{"id":"https://openalex.org/W4295899231","doi":"https://doi.org/10.1093/ehjqcco/qcac060","title":"Meta-analysis of the Placebo and Nocebo effects associated with Placebo treatment in randomized trials of lipid-lowering therapies","display_name":"Meta-analysis of the Placebo and Nocebo effects associated with Placebo treatment in randomized trials of lipid-lowering therapies","publication_year":2022,"publication_date":"2022-09-15","ids":{"openalex":"https://openalex.org/W4295899231","doi":"https://doi.org/10.1093/ehjqcco/qcac060","pmid":"https://pubmed.ncbi.nlm.nih.gov/36107462"},"language":"en","primary_location":{"id":"doi:10.1093/ehjqcco/qcac060","doi":"https://doi.org/10.1093/ehjqcco/qcac060","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ehjqcco/qcac060","pdf_url":null,"source":{"id":"https://openalex.org/S2735811053","display_name":"European Heart Journal - Quality of Care and Clinical Outcomes","issn_l":"2058-1742","issn":["2058-1742","2058-5225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Quality of Care and Clinical Outcomes","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007912393","display_name":"Yip Han Chin","orcid":"https://orcid.org/0000-0002-8417-5996","observed_orcids":["https://orcid.org/0000-0002-8417-5996"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yip H Chin","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075772617","display_name":"Oliver Zi-Hern Lim","orcid":"https://orcid.org/0000-0002-0552-0473","observed_orcids":["https://orcid.org/0000-0002-0552-0473"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Oliver Lim","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":"https://orcid.org/0000-0002-0552-0473","affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067979981","display_name":"Chaoxing Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chaoxing Lin","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Y Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yu Y Chan","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015054853","display_name":"Gwyneth Kong","orcid":"https://orcid.org/0000-0002-3385-5078","observed_orcids":["https://orcid.org/0000-0002-3385-5078"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gwyneth Kong","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072850708","display_name":"Cheng H. Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cheng H Ng","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041380818","display_name":"Bryan Chong","orcid":"https://orcid.org/0000-0002-3565-7657","observed_orcids":["https://orcid.org/0000-0002-3565-7657"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bryan Chong","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043061995","display_name":"Nicholas L. X. Syn","orcid":"https://orcid.org/0000-0002-6343-176X","observed_orcids":["https://orcid.org/0000-0002-6343-176X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nicholas Syn","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":"https://orcid.org/0000-0002-6343-176X","affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074504864","display_name":"Kai En Chan","orcid":"https://orcid.org/0000-0001-9784-2623","observed_orcids":["https://orcid.org/0000-0001-9784-2623"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kai E Chan","raw_affiliation_strings":["Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058087480","display_name":"Mark Dhinesh Muthiah","orcid":"https://orcid.org/0000-0002-9724-4743","observed_orcids":["https://orcid.org/0000-0002-9724-4743"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mark D Muthiah","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital , 119074 Singapore","National University Centre for Organ Transplantation, National University Health System , 119074 Singapore","Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital , 119074 Singapore","institution_ids":["https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"National University Centre for Organ Transplantation, National University Health System , 119074 Singapore","institution_ids":["https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004639766","display_name":"Mohammad Shadab Siddiqui","orcid":"https://orcid.org/0000-0001-7392-7489","observed_orcids":["https://orcid.org/0000-0001-7392-7489"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad S Siddiqui","raw_affiliation_strings":["Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University , Richmond, VA, 23284 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University , Richmond, VA, 23284 USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071555896","display_name":"Jiong\u2010Wei Wang","orcid":"https://orcid.org/0000-0001-7986-6082","observed_orcids":["https://orcid.org/0000-0001-7986-6082"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jiong-Wei Wang","raw_affiliation_strings":["Department of Surgery, Cardiovascular Research Institute, National University of Singapore, 117599 Singapore","Nanomedicine Translational Research Program, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore"],"raw_orcid":"https://orcid.org/0000-0001-7986-6082","affiliations":[{"raw_affiliation_string":"Department of Surgery, Cardiovascular Research Institute, National University of Singapore, 117599 Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Nanomedicine Translational Research Program, Centre for