{"id":"https://openalex.org/W4295154915","doi":"https://doi.org/10.22159/ijap.2022v14i5.45388","title":"IN SILICO INVESTIGATION OF XANTHONE DERIVATIVE POTENCY IN INHIBITING CARBONIC ANHYDRASE II (CA II) USING MOLECULAR DOCKING AND MOLECULAR DYNAMICS (MD) SIMULATION","display_name":"IN SILICO INVESTIGATION OF XANTHONE DERIVATIVE POTENCY IN INHIBITING CARBONIC ANHYDRASE II (CA II) USING MOLECULAR DOCKING AND MOLECULAR DYNAMICS (MD) SIMULATION","publication_year":2022,"publication_date":"2022-09-07","ids":{"openalex":"https://openalex.org/W4295154915","doi":"https://doi.org/10.22159/ijap.2022v14i5.45388"},"language":"en","primary_location":{"id":"doi:10.22159/ijap.2022v14i5.45388","doi":"https://doi.org/10.22159/ijap.2022v14i5.45388","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2022v14i5.45388","pdf_url":"https://innovareacademics.in/journals/index.php/ijap/article/download/45388/26924","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijap/article/download/45388/26924","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074223786","display_name":"REGINA KATELIA","orcid":"https://orcid.org/0000-0002-8258-9167","observed_orcids":["https://orcid.org/0000-0002-8258-9167"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"REGINA KATELIA","raw_affiliation_strings":["Biomedical Engineering Department, School of Electrical Engineering and Informatics, Bandung Institute of Technology, Bandung, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-8258-9167","affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, School of Electrical Engineering and Informatics, Bandung Institute of Technology, Bandung, Indonesia","institution_ids":["https://openalex.org/I134635517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048089480","display_name":"Muhammad Miftah Jauhar","orcid":"https://orcid.org/0000-0002-5826-5904","observed_orcids":["https://orcid.org/0000-0002-5826-5904"]},"institutions":[{"id":"https://openalex.org/I4405254333","display_name":"Nano Center Indonesia","ror":"https://ror.org/01pnt7129","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I4405254333"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"MUHAMMAD MIFTAH JAUHAR","raw_affiliation_strings":["Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-5826-5904","affiliations":[{"raw_affiliation_string":"Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia","institution_ids":["https://openalex.org/I4405254333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064354630","display_name":"Putri Hawa Syaifie","orcid":"https://orcid.org/0000-0001-8566-7960","observed_orcids":["https://orcid.org/0000-0001-8566-7960"]},"institutions":[{"id":"https://openalex.org/I4405254333","display_name":"Nano Center Indonesia","ror":"https://ror.org/01pnt7129","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I4405254333"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"PUTRI HAWA SYAIFIE","raw_affiliation_strings":["Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-8566-7960","affiliations":[{"raw_affiliation_string":"Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia","institution_ids":["https://openalex.org/I4405254333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089194990","display_name":"Dwi Nugroho","orcid":"https://orcid.org/0000-0002-7020-8582","observed_orcids":["https://orcid.org/0000-0002-7020-8582"]},"institutions":[{"id":"https://openalex.org/I4405254333","display_name":"Nano Center Indonesia","ror":"https://ror.org/01pnt7129","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I4405254333"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"DWI WAHYU NUGROHO","raw_affiliation_strings":["Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-7020-8582","affiliations":[{"raw_affiliation_string":"Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia","institution_ids":["https://openalex.org/I4405254333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010313005","display_name":"Donny Ramadhan","orcid":"https://orcid.org/0000-0001-6556-3160","observed_orcids":["https://orcid.org/0000-0001-6556-3160"]},"institutions":[{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"DONNY RAMADHAN","raw_affiliation_strings":["Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Jawa Barat, 16911, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-6556-3160","affiliations":[{"raw_affiliation_string":"Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Jawa Barat, 16911, Indonesia","institution_ids":["https://openalex.org/I4387154144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008244460","display_name":"Adzani Gaisani Arda","orcid":"https://orcid.org/0000-0002-2674-6295","observed_orcids":["https://orcid.org/0000-0002-2674-6295"]},"institutions":[{"id":"https://openalex.org/I4405254333","display_name":"Nano Center Indonesia","ror":"https://ror.org/01pnt7129","country_code":"ID","type":"nonprofit","lineage":["https://openalex.org/I4405254333"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"ADZANI