{"id":"https://openalex.org/W4295367129","doi":"https://doi.org/10.1002/hep4.2066","title":"Population\u2010based meta\u2010analysis and gene\u2010set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids","display_name":"Population\u2010based meta\u2010analysis and gene\u2010set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids","publication_year":2022,"publication_date":"2022-09-13","ids":{"openalex":"https://openalex.org/W4295367129","doi":"https://doi.org/10.1002/hep4.2066","pmid":"https://pubmed.ncbi.nlm.nih.gov/36098472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9592792"},"language":"en","primary_location":{"id":"doi:10.1002/hep4.2066","doi":"https://doi.org/10.1002/hep4.2066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep4.2066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.2066","source":{"id":"https://openalex.org/S4210228550","display_name":"Hepatology Communications","issn_l":"2471-254X","issn":["2471-254X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Communications","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.2066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091743949","display_name":"Samuel K. Handelman","orcid":"https://orcid.org/0000-0001-6970-2172","observed_orcids":["https://orcid.org/0000-0001-6970-2172"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel K. Handelman","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054197268","display_name":"Yindra Puentes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yindra M. Puentes","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA","Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019449522","display_name":"Annapurna Kuppa","orcid":"https://orcid.org/0000-0002-7271-063X","observed_orcids":["https://orcid.org/0000-0002-7271-063X"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annapurna Kuppa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Samuel K. Handelman, Yindra M. Puentes, and Annapurna Kuppa contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615977","display_name":"Yanhua Chen","orcid":"https://orcid.org/0000-0002-5241-258X","observed_orcids":["https://orcid.org/0000-0002-5241-258X"]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhua Chen","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101182256","display_name":"Xiaomeng Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaomeng Du","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035488928","display_name":"Mary Furlan Feitosa","orcid":"https://orcid.org/0000-0002-0933-2410","observed_orcids":["https://orcid.org/0000-0002-0933-2410"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary F. Feitosa","raw_affiliation_strings":["Division of Statistical Genomics, Department of Genetics, Washington University, St. Louis, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genomics, Department of Genetics, Washington University, St. Louis, Missouri, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113424539","display_name":"Nicholette D. Palmer","orcid":"https://orcid.org/0000-0001-8883-2511","observed_orcids":["https://orcid.org/0000-0001-8883-2511"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholette D. Palmer","raw_affiliation_strings":["Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA","Nicholette D. Palmer and Elizabeth K. Speliotes contributed equally to the supervision"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Nicholette D. Palmer and Elizabeth K. Speliotes contributed equally to the supervision","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004013405","display_name":"Elizabeth K. Speliotes","orcid":"https://orcid.org/0000-0002-1002-4140","observed_orcids":["https://orcid.org/0000-0002-1002-4140"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth K. Speliotes","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA","Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","Nicholette D. Palmer and Elizabeth K. Speliotes contributed equally to the supervision"],"raw_orcid":"https://orcid.org/0000-0002-1002-4140","affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Nicholette D. Palmer and Elizabeth K. Speliotes contributed equally to the supervision","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004013405"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.5154,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.51067504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"6","issue":"11","first_page":"3120","last_page":"3131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.25949999690055847,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.9259999990463257},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7889999747276306},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.6600000262260437},{"id":"https://openalex.org/keywords/abcg5","display_name":"ABCG5","score":0.7419999837875366},{"id":"https://openalex.org/keywords/abcg8","display_name":"ABCG8","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.7789999842643738},{"id":"https://openalex.org/keywords/fabp6","display_name":"FABP6","score":0.8009999990463257},{"id":"https://openalex.org/keywords/microsomal-triglyceride-transfer-protein","display_name":"microsomal