{"id":"https://openalex.org/W4295932130","doi":"https://doi.org/10.1021/acschemneuro.2c00274","title":"Neuroprotective Effects of \u03c3 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington\u2019s Disease","display_name":"Neuroprotective Effects of \u03c3 2 R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington\u2019s Disease","publication_year":2022,"publication_date":"2022-09-15","ids":{"openalex":"https://openalex.org/W4295932130","doi":"https://doi.org/10.1021/acschemneuro.2c00274","pmid":"https://pubmed.ncbi.nlm.nih.gov/36108101","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9547941"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.2c00274","doi":"https://doi.org/10.1021/acschemneuro.2c00274","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.2c00274","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/628cd2ba6cae1c232c155aa3/original/neuroprotective-effects-of-s2r-tmem97-receptor-modulators-in-neuronal-model-of-huntington-s-disease.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100449397","display_name":"Jing Jin","orcid":"https://orcid.org/0000-0003-1508-8036","observed_orcids":["https://orcid.org/0000-0003-1508-8036"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Jin","raw_affiliation_strings":["Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089837015","display_name":"Nicolas Arbez","orcid":"https://orcid.org/0000-0003-1038-192X","observed_orcids":["https://orcid.org/0000-0003-1038-192X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas Arbez","raw_affiliation_strings":["Cellular Sciences Department, IdRS, Croissy-sur-Seine 78290, France","Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Sciences Department, IdRS, Croissy-sur-Seine 78290, France","institution_ids":[]},{"raw_affiliation_string":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044716856","display_name":"James J. Sahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Sahn","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022560579","display_name":"Yan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Lu","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019768748","display_name":"Kathryn Linkens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn T. Linkens","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002697040","display_name":"Timothy R. Hodges","orcid":"https://orcid.org/0000-0003-1216-9551","observed_orcids":["https://orcid.org/0000-0003-1216-9551"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R. Hodges","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083437159","display_name":"Anthony Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Tang","raw_affiliation_strings":["Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071804120","display_name":"Robyn Wiseman","orcid":"https://orcid.org/0000-0002-4537-0473","observed_orcids":["https://orcid.org/0000-0002-4537-0473"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn Wiseman","raw_affiliation_strings":["Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States","Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055989647","display_name":"Stephen F. Martin","orcid":"https://orcid.org/0000-0002-4639-0695","observed_orcids":["https://orcid.org/0000-0002-4639-0695"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen F. Martin","raw_affiliation_strings":["Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States"],"raw_orcid":"https://orcid.org/0000-0002-4639-0695","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072055814","display_name":"Christopher A. Ross","orcid":"https://orcid.org/0000-0003-1882-5847","observed_orcids":["https://orcid.org/0000-0003-1882-5847"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher A. Ross","raw_affiliation_strings":["Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States","Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055989647","https://openalex.org/A5072055814"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I86519309"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.4289,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.89830508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"19","first_page":"2852","last_page":"2862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sigma-2-receptor","display_name":"sigma-2 receptor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tmem97","display_name":"TMEM97","score":0.984000027179718},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mutant-huntingtin","display_name":"mutant huntingtin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/polyglutamine","display_name":"polyglutamine","score":0.828000009059906},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.777999997138977},{"id":"https://openalex.org/keywords/sigma-1-receptor","display_name":"sigma-1 