{"id":"https://openalex.org/W4295789362","doi":"https://doi.org/10.1109/jerm.2022.3201698","title":"Spectroscopic Analysis of Candida Species, Viability, and Antifungal Drug Effects With a Microwave Flow Cytometer","display_name":"Spectroscopic Analysis of Candida Species, Viability, and Antifungal Drug Effects With a Microwave Flow Cytometer","publication_year":2022,"publication_date":"2022-09-14","ids":{"openalex":"https://openalex.org/W4295789362","doi":"https://doi.org/10.1109/jerm.2022.3201698"},"language":"en","primary_location":{"id":"doi:10.1109/jerm.2022.3201698","doi":"https://doi.org/10.1109/jerm.2022.3201698","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jerm.2022.3201698","pdf_url":null,"source":{"id":"https://openalex.org/S4210194209","display_name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","issn_l":"2469-7249","issn":["2469-7249","2469-7257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058364203","display_name":"Neelima Dahal","orcid":"https://orcid.org/0000-0003-0457-838X","observed_orcids":["https://orcid.org/0000-0003-0457-838X"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelima Dahal","raw_affiliation_strings":["Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035976307","display_name":"Jeffrey A. Osterberg","orcid":"https://orcid.org/0000-0003-0753-2440","observed_orcids":["https://orcid.org/0000-0003-0753-2440"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Osterberg","raw_affiliation_strings":["Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA"],"raw_orcid":"https://orcid.org/0000-0003-0753-2440","affiliations":[{"raw_affiliation_string":"Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benjamin Braun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Braun","raw_affiliation_strings":["School of Computing, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003746084","display_name":"Tom P. Caldwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom P. Caldwell","raw_affiliation_strings":["Department of Bioengineering, Clemson University, Clemson, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023212952","display_name":"Ralu Divan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4390039281","display_name":"Center for Nanoscale Materials","ror":"https://ror.org/045ybte48","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166","https://openalex.org/I4390039281"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralu Divan","raw_affiliation_strings":["Argonne National Laboratory, Center for Nanoscale Materials, Lemont, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Argonne National Laboratory, Center for Nanoscale Materials, Lemont, IL, USA","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I4390039281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086122127","display_name":"Sarah W. Harcum","orcid":"https://orcid.org/0000-0001-9417-0489","observed_orcids":["https://orcid.org/0000-0001-9417-0489"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah W. Harcum","raw_affiliation_strings":["Department of Bioengineering, Clemson University, Clemson, SC, USA"],"raw_orcid":"https://orcid.org/0000-0001-9417-0489","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102832258","display_name":"Pingshan Wang","orcid":"https://orcid.org/0000-0002-8024-1968","observed_orcids":["https://orcid.org/0000-0002-8024-1968"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingshan Wang","raw_affiliation_strings":["Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA"],"raw_orcid":"https://orcid.org/0000-0002-8024-1968","affiliations":[{"raw_affiliation_string":"Holcomb Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2195,"currency":"USD","value_usd":2195},"apc_paid":null,"fwci":0.4793,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.53874305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"6","issue":"4","first_page":"566","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11607","display_name":"Microwave and Dielectric Measurement Techniques","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11607","display_name":"Microwave and Dielectric Measurement Techniques","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11739","display_name":"Microwave Imaging and Scattering Analysis","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":0.800000011920929},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dielectric-constant","display_name":"dielectric constant","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-budding","display_name":"cell budding","score":0.6420000195503235},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8769999742507935},{"id":"https://openalex.org/keywords/candida-tropicalis","display_name":"Candida tropicalis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/candida-parapsilosis","display_name":"Candida parapsilosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/candida-krusei","display_name":"Candida krusei","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caspofungin","display_name":"caspofungin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/antifungal-drug-effects","display_name":"antifungal drug effects","score":0.9440000057220459},{"id":"https://openalex.org/keywords/quadratic-discriminant-analysis","display_name":"quadratic discriminant analysis","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3548886179924011}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/jerm.2022.3201698","doi":"https://doi.org/10.1109/jerm.2022.3201698","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jerm.2022.3201698","pdf_url":null,"source":{"id":"https://openalex.org/S4210194209","display_name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","issn_l":"2469-7249","issn":["2469-7249","2469-7257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G426311843","display_name":null,"funder_award_id":"DE-AC- 02-06CH11357","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1979702861","https://openalex.org/W1986721709","https://openalex.org/W2025206693","https://openalex.org/W2072092987","https://openalex.org/W2091124606","https://openalex.org/W2102557311","https://openalex.org/W2137575148","https://openalex.org/W2162007379","https://openalex.org/W2171155970","https://openalex.org/W2336043212","https://openalex.org/W2474796730","https://openalex.org/W2561436932","https://openalex.org/W2586498421","https://openalex.org/W2805422624","https://openalex.org/W2855190756","https://openalex.org/W2976411969","https://openalex.org/W2980208012","https://openalex.org/W2980717509","https://openalex.org/W3013772284","https://openalex.org/W3047289244","https://openalex.org/W3048597167","https://openalex.org/W3096798672","https://openalex.org/W3120454834","https://openalex.org/W3145205473","https://openalex.org/W4211178015"],"related_works":["https://openalex.org/W7048630247","https://openalex.org/W4385337876","https://openalex.org/W7018170985","https://openalex.org/W3120454834","https://openalex.org/W1830791693","https://openalex.org/W4235921233","https://openalex.org/W2148007957","https://openalex.org/W2066871092","https://openalex.org/W4290703685","https://openalex.org/W2052641731"],"abstract_inverted_index":{"New":[0],"methods":[1],"to":[2,25,117,153,177],"rapidly":[3],"detect":[4],"and":[5,39,51,62,65,91,157,159],"identifyCandidacells":[6],"in":[7,136],"patients\u2019":[8],"blood":[9],"is":[10,115,170],"needed":[11,116],"for":[12,140,175],"proper":[13],"candidemia":[14,180],"treatment.":[15],"In":[16],"this":[17],"work,":[18],"a":[19,53,95,171],"tunable":[20],"microwave":[21,110,146,168],"interferometer":[22],"was":[23,125,150],"used":[24],"measure":[26],"singleCandidacells":[27],"ofC.":[28],"albicans,C.":[29],"tropicalis,C.":[30],"parapsilosis,":[31],"andC.":[32],"kruseiat":[33],"multiple":[34],"frequencies":[35],"between":[36],"0.265":[37],"GHz":[38,90,93],"7.76":[40,81],"GHz.":[41,82],"The":[42],"obtained":[43],"permittivity":[44,70],"values\u0394\u03f5'and\u0394\u03f5\u201dof":[45],"non-buddingCandidawere":[46],"colinear":[47],"with":[48,77,100,132],"cell":[49,60,106,120,145,155],"volumes":[50],"had":[52,68],"coefficient":[54],"that":[55,127],"depends":[56],"on":[57],"measurement":[58,169],"frequency,":[59],"species":[61,121],"viability.":[63],"Viable":[64],"non-viable":[66],"cells":[67,131],"significant":[69,109],"differences":[71],"at":[72,80,88],"lower":[73],"frequency":[74],"spectrum,":[75],"but":[76],"substantial":[78],"overlap":[79],"For":[83],"single":[84],"non-budding":[85],"cells,":[86],"measurements":[87],"1.32":[89],"1.85":[92],"enabled":[94],"minimum":[96],"0.875":[97],"classification":[98],"accuracy":[99],"quadratic":[101],"discriminate":[102],"analysis":[103],"(QDA).":[104],"However,":[105],"budding":[107],"induced":[108],"property":[111],"overlaps.":[112],"Further":[113],"work":[114],"achieve":[118],"better":[119],"discrimination.":[122],"Additionally,":[123],"it":[124],"determined":[126],"treating":[128],"these":[129],"yeast":[130],"Caspofungin":[133],"(CSP)":[134],"diacetate":[135],"dimethyl":[137],"sulfoxide":[138],"(DMSO)":[139],"10":[141],"minutes":[142],"significantly":[143],"altered":[144],"properties.":[147],"This":[148],"change":[149,163],"likely":[151],"due":[152],"damaged":[154],"wall":[156],"membranes,":[158],"the":[160],"level":[161],"of":[162],"wasCandidaspecies":[164],"dependent.":[165],"Therefore,":[166],"broadband":[167],"promising":[172],"new":[173],"approach":[174],"physicians":[176],"provide":[178],"personalized":[179],"therapy.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-09-15T00:00:00"}