{"id":"https://openalex.org/W4295152004","doi":"https://doi.org/10.1002/jbmr.4705","title":"Multiple Vertebral Fractures After Denosumab Discontinuation: FREEDOM and FREEDOM Extension Trials Additional Post Hoc Analyses","display_name":"Multiple Vertebral Fractures After Denosumab Discontinuation: FREEDOM and FREEDOM Extension Trials Additional Post Hoc Analyses","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W4295152004","doi":"https://doi.org/10.1002/jbmr.4705","pmid":"https://pubmed.ncbi.nlm.nih.gov/36088628"},"language":"en","primary_location":{"id":"doi:10.1002/jbmr.4705","doi":"https://doi.org/10.1002/jbmr.4705","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.4705","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.4705","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.4705","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028056767","display_name":"Felicia Cosman","orcid":"https://orcid.org/0000-0003-4554-6616","observed_orcids":["https://orcid.org/0000-0003-4554-6616"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felicia Cosman","raw_affiliation_strings":["Division of Endocrinology/Department of Medicine Columbia University New York NY USA","Division of Endocrinology/Department of Medicine, Columbia University, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4554-6616","affiliations":[{"raw_affiliation_string":"Division of Endocrinology/Department of Medicine Columbia University New York NY USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Endocrinology/Department of Medicine, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765268","display_name":"Shuang Huang","orcid":"https://orcid.org/0000-0001-5040-8969","observed_orcids":["https://orcid.org/0000-0001-5040-8969"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuang Huang","raw_affiliation_strings":["Amgen Inc. Thousand Oaks CA USA","Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc. Thousand Oaks CA USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109428306","display_name":"Michele McDermott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele McDermott","raw_affiliation_strings":["Amgen Inc. Thousand Oaks CA USA","Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc. Thousand Oaks CA USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044875947","display_name":"Steven Ron Cummings","orcid":"https://orcid.org/0000-0001-8808-260X","observed_orcids":["https://orcid.org/0000-0001-8808-260X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2801780550","display_name":"California Pacific Medical Center","ror":"https://ror.org/02bjh0167","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160","https://openalex.org/I2801780550"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Cummings","raw_affiliation_strings":["San Francisco Coordinating Center California Pacific Medical Center Research Institute and University of California San Francisco CA USA","San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Francisco Coordinating Center California Pacific Medical Center Research Institute and University of California San Francisco CA USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2801780550"]},{"raw_affiliation_string":"San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I2801780550"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028056767"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":5.6121,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.96742178,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"37","issue":"11","first_page":"2112","last_page":"2120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9259999990463257},{"id":"https://openalex.org/keywords/multiple-vertebral-fractures","display_name":"multiple vertebral fractures","score":0.8930000066757202},{"id":"https://openalex.org/keywords/vertebral-fracture-risk","display_name":"vertebral fracture risk","score":0.8140000104904175},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/denosumab-discontinuation","display_name":"denosumab discontinuation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/freedom-trial","display_name":"FREEDOM trial","score":0.9279999732971191},{"id":"https://openalex.org/keywords/radiographic-follow-up","display_name":"radiographic follow-up","score":0.47600001096725464},{"id":"https://openalex.org/keywords/treatment-duration-reduction","display_name":"treatment time reduction","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8802792429924011},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8045135140419006},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7684338092803955},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6611919403076172},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5888789892196655},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5876404047012329},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5006794929504395},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.48867490887641907},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4201659858226776},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39701730012893677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3520364761352539},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08114293217658997},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005592","descriptor_name":"Fracture Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005592","descriptor_name":"Fracture Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005592","descriptor_name":"Fracture Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005610","descriptor_name":"Freedom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005610","descriptor_name":"Freedom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005610","descriptor_name":"Freedom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D016103","descriptor_name":"Spinal