{"id":"https://openalex.org/W4296041475","doi":"https://doi.org/10.1007/s12609-022-00461-3","title":"Mechanisms of Resistance to CDK4/6 Inhibitors in Hormone Receptor-Positive (HR +) Breast Cancer: Spotlight on Convergent CDK6 Upregulation and Immune Signaling","display_name":"Mechanisms of Resistance to CDK4/6 Inhibitors in Hormone Receptor-Positive (HR +) Breast Cancer: Spotlight on Convergent CDK6 Upregulation and Immune Signaling","publication_year":2022,"publication_date":"2022-09-16","ids":{"openalex":"https://openalex.org/W4296041475","doi":"https://doi.org/10.1007/s12609-022-00461-3"},"language":"en","primary_location":{"id":"doi:10.1007/s12609-022-00461-3","doi":"https://doi.org/10.1007/s12609-022-00461-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12609-022-00461-3","pdf_url":null,"source":{"id":"https://openalex.org/S145883490","display_name":"Current Breast Cancer Reports","issn_l":"1943-4588","issn":["1943-4588","1943-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Breast Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076798199","display_name":"Jamie O. Brett","orcid":"https://orcid.org/0000-0003-3112-5204","observed_orcids":["https://orcid.org/0000-0003-3112-5204"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie O. Brett","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109391364","display_name":"Paige E. Herman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige E. Herman","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775802","display_name":"Erica L. Mayer","orcid":"https://orcid.org/0000-0001-5430-8957","observed_orcids":["https://orcid.org/0000-0001-5430-8957"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica L. Mayer","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025351031","display_name":"Seth Andrew Wander","orcid":"https://orcid.org/0000-0002-4127-4708","observed_orcids":["https://orcid.org/0000-0002-4127-4708"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seth A. Wander","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA"],"raw_orcid":"https://orcid.org/0000-0002-4127-4708","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]},{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025351031"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210117453","https://openalex.org/I4210161994"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":0.3248,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57339367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"14","issue":"4","first_page":"222","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.847000002861023},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/her2-negative-metastatic-breast-cancer","display_name":"HER2-negative metastatic breast cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ink4-family","display_name":"INK4 family","score":0.8650000095367432},{"id":"https://openalex.org/keywords/p18ink4c","display_name":"p18INK4c","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9729999899864197},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.7059999704360962},{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9169999957084656},{"id":"https://openalex.org/keywords/immune-signaling","display_name":"immune signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C199649820","wikidata":"https://www.wikidata.org/wiki/Q14911762","display_name":"Cyclin-dependent kinase 6","level":5,"score":0.9029202461242676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5195406079292297},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4743684232234955},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.47377705574035645},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4440914988517761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38709557056427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34090185165405273},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.314433217048645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3045084476470947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29810792207717896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.075715571641922},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s12609-022-00461-3","doi":"https://doi.org/10.1007/s12609-022-00461-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12609-022-00461-3","pdf_url":null,"source":{"id":"https://openalex.org/S145883490","display_name":"Current Breast Cancer Reports","issn_l":"1943-4588","issn":["1943-4588","1943-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Breast Cancer Reports","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1464936406","https://openalex.org/W1525531613","https://openalex.org/W1622452956","https://openalex.org/W1985389450","https://openalex.org/W2026004604","https://openalex.org/W2027372492","https://openalex.org/W2032780125","https://openalex.org/W2034520315","https://openalex.org/W2038609770","https://openalex.org/W2051316659","https://openalex.org/W2083079645","https://openalex.org/W2103602677","https://openalex.org/W2108670367","https://openalex.org/W2115692032","https://openalex.org/W2116159991","https://openalex.org/W2122973550","https://openalex.org/W2123657823","https://openalex.org/W2131847309","https://openalex.org/W2132207113","https://openalex.org/W2152600133","https://openalex.org/W2163301096","https://openalex.org/W2166529745","https://openalex.org/W2219817965","https://openalex.org/W2235521964","https://openalex.org/W2275249553","https://openalex.org/W2309969893","https://openalex.org/W2528767298","https://openalex.org/W2537675006","https://openalex.org/W2552099557","https://openalex.org/W2558219863","https://openalex.org/W2563142578","https://openalex.org/W2617437931","https://openalex.org/W2620993107","https://openalex.org/W2750328162","https://openalex.org/W2763875663","https://openalex.org/W2769376007","https://openalex.org/W2789574985","https://openalex.org/W2802599306","https://openalex.org/W2802776309","https://openalex.org/W2805575723","https://openalex.org/W2892043300","https://openalex.org/W2896846857","https://openalex.org/W2898723593","https://openalex.org/W2899203698","https://openalex.org/W2903143832","https://openalex.org/W2903599006","https://openalex.org/W2910972034","https://openalex.org/W2917464640","https://openalex.org/W2918928681","https://openalex.org/W2920948544","https://openalex.org/W2923271724","https://openalex.org/W2925017918","https://openalex.org/W2957218735","https://openalex.org/W2974027076","https://openalex.org/W2976415870","https://openalex.org/W2980008739","https://openalex.org/W2994783539","https://openalex.org/W3010575887","https://openalex.org/W3013765366","https://openalex.org/W3016055296","https://openalex.org/W3017368995","https://openalex.org/W3024684302","https://openalex.org/W3036431336","https://openalex.org/W3045659462","https://openalex.org/W3082381786","https://openalex.org/W3099678391","https://openalex.org/W3124262210","https://openalex.org/W3126559783","https://openalex.org/W3127785161","https://openalex.org/W3130555230","https://openalex.org/W3133509869","https://openalex.org/W3133922878","https://openalex.org/W3137868312","https://openalex.org/W3168314397","https://openalex.org/W3199373900","https://openalex.org/W3200026446","https://openalex.org/W3208692915","https://openalex.org/W3213756360","https://openalex.org/W4206127585","https://openalex.org/W4211252841","https://openalex.org/W4213278392","https://openalex.org/W4220716285","https://openalex.org/W4220795493","https://openalex.org/W4223445569","https://openalex.org/W4240150408"],"related_works":["https://openalex.org/W7155164992","https://openalex.org/W4399992245","https://openalex.org/W4313251223","https://openalex.org/W4387267563","https://openalex.org/W4412149906","https://openalex.org/W3032800911","https://openalex.org/W4292866406","https://openalex.org/W7170902509","https://openalex.org/W3024513991","https://openalex.org/W4210845214"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-09-17T00:00:00"}
