{"id":"https://openalex.org/W4295413486","doi":"https://doi.org/10.3389/fonc.2022.990672","title":"Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis","display_name":"Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis","publication_year":2022,"publication_date":"2022-09-13","ids":{"openalex":"https://openalex.org/W4295413486","doi":"https://doi.org/10.3389/fonc.2022.990672","pmid":"https://pubmed.ncbi.nlm.nih.gov/36176395","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9513553"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2022.990672","doi":"https://doi.org/10.3389/fonc.2022.990672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.990672","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.990672/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.990672/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017994375","display_name":"Maria T. Bengoechea-Alonso","orcid":"https://orcid.org/0009-0006-4210-6999","observed_orcids":["https://orcid.org/0009-0006-4210-6999"]},"institutions":[{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Maria T. Bengoechea-Alonso","raw_affiliation_strings":["Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028116511","display_name":"Arwa Aldaalis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Arwa Aldaalis","raw_affiliation_strings":["Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046317472","display_name":"Johan Ericsson","orcid":"https://orcid.org/0000-0003-1186-6574","observed_orcids":["https://orcid.org/0000-0003-1186-6574"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]}],"countries":["IE","QA"],"is_corresponding":true,"raw_author_name":"Johan Ericsson","raw_affiliation_strings":["Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","School of Medicine and Medical Science, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"School of Medicine and Medical Science, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046317472"],"corresponding_institution_ids":["https://openalex.org/I100930933","https://openalex.org/I4210144839"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2300,"currency":"EUR","value_usd":2480},"fwci":0.6975,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.59902649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":null,"first_page":"990672","last_page":"990672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fbxw7","display_name":"FBXW7","score":0.9850000143051147},{"id":"https://openalex.org/keywords/srebp-2","display_name":"SREBP2","score":0.765999972820282},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-maturation","display_name":"protein maturation","score":0.4429999887943268},{"id":"https://openalex.org/keywords/cholesterol-accumulation","display_name":"cholesterol accumulation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.5929999947547913},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.6150000095367432},{"id":"https://openalex.org/keywords/negative-feedback-loop","display_name":"negative feedback loop","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.8910510540008545},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.7195996046066284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5994879007339478},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5900478959083557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5593671202659607},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5579516291618347},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5128198266029358},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4321577250957489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36463767290115356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18867948651313782},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13574177026748657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07794108986854553}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2022.990672","doi":"https://doi.org/10.3389/fonc.2022.990672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.990672","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.990672/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:36176395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36176395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9513553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9513553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a31c23f34fe0451a891fed8adde7bcfa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a31c23f34fe0451a891fed8adde7bcfa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 12 (2022)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/25611660","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Loss_of_the_Fbw7_tumor_suppressor_rewires_cholesterol_metabolism_in_cancer_cells_leading_to_activation_of_the_PI3K-AKT_signalling_axis/25611660","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fonc.2022.990672","doi":"https://doi.org/10.3389/fonc.2022.990672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2022.990672","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2022.990672/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8531103004","display_name":null,"funder_award_id":"NPRP13S-0127-200178","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"}],"funders":[{"id":"https://openalex.org/F4320319188","display_name":"Hamad Bin Khalifa University","ror":"https://ror.org/03eyq4y97"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320332753","display_name":"Qatar National Research Fund","ror":"https://ror.org/01svaqq28"},{"id":"https://openalex.org/F4320334468","display_name":"Qatar National Library","ror":"https://ror.org/02jv93662"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295413486.pdf","grobid_xml":"https://content.openalex.org/works/W4295413486.