{"id":"https://openalex.org/W4295431304","doi":"https://doi.org/10.1136/jitc-2022-004554","title":"Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity","display_name":"Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4295431304","doi":"https://doi.org/10.1136/jitc-2022-004554","pmid":"https://pubmed.ncbi.nlm.nih.gov/36096528","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9472124"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2022-004554","doi":"https://doi.org/10.1136/jitc-2022-004554","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004554","pdf_url":"https://jitc.bmj.com/content/jitc/10/9/e004554.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/10/9/e004554.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033271076","display_name":"Odd Lilleng Gammelgaard","orcid":"https://orcid.org/0000-0002-5911-7276","observed_orcids":["https://orcid.org/0000-0002-5911-7276"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Odd L Gammelgaard","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5911-7276","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000608582","display_name":"Mikkel G. Terp","orcid":"https://orcid.org/0000-0002-4468-6900","observed_orcids":["https://orcid.org/0000-0002-4468-6900"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mikkel G Terp","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-4468-6900","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060140852","display_name":"Christian Renn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Renn","raw_affiliation_strings":["PharmaCenter Bonn, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaCenter Bonn, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023653622","display_name":"Aran F. Labrijn","orcid":"https://orcid.org/0000-0001-9239-8439","observed_orcids":["https://orcid.org/0000-0001-9239-8439"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aran F Labrijn","raw_affiliation_strings":["Genmab BV, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9239-8439","affiliations":[{"raw_affiliation_string":"Genmab BV, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068328281","display_name":"Oliver Hamaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Oliver Hamaker","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012636720","display_name":"Aaraby Nielsen","orcid":"https://orcid.org/0000-0003-2199-2857","observed_orcids":["https://orcid.org/0000-0003-2199-2857"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Aaraby Y Nielsen","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2199-2857","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081556791","display_name":"Henriette Vever","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henriette Vever","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074321510","display_name":"S\u00f8ren Hansen","orcid":"https://orcid.org/0000-0002-8186-4630","observed_orcids":["https://orcid.org/0000-0002-8186-4630"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Soren WK Hansen","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8186-4630","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078320465","display_name":"Morten F. Gjerstorff","orcid":"https://orcid.org/0000-0002-0845-1952","observed_orcids":["https://orcid.org/0000-0002-0845-1952"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten F Gjerstorff","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","Department of Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-0845-1952","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635825","display_name":"Christa Elisabeth M\u00fcller","orcid":"https://orcid.org/0000-0002-0013-6624","observed_orcids":["https://orcid.org/0000-0002-0013-6624"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christa E M\u00fcller","raw_affiliation_strings":["PharmaCenter Bonn, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0013-6624","affiliations":[{"raw_affiliation_string":"PharmaCenter Bonn, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039190287","display_name":"Paul W.H.I. Parren","orcid":"https://orcid.org/0000-0002-4365-3859","observed_orcids":["https://orcid.org/0000-0002-4365-3859"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["DK","NL"],"is_corresponding":false,"raw_author_name":"Paul WHI Parren","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4365-3859","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011720560","display_name":"Henrik J. Ditzel","orcid":"https://orcid.org/0000-0003-3927-5135","observed_orcids":["https://orcid.org/0000-0003-3927-5135"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Henrik J Ditzel","raw_affiliation_strings":["Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","Department of Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3927-5135","affiliations":[{"raw_affiliation_string":"Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011720560"],"corresponding_institution_ids":["https://openalex.org/I177969490","https://openalex.org/I2801498763"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.1526,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.88859969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":"9","first_page":"e004554","last_page":"e004554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/biparatopic-antibody","display_name":"biparatopic