{"id":"https://openalex.org/W4295752271","doi":"https://doi.org/10.1542/hpeds.2021-006169","title":"Nephrotoxic Exposures and Acute Kidney Injury in Noncritically Ill Children Stratified by Service","display_name":"Nephrotoxic Exposures and Acute Kidney Injury in Noncritically Ill Children Stratified by Service","publication_year":2022,"publication_date":"2022-09-14","ids":{"openalex":"https://openalex.org/W4295752271","doi":"https://doi.org/10.1542/hpeds.2021-006169","pmid":"https://pubmed.ncbi.nlm.nih.gov/36102129"},"language":"en","primary_location":{"id":"doi:10.1542/hpeds.2021-006169","doi":"https://doi.org/10.1542/hpeds.2021-006169","is_oa":false,"landing_page_url":"https://doi.org/10.1542/hpeds.2021-006169","pdf_url":null,"source":{"id":"https://openalex.org/S2764949224","display_name":"Hospital Pediatrics","issn_l":"2154-1663","issn":["2154-1663","2154-1671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hospital Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051881825","display_name":"Page Holsteen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Page E. Holsteen","raw_affiliation_strings":["aDepartment of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052889588","display_name":"Katja M. Gist","orcid":"https://orcid.org/0000-0002-7427-670X","observed_orcids":["https://orcid.org/0000-0002-7427-670X"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katja M. Gist","raw_affiliation_strings":["bSection of Cardiology, Children\u2019s Hospital Colorado, Department of Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bSection of Cardiology, Children\u2019s Hospital Colorado, Department of Pediatrics","institution_ids":["https://openalex.org/I4210096275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027741427","display_name":"John T. Brinton","orcid":"https://orcid.org/0000-0003-3310-0422","observed_orcids":["https://orcid.org/0000-0003-3310-0422"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Brinton","raw_affiliation_strings":["cDepartment of Biostatistics and Informatics, Colorado School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cDepartment of Biostatistics and Informatics, Colorado School of Public Health","institution_ids":["https://openalex.org/I151808059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044733766","display_name":"Maxwell Hebert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maxwell Hebert","raw_affiliation_strings":["aDepartment of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016409191","display_name":"Melissa Iwanowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Iwanowski","raw_affiliation_strings":["dQuality and Patient Safety"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dQuality and Patient Safety","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abby Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abby Kim","raw_affiliation_strings":["aDepartment of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045308273","display_name":"Alexandra Leath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Leath","raw_affiliation_strings":["aDepartment of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Pharmacy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070889339","display_name":"Ananya Shah","orcid":"https://orcid.org/0000-0003-0400-7755","observed_orcids":["https://orcid.org/0000-0003-0400-7755"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananya Shah","raw_affiliation_strings":["eHeart Institute, Department of Pediatrics, Children\u2019s Hospital Colorado, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eHeart Institute, Department of Pediatrics, Children\u2019s Hospital Colorado, Aurora, Colorado","institution_ids":["https://openalex.org/I4210096275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066720542","display_name":"Danielle Elise Soranno","orcid":"https://orcid.org/0000-0001-7019-809X","observed_orcids":["https://orcid.org/0000-0001-7019-809X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle E. Soranno","raw_affiliation_strings":["fDepartment of Pediatrics, Section of Nephrology, University of Colorado, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"fDepartment of Pediatrics, Section of Nephrology, University of Colorado, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022302614","display_name":"Magda N. Marschner","orcid":"https://orcid.org/0000-0001-5320-9199","observed_orcids":["https://orcid.org/0000-0001-5320-9199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magda N. Marschner","raw_affiliation_strings":["aDepartment of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Pharmacy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.317,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55242397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"10","first_page":"866","last_page":"877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotoxic-drugs","display_name":"nephrotoxic drugs","score":0.8519999980926514},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6759999990463257},{"id":"https://openalex.org/keywords/vancomycin-nephrotoxicity","display_name":"vancomycin nephrotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9470000267028809},{"id":"https://openalex.org/keywords/intravenous-contrast","display_name":"intravenous contrast