NanoMedicine, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010661645","display_name":"Gemma  Alexandra Figtree","orcid":"https://orcid.org/0000-0002-5080-6083","observed_orcids":["https://orcid.org/0000-0002-5080-6083"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gemma Figtree","raw_affiliation_strings":["Department of Cardiology, Royal North Shore Hospital , Sydney, NSW, 2065 , Australia","Northern Clinical School, Kolling Institute of Medical Research, University of Sydney , Sydney, NSW, 2065 , Australia"],"raw_orcid":"https://orcid.org/0000-0002-5080-6083","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Royal North Shore Hospital , Sydney, NSW, 2065 , Australia","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"Northern Clinical School, Kolling Institute of Medical Research, University of Sydney , Sydney, NSW, 2065 , Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073765015","display_name":"Mark Y. Chan","orcid":"https://orcid.org/0000-0003-0389-7450","observed_orcids":["https://orcid.org/0000-0003-0389-7450","https://orcid.org/0000-0003-4768-5820"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210107866","display_name":"National University Heart Centre Singapore","ror":"https://ror.org/01vvdem88","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210107866"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mark Y Chan","raw_affiliation_strings":["Department of Cardiology, National University Heart Centre , 119074 Singapore","Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, National University Heart Centre , 119074 Singapore","institution_ids":["https://openalex.org/I4210107866"]},{"raw_affiliation_string":"Yong Loo Lin School of Medicine, National University of Singapore , 119077 , Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080623484","display_name":"Nicholas Chew","orcid":"https://orcid.org/0000-0002-0640-0430","observed_orcids":["https://orcid.org/0000-0002-0640-0430"]},"institutions":[{"id":"https://openalex.org/I4210107866","display_name":"National University Heart Centre Singapore","ror":"https://ror.org/01vvdem88","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210107866"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Nicholas W S Chew","raw_affiliation_strings":["Department of Cardiology, National University Heart Centre , 119074 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, National University Heart Centre , 119074 Singapore","institution_ids":["https://openalex.org/I4210107866"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5080623484"],"corresponding_institution_ids":["https://openalex.org/I4210107866"],"apc_list":{"value":3650,"currency":"EUR","value_usd":3846},"apc_paid":null,"fwci":0.9787,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.69660194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":"5","first_page":"511","last_page":"519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nocebo-effect","display_name":"nocebo effect","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7910000085830688},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.5239999890327454},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7260000109672546},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.8180000185966492},{"id":"https://openalex.org/keywords/trial-design","display_name":"trial design","score":0.6589999794960022},{"id":"https://openalex.org/keywords/musculoskeletal-symptoms","display_name":"musculoskeletal symptoms","score":0.847000002861023},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.7599999904632568},{"id":"https://openalex.org/keywords/headache","display_name":"headache","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.927814245223999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8399084806442261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7056986689567566},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6810619831085205},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5860421657562256},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.550090491771698},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.521238386631012},{"id":"https://openalex.org/C2778360308","wikidata":"https://www.wikidata.org/wiki/Q1332954","display_name":"Nocebo","level":4,"score":0.5124390721321106},{"id":"https://openalex.org/C2909182145","wikidata":"https://www.wikidata.org/wiki/Q1332954","display_name":"Nocebo Effect","level":4,"score":0.48976826667785645},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42178580164909363},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06293061375617981},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D064786","descriptor_name":"Nocebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ehjqcco/qcac060","doi":"https://doi.org/10.1093/ehjqcco/qcac060","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ehjqcco/qcac060","pdf_url":null,"source":{"id":"https://openalex.org/S2735811053","display_name":"European Heart Journal - Quality of Care and Clinical Outcomes","issn_l":"2058-1742","issn":["2058-1742","2058-5225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Quality of Care and Clinical Outcomes","raw_type":"journal-article"},{"id":"pmid:36107462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36107462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal. Quality of care & clinical