{"id":"https://openalex.org/W4295458261","doi":"https://doi.org/10.2147/copd.s365771","title":"New Perspectives on Chronic Obstructive Pulmonary Disease","display_name":"New Perspectives on Chronic Obstructive Pulmonary Disease","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4295458261","doi":"https://doi.org/10.2147/copd.s365771","pmid":"https://pubmed.ncbi.nlm.nih.gov/36097591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9464005"},"language":"en","primary_location":{"id":"doi:10.2147/copd.s365771","doi":"https://doi.org/10.2147/copd.s365771","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s365771","pdf_url":"https://www.dovepress.com/getfile.php?fileID=83656","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=83656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008555938","display_name":"Bartolom\u00e9 R. Celli","orcid":"https://orcid.org/0000-0002-7266-8371","observed_orcids":["https://orcid.org/0000-0002-7266-8371"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bartolome R Celli","raw_affiliation_strings":["School of Medicine, Harvard University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068917661","display_name":"Dave Singh","orcid":"https://orcid.org/0000-0001-8918-7075","observed_orcids":["https://orcid.org/0000-0001-8918-7075"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dave Singh","raw_affiliation_strings":["Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester University NHS Hospital Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester University NHS Hospital Trust, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059684830","display_name":"Claus Franz Vogelmeier","orcid":"https://orcid.org/0000-0002-9798-2527","observed_orcids":["https://orcid.org/0000-0002-9798-2527"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Vogelmeier","raw_affiliation_strings":["Department of Medicine, Pulmonary and Critical Care Medicine, German Center for Lung Research (DZL), University of Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Pulmonary and Critical Care Medicine, German Center for Lung Research (DZL), University of Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054165025","display_name":"Alvar G.N. Agust\u00ed","orcid":"https://orcid.org/0000-0003-3271-3788","observed_orcids":["https://orcid.org/0000-0003-3271-3788"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alvar Agusti","raw_affiliation_strings":["Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008555938"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.9015,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.92573196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"Volume 17","issue":null,"first_page":"2127","last_page":"2136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-acting-bronchodilators","display_name":"long-acting bronchodilators","score":0.9350000023841858},{"id":"https://openalex.org/keywords/inhaler-selection","display_name":"inhaler selection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.7080000042915344},{"id":"https://openalex.org/keywords/eosinophil-count","display_name":"eosinophil count","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9829999804496765},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7409999966621399},{"id":"https://openalex.org/keywords/early-life-events","display_name":"early life events","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.916241466999054},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8504009246826172},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7206667065620422},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4885050058364868},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.42031747102737427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3758062422275543}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/copd.s365771","doi":"https://doi.org/10.2147/copd.s365771","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s365771","pdf_url":"https://www.dovepress.com/getfile.php?fileID=83656","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9464005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9464005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Chron Obstruct Pulmon Dis","raw_type":"Text"},{"id":"pmid:36097591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36097591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of chronic obstructive pulmonary disease","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/198610","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/198610","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biom\u00e8diques August Pi i Sunyer)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:39051d5a4d164918a0f79906cc70a298","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/39051d5a4d164918a0f79906cc70a298","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of COPD, Vol Volume 17, Pp 2127-2136 (2022)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/77991","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/new-perspectives-on-chronic-obstructive-pulmonary-disease-peer-reviewed-fulltext-article-COPD","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/copd.s365771","doi":"https://doi.org/10.2147/copd.s365771","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s365771","pdf_url":"https://www.dovepress.com/getfile.php?fileID=83656","source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320328419","display_name":"Menarini Group","ror":"https://ror.org/02h1wg091"},{"id":"https://openalex.org/F4320333687","display_name":"Manchester Biomedical Research Centre","ror":"https://ror.org/05njkjr15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295458261.pdf","grobid_xml":"https://content.openalex.org/works/W4295458261.