{"id":"https://openalex.org/W4295756779","doi":"https://doi.org/10.1093/nar/gkac784","title":"Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides","display_name":"Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides","publication_year":2022,"publication_date":"2022-09-08","ids":{"openalex":"https://openalex.org/W4295756779","doi":"https://doi.org/10.1093/nar/gkac784","pmid":"https://pubmed.ncbi.nlm.nih.gov/36099434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9508827"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkac784","doi":"https://doi.org/10.1093/nar/gkac784","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac784","pdf_url":"https://academic.oup.com/nar/article-pdf/50/17/9647/45990384/gkac784.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/50/17/9647/45990384/gkac784.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079557791","display_name":"Marco Todisco","orcid":"https://orcid.org/0000-0001-6627-5283","observed_orcids":["https://orcid.org/0000-0001-6627-5283"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco Todisco","raw_affiliation_strings":["Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, MA 02115, USA","Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street, Boston, MA 02114, USA"],"raw_orcid":"https://orcid.org/0000-0001-6627-5283","affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023274897","display_name":"Jack W. Szostak","orcid":"https://orcid.org/0000-0003-4131-1203","observed_orcids":["https://orcid.org/0000-0003-4131-1203"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack W Szostak","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, MA 02138, USA","Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, MA 02115, USA","Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023274897"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4405271026"],"apc_list":{"value":3876,"currency":"USD","value_usd":3876},"apc_paid":{"value":3876,"currency":"USD","value_usd":3876},"fwci":1.5009,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82716822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"17","first_page":"9647","last_page":"9662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.12790000438690186,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetic-traps","display_name":"kinetic traps","score":0.7770000100135803},{"id":"https://openalex.org/keywords/association-and-dissociation-rates","display_name":"association and dissociation rates","score":0.8220000267028809},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.9279999732971191},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.8946137428283691},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.821629524230957},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7567330598831177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6826590299606323},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5804082155227661},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5281438827514648},{"id":"https://openalex.org/C54871578","wikidata":"https://www.wikidata.org/wiki/Q2074275","display_name":"Nucleic acid thermodynamics","level":4,"score":0.4687006175518036},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45427781343460083},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.4473001956939697},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.4407021999359131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25229430198669434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19155839085578918},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.11588284373283386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09928861260414124},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07368117570877075},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009843","descriptor_name":"Oligoribonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gkac784","doi":"https://doi.org/10.1093/nar/gkac784","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac784","pdf_url":"https://academic.oup.com/nar/article-pdf/50/17/9647/45990384/gkac784.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"doi:10.1101/2022.06.09.495531","doi":"https://doi.org/10.1101/2022.06.09.495531","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.09.495531","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/09/2022.06.09.495531.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9508827","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9508827","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:36099434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36099434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1138640","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1138640","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:share.osf.io:38f850e1-f24f-4eed-b8b5-52492613b1b8","doi":null,"is_oa":false,"landing_page_url":"https://osf.io/b6kfy","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},{"id":"pmh:oai:share.osf.io:E01F4-FAC-744","doi":null,"is_oa":false,"landing_page_url":"http://osf.io/b6kfy/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"project"}],"best_oa_location":{"id":"doi:10.1093/nar/gkac784","doi":"https://doi.org/10.1093/nar/gkac784","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac784","pdf_url":"https://academic.oup.com/nar/article-pdf/50/17/9647/45990384/gkac784.