antibody","score":0.9430000185966492},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.6639999747276306},{"id":"https://openalex.org/keywords/extracellular-adenosine","display_name":"extracellular adenosine","score":0.7139999866485596},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/antibody-internalization","display_name":"antibody internalization","score":0.7710000276565552},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6110000014305115},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.765999972820282},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/fab-arm-exchange","display_name":"Fab-arm exchange","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6683266162872314},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.597728967666626},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.551765501499176},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5403997302055359},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5084563493728638},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4854153096675873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44374755024909973},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.437669038772583},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.4273512065410614},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3862067461013794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3676123023033142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28986579179763794},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2664145231246948},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24408507347106934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22538447380065918},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1136/jitc-2022-004554","doi":"https://doi.org/10.1136/jitc-2022-004554","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004554","pdf_url":"https://jitc.bmj.com/content/jitc/10/9/e004554.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9472124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9472124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmid:36096528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36096528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire/2a8a8e06-1f9a-48b7-8337-799de89dd021","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/2a8a8e06-1f9a-48b7-8337-799de89dd021","pdf_url":"https://findresearcher.sdu.dk/ws/files/209391088/e004554.full.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gammelgaard, O L, Terp, M G, Renn, C, Labrijn, A F, Hamaker, O, Nielsen, A Y, Vever, H, Hansen, S W, Gjerstorff, M F, M\u00fcller, C E, Parren, P W & Ditzel, H J 2022, 'Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity', Journal for ImmunoTherapy of Cancer, vol. 10, no. 9, e004554. https://doi.org/10.1136/jitc-2022-004554","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940745105602711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3570584","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/3570584/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, No. 9","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3570584","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1887/3570584","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, 10(9). BMJ PUBLISHING GROUP","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:545f0eb7e81a46de9104ffcb29d1c784","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/545f0eb7e81a46de9104ffcb29d1c784","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)","raw_type":"article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3570584","doi":null,"is_oa":true,"landing_page_url":"https://jitc.bmj.com/content/10/9/e004554","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/2a8a8e06-1f9a-48b7-8337-799de89dd021","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/2a8a8e06-1f9a-48b7-8337-799de89dd021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gammelgaard, O L, Terp, M G, Renn, C, Labrijn, A F, Hamaker, O, Nielsen, A Y, Vever, H, Hansen, S W, Gjerstorff, M F, M\u00fcller, C E, Parren, P W & Ditzel, H J 2022, 'Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity', Journal for ImmunoTherapy of Cancer, vol. 10, no. 9, e004554. https://doi.org/10.1136/jitc-2022-004554","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2022-004554","doi":"https://doi.org/10.1136/jitc-2022-004554","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2022-004554","pdf_url":"https://jitc.bmj.com/content/jitc/10/9/e004554.