{"id":"https://openalex.org/W4295880353","doi":"https://doi.org/10.1371/journal.ppat.1010811","title":"SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein","display_name":"SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein","publication_year":2022,"publication_date":"2022-09-12","ids":{"openalex":"https://openalex.org/W4295880353","doi":"https://doi.org/10.1371/journal.ppat.1010811","pmid":"https://pubmed.ncbi.nlm.nih.gov/35018374","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8750649"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1010811","doi":"https://doi.org/10.1371/journal.ppat.1010811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010811","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.ppat.1010811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056848730","display_name":"Marius Walter","orcid":"https://orcid.org/0000-0002-2476-9661","observed_orcids":["https://orcid.org/0000-0002-2476-9661"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marius Walter","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2476-9661","affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068461441","display_name":"Irene P. Chen","orcid":"https://orcid.org/0000-0002-5766-9253","observed_orcids":["https://orcid.org/0000-0002-5766-9253"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene P. Chen","raw_affiliation_strings":["Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002353515","display_name":"Albert Vallejo-Gracia","orcid":"https://orcid.org/0000-0003-4815-5039","observed_orcids":["https://orcid.org/0000-0003-4815-5039"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Vallejo-Gracia","raw_affiliation_strings":["Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048555692","display_name":"Ik-Jung Kim","orcid":"https://orcid.org/0000-0003-1246-5019","observed_orcids":["https://orcid.org/0000-0003-1246-5019"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ik-Jung Kim","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081711862","display_name":"Olga Bielska","orcid":"https://orcid.org/0000-0001-5826-0778","observed_orcids":["https://orcid.org/0000-0001-5826-0778"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Bielska","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077256544","display_name":"Victor L. Lam","orcid":"https://orcid.org/0000-0001-5384-6542","observed_orcids":["https://orcid.org/0000-0001-5384-6542"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor L. Lam","raw_affiliation_strings":["University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084131063","display_name":"Jennifer M. Hayashi","orcid":"https://orcid.org/0000-0001-7153-9212","observed_orcids":["https://orcid.org/0000-0001-7153-9212"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Hayashi","raw_affiliation_strings":["Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051901396","display_name":"Andrew Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Cruz","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021159285","display_name":"Samah Shah","orcid":"https://orcid.org/0000-0003-4688-1248","observed_orcids":["https://orcid.org/0000-0003-4688-1248"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samah Shah","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021768841","display_name":"Frank W. Soveg","orcid":"https://orcid.org/0000-0002-3403-0190","observed_orcids":["https://orcid.org/0000-0002-3403-0190"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank W. Soveg","raw_affiliation_strings":["Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040138828","display_name":"John D. Gross","orcid":"https://orcid.org/0000-0002-1377-4705","observed_orcids":["https://orcid.org/0000-0002-1377-4705"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Gross","raw_affiliation_strings":["Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026080576","display_name":"Nevan J. Krogan","orcid":"https://orcid.org/0000-0003-4902-337X","observed_orcids":["https://orcid.org/0000-0003-4902-337X"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nevan J. Krogan","raw_affiliation_strings":["Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014597522","display_name":"Keith R. Jerome","orcid":"https://orcid.org/0000-0002-8212-3789","observed_orcids":["https://orcid.org/0000-0002-8212-3789"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith R. Jerome","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America","Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003883020","display_name":"Birgit Schilling","orcid":"https://orcid.org/0000-0001-9907-2749","observed_orcids":["https://orcid.org/0000-0001-9907-2749"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Birgit Schilling","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068579765","display_name":"M\u00e9lanie Ott","orcid":"https://orcid.org/0000-0002-5697-1274","observed_orcids":["https://orcid.org/0000-0002-5697-1274"]},"institutions":[{"id":"https://openalex.org/I1321430492","display_name":"Gladstone Institutes","ror":"https://ror.org/038321296","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321430492"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Ott","raw_affiliation_strings":["Chan