{"id":"https://openalex.org/W4295709196","doi":"https://doi.org/10.1016/j.ibmed.2022.100075","title":"Towards automation of transcranial Doppler ultrasound data in pediatric cerebral malaria","display_name":"Towards automation of transcranial Doppler ultrasound data in pediatric cerebral malaria","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4295709196","doi":"https://doi.org/10.1016/j.ibmed.2022.100075"},"language":"en","primary_location":{"id":"doi:10.1016/j.ibmed.2022.100075","doi":"https://doi.org/10.1016/j.ibmed.2022.100075","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibmed.2022.100075","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266652122200028X/pdf","source":{"id":"https://openalex.org/S4210227372","display_name":"Intelligence-Based Medicine","issn_l":"2666-5212","issn":["2666-5212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligence-Based Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S266652122200028X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100335278","display_name":"Bo Zhang","orcid":"https://orcid.org/0000-0002-4381-1124","observed_orcids":["https://orcid.org/0000-0002-4381-1124"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bo Zhang","raw_affiliation_strings":["Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4381-1124","affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022482412","display_name":"Yuzhou Lin","orcid":"https://orcid.org/0000-0002-6456-7140","observed_orcids":["https://orcid.org/0000-0002-6456-7140"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuzhou Lin","raw_affiliation_strings":["Department of Statistics, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090252563","display_name":"Dylan S. Small","orcid":"https://orcid.org/0000-0003-4928-2646","observed_orcids":["https://orcid.org/0000-0003-4928-2646"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan S. Small","raw_affiliation_strings":["Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4928-2646","affiliations":[{"raw_affiliation_string":"Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033337244","display_name":"Terrie Ellen Taylor","orcid":"https://orcid.org/0000-0001-7416-3986","observed_orcids":["https://orcid.org/0000-0001-7416-3986"]},"institutions":[{"id":"https://openalex.org/I4403928428","display_name":"Kamuzu University of Health Sciences","ror":"https://ror.org/00khnq787","country_code":"MW","type":"education","lineage":["https://openalex.org/I4403928428"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["MW","US"],"is_corresponding":false,"raw_author_name":"Terrie E. Taylor","raw_affiliation_strings":["Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi","Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, MI, USA"],"raw_orcid":"https://orcid.org/0000-0001-7416-3986","affiliations":[{"raw_affiliation_string":"Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi","institution_ids":["https://openalex.org/I4403928428"]},{"raw_affiliation_string":"Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, MI, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046806990","display_name":"Nicole Fortier O'Brien","orcid":"https://orcid.org/0000-0002-8826-8671","observed_orcids":["https://orcid.org/0000-0002-8826-8671"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole F. O'Brien","raw_affiliation_strings":["Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100335278"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":0.2211,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52221328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"100075","last_page":"100075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.8799999952316284},{"id":"https://openalex.org/keywords/functional-principal-component-analysis","display_name":"functional principal component analysis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/functional-data-clustering","display_name":"functional data clustering","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.6230000257492065},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"middle cerebral artery","score":0.8769999742507935},{"id":"https://openalex.org/keywords/basilar-artery","display_name":"basilar artery","score":0.9929999709129333},{"id":"https://openalex.org/keywords/blood-flow-velocity","display_name":"blood flow