triglyceride transfer protein","score":0.9570000171661377},{"id":"https://openalex.org/keywords/slc4a2","display_name":"SLC4A2","score":0.8740000128746033},{"id":"https://openalex.org/keywords/nr0b2","display_name":"NR0B2","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9089999794960022},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.6899999976158142},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.49000000953674316},{"id":"https://openalex.org/keywords/bile-acid-transport","display_name":"bile acid transport","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C203862802","wikidata":"https://www.wikidata.org/wiki/Q14905041","display_name":"Farnesoid X receptor","level":5,"score":0.7560729384422302},{"id":"https://openalex.org/C13028836","wikidata":"https://www.wikidata.org/wiki/Q21122998","display_name":"Microsomal triglyceride transfer protein","level":5,"score":0.722123384475708},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.6301460862159729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5752196311950684},{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.4990551471710205},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4900628328323364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46489447355270386},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.443051815032959},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4350462555885315},{"id":"https://openalex.org/C183481951","wikidata":"https://www.wikidata.org/wiki/Q15312971","display_name":"Small heterodimer partner","level":5,"score":0.4276488125324249},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.389076292514801},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3535875678062439},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.3179221749305725},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2763742208480835},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.24248525500297546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1564076542854309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15312227606773376},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1302354633808136},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001053","descriptor_name":"Apolipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012394","descriptor_name":"Rosaniline Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027963","descriptor_name":"Chloride-Bicarbonate Antiporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047488","descriptor_name":"Retinoid X Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050556","descriptor_name":"Fatty Acid-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060752","descriptor_name":"Fetuin-B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/hep4.2066","doi":"https://doi.org/10.1002/hep4.2066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep4.2066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.2066","source":{"id":"https://openalex.org/S4210228550","display_name":"Hepatology Communications","issn_l":"2471-254X","issn":["2471-254X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9592792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9592792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatol Commun","raw_type":"Text"},{"id":"pmid:36098472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36098472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology communications","raw_type":"Meta-Analysis"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/175051","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2027.42/175051","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:6137dffe57de48ee805a74226afa396a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6137dffe57de48ee805a74226afa396a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hepatology Communications, Vol 6, Iss 11, Pp 3120-3131 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/hep4.2066","doi":"https://doi.org/10.1002/hep4.2066","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep4.2066","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep4.2066","source":{"id":"https://openalex.org/S4210228550","display_name":"Hepatology Communications","issn_l":"2471-254X","issn":["2471-254X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G113643392","display_name":"Genetics of Adiposity and Glucose Homeostastis","funder_award_id":"R01HL061210","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1295889178","display_name":null,"funder_award_id":"HHSN268201800013I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G159819824","display_name":"THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM","funder_award_id":"n01ag12100-57-0-2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1742119064","display_name":"Identification and Characterization of Loci Associated with Non-alcoholic Fatty Liver