receptor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/small-molecule-ligands","display_name":"small-molecule ligands","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.49900001287460327},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.5809999704360962},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.90462327003479},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9010922908782959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6357300877571106},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.57326740026474},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4546350836753845},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4544934332370758},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.41239264607429504},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3953110873699188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38689059019088745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29507994651794434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17856177687644958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11428755521774292}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017480","descriptor_name":"Receptors, sigma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acschemneuro.2c00274","doi":"https://doi.org/10.1021/acschemneuro.2c00274","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.2c00274","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2022-l6xtv","doi":"https://doi.org/10.26434/chemrxiv-2022-l6xtv","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2022-l6xtv","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/628cd2ba6cae1c232c155aa3/original/neuroprotective-effects-of-s2r-tmem97-receptor-modulators-in-neuronal-model-of-huntington-s-disease.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:36108101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36108101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9547941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9547941","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv-2022-l6xtv","doi":"https://doi.org/10.26434/chemrxiv-2022-l6xtv","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2022-l6xtv","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/628cd2ba6cae1c232c155aa3/original/neuroprotective-effects-of-s2r-tmem97-receptor-modulators-in-neuronal-model-of-huntington-s-disease.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2476831334","display_name":null,"funder_award_id":"HHSN-271-2018-00023-C","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5551017590","display_name":"Validation of Novel Pathogenic Post-Translational Modifications of Huntingtin, and of Modifying Enzymes as Therapeutic Targets for Huntington's Disease","funder_award_id":"R01NS086452","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5665105880","display_name":null,"funder_award_id":"NS086452","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6867265530","display_name":null,"funder_award_id":"F-0652","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G7009490193","display_name":null,"funder_award_id":"HHSN-271-2018-00023-C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7317107709","display_name":null,"funder_award_id":"HHSN-271-2018-00023-C","funder_id":"https://openalex.org/F4320318855","funder_display_name":"National Institute of Mental Health and Neurosciences"},{"id":"https://openalex.org/G9000878588","display_name":"Pharmacology and Molecular Sciences Training Program","funder_award_id":"T32GM135083","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320318855","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332524","display_name":"Gillings School of Public Health","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320333558","display_name":"Dell Medical School, University of Texas at Austin","ror":null},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295932130.pdf","grobid_xml":"https://content.openalex.org/works/W4295932130.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W262238300","https://openalex.org/W1523583251","https://openalex.org/W1925196301","https://openalex.org/W1948622783","https://openalex.org/W1971409228","https://openalex.org/W1975201747","https://openalex.org/W1984954364","https://openalex.org/W1994758764","https://openalex.org/W1998857499","https://openalex.org/W2002439304","https://openalex.org/W2008752021","https://openalex.org/W2019079031","https://openalex.org/W2020096302","https://openalex.org/W2032032613","https://openalex.org/W2034475831","https://openalex.org/W2049538345","https://openalex.org/W2060972405","https://openalex.org/W2065500745","https://openalex.org/W2078093436","https://openalex.org/W2089351812","https://openalex.org/W2091812013","https://openalex.org/W2107979600","https://openalex.org/W2114326728","https://openalex.org/W2118546680","https://openalex.org/W2121642311","https://openalex.org/W2167353335","https://openalex.org/W2282510442","https://openalex.org/W2291779372","https://openalex.org/W2471059767","https://openalex.org/W2493372949","https://openalex.org/W2547401413","https://openalex.org/W2560084727","https://openalex.org/W2595101650","https://openalex.org/W2595510867","https://openalex.org/W2595836464","https://openalex.org/W2597190264","https://openalex.org/W2597717383","https://openalex.org/W2618221287","https://openalex.org/W2669040921","https://openalex.org/W2749718288","https://openalex.org/W2764161959","https://openalex.org/W2787503105","https://openalex.org/W2794891295","https://openalex.org/W2800940990","https://openalex.org/W2809936606","https://openalex.org/W2899553700","https://openalex.org/W2901780362","https://openalex.org/W2912759859","https://openalex.org/W2946645772","https://openalex.org/W2946929140","https://openalex.org/W2964747275","https://openalex.org/W2966063114","https://openalex.org/W3012494814","https://openalex.org/W3036273457","https://openalex.org/W3045443729","https://openalex.org/W3047126352","https://openalex.org/W3047418311","https://openalex.org/W3049633837","https://openalex.org/W3098082001","https://openalex.org/W3099765926","https://openalex.org/W3125282171","https://openalex.org/W3133174712"],"related_works":["https://openalex.org/W2946645772","https://openalex.org/W2770027787","https://openalex.org/W3139398697","https://openalex.org/W1570695002","https://openalex.org/W2771891917","https://openalex.org/W2026384413","https://openalex.org/W4416455233","https://openalex.org/W2068434142","https://openalex.org/W2014377303","https://openalex.org/W4402373941"],"abstract_inverted_index":{"Huntington's":[0],"disease":[1,7,55],"(HD)":[2],"is":[3,48,70],"a":[4,125,235,263],"genetic":[5],"neurodegenerative":[6],"caused":[8],"by":[9,224,233],"an":[10,22,106],"expanded":[11,23],"CAG":[12],"repeat":[13,26,41],"in":[14,27,43,81,102,154,164,213],"the":[15,30,63,112,220,243],"human":[16,31],"Huntingtin":[17],"gene":[18],"(HTT)":[19],"that":[20,53,59,246,258],"yields":[21],"polyglutamine":[24],"(polyQ)":[25],"exon-1":[28],"of":[29,38,114,127,138],"mutant":[32],"huntingtin":[33],"(mHTT)":[34],"protein.":[35],"The":[36],"presence":[37],"this":[39],"polyQ":[40],"results":[42,240],"neuronal":[44,120,221,255],"degeneration,":[45],"and":[46,87,134,169,200,204,226],"there":[47],"no":[49],"cure":[50],"nor":[51],"treatment":[52],"modifies":[54],"progression.":[56],"Small":[57],"molecules":[58],"bind":[60,131],"selectively":[61],"to":[62,72,77,110,130,132,150,209,267],"recently-cloned":[64],"sigma":[65],"2":[66],"receptor":[67],"(\uf0732R),":[68],"which":[69],"identical":[71],"TMEM97,":[73],"have":[74,78],"been":[75],"shown":[76],"neuroprotective":[79,228],"effects":[80,113,229],"Alzheimer's":[82],"disease,":[83],"traumatic":[84],"brain":[85],"injury":[86],"several":[88],"other":[89],"neurological":[90],"disorders.":[91],"To":[92],"assess":[93,210],"whether":[94],"modulating":[95],"pathways":[96],"involving":[97],"\uf020\uf0732R/TMEM97":[98,115],"can":[99,249],"provide":[100,262],"protection":[101],"HD,":[103],"we":[104],"used":[105],"HD":[107,156,269],"cell":[108,157,211],"model":[109],"evaluate":[111],"ligands":[116,140],"on":[117],"mHTT":[118,180,253],"induced":[119,223,254],"toxicity.":[121],"We":[122],"first":[123,244],"synthesized":[124],"set":[126],"compounds":[128],"designed":[129],"\uf0732R/TMEM97,":[133],"binding":[135],"profiles":[136],"(Ki)":[137],"these":[139],"were":[141,162,185,198,207],"determined.":[142],"Modulators":[143],"with":[144,172,187,202],"high":[145],"selectivity":[146],"for":[147,166,192,242],"\uf0732R/TMEM97":[148,188,217,247,260],"relative":[149],"\uf0731R\uf020were":[151],"then":[152,170],"tested":[153],"our":[155],"model.":[158],"Primary":[159],"cortical":[160],"neurons":[161,184,197,251],"cultured":[163],"vitro":[165],"seven":[167],"days":[168],"co-transfected":[171],"either":[173],"normal":[174],"HTT":[175],"construct":[176,181],"(Htt":[177],"N-586-22Q/GFP)":[178],"or":[179,189],"(Htt-N586-82Q/GFP).":[182],"Transfected":[183],"treated":[186],"\uf0731R":[190,237],"modulators":[191,218,248],"48":[193],"h.":[194],"After":[195],"treatment,":[196],"fixed":[199],"stained":[201],"Hoechst,":[203],"condensed":[205],"nuclei":[206],"quantified":[208],"death":[212],"transfected":[214],"neurons.":[215],"Significantly,":[216],"reduce":[219],"toxicity":[222],"mHTT,":[225],"their":[227],"are":[230],"not":[231],"blocked":[232],"NE-100,":[234],"selective":[236],"antagonist.":[238],"These":[239],"indicate":[241],"time":[245],"protect":[250],"from":[252],"toxicity,":[256],"suggesting":[257],"targeting":[259],"may":[261],"novel":[264],"therapeutic":[265],"approach":[266],"treat":[268],"patients.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-16T00:00:00"}