{"id":"https://openalex.org/W4295259596","doi":"https://doi.org/10.1136/jnnp-2022-ehdn.72","title":"D16 Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity","display_name":"D16 Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4295259596","doi":"https://doi.org/10.1136/jnnp-2022-ehdn.72"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2022-ehdn.72","doi":"https://doi.org/10.1136/jnnp-2022-ehdn.72","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2022-ehdn.72","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D: Wet biomarkers","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012497314","display_name":"Nicholas S. Caron","orcid":"https://orcid.org/0000-0002-3877-455X","observed_orcids":["https://orcid.org/0000-0002-3877-455X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nicholas S Caron","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003550473","display_name":"Arsalan S. Haqqani","orcid":"https://orcid.org/0000-0003-2454-8989","observed_orcids":["https://orcid.org/0000-0003-2454-8989"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arsalan S Haqqani","raw_affiliation_strings":["Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akshdeep Sandhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Akshdeep Sandhu","raw_affiliation_strings":["BC Children\u2019s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BC Children\u2019s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049111618","display_name":"Amirah E.-E. Aly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amirah E Aly","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015367083","display_name":"Hailey Findlay Black","orcid":"https://orcid.org/0000-0003-2479-2463","observed_orcids":["https://orcid.org/0000-0003-2479-2463"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hailey Findlay Black","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082112381","display_name":"Jeffrey N. Bone","orcid":"https://orcid.org/0000-0001-7704-1677","observed_orcids":["https://orcid.org/0000-0001-7704-1677"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey N Bone","raw_affiliation_strings":["BC Children\u2019s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BC Children\u2019s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056799105","display_name":"Jodi L. McBride","orcid":"https://orcid.org/0000-0002-4816-7569","observed_orcids":["https://orcid.org/0000-0002-4816-7569"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jodi L McBride","raw_affiliation_strings":["Oregon Health and Science University, Department of Behavioral Neuroscience, Portland, OR, USA","Oregon National Primate Research Center, Division of Neuroscience, Beaverton, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Department of Behavioral Neuroscience, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon National Primate Research Center, Division of Neuroscience, Beaverton, OR, USA","institution_ids":["https://openalex.org/I102507086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076511944","display_name":"Abedelnasser Abulrob","orcid":"https://orcid.org/0000-0002-7617-9735","observed_orcids":["https://orcid.org/0000-0002-7617-9735"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abedelnasser Abulrob","raw_affiliation_strings":["Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043006925","display_name":"Danica B Stanimirovic","orcid":"https://orcid.org/0000-0001-6678-407X","observed_orcids":["https://orcid.org/0000-0001-6678-407X"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danica Stanimirovic","raw_affiliation_strings":["Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062884561","display_name":"Blair R. Leavitt","orcid":"https://orcid.org/0000-0002-4532-766X","observed_orcids":["https://orcid.org/0000-0002-4532-766X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Blair R Leavitt","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047722409","display_name":"Michael R. Hayden","orcid":"https://orcid.org/0000-0001-5159-1419","observed_orcids":["https://orcid.org/0000-0001-5159-1419"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405258907","display_name":"BC Children's Hospital Research Institute","ror":"https://ror.org/01cvasn76","country_code":"CA","type":"education","lineage":["https://openalex.org/I4210153200","https://openalex.org/I4405258907"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael R Hayden","raw_affiliation_strings":["Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children\u2019s Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]},{"raw_affiliation_string":"Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405258907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A25.3","last_page":"A26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9909999966621399},{"id":"https://openalex.org/keywords/premanifest-huntington-disease","display_name":"premanifest Huntington disease","score":0.7620000243186951},{"id":"https://openalex.org/keywords/disease-onset-prediction","display_name":"disease