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W770714277","https://openalex.org/W1920721512","https://openalex.org/W1951292309","https://openalex.org/W1982193727","https://openalex.org/W1999226863","https://openalex.org/W2045749557","https://openalex.org/W2106065407","https://openalex.org/W2107134975","https://openalex.org/W2113430717","https://openalex.org/W2117356108","https://openalex.org/W2127951128","https://openalex.org/W2133119676","https://openalex.org/W2138808616","https://openalex.org/W2141034778","https://openalex.org/W2156248782","https://openalex.org/W2162340140","https://openalex.org/W2166733695","https://openalex.org/W2167574236","https://openalex.org/W2234612484","https://openalex.org/W2258058790","https://openalex.org/W2263808047","https://openalex.org/W2268275976","https://openalex.org/W2322866941","https://openalex.org/W2365138737","https://openalex.org/W2468772595","https://openalex.org/W2545337398","https://openalex.org/W2580357067","https://openalex.org/W2604938386","https://openalex.org/W2607275024","https://openalex.org/W2613360457","https://openalex.org/W2766749708","https://openalex.org/W2768767566","https://openalex.org/W2769297698","https://openalex.org/W2783705291","https://openalex.org/W2785999277","https://openalex.org/W2788818112","https://openalex.org/W2794699839","https://openalex.org/W2800157982","https://openalex.org/W2802070697","https://openalex.org/W2802221596","https://openalex.org/W2885480715","https://openalex.org/W2891935263","https://openalex.org/W2912538051","https://openalex.org/W2920859047","https://openalex.org/W2922821217","https://openalex.org/W2923446750","https://openalex.org/W2942978027","https://openalex.org/W2944206817","https://openalex.org/W2976155501","https://openalex.org/W3037411127","https://openalex.org/W3088908519","https://openalex.org/W3102911407","https://openalex.org/W4211263216","https://openalex.org/W4236132672","https://openalex.org/W4320288047"],"related_works":["https://openalex.org/W3005838952","https://openalex.org/W3145086927","https://openalex.org/W2087918712","https://openalex.org/W4362666209","https://openalex.org/W3209565453","https://openalex.org/W7214064158","https://openalex.org/W2783084801","https://openalex.org/W2920797638","https://openalex.org/W2130731650","https://openalex.org/W7140273626"],"abstract_inverted_index":{"Chronic":[0],"obstructive":[1],"pulmonary":[2],"disease":[3,115,286],"(COPD)":[4],"is":[5,31,85,95,102,112,139],"a":[6,103,107,113,121,152,156,171,197,251],"major":[7],"cause":[8],"of":[9,23,28,37,43,46,60,65,76,82,92,124,136,144,158,165,173,209,240,246,262,269,275,279,284],"morbidity":[10,130],"and":[11,34,120,131,259,281],"mortality":[12],"worldwide;":[13],"many":[14,21],"recent":[15,230],"advances":[16,39,205],"have":[17,50,232,264],"been":[18,193],"made":[19],"in":[20,40,181,201],"aspects":[22],"the":[24,41,58,63,88,137,149,163,166,207,213,218,222,226,244,273,277,282],"disease.":[25],"The":[26,79],"aim":[27],"this":[29,161,249],"article":[30],"to":[32,73,98,105,177,195,254],"illustrate":[33],"discuss":[35],"some":[36],"these":[38],"management":[42,108],"different":[44],"types":[45],"patients.":[47,93,159],"Large-scale":[48],"trials":[49],"confirmed":[51],"that":[52,100,127,215,234],"long-acting":[53],"bronchodilator":[54,186],"therapy,":[55,187],"particularly":[56],"using":[57],"combination":[59],"LABA/LAMA,":[61],"remains":[62],"mainstay":[64],"COPD":[66,111],"treatment,":[67],"with":[68,116,212,272],"special":[69],"attention":[70],"being":[71],"paid":[72],"careful":[74],"selection":[75],"inhaler":[77],"devices.":[78],"initial":[80],"choice":[81],"pharmacological":[83],"therapy":[84,280],"based":[86],"on":[87],"GOLD":[89],"ABCD":[90],"grouping":[91],"It":[94],"very":[96],"important":[97,267],"stress":[99],"there":[101],"need":[104],"implement":[106],"cycle":[109],"because":[110],"chronic":[114],"varying":[117],"clinical":[118],"course":[119],"high":[122],"number":[123],"potential":[125],"comorbidities":[126],"may":[128,238],"affect":[129],"mortality.":[132],"Therefore,":[133],"regular":[134],"reevaluation":[135],"patient":[138,154],"mandatory.":[140],"This":[141],"allows":[142],"identification":[143,261],"characteristics":[145],"aimed":[146],"at":[147,221,257],"maximizing":[148,276],"benefits":[150],"for":[151,225,243],"specific":[153],"or":[155],"subset":[157],"Within":[160],"context,":[162],"role":[164],"blood":[167],"eosinophil":[168],"count":[169],"as":[170,250],"marker":[172],"inhaled":[174],"corticosteroids":[175],"response":[176],"prevent":[178],"future":[179],"exacerbations":[180],"patients":[182,216],"who,":[183],"despite":[184],"appropriate":[185],"still":[188],"suffer":[189],"from":[190],"them":[191],"has":[192],"proven":[194],"be":[196,239],"useful":[198],"simple":[199],"biomarker":[200],"medication":[202],"selection.":[203],"These":[204],"support":[206],"concept":[208],"precision":[210],"medicine,":[211],"goal":[214],"get":[217],"right":[219,223,227],"medicine":[220],"time":[224],"reason.":[228],"Finally,":[229],"studies":[231],"shown":[233],"early":[235,260],"life":[236],"events":[237],"critical":[241],"relevance":[242],"development":[245],"COPD.":[247],"With":[248],"background,":[252],"concepts":[253],"identify":[255],"individuals":[256],"risk":[258],"cases":[263],"become":[265],"an":[266],"objective":[268],"current":[270],"research":[271],"hope":[274],"effects":[278],"possibility":[283],"impacting":[285],"progression.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-14T00:00:00"}