velocity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.7737677097320557},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.49747827649116516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4890347421169281},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.44408443570137024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34340065717697144},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3396757245063782},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3382098972797394},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3381592929363251},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3203583061695099},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26310211420059204},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17167344689369202}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ibmed.2022.100075","doi":"https://doi.org/10.1016/j.ibmed.2022.100075","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibmed.2022.100075","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266652122200028X/pdf","source":{"id":"https://openalex.org/S4210227372","display_name":"Intelligence-Based Medicine","issn_l":"2666-5212","issn":["2666-5212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligence-Based Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ibmed.2022.100075","doi":"https://doi.org/10.1016/j.ibmed.2022.100075","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ibmed.2022.100075","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266652122200028X/pdf","source":{"id":"https://openalex.org/S4210227372","display_name":"Intelligence-Based Medicine","issn_l":"2666-5212","issn":["2666-5212"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligence-Based Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295709196.pdf","grobid_xml":"https://content.openalex.org/works/W4295709196.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1603304768","https://openalex.org/W1607071244","https://openalex.org/W2029473027","https://openalex.org/W2047741328","https://openalex.org/W2075500083","https://openalex.org/W2101228770","https://openalex.org/W2146855196","https://openalex.org/W2163498887","https://openalex.org/W2337858389","https://openalex.org/W2418259748","https://openalex.org/W2891629187","https://openalex.org/W2913263910","https://openalex.org/W3004624556","https://openalex.org/W3021971632","https://openalex.org/W3147894994","https://openalex.org/W4240093485"],"related_works":["https://openalex.org/W4283330960","https://openalex.org/W2891629187","https://openalex.org/W4401544218","https://openalex.org/W2011527386","https://openalex.org/W3004624556","https://openalex.org/W2348646318","https://openalex.org/W2470493286","https://openalex.org/W2075232542","https://openalex.org/W2464513898","https://openalex.org/W4417012825"],"abstract_inverted_index":{"To":[0],"work":[1],"towards":[2],"automating":[3],"Transcranial":[4],"Doppler":[5],"(TCD)":[6],"imaging":[7],"data":[8,27,62,118,156],"in":[9,120,191],"cerebral":[10,123],"malaria":[11],"(CM)":[12],"patients.":[13],"Functional":[14],"principal":[15],"component":[16],"analysis":[17,72],"(FPCA)":[18],"was":[19,38,55],"used":[20,39,77],"to":[21,40,58,78,197],"identify":[22],"important":[23],"features":[24],"of":[25,73,115,205],"TCD":[26,45,60,117,131,165,181],"and":[28,47,70,87,95,101,126,144,172,188],"quantify":[29],"its":[30],"variation":[31,119],"explained":[32,111],"by":[33],"each":[34],"feature.":[35],"Cox":[36],"regression":[37],"test":[41,69,79,147],"the":[42,80,83,107,121,127,136,163,199,203],"association":[43,81],"between":[44,82,169],"measurements":[46,132,178],"mortality":[48],"hazards":[49,138],"rate.":[50],"A":[51,154],"functional":[52,155],"clustering":[53,157],"algorithm":[54,158],"also":[56],"employed":[57],"cluster":[59],"waveform":[61],"into":[63],"distinct":[64],"phenotypic":[65,85,170],"groups.":[66],"Fisher's":[67],"exact":[68],"one-way":[71],"variance":[74],"(ANOVA)":[75],"were":[76,133,179],"TCD-defined":[84],"groups":[86,171],"14":[88],"variables":[89],"including":[90],"demographic":[91],"data,":[92],"laboratory":[93,177],"measurements,":[94],"clinical":[96,174],"features.":[97],"The":[98],"systolic,":[99],"diastolic,":[100],"mean":[102],"velocities":[103],"as":[104,106,185],"well":[105],"Windkessel":[108],"notch":[109],"together":[110],"more":[112],"than":[113],"98%":[114],"total":[116],"middle":[122],"arteries":[124],"(MCAs)":[125],"basilar":[128],"artery":[129],"(BA).":[130],"associated":[134],"with":[135],"survival":[137],"rates":[139],"after":[140],"adjusting":[141],"for":[142,162],"age":[143],"gender":[145],"(chi-squared":[146],"statistic":[148],"=":[149,152],"31.56,":[150],"p-value":[151],"0.025).":[153],"identified":[159],"7":[160],"clusters":[161],"MCA":[164],"data.":[166],"No":[167],"associations":[168],"demographics,":[173],"features,":[175],"or":[176],"detected.":[180],"may":[182],"be":[183],"useful":[184],"a":[186],"diagnostic":[187],"monitoring":[189],"tool":[190],"CM.":[192],"Developing":[193],"an":[194],"algorithm-driven":[195],"approach":[196],"interpreting":[198],"waveforms":[200],"will":[201],"enhance":[202],"scalability":[204],"this":[206],"tool.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-09-14T00:00:00"}
