{"id":"https://openalex.org/W4296006445","doi":"https://doi.org/10.3390/molecules27185954","title":"Phytochemical Evaluation and Anti-Inflammatory Potential of Miconia albicans (Sw.) Triana Extracts","display_name":"Phytochemical Evaluation and Anti-Inflammatory Potential of Miconia albicans (Sw.) Triana Extracts","publication_year":2022,"publication_date":"2022-09-13","ids":{"openalex":"https://openalex.org/W4296006445","doi":"https://doi.org/10.3390/molecules27185954","pmid":"https://pubmed.ncbi.nlm.nih.gov/36144693","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500825"},"language":"en","primary_location":{"id":"doi:10.3390/molecules27185954","doi":"https://doi.org/10.3390/molecules27185954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27185954","pdf_url":"https://www.mdpi.com/1420-3049/27/18/5954/pdf?version=1663077435","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/27/18/5954/pdf?version=1663077435","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102486642","display_name":"Mariana Inocencio Manzano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Inocencio Manzano","raw_affiliation_strings":["Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045949085","display_name":"Ariana Centa","orcid":"https://orcid.org/0000-0002-0419-141X","observed_orcids":["https://orcid.org/0000-0002-0419-141X"]},"institutions":[{"id":"https://openalex.org/I4210159009","display_name":"University Alto Vale do Rio do Peixe","ror":"https://ror.org/05b5kg436","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210159009"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ariana Centa","raw_affiliation_strings":["Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","Laborat\u00f3rio de Pesquisa Translacional em Sa\u00fade, Universidade Alto Vale do Rio do Peixe, Rua Victor Baptista Adami, 800, Centro, Ca\u00e7ador CEP 89500-000, SC, Brazil","Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil; Laborat\u00f3rio de Pesquisa Translacional em Sa\u00fade, Universidade Alto Vale do Rio do Peixe, Rua Victor Baptista Adami, 800, Centro, Ca\u00e7ador CEP 89500-000, SC, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Laborat\u00f3rio de Pesquisa Translacional em Sa\u00fade, Universidade Alto Vale do Rio do Peixe, Rua Victor Baptista Adami, 800, Centro, Ca\u00e7ador CEP 89500-000, SC, Brazil","institution_ids":["https://openalex.org/I4210159009"]},{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil; Laborat\u00f3rio de Pesquisa Translacional em Sa\u00fade, Universidade Alto Vale do Rio do Peixe, Rua Victor Baptista Adami, 800, Centro, Ca\u00e7ador CEP 89500-000, SC, Brazil","institution_ids":["https://openalex.org/I4210159009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063941953","display_name":"Alan de Almeida Veiga","orcid":"https://orcid.org/0000-0002-0488-3010","observed_orcids":["https://orcid.org/0000-0002-0488-3010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan de Almeida Veiga","raw_affiliation_strings":["Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0488-3010","affiliations":[{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103175204","display_name":"Nayara de Souza da Costa","orcid":"https://orcid.org/0000-0001-6134-9458","observed_orcids":["https://orcid.org/0000-0001-6134-9458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nayara Souza da Costa","raw_affiliation_strings":["Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010234396","display_name":"Sandro Jos\u00e9 Ribeiro Bonatto","orcid":"https://orcid.org/0000-0001-7262-3766","observed_orcids":["https://orcid.org/0000-0001-7262-3766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandro J. R. Bonatto","raw_affiliation_strings":["Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7262-3766","affiliations":[{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018555525","display_name":"Lauro Mera de Souza","orcid":"https://orcid.org/0000-0001-9166-2146","observed_orcids":["https://orcid.org/0000-0001-9166-2146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauro M. de Souza","raw_affiliation_strings":["Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9166-2146","affiliations":[{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086995155","display_name":"Fhernanda Ribeiro Smiderle","orcid":"https://orcid.org/0000-0002-9094-2258","observed_orcids":["https://orcid.org/0000-0002-9094-2258"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fhernanda Ribeiro