GAISANI ARDA","raw_affiliation_strings":["Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-2674-6295","affiliations":[{"raw_affiliation_string":"Nano Center Indonesia, Jl. PUSPIPTEK, South Tangerang, Banten, 15314, Indonesia","institution_ids":["https://openalex.org/I4405254333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070975087","display_name":"Etik Mardliyati","orcid":"https://orcid.org/0000-0002-3621-9659","observed_orcids":["https://orcid.org/0000-0002-3621-9659"]},"institutions":[{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"ETIK MARDLIYATI","raw_affiliation_strings":["Research Center for Vaccine and Drug, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Jawa Barat, 16911, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Vaccine and Drug, National Research and Innovation Agency (BRIN), Cibinong, Bogor, Jawa Barat, 16911, Indonesia","institution_ids":["https://openalex.org/I4387154144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082310968","display_name":"Isa Anshori","orcid":"https://orcid.org/0000-0001-5134-7264","observed_orcids":["https://orcid.org/0000-0001-5134-7264"]},"institutions":[{"id":"https://openalex.org/I134635517","display_name":"Bandung Institute of Technology","ror":"https://ror.org/00apj8t60","country_code":"ID","type":"education","lineage":["https://openalex.org/I134635517"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"ISA ANSHORI","raw_affiliation_strings":["Biomedical Engineering Department, School of Electrical Engineering and Informatics, Bandung Institute of Technology, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, School of Electrical Engineering and Informatics, Bandung Institute of Technology, Bandung, Indonesia","institution_ids":["https://openalex.org/I134635517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.292,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.39176671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"190","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthone-derivatives","display_name":"xanthone derivatives","score":0.828000009059906},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii-inhibition","display_name":"carbonic anhydrase II inhibition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prenylated-xanthones","display_name":"prenylated xanthones","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6389999985694885},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chlorthalidone","display_name":"chlorthalidone","score":0.9620000123977661},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/toxicity-assessment","display_name":"toxicity prediction","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lipinski-s-rule-of-five","display_name":"Lipinski's rule of five","score":0.8389999866485596},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C41847442","wikidata":"https://www.wikidata.org/wiki/Q916723","display_name":"Lipinski's rule of five","level":4,"score":0.6825912594795227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6736046671867371},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.6330786943435669},{"id":"https://openalex.org/C2775842281","wikidata":"https://www.wikidata.org/wiki/Q421789","display_name":"Xanthone","level":2,"score":0.6292648315429688},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5980146527290344},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5881184339523315},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.5609263777732849},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5529678463935852},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.538200855255127},{"id":"https://openalex.org/C2780427769","wikidata":"https://www.wikidata.org/wiki/Q425289","display_name":"Chlorthalidone","level":3,"score":0.48503202199935913},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.48377320170402527},{"id":"https://openalex.org/C158180186","wikidata":"https://www.wikidata.org/wiki/Q278487","display_name":"PubChem","level":2,"score":0.422394335269928},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.30626338720321655},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.26997506618499756},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26532018184661865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1701858639717102},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15802735090255737},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.06614044308662415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22159/ijap.2022v14i5.45388","doi":"https://doi.org/10.22159/ijap.2022v14i5.45388","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2022v14i5.45388","pdf_url":"https://innovareacademics.in/journals/index.php/ijap/article/download/45388/26924","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22159/ijap.2022v14i5.45388","doi":"https://doi.org/10.22159/ijap.2022v14i5.45388","is_oa":true,"landing_page_url":"https://doi.org/10.22159/ijap.2022v14i5.45388","pdf_url":"https://innovareacademics.in/journals/index.php/ijap/article/download/45388/26924","source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329091","display_name":"Institut Teknologi Bandung","ror":"https://ror.org/00apj8t60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295154915.pdf","grobid_xml":"https://content.openalex.org/works/W4295154915.