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2648730350","display_name":null,"funder_award_id":"290363","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"},{"id":"https://openalex.org/G3092413139","display_name":null,"funder_award_id":"CHE-2104708","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G33035646","display_name":null,"funder_award_id":"2104708","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G5063143151","display_name":"Nonenzymatic RNA Replication","funder_award_id":"2104708","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295756779.pdf","grobid_xml":"https://content.openalex.org/works/W4295756779.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1545593861","https://openalex.org/W1966139019","https://openalex.org/W1975335922","https://openalex.org/W1977312644","https://openalex.org/W1980301976","https://openalex.org/W1989020100","https://openalex.org/W1990376706","https://openalex.org/W1994217898","https://openalex.org/W1995812283","https://openalex.org/W1996114000","https://openalex.org/W2004361937","https://openalex.org/W2011428226","https://openalex.org/W2014793784","https://openalex.org/W2016638271","https://openalex.org/W2016982504","https://openalex.org/W2017635466","https://openalex.org/W2018604878","https://openalex.org/W2018778192","https://openalex.org/W2051713039","https://openalex.org/W2054575184","https://openalex.org/W2066649475","https://openalex.org/W2067008143","https://openalex.org/W2082280007","https://openalex.org/W2087657020","https://openalex.org/W2089886975","https://openalex.org/W2096883982","https://openalex.org/W2100397090","https://openalex.org/W2108700458","https://openalex.org/W2110298114","https://openalex.org/W2112333437","https://openalex.org/W2128014753","https://openalex.org/W2148304424","https://openalex.org/W2150963761","https://openalex.org/W2154115141","https://openalex.org/W2154475799","https://openalex.org/W2155418451","https://openalex.org/W2171439027","https://openalex.org/W2172262121","https://openalex.org/W2253375036","https://openalex.org/W2341889210","https://openalex.org/W2511821457","https://openalex.org/W2626587863","https://openalex.org/W2746110176","https://openalex.org/W2809746568","https://openalex.org/W2884550364","https://openalex.org/W2909043532","https://openalex.org/W2941270675","https://openalex.org/W2953129419","https://openalex.org/W2963138573","https://openalex.org/W2980997956","https://openalex.org/W2986739588","https://openalex.org/W3030803346","https://openalex.org/W3036183050","https://openalex.org/W3081179777","https://openalex.org/W3092111049","https://openalex.org/W3105782922","https://openalex.org/W3112657724","https://openalex.org/W3123235490","https://openalex.org/W3132613076","https://openalex.org/W3136673747","https://openalex.org/W3142229224","https://openalex.org/W3147730703","https://openalex.org/W3158678351","https://openalex.org/W3184980602","https://openalex.org/W3199126009","https://openalex.org/W3206192433","https://openalex.org/W3213075371","https://openalex.org/W4287958970","https://openalex.org/W4288010172","https://openalex.org/W4301441647"],"related_works":["https://openalex.org/W4409356828","https://openalex.org/W1562791397","https://openalex.org/W4384820713","https://openalex.org/W2150963761","https://openalex.org/W4310937913","https://openalex.org/W4391785877","https://openalex.org/W4402272852","https://openalex.org/W3213075371","https://openalex.org/W2163636059","https://openalex.org/W4399906708"],"abstract_inverted_index":{"Hybridization":[0],"and":[1,30,65,76,102,152],"strand":[2,77],"displacement":[3,78],"kinetics":[4,64],"determine":[5],"the":[6,9,26,35,45,73,111,119,128,144,162,174,184,190],"evolution":[7],"of":[8,13,15,28,48,61,94,100,104,127,134,160,167,177,187,192],"base":[10,32],"paired":[11],"configurations":[12],"mixtures":[14,133,180],"oligonucleotides":[16,83],"over":[17],"time.":[18],"Although":[19],"much":[20,38],"attention":[21],"has":[22,41],"been":[23,42],"focused":[24],"on":[25,44],"thermodynamics":[27],"DNA":[29],"RNA":[31,137,188],"pairing":[33],"in":[34,54,125,132],"scientific":[36],"literature,":[37],"less":[39],"work":[40],"done":[43],"time":[46,122],"dependence":[47],"interactions":[49],"involving":[50],"multiple":[51,135],"strands,":[52],"especially":[53],"RNA.":[55],"Here":[56],"we":[57],"provide":[58],"a":[59],"study":[60],"oligoribonucleotide":[62],"interaction":[63],"show":[66,109,140],"that":[67,85,110,141,156,173],"it":[68,147],"is":[69,148],"possible":[70,149],"to":[71,150],"calculate":[72],"association,":[74],"dissociation":[75],"rates":[79],"displayed":[80],"by":[81,142,158],"short":[82],"(5nt-12nt)":[84],"exhibit":[86],"no":[87],"expected":[88],"secondary":[89],"structure":[90],"as":[91],"simple":[92],"functions":[93],"oligonucleotide":[95,179],"length,":[96],"CG":[97],"content,":[98],"\u0394G":[99,103],"hybridization":[101,165],"toehold":[105],"binding.":[106],"We":[107,139,171],"then":[108],"resultant":[112],"calculated":[113],"kinetic":[114,154],"parameters":[115],"are":[116],"consistent":[117],"with":[118],"experimentally":[120],"observed":[121],"dependent":[123],"changes":[124],"concentrations":[126],"different":[129],"species":[130],"present":[131],"competing":[136],"strands.":[138],"changing":[143],"mixture":[145],"composition,":[146],"create":[151],"tune":[153],"traps":[155],"extend":[157],"orders":[159],"magnitude":[161],"typical":[163],"sub-second":[164],"timescale":[166],"two":[168],"complementary":[169],"oligonucleotides.":[170],"suggest":[172],"slow":[175],"equilibration":[176],"complex":[178],"may":[181],"have":[182],"facilitated":[183],"nonenzymatic":[185],"replication":[186],"during":[189],"origin":[191],"life.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-15T00:00:00"}