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W166106332","https://openalex.org/W1966350789","https://openalex.org/W1970761589","https://openalex.org/W1972561828","https://openalex.org/W1975189993","https://openalex.org/W1982219839","https://openalex.org/W1983833347","https://openalex.org/W1984357379","https://openalex.org/W1984621921","https://openalex.org/W1986214532","https://openalex.org/W1994173047","https://openalex.org/W2007809519","https://openalex.org/W2011123221","https://openalex.org/W2015866661","https://openalex.org/W2016559074","https://openalex.org/W2020988004","https://openalex.org/W2023719883","https://openalex.org/W2033486224","https://openalex.org/W2040962503","https://openalex.org/W2048258966","https://openalex.org/W2051823539","https://openalex.org/W2054318449","https://openalex.org/W2055874017","https://openalex.org/W2056040807","https://openalex.org/W2056891806","https://openalex.org/W2063104773","https://openalex.org/W2070732456","https://openalex.org/W2080082392","https://openalex.org/W2081522152","https://openalex.org/W2081933104","https://openalex.org/W2090350705","https://openalex.org/W2094707025","https://openalex.org/W2099711117","https://openalex.org/W2099765629","https://openalex.org/W2110646266","https://openalex.org/W2115420718","https://openalex.org/W2115959117","https://openalex.org/W2124615340","https://openalex.org/W2125076437","https://openalex.org/W2127229383","https://openalex.org/W2129185045","https://openalex.org/W2130616164","https://openalex.org/W2134292324","https://openalex.org/W2142183096","https://openalex.org/W2144310607","https://openalex.org/W2146544786","https://openalex.org/W2150745942","https://openalex.org/W2171640413","https://openalex.org/W2467091785","https://openalex.org/W2504563518","https://openalex.org/W2508551534","https://openalex.org/W2606513998","https://openalex.org/W2744377419","https://openalex.org/W2745669578","https://openalex.org/W2783958861","https://openalex.org/W2789802594","https://openalex.org/W2811123003","https://openalex.org/W2984955289","https://openalex.org/W2998488520","https://openalex.org/W3003322304","https://openalex.org/W3007168232","https://openalex.org/W3087225814","https://openalex.org/W3093530554","https://openalex.org/W3102357733","https://openalex.org/W3109333323","https://openalex.org/W3138173231","https://openalex.org/W3146582235","https://openalex.org/W3203440177","https://openalex.org/W4224241286","https://openalex.org/W4224925615","https://openalex.org/W4225122437","https://openalex.org/W4252021281","https://openalex.org/W4285176149","https://openalex.org/W4293011063","https://openalex.org/W6606673335"],"related_works":["https://openalex.org/W4293011063","https://openalex.org/W6917444893","https://openalex.org/W2144310607","https://openalex.org/W7163580011","https://openalex.org/W2913878620","https://openalex.org/W2206816936","https://openalex.org/W4323567291","https://openalex.org/W2281530947","https://openalex.org/W2073856026","https://openalex.org/W1552764887"],"abstract_inverted_index":{"The":[0,33,46,88,145],"sterol":[1],"regulatory-element":[2],"binding":[3],"proteins":[4,48],"(SREBPs)":[5],"are":[6,18,49,94],"transcription":[7,31,86],"factors":[8],"controlling":[9],"cholesterol":[10,167,239,241],"and":[11,15,24,83,121,123,267,291],"fatty":[12],"acid":[13],"synthesis":[14],"metabolism.":[16],"There":[17],"three":[19],"SREBP":[20,47],"proteins,":[21,77],"SREBP1a,":[22],"SREBP1c":[23],"SREBP2,":[25,188],"with":[26,224],"SREBP1a":[27,36],"being":[28],"the":[29,57,71,76,81,92,98,106,116,132,140,158,184,191,201,233,248,254,259,269,277],"strongest":[30],"factor.":[32],"expression":[34,125],"of":[35,75,91,112,118,126,134,143,160,177,187,193,204,235,238,250,256,261,271,279],"is":[37,147,162],"restricted":[38],"to":[39,56,80,166,228,287],"rapidly":[40,95],"proliferating":[41],"cells,":[42],"including":[43],"cancer":[44,137,208,222,285],"cells.":[45,209],"translated":[50],"as":[51,85],"large,":[52],"inactive":[53],"precursors":[54,63],"bound":[55],"endoplasmic":[58],"reticulum":[59],"(ER)":[60],"membranes.":[61],"These":[62],"undergo":[64],"a":[65,102,152],"two-step":[66],"cleavage":[67],"process":[68],"that":[69,131,170,190,212,247,276],"releases":[70],"amino":[72],"terminal":[73],"domains":[74],"which":[78],"translocate":[79],"nucleus":[82],"function":[84],"factors.":[87],"nuclear":[89],"forms":[90],"SREBPs":[93],"degraded":[96],"by":[97],"ubiquitin-proteasome":[99],"system":[100],"in":[101,115,136,149,164,179,206,221,253,284],"manner":[103],"dependent":[104,264],"on":[105,265,268],"Fbw7":[107,113,135,155,225,251,280],"ubiquitin":[108],"ligase.":[109],"Consequently,":[110],"inactivation":[111,133,176,249],"results":[114],"stabilization":[117,192],"active":[119,194],"SREBP1":[120,178,195,266],"SREBP2":[122,161,205],"enhanced":[124],"target":[127],"genes.":[128],"We":[129,210],"report":[130],"cells":[138,150,172,181,223,231,286],"blocks":[139],"proteolytic":[141],"maturation":[142],"SREBP2.":[144],"same":[146],"true":[148],"expressing":[151],"cancer-specific":[153],"loss-of-function":[154,226],"protein.":[156],"Interestingly,":[157],"activation":[159,203,255,260],"restored":[163],"response":[165],"depletion,":[168],"suggesting":[169,189],"Fbw7-deficient":[171,180,207],"accumulate":[173],"cholesterol.":[174,272],"Importantly,":[175,258],"also":[182,245],"restores":[183],"cholesterol-dependent":[185],"regulation":[186],"molecules":[196],"could":[197,214],"be":[198,215],"responsible":[199],"for":[200],"blunted":[202],"suggest":[211,275],"this":[213],"an":[216],"important":[217],"negative":[218],"feedback":[219],"loop":[220],"mutations":[227],"protect":[229],"these":[230],"from":[232],"accumulation":[234,270],"toxic":[236],"levels":[237],"and/or":[240],"metabolites.":[242],"Surprisingly,":[243],"we":[244,274],"found":[246],"resulted":[252],"AKT.":[257],"AKT":[262],"was":[263],"Thus,":[273],"loss":[278],"rewires":[281],"lipid":[282],"metabolism":[283],"support":[288],"cell":[289],"proliferation":[290],"survival.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-13T00:00:00"}