Smiderle","raw_affiliation_strings":["Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9094-2258","affiliations":[{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]},{"raw_affiliation_string":"Faculdades Pequeno Pr\u00edncipe, Av. Igua\u00e7u, 333, Rebou\u00e7as, Curitiba CEP 80230-020, PR, Brazil; Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe, Av. Silva Jardim, 1632, \u00c1gua Verde, Curitiba CEP 80250-060, PR, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086995155"],"corresponding_institution_ids":[],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.3908,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52572398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"27","issue":"18","first_page":"5954","last_page":"5954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/miconia-albicans","display_name":"Miconia albicans","score":1.0},{"id":"https://openalex.org/keywords/phytochemistry","display_name":"phytochemistry","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9700000286102295},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myricetin","display_name":"myricetin","score":0.996999979019165},{"id":"https://openalex.org/keywords/flavonoid-glycosides","display_name":"flavonoid glycosides","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.800000011920929},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.9190000295639038},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/aqueous-and-ethanolic-extracts","display_name":"aqueous and ethanolic extracts","score":0.7960000038146973},{"id":"https://openalex.org/keywords/n-butanol-fraction","display_name":"n-butanol fraction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.5999219417572021},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5693652033805847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5650095343589783},{"id":"https://openalex.org/C523307889","wikidata":"https://www.wikidata.org/wiki/Q640068","display_name":"Phytochemistry","level":2,"score":0.5584626793861389},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.5474971532821655},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.540280818939209},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5373121500015259},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.5332614779472351},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.49195143580436707},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.46152442693710327},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.4563473165035248},{"id":"https://openalex.org/C2777713963","wikidata":"https://www.wikidata.org/wiki/Q663902","display_name":"Butanol","level":3,"score":0.4536074101924896},{"id":"https://openalex.org/C2778173338","wikidata":"https://www.wikidata.org/wiki/Q951449","display_name":"Myricetin","level":5,"score":0.4502635598182678},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4316319227218628},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.4155734181404114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37949562072753906},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3286624252796173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3272736668586731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1297147274017334},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002725","descriptor_name":"Chloroform","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020001","descriptor_name":"1-Butanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035322","descriptor_name":"Melastomataceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules27185954","doi":"https://doi.org/10.3390/molecules27185954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27185954","pdf_url":"https://www.mdpi.com/1420-3049/27/18/5954/pdf?version=1663077435","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:36144693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36144693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9500825","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9500825/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:04102310886342b49e077dace0595156","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04102310886342b49e077dace0595156","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 27, Iss 18, p 5954 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules27185954","doi":"https://doi.org/10.3390/molecules27185954","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27185954","pdf_url":"https://www.mdpi.com/1420-3049/27/18/5954/pdf?version=1663077435","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322772","display_name":"Funda\u00e7\u00e3o Arauc\u00e1ria","ror":"https://ror.org/02r7nkw81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4296006445.pdf","grobid_xml":"https://content.openalex.org/works/W4296006445.