{"id":"https://openalex.org/W4295539596","doi":"https://doi.org/10.3390/medicina58091249","title":"Early Transcriptional Changes of Adipose-Derived Stem Cells (ADSCs) in Cell Culture","display_name":"Early Transcriptional Changes of Adipose-Derived Stem Cells (ADSCs) in Cell Culture","publication_year":2022,"publication_date":"2022-09-09","ids":{"openalex":"https://openalex.org/W4295539596","doi":"https://doi.org/10.3390/medicina58091249","pmid":"https://pubmed.ncbi.nlm.nih.gov/36143926","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9501538"},"language":"en","primary_location":{"id":"doi:10.3390/medicina58091249","doi":"https://doi.org/10.3390/medicina58091249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58091249","pdf_url":"https://www.mdpi.com/1648-9144/58/9/1249/pdf?version=1663041351","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/58/9/1249/pdf?version=1663041351","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sara Taha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260186","display_name":"Institut f\u00fcr Muskuloskelettale Medizin","ror":"https://ror.org/03cmqx484","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara Taha","raw_affiliation_strings":["Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany; Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","institution_ids":["https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany; Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074009771","display_name":"Elif Akova","orcid":"https://orcid.org/0000-0002-2784-361X","observed_orcids":["https://orcid.org/0000-0002-2784-361X"]},"institutions":[{"id":"https://openalex.org/I4405260186","display_name":"Institut f\u00fcr Muskuloskelettale Medizin","ror":"https://ror.org/03cmqx484","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elif Akova","raw_affiliation_strings":["Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2784-361X","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","institution_ids":["https://openalex.org/I4405260186","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082776745","display_name":"Maximilian Michael Saller","orcid":"https://orcid.org/0000-0001-8774-7892","observed_orcids":["https://orcid.org/0000-0001-8774-7892"]},"institutions":[{"id":"https://openalex.org/I4405260186","display_name":"Institut f\u00fcr Muskuloskelettale Medizin","ror":"https://ror.org/03cmqx484","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Michael Saller","raw_affiliation_strings":["Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8774-7892","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","institution_ids":["https://openalex.org/I4405260186","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088090412","display_name":"Riccardo Enzo Giunta","orcid":"https://orcid.org/0009-0007-7421-1213","observed_orcids":["https://orcid.org/0009-0007-7421-1213"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Riccardo Enzo Giunta","raw_affiliation_strings":["Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084912819","display_name":"Elisabeth Maria Haas-L\u00fctzenberger","orcid":"https://orcid.org/0000-0003-0458-4122","observed_orcids":["https://orcid.org/0000-0003-0458-4122"]},"institutions":[{"id":"https://openalex.org/I4405260186","display_name":"Institut f\u00fcr Muskuloskelettale Medizin","ror":"https://ror.org/03cmqx484","country_code":"DE","type":"facility","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elisabeth Maria Haas-L\u00fctzenberger","raw_affiliation_strings":["Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany; Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany","institution_ids":["https://openalex.org/I4405260186","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Orthopaedic, Trauma and Rehabilitative Medicine, Musculoskeletal University Center Munich, Ludwig-Maximilians-University (LMU), Fraunhoferstra\u00dfe 20, 82152 Planegg-Martinsried, Germany; Division of Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians-University (LMU), Ziemssenstr. 5, 80336 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084912819"],"corresponding_institution_ids":["https://openalex.org/I4405260186","https://openalex.org/I8204097"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":2003,"currency":"EUR","value_usd":2160},"fwci":0.4848,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.50358953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"58","issue":"9","first_page":"1249","last_page":"1249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.6480000019073486},{"id":"https://openalex.org/keywords/in-vitro-cell-expansion","display_name":"in vitro cell expansion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/extracellular-matrix-genes","display_name":"extracellular matrix genes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fat-metabolism","display_name":"fat metabolism","score":0.4580000042915344},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/autologous-fat-grafting","display_name":"autologous fat grafting","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7475275993347168},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6397162675857544},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5678654909133911},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5615663528442383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5303654670715332},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4868397116661072},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4837512969970703},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47086015343666077},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45640313625335693},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43787842988967896},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.4190579056739807},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33241158723831177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12044787406921387},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09518605470657349}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/medicina58091249","doi":"https://doi.org/10.3390/medicina58091249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58091249","pdf_url":"https://www.mdpi.com/1648-9144/58/9/1249/pdf?version=1663041351","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9501538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9501538","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmid:36143926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36143926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1d7b920c18084773b60f19399d5f5de7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d7b920c18084773b60f19399d5f5de7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 