Zuckerberg Biohub, San Francisco, California, United States of America","Gladstone Institutes, San Francisco, California, United States of America","QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","University of California San Francisco, San Francisco, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Gladstone Institutes, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1321430492"]},{"raw_affiliation_string":"QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025168089","display_name":"Eric M. Verdin","orcid":"https://orcid.org/0000-0003-3703-3183","observed_orcids":["https://orcid.org/0000-0003-3703-3183"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric Verdin","raw_affiliation_strings":["Buck Institute for Research on Aging, Novato, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3703-3183","affiliations":[{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025168089","https://openalex.org/A5056848730"],"corresponding_institution_ids":["https://openalex.org/I1337826666"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.6356,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.96435217,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"18","issue":"9","first_page":"e1010811","last_page":"e1010811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt5","display_name":"SIRT5","score":0.996999979019165},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nsp14","display_name":"nsp14","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nsp10","display_name":"nsp10","score":0.9800000190734863},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/proviral-factors","display_name":"proviral factors","score":0.734000027179718},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.8700000047683716},{"id":"https://openalex.org/keywords/succinylation","display_name":"succinylation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mavs","display_name":"MAVS","score":0.621999979019165},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.6636167764663696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199543237686157},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.46074071526527405},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3479723632335663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3176411986351013},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3074948787689209},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.2570686936378479},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10468682646751404}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1010811","doi":"https://doi.org/10.1371/journal.ppat.1010811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010811","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"doi:10.1101/2022.01.04.474979","doi":"https://doi.org/10.1101/2022.01.04.474979","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.01.04.474979","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/01/05/2022.01.04.474979.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9499238","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9499238","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:35018374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35018374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:36095012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36095012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt47w381wd","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/47w381wd","pdf_url":"https://escholarship.org/content/qt47w381wd/qt47w381wd.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Pathogens, vol 18, iss 9","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8750649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8750649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:19538024418c4582aee777208e569149","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/19538024418c4582aee777208e569149","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 18, Iss 9, p e1010811 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1010811","doi":"https://doi.org/10.1371/journal.ppat.1010811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1010811","pdf_url":null,"source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1689835210","display_name":null,"funder_award_id":"1S10 OD016281","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1769117214","display_name":"Suppression of Host Antiviral Responses by a SARS-CoV-2 Histone Mimetic","funder_award_id":"F31AI164671","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4016957444","display_name":"Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencin","funder_award_id":"1s10od010786-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4995325264","display_name":null,"funder_award_id":"1S10OD010786-01","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8762224506","display_name":"TripleTOF 5600 High Resolution Mass Spectrometer","funder_award_id":"1s10od016281-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8806149039","display_name":null,"funder_award_id":"OD016281","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320311491","display_name":"Roddenberry