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1772174995","https://openalex.org/W2011867519","https://openalex.org/W2027065592","https://openalex.org/W2052541369","https://openalex.org/W2065688111","https://openalex.org/W2103495251","https://openalex.org/W2135510881","https://openalex.org/W2140239410","https://openalex.org/W2140525205","https://openalex.org/W2151698033","https://openalex.org/W2311978772","https://openalex.org/W2314238318","https://openalex.org/W2398664613","https://openalex.org/W2514073779","https://openalex.org/W2625536757","https://openalex.org/W2743028948","https://openalex.org/W2747777164","https://openalex.org/W2762199797","https://openalex.org/W2797210343","https://openalex.org/W2905725953","https://openalex.org/W2920832988","https://openalex.org/W2944842866","https://openalex.org/W2950087961","https://openalex.org/W2969810988","https://openalex.org/W3001981231","https://openalex.org/W3022527618","https://openalex.org/W3022827246","https://openalex.org/W3086382359","https://openalex.org/W4206953917","https://openalex.org/W6777207901"],"related_works":["https://openalex.org/W3133619938","https://openalex.org/W4320489579","https://openalex.org/W3022827246","https://openalex.org/W7120310468","https://openalex.org/W7120485729","https://openalex.org/W2065688111","https://openalex.org/W3022527618","https://openalex.org/W3197956708","https://openalex.org/W2130438098","https://openalex.org/W4324316377"],"abstract_inverted_index":{"The":[0,95,133,146],"plant":[1],"Miconia":[2],"albicans":[3,213],"(Sw.)":[4],"Triana":[5],"has":[6],"been":[7],"popularly":[8],"used":[9],"in":[10,74,123,155,180],"Brazil":[11],"to":[12,143,192,218],"treat":[13],"chronic":[14],"inflammatory":[15],"disturbances,":[16],"such":[17,126],"as":[18,127],"osteoarthritis.":[19],"This":[20],"disease":[21],"affects":[22],"250":[23],"million":[24],"people":[25],"worldwide,":[26],"and":[27,33,47,62,70,78,93,101,115,130,136,163],"is":[28,39],"associated":[29],"with":[30,67,169],"intense":[31],"pain":[32],"loss":[34],"of":[35,42,49,59,157,183,205,223],"articular":[36],"function.":[37],"There":[38],"a":[40,84],"lack":[41],"information":[43],"about":[44],"the":[45,56,144,170,181,186,194,203],"phytochemistry":[46],"bioactivity":[48],"M.":[50,212],"albicans.":[51],"Therefore,":[52],"this":[53],"study":[54],"determined":[55],"chemical":[57],"composition":[58],"some":[60],"extracts":[61,80,96,135,214],"evaluated":[63,106,154],"their":[64,68,102,131,220],"cytotoxicity,":[65],"along":[66],"antioxidant":[69,151],"anti-inflammatory,":[71],"activities":[72,104],"using":[73,89],"vitro":[75],"models.":[76],"Aqueous":[77],"ethanolic":[79],"were":[81,97,105],"prepared.":[82],"Afterwards,":[83],"liquid\u2013liquid":[85],"partition":[86],"was":[87],"developed":[88],"chloroform,":[90],"ethyl":[91],"acetate,":[92],"n-butanol.":[94],"characterized":[98],"by":[99],"LC\u2013MS,":[100],"biological":[103],"on":[107,211],"epithelial":[108],"cells":[109,113],"(Vero),":[110],"tumoral":[111],"hepatic":[112],"(Hep-G2),":[114],"THP-1":[116,166],"macrophages.":[117],"LC\u2013MS":[118],"analyses":[119],"identified":[120],"several":[121],"flavonoids":[122],"all":[124],"fractions,":[125],"quercetin,":[128],"myricetin,":[129],"glycosides.":[132],"crude":[134],"n-butanol":[137,171],"fractions":[138,148],"did":[139],"not":[140],"present":[141],"cytotoxicity":[142],"cells.":[145],"non-toxic":[147],"presented":[149],"significant":[150],"activity":[152],"when":[153],"terms":[156],"DPPH":[158],"scavenging":[159],"activity,":[160],"lipid":[161],"peroxidation,":[162],"ROS":[164],"inhibition.":[165],"macrophages":[167],"treated":[168],"fraction":[172],"(250":[173],"\u00b5g/mL)":[174],"released":[175],"fewer":[176],"pro-inflammatory":[177],"cytokines,":[178],"even":[179],"presence":[182],"LPS.":[184],"In":[185,208],"future,":[187],"it":[188],"will":[189],"be":[190],"necessary":[191],"identify":[193],"phytochemicals":[195],"that":[196],"are":[197,215],"responsible":[198],"for":[199,202],"anti-inflammatory":[200],"effects":[201],"discovery":[204],"new":[206],"drugs.":[207],"vivo":[209],"studies":[210],"still":[216],"required":[217],"confirm":[219],"possible":[221],"mechanisms":[222],"action.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-17T00:00:00"}