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1245107021","display_name":null,"funder_award_id":"SFB1328","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310455","display_name":"Kr\u00e6ftens Bek\u00e6mpelse","ror":"https://ror.org/03ytt7k16"},{"id":"https://openalex.org/F4320311316","display_name":"Agnes og Poul Friis Fond","ror":"https://ror.org/00jtd8b17"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"},{"id":"https://openalex.org/F4320326371","display_name":"Grosserer M. Brogaard og Hustrus Mindefond","ror":"https://ror.org/026r5vg79"},{"id":"https://openalex.org/F4320335119","display_name":"Fonden til L\u00e6gevidenskabens Fremme","ror":"https://ror.org/02kdrgt12"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295431304.pdf","grobid_xml":"https://content.openalex.org/works/W4295431304.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1562093278","https://openalex.org/W1792542720","https://openalex.org/W1842798465","https://openalex.org/W1895156328","https://openalex.org/W1919706800","https://openalex.org/W1928191259","https://openalex.org/W1935723672","https://openalex.org/W1976402545","https://openalex.org/W1980839596","https://openalex.org/W1983104536","https://openalex.org/W1987534017","https://openalex.org/W1992815045","https://openalex.org/W1992873722","https://openalex.org/W2003598902","https://openalex.org/W2029887979","https://openalex.org/W2049601932","https://openalex.org/W2053908301","https://openalex.org/W2062761137","https://openalex.org/W2077703512","https://openalex.org/W2081410060","https://openalex.org/W2082361648","https://openalex.org/W2094990615","https://openalex.org/W2102478114","https://openalex.org/W2106572080","https://openalex.org/W2108616222","https://openalex.org/W2113661022","https://openalex.org/W2117100825","https://openalex.org/W2139233049","https://openalex.org/W2151070736","https://openalex.org/W2161546085","https://openalex.org/W2168356942","https://openalex.org/W2168786562","https://openalex.org/W2266408649","https://openalex.org/W2270180142","https://openalex.org/W2493113067","https://openalex.org/W2519184848","https://openalex.org/W2584913109","https://openalex.org/W2605136479","https://openalex.org/W2617135370","https://openalex.org/W2743088462","https://openalex.org/W2765132620","https://openalex.org/W2945715301","https://openalex.org/W3006617390","https://openalex.org/W3033331291","https://openalex.org/W3097568196"],"related_works":["https://openalex.org/W2493113067","https://openalex.org/W4386936475","https://openalex.org/W7164138656","https://openalex.org/W3097568196","https://openalex.org/W4405894655","https://openalex.org/W3083370002","https://openalex.org/W3079107188","https://openalex.org/W4282962871","https://openalex.org/W4282932361","https://openalex.org/W7128709898"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunosuppressive":[1],"extracellular":[2],"adenosine":[3],"is":[4],"generated":[5,50],"by":[6,114],"the":[7,91,95,101,128,187,192],"enzymatic":[8,32],"activity":[9,24,66,98,184],"of":[10,31,35,41,108,124,134,143,162,164,180,200],"CD73.":[11,42],"In":[12],"preclinical":[13],"models,":[14],"antibodies":[15,53],"(Abs)":[16],"targeting":[17,199],"different":[18,80],"epitopes":[19],"on":[20],"CD73":[21,137,201],"exert":[22],"anticancer":[23,61,65,81,160],"through":[25],"distinct":[26,60,165],"mechanisms":[27,161,179],"such":[28],"as":[29,112],"inhibition":[30],"activity,":[33],"engagement":[34,142],"Fc":[36],"receptors,":[37],"and":[38,72,116,121,138,150,171,182],"spatial":[39],"redistribution":[40],"METHODS:":[43],"Using":[44],"controlled":[45],"Fab":[46],"arm":[47],"exchange,":[48],"we":[49],"biparatopic":[51,88,175],"bispecific":[52],"(bsAbs)":[54],"from":[55],"parental":[56,102,189],"anti-CD73":[57,166],"Abs":[58,167,190],"with":[59,100,186],"activities.":[62],"The":[63,177],"resulting":[64],"was":[67],"evaluated":[68],"using":[69],"in":[70,73,86,148,151,173,202],"vitro":[71,149],"vivo":[74],"models.":[75],"RESULTS:":[76],"We":[77],"demonstrate":[78,157],"that":[79,158],"activities":[82],"can":[83,168],"be":[84,169],"combined":[85,170],"a":[87,174,194],"bsAb.":[89,176],"Remarkably,":[90],"bsAb":[92,129,193],"significantly":[93],"improved":[94],"enzyme":[96],"inhibitory":[97],"compared":[99,185],"Abs,":[103],"which":[104],"led":[105],"to":[106],"neutralization":[107],"adenosine-mediated":[109],"T-cell":[110],"suppression":[111],"demonstrated":[113],"proliferation":[115],"interferon":[117],"gamma":[118],"(IFN-\u03b3)":[119],"production":[120],"prolonged":[122],"survival":[123],"tumor-bearing":[125],"mice.":[126],"Additionally,":[127],"caused":[130],"more":[131],"efficient":[132],"internalization":[133],"cell":[135],"surface":[136],"stimulated":[139],"potent":[140],"Fc-mediated":[141],"human":[144],"immune":[145],"effector":[146],"cells":[147],"vivo.":[152],"CONCLUSIONS:":[153],"Our":[154],"data":[155],"collectively":[156],"complementary":[159],"action":[163,181],"enhanced":[172],"multiple":[178],"superior":[183],"monospecific":[188],"make":[191],"promising":[195],"candidate":[196],"for":[197],"therapeutic":[198],"cancer.":[203],"This":[204],"concept":[205],"may":[206],"greatly":[207],"improve":[208],"future":[209],"Ab":[210],"design.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":13}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-09-14T00:00:00"}
