{"id":"https://openalex.org/W4295863577","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p349","title":"Abstract P349: Decreased Complement Component C3 In Islets Is Associated With A Reduction In Pancreatic Beta Cell Area In Rat Offspring Following Chronic Placental Ischemia-induced Hypertension","display_name":"Abstract P349: Decreased Complement Component C3 In Islets Is Associated With A Reduction In Pancreatic Beta Cell Area In Rat Offspring Following Chronic Placental Ischemia-induced Hypertension","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4295863577","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p349"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.79.suppl_1.p349","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p349","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.79.suppl_1.p349","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091607844","display_name":"Jean F. Regal","orcid":"https://orcid.org/0000-0001-5713-0891","observed_orcids":["https://orcid.org/0000-0001-5713-0891"]},"institutions":[{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean F Regal","raw_affiliation_strings":["Univ of Minnesota, Duluth, MN","Jean F Regal Univ of Minnesota, Duluth, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]},{"raw_affiliation_string":"Jean F Regal Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048829770","display_name":"Melissa A. Cedars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A Cedars","raw_affiliation_strings":["Univ of Minnesota, Duluth, MN","Melissa A Cedars Univ of Minnesota, Duluth, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]},{"raw_affiliation_string":"Melissa A Cedars Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031343123","display_name":"Kate M. Root","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate M Root","raw_affiliation_strings":["Univ of Minnesota, Duluth, MN","Kate M Root Univ of Minnesota, Duluth, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]},{"raw_affiliation_string":"Kate M Root Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016906796","display_name":"Margaretta E. Huchthausen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaretta E Huchthausen","raw_affiliation_strings":["Univ of Minnesota, Duluth, MN","Margaretta E Huchthausen Univ of Minnesota, Duluth, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]},{"raw_affiliation_string":"Margaretta E Huchthausen Univ of Minnesota, Duluth, MN","institution_ids":["https://openalex.org/I4210115145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035078077","display_name":"Brian Akhaphong","orcid":"https://orcid.org/0000-0002-1268-6623","observed_orcids":["https://orcid.org/0000-0002-1268-6623"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Akhaphong","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Brian Akhaphong Univ of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Brian Akhaphong Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079563103","display_name":"Emilyn U. Alejandro","orcid":"https://orcid.org/0000-0002-7941-8439","observed_orcids":["https://orcid.org/0000-0002-7941-8439"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilyn U Alejandro","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","Emilyn U Alejandro Univ of Minnesota, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Emilyn U Alejandro Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8989999890327454},{"id":"https://openalex.org/keywords/beta-cell-mass","display_name":"beta-cell mass","score":0.8309999704360962},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.8069999814033508},{"id":"https://openalex.org/keywords/gestational-hypertension","display_name":"gestational hypertension","score":0.9610000252723694},{"id":"https://openalex.org/keywords/reduced-uterine-perfusion-pressure","display_name":"reduced uterine perfusion pressure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/type-2-diabetes-risk","display_name":"type 2 diabetes risk","score":0.8119999766349792},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.5600000023841858},{"id":"https://openalex.org/keywords/offspring","display_name":"offspring","score":0.37700000405311584},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.890446662902832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7949880361557007},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7811087369918823},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6448908448219299},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.5529029965400696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5232283473014832},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5229595303535461},{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.4818102717399597},{"id":"https://openalex.org/C2776886772","wikidata":"https://www.wikidata.org/wiki/Q2099138","display_name":"Placental insufficiency","level":5,"score":0.44937896728515625},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.42389976978302},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4010744094848633},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.39772000908851624},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2920230031013489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2894427180290222},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.2700106203556061},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.10757061839103699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.79.suppl_1.p349","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p349","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.79.suppl_1.p349","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3172663323","https://openalex.org/W3084417586","https://openalex.org/W3016795407","https://openalex.org/W4225401828","https://openalex.org/W4297855342","https://openalex.org/W2897469252","https://openalex.org/W4387529045","https://openalex.org/W4407132878","https://openalex.org/W2291671729","https://openalex.org/W2769685185"],"abstract_inverted_index":{"Gestational":[0],"hypertension":[1,55,155],"with":[2,10,105,223],"or":[3],"without":[4],"low":[5],"birth":[6],"weight":[7],"is":[8,23,103],"associated":[9,104],"increased":[11,68,197],"risk":[12],"for":[13,81,255],"Type":[14,36,72,256],"2":[15,37,73,257],"diabetes":[16],"in":[17,27,64,71,85,92,101,107,111,132,154,156,184,198,211,216,228,239],"offspring.":[18,207],"Pancreatic":[19,159],"beta":[20,59,90,108,249],"cell":[21,60,91,109,250],"mass":[22],"set":[24],"very":[25],"early":[26],"life":[28],"and":[29,142,161,168,177,188,252],"can":[30],"influence":[31],"whether":[32],"an":[33,78],"individual":[34],"develops":[35],"diabetes.":[38,258],"We":[39],"previously":[40],"demonstrated":[41],"that":[42,98,236],"postnatal":[43],"day":[44,147],"(PD)13":[45],"female":[46,173,201,205,218],"offspring":[47,113,174,219,243],"of":[48,88,149,175,182,200,241,248],"rats":[49],"subjected":[50],"to":[51,127,204,221,246],"chronic":[52],"placental":[53,115,130],"ischemia-induced":[54],"had":[56],"significantly":[57,196,214],"reduced":[58],"area.":[61],"Previous":[62],"studies":[63],"humans":[65],"have":[66],"noted":[67],"circulating":[69],"C3":[70,84,100,183,194,210,230,238],"diabetics,":[74],"as":[75,77],"well":[76],"important":[79],"role":[80],"intracellular":[82],"complement":[83],"maintaining":[86],"integrity":[87],"the":[89,93,133,157],"islet.":[94],"Thus,":[95,232],"we":[96],"hypothesized":[97],"decreased":[99,215,237],"islets":[102,160,187,212,240],"reductions":[106],"area":[110,251],"rat":[112,118],"following":[114],"insufficiency.":[116],"The":[117,180],"Reduced":[119],"Uterine":[120],"Perfusion":[121],"Pressure":[122],"(RUPP)":[123],"model":[124],"was":[125,190,195,213],"used":[126],"mechanically":[128],"induce":[129],"insufficiency":[131],"dam":[134],"by":[135,165,192],"placing":[136],"silver":[137],"clips":[138],"on":[139,145],"abdominal":[140],"aorta":[141],"uterine":[143],"arteries":[144],"gestation":[146],"14":[148],"a":[150],"21-day":[151],"gestation,":[152],"resulting":[153],"dam.":[158],"acinar":[162,189,229],"were":[163],"isolated":[164,186],"collagenase":[166],"perfusion":[167],"hand":[169],"picking":[170],"from":[171],"PD13":[172,242],"RUPP":[176,202,217],"Sham":[178,206,222],"dams.":[179],"concentration":[181],"serum,":[185],"determined":[191],"ELISA.":[193],"serum":[199],"compared":[203,220],"In":[208],"contrast,":[209],"no":[224],"significant":[225],"differences":[226],"detected":[227],"concentrations.":[231],"these":[233],"data":[234],"suggest":[235],"may":[244],"contribute":[245],"reduction":[247],"long-term":[253],"susceptibility":[254]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-09-15T00:00:00"}