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1981021420","https://openalex.org/W1987405309","https://openalex.org/W1994376251","https://openalex.org/W2009356149","https://openalex.org/W2017219641","https://openalex.org/W2055257794","https://openalex.org/W2056204713","https://openalex.org/W2071645194","https://openalex.org/W2108959130","https://openalex.org/W2122854841","https://openalex.org/W2129832544","https://openalex.org/W2134967712","https://openalex.org/W2135732933","https://openalex.org/W2156121263","https://openalex.org/W2160690759","https://openalex.org/W2346802035","https://openalex.org/W2379628571","https://openalex.org/W2592656516","https://openalex.org/W2612329522","https://openalex.org/W2733347532","https://openalex.org/W2794075195","https://openalex.org/W2800892557","https://openalex.org/W2962878601","https://openalex.org/W2965974558","https://openalex.org/W2970801631","https://openalex.org/W2994192461","https://openalex.org/W3003133348","https://openalex.org/W3006355415","https://openalex.org/W3012990101","https://openalex.org/W3085622632","https://openalex.org/W3119700671","https://openalex.org/W3137171605","https://openalex.org/W4211019091","https://openalex.org/W4211073165","https://openalex.org/W4212841300"],"related_works":["https://openalex.org/W7135023449","https://openalex.org/W7161985617","https://openalex.org/W3000416119","https://openalex.org/W7167599281","https://openalex.org/W4392342664","https://openalex.org/W7204496032","https://openalex.org/W4214526494","https://openalex.org/W2246867031","https://openalex.org/W4406047221","https://openalex.org/W2968468595"],"abstract_inverted_index":{"Objective:":[0],"Hypertension":[1],"is":[2,20,45,49,160,173,218],"the":[3,14,34,54,99,108,140,143,147,199,220,233,238],"leading":[4],"contributor":[5],"to":[6,33,68,138,162,170,175,181,187,201,244],"all-cause":[7],"death":[8],"and":[9,123,183,215],"disability":[10],"worldwide.":[11],"One":[12],"of":[13,37,39,142,149,209,212,228,240],"most":[15],"well-known":[16],"first-line":[17],"antihypertensive":[18,78],"drugs":[19],"chlorthalidone":[21,182],"which":[22],"treats":[23],"hypertension":[24,246],"through":[25],"carbonic":[26],"anhydrase":[27],"(CA)":[28],"II":[29,110,151,167,242],"inhibition.":[30],"However,":[31],"due":[32,174],"high":[35],"number":[36],"cases":[38],"hypertension,":[40],"a":[41,50,75,132,164,226],"more":[42],"potent":[43],"medication":[44],"still":[46],"needed.":[47],"Xanthone":[48],"potential":[51,144,200,235],"candidate":[52],"for":[53,57,87],"compound":[55],"group":[56],"its":[58,176,184,216],"potency":[59,73,89],"in":[60,91],"inhibiting":[61],"CA":[62,109,150,166,188,241],"II.":[63],"Therefore,":[64],"this":[65],"research":[66,155],"aims":[67],"evaluate":[69,139],"around":[70],"500":[71],"xanthones\u2019":[72],"as":[74,146,237],"better":[76,165],"oral":[77],"drug":[79],"than":[80],"chlorthalidone.":[81,171],"Methods:":[82],"507":[83],"xanthones":[84,230],"were":[85,96,126],"analyzed":[86],"their":[88],"using":[90,104],"silico":[92],"method.":[93],"Xanthone\u2019s":[94],"structures":[95],"retrieved":[97,113],"from":[98,114,128],"PubChem":[100],"website":[101],"or":[102],"built":[103],"Avogadro":[105],"software,":[106],"while":[107],"receptor":[111],"was":[112,136],"The":[115],"RCSB":[116],"website.":[117],"Then":[118],"molecular":[119,133],"docking,":[120],"ADME":[121],"evaluation,":[122],"toxicity":[124,217],"test":[125],"evaluated":[127],"selected":[129],"ligands.":[130],"Finally,":[131],"dynamics":[134],"simulation":[135],"conducted":[137],"stability":[141],"ligand":[145],"inhibitor":[148,168,239],"protein.":[152],"Results:":[153],"This":[154],"found":[156],"that":[157],"globulixanthone":[158],"c":[159],"considered":[161],"be":[163,202],"compared":[169,180],"It":[172,196],"lower":[177],"binding":[178,186],"affinity":[179],"stable":[185],"II\u2019s":[189],"important":[190],"inhibition":[191],"sites":[192],"with":[193],"low":[194],"fluctuation.":[195],"also":[197],"has":[198],"consumed":[203],"orally":[204],"because":[205],"it":[206],"fulfills":[207],"all":[208],"Lipinski's":[210],"rule":[211],"five":[213],"standards":[214],"on":[219],"moderate":[221],"level.":[222],"Conclusion:":[223],"Globulixanthone":[224],"c,":[225],"type":[227],"prenylated":[229],"group,":[231],"showed":[232],"best":[234],"activity":[236],"protein":[243],"treat":[245],"among":[247],"other":[248],"xanthones.":[249]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-11T00:00:00"}