Disease","funder_award_id":"R01DK128871","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2050560213","display_name":null,"funder_award_id":"P60 DK-079637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2105483136","display_name":null,"funder_award_id":"HL085571","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2136672813","display_name":null,"funder_award_id":"HL-061019","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G222498687","display_name":null,"funder_award_id":"HL060944","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2278839098","display_name":"Genetic Architecture of Adiposity in Multiple Large Cohorts","funder_award_id":"R01DK089256","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G230712557","display_name":null,"funder_award_id":"N01-AG12100","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G240488633","display_name":"Diabetes Research and Training Center","funder_award_id":"5p60dk079637-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2415573643","display_name":null,"funder_award_id":"HHSN268201800010 I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2535778770","display_name":"Longevity Genes in Founder Populations","funder_award_id":"R01AG018728","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2563963086","display_name":"GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS","funder_award_id":"R01HL060919","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G265762973","display_name":null,"funder_award_id":"HHSN268201800013 I","funder_id":"https://openalex.org/F4320309423","funder_display_name":"Jackson State University"},{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2809357584","display_name":null,"funder_award_id":"HHSN268201800014 I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3042145041","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3205625555","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3402222819","display_name":null,"funder_award_id":"N01-AG-1-2100","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3405256882","display_name":null,"funder_award_id":"HHSN268201500001C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3430808022","display_name":"Genome-wide Association in Families: Data Integrity, Design and Methods Issue","funder_award_id":"U01HL084756","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3454990118","display_name":"Genomic Predictors of Arteriosclerosis in Hypertensives","funder_award_id":"R01HL087660","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3479217851","display_name":null,"funder_award_id":"DK085175","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G350245564","display_name":null,"funder_award_id":"HHSN268201800012 I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G36937976","display_name":null,"funder_award_id":"N02- HL-64278","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4026181260","display_name":"Genetic and Epidemiological Predictors of Glucose Homeostasis Measures","funder_award_id":"R01DK118062","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4690953377","display_name":null,"funder_award_id":"HL-060919","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G47192932","display_name":null,"funder_award_id":"HHSN268201800014C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4897018079","display_name":null,"funder_award_id":"HHSN268201800015 I","funder_id":"https://openalex.org/F4320317894","funder_display_name":"Mississippi State Department of Health"},{"id":"https://openalex.org/G4976486911","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4983810294","display_name":null,"funder_award_id":"R01 HL08770003","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5101955913","display_name":null,"funder_award_id":"HL-087660","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5249188777","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5267604781","display_name":null,"funder_award_id":"DK118062","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5331993534","display_name":"UK Biobank (core renewal)","funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5661647164","display_name":"Human population based genetic studies to elucidate the biology of NAFLD","funder_award_id":"R01DK107904","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5755622425","display_name":"Molecular genetics of glucose homeostasis and fat","funder_award_id":"R01HL060894","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G579045871","display_name":null,"funder_award_id":"HHSN268201800015I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5825472970","display_name":null,"funder_award_id":"HL 100245","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5851953877","display_name":"Genetics of Adiposity and Glucose Homeostasis","funder_award_id":"R01HL061019","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6130872683","display_name":null,"funder_award_id":"DK089256","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6156766399","display_name":null,"funder_award_id":"HHSN268201800013I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6283825325","display_name":"Genetic