Foundation","ror":"https://ror.org/00cs24427"},{"id":"https://openalex.org/F4320314571","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1631074248","https://openalex.org/W1684533821","https://openalex.org/W1925644262","https://openalex.org/W1955146052","https://openalex.org/W1971168306","https://openalex.org/W1994542643","https://openalex.org/W2010457001","https://openalex.org/W2018212701","https://openalex.org/W2028178274","https://openalex.org/W2035618305","https://openalex.org/W2052108354","https://openalex.org/W2053476949","https://openalex.org/W2063228821","https://openalex.org/W2074692187","https://openalex.org/W2075351796","https://openalex.org/W2078673393","https://openalex.org/W2083378095","https://openalex.org/W2085853684","https://openalex.org/W2088511656","https://openalex.org/W2090008797","https://openalex.org/W2108226298","https://openalex.org/W2110905563","https://openalex.org/W2111058723","https://openalex.org/W2118132981","https://openalex.org/W2122511992","https://openalex.org/W2126428749","https://openalex.org/W2130879922","https://openalex.org/W2138207763","https://openalex.org/W2169363615","https://openalex.org/W2169880855","https://openalex.org/W2179438025","https://openalex.org/W2210729715","https://openalex.org/W2225619624","https://openalex.org/W2284984697","https://openalex.org/W2516495404","https://openalex.org/W2519014298","https://openalex.org/W2523099503","https://openalex.org/W2563686910","https://openalex.org/W2726524491","https://openalex.org/W2765089684","https://openalex.org/W2765440400","https://openalex.org/W2768840943","https://openalex.org/W2777914188","https://openalex.org/W2799579025","https://openalex.org/W2803912979","https://openalex.org/W2878721160","https://openalex.org/W2894565780","https://openalex.org/W2900601355","https://openalex.org/W2950243974","https://openalex.org/W2977961280","https://openalex.org/W3016392220","https://openalex.org/W3016489853","https://openalex.org/W3022285953","https://openalex.org/W3035082673","https://openalex.org/W3037945517","https://openalex.org/W3043868614","https://openalex.org/W3082059062","https://openalex.org/W3086108939","https://openalex.org/W3089118811","https://openalex.org/W3093213262","https://openalex.org/W3093938065","https://openalex.org/W3095032459","https://openalex.org/W3102558410","https://openalex.org/W3124517608","https://openalex.org/W3125590130","https://openalex.org/W3157249971","https://openalex.org/W3157881218","https://openalex.org/W3160235188","https://openalex.org/W3165059311","https://openalex.org/W3165149216","https://openalex.org/W3165788001","https://openalex.org/W3175341024","https://openalex.org/W3186956315"],"related_works":["https://openalex.org/W4283320458","https://openalex.org/W3134653186","https://openalex.org/W4411624698","https://openalex.org/W3159182925","https://openalex.org/W7038472051","https://openalex.org/W4206020908","https://openalex.org/W7163899147","https://openalex.org/W4200485684","https://openalex.org/W6902264771","https://openalex.org/W3048368880"],"abstract_inverted_index":{"SARS-CoV-2":[0,75,134],"non-structural":[1,19],"protein":[2,20,46],"Nsp14":[3,13,113],"is":[4,43,104,170],"a":[5,15,36,153,171],"highly":[6],"conserved":[7],"enzyme":[8],"necessary":[9,105,174],"for":[10,49,106,175,183],"viral":[11,135,177],"replication.":[12],"forms":[14],"stable":[16],"complex":[17],"with":[18,82,86,109,129],"Nsp10":[21,92],"and":[22,25,55,69,91,151],"exhibits":[23],"exoribonuclease":[24],"N7-methyltransferase":[26],"activities.":[27],"Protein-interactome":[28],"studies":[29],"identified":[30],"human":[31],"sirtuin":[32],"5":[33],"(SIRT5)":[34],"as":[35],"putative":[37],"binding":[38],"partner":[39],"of":[40,66,72,95,125,147,158],"Nsp14.":[41],"SIRT5":[42,73,80,90,101,126,131,140,169],"an":[44],"NAD-dependent":[45],"deacylase":[47],"critical":[48],"cellular":[50],"metabolism":[51],"that":[52,79,89,100,112,168],"removes":[53],"succinyl":[54],"malonyl":[56],"groups":[57],"from":[58],"lysine":[59],"residues.":[60],"Here":[61],"we":[62],"investigated":[63],"the":[64,70,107,159],"nature":[65],"this":[67],"interaction":[68,108],"role":[71],"during":[74],"infection.":[76],"We":[77,98],"showed":[78],"interacts":[81],"Nsp14,":[83,110],"but":[84,111],"not":[85,115],"Nsp10,":[87],"suggesting":[88],"are":[93],"parts":[94],"separate":[96],"complexes.":[97],"found":[99],"catalytic":[102],"domain":[103],"does":[114],"appear":[116],"to":[117],"be":[118],"directly":[119],"deacylated":[120],"by":[121],"SIRT5.":[122],"Furthermore,":[123],"knock-out":[124,141],"or":[127],"treatment":[128],"specific":[130],"inhibitors":[132],"reduced":[133],"levels":[136,146],"in":[137],"cell-culture":[138],"experiments.":[139],"cells":[142],"expressed":[143],"higher":[144],"basal":[145],"innate":[148],"immunity":[149],"markers":[150],"mounted":[152],"stronger":[154],"antiviral":[155],"response,":[156],"independently":[157],"Mitochondrial":[160],"Antiviral":[161],"Signaling":[162],"Protein":[163],"MAVS.":[164],"Our":[165],"results":[166],"indicate":[167],"proviral":[172],"factor":[173],"efficient":[176],"replication,":[178],"which":[179],"opens":[180],"novel":[181],"avenues":[182],"therapeutic":[184],"interventions.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-09-15T00:00:00"}