outcomes","raw_type":"Meta-Analysis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G5160676589","display_name":null,"funder_award_id":"US9638699B2","funder_id":"https://openalex.org/F4320333256","funder_display_name":"Abbott Diabetes Care"}],"funders":[{"id":"https://openalex.org/F4320310951","display_name":"Heart Research Australia","ror":"https://ror.org/046fa4y88"},{"id":"https://openalex.org/F4320333256","display_name":"Abbott Diabetes Care","ror":"https://ror.org/03vb88585"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W161816689","https://openalex.org/W1596902544","https://openalex.org/W1974170500","https://openalex.org/W2014375653","https://openalex.org/W2030711540","https://openalex.org/W2039542922","https://openalex.org/W2103647780","https://openalex.org/W2105299596","https://openalex.org/W2114691160","https://openalex.org/W2118184073","https://openalex.org/W2125435699","https://openalex.org/W2136145129","https://openalex.org/W2137591261","https://openalex.org/W2163223903","https://openalex.org/W2164089346","https://openalex.org/W2165884492","https://openalex.org/W2170892587","https://openalex.org/W2200285648","https://openalex.org/W2229293842","https://openalex.org/W2247997571","https://openalex.org/W2345601318","https://openalex.org/W2396139649","https://openalex.org/W2465758073","https://openalex.org/W2766489639","https://openalex.org/W2783298701","https://openalex.org/W2790016872","https://openalex.org/W2806690659","https://openalex.org/W2807782653","https://openalex.org/W2883526378","https://openalex.org/W2902007237","https://openalex.org/W2909842054","https://openalex.org/W2930850699","https://openalex.org/W2970684805","https://openalex.org/W2975424845","https://openalex.org/W2982546830","https://openalex.org/W2996258364","https://openalex.org/W3015010867","https://openalex.org/W3091403751","https://openalex.org/W3113178943","https://openalex.org/W3118615836","https://openalex.org/W3119531265","https://openalex.org/W3153186461","https://openalex.org/W3186618404","https://openalex.org/W3200521827","https://openalex.org/W4206216291","https://openalex.org/W4210347219","https://openalex.org/W4240484632","https://openalex.org/W6807556630"],"related_works":["https://openalex.org/W2077835295","https://openalex.org/W4410792825","https://openalex.org/W3176157893","https://openalex.org/W2044743761","https://openalex.org/W2765867613","https://openalex.org/W2905013711","https://openalex.org/W4416354321","https://openalex.org/W2388471644","https://openalex.org/W4415601390","https://openalex.org/W2343469006"],"abstract_inverted_index":{"BACKGROUND:":[0],"Randomized":[1],"controlled":[2],"trials":[3],"(RCTs)":[4],"of":[5,28,56,73,83,97,173,213,221,239,258],"lipid-lowering":[6,29],"therapy":[7],"(LLT)":[8],"in":[9,164,204,224],"which":[10],"the":[11,23,79,210,256],"control":[12],"groups":[13],"received":[14],"placebo":[15,24,134,211,233],"without":[16],"background":[17,48,228],"LLT":[18,49,229,260],"offer":[19],"unique":[20],"insights":[21],"into":[22],"and":[25,35,67,93,100,115,124,149,158,191,215,242],"nocebo":[26,139,175,205,237],"effects":[27,176,206],"RCTs.":[30,251,261],"METHODS":[31],"AND":[32],"RESULTS:":[33],"Embase":[34],"Medline":[36],"were":[37,50,105,117,207],"searched":[38],"for":[39,111,146,151,155,160],"hyperlipidaemia":[40],"RCTs":[41,99,167,225],"with":[42,47,226],"placebo-controlled":[43],"arms.":[44],"Placebo":[45],"arms":[46,212],"excluded.":[51],"A":[52,71],"single":[53],"arm":[54],"meta-analysis":[55,72,220],"proportions":[57],"was":[58,75,144,246],"used":[59,76],"to":[60,77],"estimate":[61,78],"major":[62],"adverse":[63,68],"cardiovascular":[64],"events":[65,69],"(MACE)":[66],"(AE).":[70],"means":[74],"pooled":[80,108,137],"mean":[81,109],"differences":[82,203],"total":[84,96],"cholesterol":[85],"(TC),":[86],"low-density":[87],"lipoprotein":[88],"(LDL),":[89],"high-density":[90],"lipoproteins":[91],"(HDL)":[92],"triglycerides":[94],"(TG).A":[95],"40":[98],"37":[101],"668":[102],"placebo-treated":[103,129,142,222],"participants":[104,143,163,223],"included.":[106],"The":[107,136],"changes":[110],"TC,":[112],"LDL,":[113],"HDL,":[114],"TG":[116],"-0.019":[118],"mmol/L,":[119,121,123],"-0.028":[120],"0.013":[122],"0.062":[125],"mmol/L":[126],"respectively":[127],"among":[128,141,248],"participants,":[130],"indicating":[131],"a":[132,169,231],"modest":[133,232],"effect.":[135],"average":[138],"effect":[140,234,238],"42.62%":[145],"all":[147],"AEs":[148,182],"3.38%":[150],"musculoskeletal-related":[152],"AEs,":[153,157],"11.36%":[154],"gastrointestinal-related":[156,192],"6.62%":[159],"headaches.":[161],"Placebo-treated":[162],"secondary":[165,249],"prevention":[166,179,250],"had":[168],"far":[170],"higher":[171],"incidence":[172],"these":[174],"than":[177],"primary":[178],"RCTs:":[180],"any":[181],"(OR":[183,194],"6.76,":[184],"95%":[185,196],"CI:":[186,197],"5.56-8.24,":[187],"P":[188,199],"<":[189],"0.001),":[190],"AE":[193],"1.23,":[195],"1.00-1.51,":[198],"=":[200],"0.049).":[201],"No":[202],"found":[208],"between":[209],"statin":[214],"non-statin":[216],"trials.":[217],"CONCLUSION:":[218],"Our":[219],"no":[227],"indicate":[230],"but":[235],"prominent":[236],"musculoskeletal,":[240],"headache,":[241],"gastrointestinal":[243],"symptoms":[244],"that":[245],"greatest":[247],"These":[252],"findings":[253],"may":[254],"inform":[255],"design":[257],"future":[259]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-16T00:00:00"}