Influences on Coronary Artery Calcification","funder_award_id":"R01HL088119","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6448136916","display_name":"Genetics of Hypertension Risk Factors and Sequela in African Americans","funder_award_id":"RC1HL100245","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6476052998","display_name":"Genetic Epidemiology of NAFLD and T2DM","funder_award_id":"K01DK067207","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6571475356","display_name":null,"funder_award_id":"HHSN268201800015I","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G6645568980","display_name":"Genetics of Adiposity and Glucose Homeostasis","funder_award_id":"R01HL060944","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6719065438","display_name":"SNP HEALTH ASSOCIATION RESOURCE (SHARE)","funder_award_id":"n02hl64278-6-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6971979224","display_name":"Mid-Atlantic Nutrition Obesity Research Center","funder_award_id":"P30DK072488","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7091571603","display_name":null,"funder_award_id":"HHSN268201800011I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G715434095","display_name":"Identification and functional impact of NAFLD associated genetic variants","funder_award_id":"R01DK106621","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7373387228","display_name":null,"funder_award_id":"N01-AG-1-2100","funder_id":"https://openalex.org/F4320327881","funder_display_name":"Hjartavernd"},{"id":"https://openalex.org/G7526106616","display_name":null,"funder_award_id":"HHSN268201800015I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7852589027","display_name":null,"funder_award_id":"U01 HL7251","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8022447037","display_name":"Probing The Dark Matter of the Genome in the NHLBI Family Heart Study","funder_award_id":"R01HL117078","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G857349569","display_name":null,"funder_award_id":"R01 HL06","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8683204365","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8870130941","display_name":"Predictors of Coronary Artery Calcification in an African-American Cohort","funder_award_id":"R01HL085571","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G89699440","display_name":null,"funder_award_id":"HHSN268201800013I","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G9000050004","display_name":null,"funder_award_id":"N02-HL-64278","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000077244","display_name":null,"funder_award_id":"P60-DK079637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000124674","display_name":null,"funder_award_id":"N01-HC 25195","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000196033","display_name":null,"funder_award_id":"DK-079637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000873105","display_name":"Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver Disease","funder_award_id":"R01DK131787","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309423","display_name":"Jackson State University","ror":"https://ror.org/01ecnnp60"},{"id":"https://openalex.org/F4320317894","display_name":"Mississippi State Department of Health","ror":"https://ror.org/019c4md20"},{"id":"https://openalex.org/F4320327881","display_name":"Hjartavernd","ror":"https://ror.org/051snsd81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295367129.pdf","grobid_xml":"https://content.openalex.org/works/W4295367129.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W11277746","https://openalex.org/W1437089628","https://openalex.org/W1488397342","https://openalex.org/W1925369262","https://openalex.org/W1963533730","https://openalex.org/W1984068087","https://openalex.org/W1988885242","https://openalex.org/W1999921068","https://openalex.org/W2001736262","https://openalex.org/W2004129520","https://openalex.org/W2007667022","https://openalex.org/W2027663543","https://openalex.org/W2036701949","https://openalex.org/W2038654926","https://openalex.org/W2045314772","https://openalex.org/W2048375374","https://openalex.org/W2067052007","https://openalex.org/W2073487143","https://openalex.org/W2080361134","https://openalex.org/W2082702559","https://openalex.org/W2082704080","https://openalex.org/W2101605059","https://openalex.org/W2102270144","https://openalex.org/W2115801316","https://openalex.org/W2147040117","https://openalex.org/W2147311167","https://openalex.org/W2150806217","https://openalex.org/W2151701113","https://openalex.org/W2152921740","https://openalex.org/W2155096309","https://openalex.org/W2156504663","https://openalex.org/W2156760391","https://openalex.org/W2157579240","https://openalex.org/W2165737516","https://openalex.org/W2167806431","https://openalex.org/W2310542696","https://openalex.org/W2313404845","https://openalex.org/W2343131997","https://openalex.org/W2345621280","https://openalex.org/W2558996269","https://openalex.org/W2574726211","https://openalex.org/W2584401547","https://openalex.org/W2588220066","https://openalex.org/W2605955022","https://openalex.org/W2734434515","https://openalex.org/W2766546480","https://openalex.org/W2770864915","https://openalex.org/W2950958620","https://openalex.org/W2980805882","https://openalex.org/W2993039085","https://openalex.org/W3208129759","https://openalex.org/W4247935329"],"related_works":["https://openalex.org/W2160216804","https://openalex.org/W2562093595","https://openalex.org/W2111137336","https://openalex.org/W4396997778","https://openalex.org/W4309732280","https://openalex.org/W4386741123","https://openalex.org/W3191552041","https://openalex.org/W3211151734","https://openalex.org/W4402576845","https://openalex.org/W3157193403"],"abstract_inverted_index":{"Nonalcoholic":[0],"fatty":[1],"liver":[2,289,304],"disease":[3],"(NAFLD)":[4],"is":[5,9],"prevalent":[6],"worldwide.":[7],"NAFLD":[8,27,110,132],"associated":[10,154],"with":[11,108,155,281,287],"elevated":[12],"serum":[13,58,78,142,282,288,307],"triglycerides":[14],"(TG),":[15],"low-density":[16],"lipoprotein":[17,23],"cholesterol":[18,24,309],"(LDL),":[19],"and":[20,28,35,49,60,69,93,137,144,177,276],"reduced":[21],"high-density":[22],"(HDL).":[25],"Both":[26],"blood":[29],"lipid":[30,340],"levels":[31,284],"are":[32],"genetically":[33],"influenced":[34],"may":[36],"share":[37],"a":[38,139],"common":[39],"genetic":[40,325],"etiology.":[41],"We":[42,62,80],"used":[43,81,352],"genome-wide":[44],"association":[45,128],"studies":[46],"(GWAS)-ranked":[47],"genes":[48,65,147],"gene-set":[50],"enrichment":[51,327],"analysis":[52,328],"to":[53,83,356],"identify":[54,84],"pathways":[55,68,87,102,254],"that":[56,279,301],"affect":[57],"lipids":[59,143],"NAFLD.":[61,145],"identified":[63],"credible":[64],"in":[66,73,129,141,149,261,292,298,312,353],"these":[67,74,101,322],"characterized":[70],"missense":[71,348],"variants":[72,260,297,311,349],"for":[75,106,127,338],"effects":[76,320],"on":[77,321,360],"traits.":[79,323],"MAGENTA":[82],"58":[85],"enriched":[86,105],"from":[88],"publicly":[89],"available":[90],"TG,":[91],"LDL,":[92],"HDL":[94],"GWAS":[95,111,133],"(n":[96,112,134],"=":[97,113,135],"99,000).":[98],"Three":[99],"of":[100,214,315],"were":[103],"also":[104,285],"associations":[107],"European-ancestry":[109],"7176).":[114],"One":[115],"pathway,":[116],"farnesoid":[117],"X":[118,121],"receptor":[119,122,219,232,245],"(FXR)/retinoid":[120],"(RXR)":[123],"activation,":[124],"was":[125],"replicated":[126],"an":[130],"African-ancestry":[131],"3214)":[136],"plays":[138],"role":[140],"Credible":[146],"(proteins)":[148],"FXR/RXR":[150],"activation":[151],"include":[152],"those":[153],"cholesterol/bile/bilirubin":[156],"transport/absorption":[157],"(ABCC2":[158],"(MRP2)":[159],"[ATP":[160],"binding":[161,187],"cassette":[162,173],"subfamily":[163,220,233],"C":[164],"member":[165,205,224,237],"(multidrug":[166],"resistance-associated":[167],"protein":[168,188,209],"2)],":[169],"ABCG5,":[170],"ABCG8":[171,266],"[ATP-binding":[172],"(ABC)":[174],"transporters":[175],"G5":[176],"G8],":[178],"APOB":[179,268],"(APOB)":[180],"[apolipoprotein":[181],"B],":[182],"FABP6":[183],"(ILBP)":[184],"[fatty":[185],"acid":[186],"6":[189],"(ileal":[190],"lipid-binding":[191],"protein)],":[192],"MTTP":[193,270],"(MTP)":[194],"[microsomal":[195],"triglyceride":[196],"transfer":[197],"protein],":[198],"SLC4A2":[199],"(AE2)":[200],"[solute":[201],"carrier":[202],"family":[203,317],"4":[204,238],"2":[206,225],"(anion":[207],"exchange":[208],"2)]),":[210],"nuclear":[211],"hormone-mediated":[212],"control":[213],"metabolism":[215],"(NR0B2":[216],"(SHP)":[217],"[nuclear":[218,231],"0":[221],"group":[222,235],"B":[223],"(small":[226],"heterodimer":[227],"partner)],":[228],"NR1H4":[229,274,299],"(FXR)":[230,300],"1":[234],"H":[236],"(FXR)],":[239],"PPARA":[240,277],"(PPAR)":[241,278],"[peroxisome":[242],"proliferator":[243],"activated":[244],"alpha],":[246],"FOXO1":[247],"(FOXO1A)":[248],"[forkhead":[249],"box":[250],"O1]),":[251],"or":[252],"other":[253,313],"(FETUB":[255],"(FETUB)":[256],"[fetuin":[257],"B]).":[258],"Missense":[259],"ABCC2":[262],"(MRP2),":[263],"ABCG5":[264],"(ABCG5),":[265],"(ABCG8),":[267],"(APOB),":[269],"(MTP),":[271],"NR0B2":[272],"(SHP),":[273],"(FXR),":[275],"associate":[280,286],"LDL":[283,308],"function":[290],"tests":[291],"UK":[293],"Biobank.":[294],"Conclusion:":[295],"Genetic":[296],"protect":[302],"against":[303],"steatosis":[305],"increase":[306],"while":[310,342],"members":[314],"the":[316],"have":[318],"congruent":[319],"Human":[324],"pathway":[326],"can":[329],"help":[330],"guide":[331],"therapeutic":[332],"development":[333],"by":[334],"identifying":[335],"effective":[336],"targets":[337],"NAFLD/serum":[339],"manipulation":[341],"minimizing":[343],"side":[344],"effects.":[345],"In":[346],"addition,":[347],"could":[350],"be":[351],"companion":[354],"diagnostics":[355],"determine":[357],"their":[358],"influence":[359],"drug":[361],"effectiveness.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-09-13T00:00:00"}