onset prediction","score":0.875},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.5870000123977661},{"id":"https://openalex.org/keywords/prodynorphin","display_name":"prodynorphin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proenkephalin","display_name":"proenkephalin","score":1.0},{"id":"https://openalex.org/keywords/mutation-carriers","display_name":"mutation carriers","score":0.6449999809265137},{"id":"https://openalex.org/keywords/biomarker-panel","display_name":"biomarker panel","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.7934679985046387},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7064545154571533},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.69359290599823},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4995276927947998},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.470664381980896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45626047253608704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3904148042201996},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33799198269844055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2794969081878662},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19268009066581726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08756154775619507}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jnnp-2022-ehdn.72","doi":"https://doi.org/10.1136/jnnp-2022-ehdn.72","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2022-ehdn.72","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D: Wet biomarkers","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018184520","https://openalex.org/W2538892584","https://openalex.org/W4402392135","https://openalex.org/W2060257772","https://openalex.org/W4385649027","https://openalex.org/W2058773221","https://openalex.org/W2002742028","https://openalex.org/W2003001535","https://openalex.org/W2076380007","https://openalex.org/W2076117072"],"abstract_inverted_index":{"The":[0,31],"identification":[1],"of":[2,17,28,34,72,78,102,167,175,190,222,252,270,281],"molecular":[3],"biomarkers":[4,136,290],"in":[5,43,53,88,107,132,153],"CSF":[6,44,54,79,108,135,146,169,191,224,253,271],"from":[7,55,109],"individuals":[8,202,230,261],"affected":[9],"by":[10],"Huntington":[11,56,112,117,154,200,238,293],"disease":[12,18,22,57,91,113,118,155,160,176,201,239,243,263,282,294],"may":[13,274],"help":[14],"improve":[15],"prediction":[16,279],"onset,":[19],"better":[20],"define":[21,267],"progression,":[23],"and":[24,47,60,76,86,121,139,198,218,234,242,284,288],"could":[25],"facilitate":[26],"evaluation":[27],"potential":[29,71],"therapies.":[30],"primary":[32],"objective":[33,65],"our":[35],"study":[36],"was":[37,66],"to":[38,67,82,128],"assess":[39,83],"previously":[40,133],"reported":[41,130],"changes":[42,131],"protein":[45,51,74,80,105,147,170,192,225],"markers":[46,81,193,226,258],"investigate":[48],"novel":[49,144,268],"exploratory":[50,145,211],"candidates":[52],"mutation":[58,119,156,240],"carriers":[59,120,157],"healthy":[61,123],"controls.":[62],"Our":[63],"secondary":[64],"compare":[68],"the":[69],"discriminatory":[70,205],"individual":[73,257],"analytes":[75,106,148,171],"combinations":[77,251,269],"their":[84],"sensitivity":[85,233],"specificity":[87,235],"distinguishing":[89],"between":[90,196],"stages.":[92,161,264],"We":[93,162],"conducted":[94],"a":[95,188],"hypothesis-driven,":[96],"parallel-reaction":[97],"monitoring":[98,292],"mass":[99],"spectrometry-based":[100],"analysis":[101,217],"26":[103],"pre-specified":[104],"sixteen":[110],"manifest":[111,199],"subjects,":[114],"eight":[115,122],"premanifest":[116,197],"control":[124],"individuals.":[125],"In":[126,245],"addition":[127],"reproducing":[129],"investigated":[134],"(NEFL,":[137],"PDYN,":[138],"PENK),":[140],"we":[141,185,208,248,266],"also":[142,163],"identified":[143,219],"whose":[149],"levels":[150],"were":[151],"altered":[152],"and/or":[158],"across":[159,262],"observed":[164],"significant":[165],"associations":[166],"select":[168],"with":[172,203,231],"clinical":[173,287],"outcomes":[174],"severity.":[177,244,295],"Using":[178],"sparse":[179],"partial":[180],"least":[181],"square":[182],"discrimination":[183],"analysis,":[184],"showed":[186],"that":[187,227,250,273],"combination":[189],"can":[194,228,255],"distinguish":[195],"high":[204,232],"accuracy.":[206],"Finally,":[207],"performed":[209],"an":[210],"combinatorial":[212],"receiver":[213],"operating":[214],"characteristic":[215],"curve":[216],"optimized":[220],"panels":[221],"specific":[223],"discriminate":[229],"based":[236],"on":[237],"status":[241],"this":[246],"study,":[247],"demonstrate":[249],"proteins":[254,272],"outperform":[256],"for":[259,277,291],"classifying":[260],"Moreover,":[265],"be":[275],"useful":[276],"improving":[278],"accuracy":[280],"onset":[283],"complement":[285],"existing":[286],"imaging":[289]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}