58, Iss 9, p 1249 (2022)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:106701","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-106701-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina-Lithuania","raw_type":"doc-type:article"}],"best_oa_location":{"id":"doi:10.3390/medicina58091249","doi":"https://doi.org/10.3390/medicina58091249","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina58091249","pdf_url":"https://www.mdpi.com/1648-9144/58/9/1249/pdf?version=1663041351","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295539596.pdf","grobid_xml":"https://content.openalex.org/works/W4295539596.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1891660453","https://openalex.org/W1970333051","https://openalex.org/W1972567139","https://openalex.org/W1972845238","https://openalex.org/W1974163213","https://openalex.org/W1974601142","https://openalex.org/W1981045629","https://openalex.org/W1988237668","https://openalex.org/W1989468162","https://openalex.org/W1991761391","https://openalex.org/W2017381726","https://openalex.org/W2033043906","https://openalex.org/W2035618305","https://openalex.org/W2041896633","https://openalex.org/W2042392244","https://openalex.org/W2052774003","https://openalex.org/W2064291716","https://openalex.org/W2067738652","https://openalex.org/W2100221605","https://openalex.org/W2106193879","https://openalex.org/W2107726648","https://openalex.org/W2110218691","https://openalex.org/W2132913909","https://openalex.org/W2136514583","https://openalex.org/W2144623968","https://openalex.org/W2154399948","https://openalex.org/W2169456326","https://openalex.org/W2263106295","https://openalex.org/W2283399982","https://openalex.org/W2315635028","https://openalex.org/W2323630222","https://openalex.org/W2345867153","https://openalex.org/W2505322038","https://openalex.org/W2604831436","https://openalex.org/W2727313449","https://openalex.org/W2801243089","https://openalex.org/W2887309038","https://openalex.org/W2945115272","https://openalex.org/W2953650947","https://openalex.org/W2964844776","https://openalex.org/W2967125449","https://openalex.org/W2985519430","https://openalex.org/W3015101896"],"related_works":["https://openalex.org/W1960932709","https://openalex.org/W2608281596","https://openalex.org/W2345351601","https://openalex.org/W1797433741","https://openalex.org/W3173777877","https://openalex.org/W2169792947","https://openalex.org/W2883632408","https://openalex.org/W2059623065","https://openalex.org/W2336131014","https://openalex.org/W2047875371"],"abstract_inverted_index":{"Background":[0],"and":[1,22,40,112,146,178,191,214],"Objectives:":[2],"While":[3],"autologous":[4],"fat":[5],"grafting":[6],"has":[7],"been":[8],"carried":[9],"out":[10],"in":[11,31,43,48,64,71,98,123,158,234,247],"the":[12,18,49,56,75,84,99,127,130,142,168,182,235],"clinical":[13],"field":[14,50],"for":[15,108,122],"many":[16,32,44,72],"years,":[17],"utilization":[19,57],"of":[20,51,58,78,86,91,103,129,209,218,239],"isolated":[21,148],"cultured":[23,145,240],"adipose-derived":[24],"stem":[25],"cells":[26],"(ADSCs)":[27],"is":[28],"highly":[29],"restricted":[30],"countries.":[33],"However,":[34],"ADSCs":[35,79,104,115,159],"are":[36,187],"under":[37],"investigation":[38],"currently":[39],"heavily":[41],"researched":[42],"cell-based":[45,60],"therapy":[46],"approaches":[47],"regenerative":[52],"medicine.":[53],"Objective:":[54],"For":[55,126],"future":[59,248],"therapies":[61],"with":[62],"ADSCs,":[63],"vitro":[65,124],"cell":[66,106,163,203],"expansion":[67,107],"might":[68],"be":[69,81,245],"necessary":[70],"cases.":[73],"Thus,":[74],"cellular":[76],"characteristics":[77],"may":[80],"altered":[82],"though":[83],"process":[85],"being":[87],"cultured.":[88],"The":[89],"aim":[90],"this":[92],"study":[93,152,226],"was":[94,138],"to":[95,140,207,215],"assess":[96],"changes":[97,157,233],"gene":[100,131,236],"expression":[101,132,237],"profile":[102,238],"after":[105,160],"48":[109],"h.":[110],"Materials":[111],"Methods:":[113],"Isolated":[114],"from":[116],"five":[117],"different":[118,196],"donors":[119],"were":[120],"used":[121],"expansion.":[125],"evaluation":[128],"profile,":[133],"mRNA":[134],"deep":[135],"Next-Generation":[136],"Sequencing":[137],"performed":[139],"evaluate":[141],"differences":[143],"between":[144],"freshly":[147],"cells.":[149],"Results:":[150],"Our":[151,242],"gives":[153],"insight":[154,230],"into":[155,231],"transcriptional":[156],"a":[161,228],"short":[162],"cultivation":[164],"period.":[165],"This":[166],"includes":[167],"most":[169,183],"prominent":[170],"upregulated":[171],"genes":[172],"such":[173],"as":[174,180],"PPL,":[175],"PRR15,":[176],"CCL11":[177],"ABCA9,":[179],"well":[181],"downregulated":[184],"genes,":[185],"which":[186,205],"FOSB,":[188],"FOS,":[189],"EGR1":[190],"DUSP6.":[192],"Furthermore,":[193],"we":[194],"showed":[195],"biological":[197],"processes":[198,213],"that":[199],"changed":[200],"during":[201],"short-term":[202],"expansion,":[204],"led":[206],"downregulation":[208],"fat-associated":[210],"metabolism":[211],"hormone":[212],"an":[216],"upregulation":[217],"extracellular":[219],"matrix-associated":[220],"genes.":[221],"Conclusion:":[222],"In":[223],"conclusion,":[224],"our":[225],"reveals":[227],"detailed":[229],"early":[232],"ADSCs.":[241],"results":[243],"can":[244],"utilized":[246],"experiments.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-09-14T00:00:00"}