":[187],"alprazolam":[189],"hydrocodone":[191],"tizanidine.":[193],"These":[194],"help":[197],"researchers":[198],"prioritize":[199],"future":[200],"etiologic":[201],"studies":[202],"investigate":[204],"higher-order":[205],"interactions.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-17T00:00:00"}