media","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963422417640686},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7464993596076965},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7240539789199829},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.6815199851989746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44291532039642334},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4319358468055725},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4252707362174988},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3909614682197571},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1530124843120575},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.06274119019508362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/hpeds.2021-006169","doi":"https://doi.org/10.1542/hpeds.2021-006169","is_oa":false,"landing_page_url":"https://doi.org/10.1542/hpeds.2021-006169","pdf_url":null,"source":{"id":"https://openalex.org/S2764949224","display_name":"Hospital Pediatrics","issn_l":"2154-1663","issn":["2154-1663","2154-1671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hospital Pediatrics","raw_type":"journal-article"},{"id":"pmid:36102129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36102129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hospital pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1998307146","https://openalex.org/W2003500862","https://openalex.org/W2023483267","https://openalex.org/W2072597369","https://openalex.org/W2108854242","https://openalex.org/W2112261155","https://openalex.org/W2122855609","https://openalex.org/W2146105386","https://openalex.org/W2152073293","https://openalex.org/W2160953859","https://openalex.org/W2163806204","https://openalex.org/W2172231857","https://openalex.org/W2405517316","https://openalex.org/W2550172802","https://openalex.org/W2752404888","https://openalex.org/W2790528524","https://openalex.org/W2885141063","https://openalex.org/W2907121739","https://openalex.org/W2943740139","https://openalex.org/W2986078123","https://openalex.org/W2990093987","https://openalex.org/W2998903403","https://openalex.org/W3029088600","https://openalex.org/W3119618830","https://openalex.org/W3124866124","https://openalex.org/W3173565930","https://openalex.org/W4299689471"],"related_works":["https://openalex.org/W4396991897","https://openalex.org/W2986078123","https://openalex.org/W4416108988","https://openalex.org/W4318069201","https://openalex.org/W7220060546","https://openalex.org/W4413439324","https://openalex.org/W4292121054","https://openalex.org/W4406845700","https://openalex.org/W4406845690","https://openalex.org/W4389730748"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,28,143,159,172],"Nephrotoxic":[2],"Injury":[3],"Negated":[4],"by":[5,52],"Just-in-Time":[6],"Action":[7],"(NINJA)":[8],"program":[9],"is":[10,66,236],"a":[11,67],"multicenter,":[12],"quality":[13],"improvement":[14],"initiative":[15],"that":[16],"identifies":[17],"patients":[18,136,177,239],"at":[19],"risk":[20],"for":[21,121],"nephrotoxic":[22],"medication-associated":[23],"acute":[24],"kidney":[25],"injury":[26],"(NTMx-AKI).":[27],"purpose":[29],"of":[30,41,49,72,97,104,126,141,199,206,245],"this":[31],"study":[32],"was":[33,151,187],"to":[34,78,112,181,191,230],"(1)":[35],"evaluate":[36],"the":[37,47],"prevalence":[38,48,145],"and":[39,44,62,107,137,156,168,197,215,225],"types":[40],"NTMx":[42,73,86,106,132,144,163,200,213],"exposures":[43,74,87,133,214],"(2)":[45],"determine":[46],"NTMx-AKI":[50,108,173,207,216,232],"categorized":[51],"service.":[53],"Exploratory":[54],"analysis":[55,119],"evaluated":[56],"potential":[57,122],"associations":[58,123],"between":[59],"hospital":[60],"measures":[61],"NTMx-AKI.":[63,127,142],"METHODS:":[64],"This":[65],"single-center,":[68],"retrospective":[69,117],"chart":[70],"review":[71],"from":[75,179],"January":[76],"2019":[77],"June":[79],"2020":[80],"in":[81,134,175,238],"noncritically":[82],"ill":[83],"children.":[84],"High":[85],"were":[88,110,130,164],"defined":[89],"as":[90],"\u22653":[91,95],"simultaneous":[92],"nephrotoxins":[93],"or":[94,101],"days":[96,150],"either":[98],"intravenous":[99,166],"vancomycin":[100],"aminoglycoside.":[102],"Prevalence":[103],"high":[105],"rate":[109,146,174],"normalized":[111],"1000":[113,148],"patient":[114,149],"days.":[115],"A":[116],"case-control":[118],"assessed":[120],"with":[124,204,210,222],"development":[125,205],"RESULTS:":[128],"There":[129],"609":[131],"565":[135],"44":[138],"(7.2%)":[139],"episodes":[140],"per":[147],"highest":[152],"among":[153],"liver,":[154],"neurosurgery,":[155],"gastroenterology":[157],"services.":[158,220],"most":[160,188],"commonly":[161],"used":[162],"vancomycin,":[165],"contrast,":[167],"nonsteroidal":[169],"antiinflammatory":[170],"drugs.":[171],"exposed":[176],"ranged":[178],"0%":[180],"14%":[182],"across":[183,219],"service":[184],"lines.":[185],"AKI":[186],"often":[189],"attributable":[190],"vancomycin.":[192],"Univariable":[193],"analyses":[194],"suggest":[195],"type":[196],"duration":[198],"exposure":[201],"are":[202,217,228],"associated":[203],"but":[208],"not":[209,242],"severity.":[211],"CONCLUSIONS:":[212],"variable":[218],"Partnerships":[221],"antimicrobial":[223],"stewardship":[224],"multicenter":[226],"studies":[227],"needed":[229,237],"modify":[231],"risk.":[233],"Ongoing":[234],"surveillance":[235],"who":[240],"do":[241],"have":[243],"normalization":[244],"creatinine":[246],"before":[247],"discharge.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-15T00:00:00"}