Fractures","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058866","descriptor_name":"Osteoporotic Fractures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058866","descriptor_name":"Osteoporotic Fractures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D058866","descriptor_name":"Osteoporotic Fractures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jbmr.4705","doi":"https://doi.org/10.1002/jbmr.4705","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.4705","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.4705","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:36088628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36088628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10092421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10092421","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10092421/pdf/JBMR-37-2112.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Bone Miner Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jbmr.4705","doi":"https://doi.org/10.1002/jbmr.4705","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbmr.4705","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.4705","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Gender equality","id":"https://metadata.un.org/sdg/5","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295152004.pdf","grobid_xml":"https://content.openalex.org/works/W4295152004.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W13052883","https://openalex.org/W2078110114","https://openalex.org/W2087519912","https://openalex.org/W2134910437","https://openalex.org/W2160005424","https://openalex.org/W2163058169","https://openalex.org/W2220606005","https://openalex.org/W2584827529","https://openalex.org/W2594420699","https://openalex.org/W2619448414","https://openalex.org/W2764233026","https://openalex.org/W2766957057","https://openalex.org/W2787273932","https://openalex.org/W2982252132","https://openalex.org/W2982598109","https://openalex.org/W3014403794","https://openalex.org/W3030624497","https://openalex.org/W3041733543","https://openalex.org/W3093685566","https://openalex.org/W3094494322","https://openalex.org/W3116358764","https://openalex.org/W3120383256","https://openalex.org/W3133129058","https://openalex.org/W3145467021","https://openalex.org/W3160792603","https://openalex.org/W3162326693"],"related_works":["https://openalex.org/W2065962239","https://openalex.org/W2802583240","https://openalex.org/W2907630950","https://openalex.org/W4235887951","https://openalex.org/W4312129555","https://openalex.org/W2771455692","https://openalex.org/W2992270627","https://openalex.org/W2912223367","https://openalex.org/W3132139696","https://openalex.org/W2039052235"],"abstract_inverted_index":{"It":[0],"is":[1,21],"uncertain":[2],"whether":[3],"the":[4,74],"risk":[5,252,279],"of":[6,29,33,80,109,113,280,289,304,327,339],"vertebral":[7,12],"fracture":[8],"(VF)":[9],"and":[10,41,53,77,82,92,158,193,214,234,314,319,329,344],"multiple":[11],"fractures":[13],"(MVFs;":[14],"\u22652":[15],"VFs)":[16],"after":[17,96,126,282,296],"denosumab":[18],"(DMAb)":[19],"discontinuation":[20,144,284],"related":[22],"to":[23,106,310],"treatment":[24,150],"duration.":[25],"A":[26,101],"prior":[27],"analysis":[28,103,121],"Fracture":[30],"Reduction":[31],"Evaluation":[32],"Denosumab":[34],"in":[35,86],"Osteoporosis":[36],"Every":[37],"6":[38],"Months":[39],"(FREEDOM)":[40],"FREEDOM":[42,135,137],"Extension":[43,138],"trials":[44],"did":[45,64],"not":[46,65],"find":[47],"a":[48,241],"relationship":[49],"with":[50,88,115,250,262,286],"DMAb":[51,132,143,245,267,283,290,295],"duration":[52,246,288],"may":[54,299],"have":[55,66],"underreported":[56],"MVF":[57,83,204,251,281],"incidence":[58,76],"because":[59],"it":[60],"included":[61,122],"women":[62,123],"who":[63,124],"radiographs.":[67],"In":[68,240],"this":[69],"post":[70],"hoc":[71],"exploratory":[72],"analysis,":[73],"crude":[75],"annualized":[78,170],"rates":[79,171,202,221],"VF":[81],"were":[84,118,179,205,225],"determined":[85],"patients":[87,114,261],"\u22657":[89],"months'":[90],"follow-up":[91],"\u22651":[93],"spine":[94],"radiograph":[95],"discontinuing":[97],"placebo":[98,127],"or":[99,131,136,307],"DMAb.":[100,200],"multivariate":[102,242],"was":[104,146,247],"performed":[105],"identify":[107],"predictors":[108],"MVF.":[110,321],"Clinical":[111],"characteristics":[112],"\u22654":[116,223,263],"VFs":[117,224],"explored.":[119],"This":[120],"discontinued":[125],"(n":[128,139],"=":[129,140,156,163],"327)":[130],"either":[133],"from":[134],"425).":[141],"The":[142,278,324],"group":[145],"subsequently":[147],"dichotomized":[148],"by":[149,333],"duration:":[151],"short-term":[152,191],"(\u22643":[153],"years;":[154,161],"n":[155,162],"262)":[157],"long-term":[159,199],"(>3":[160],"213)":[164],"treatment.":[165,291],"For":[166],"any":[167],"VF,":[168],"exposure-adjusted":[169],"per":[172],"100":[173],"patient-years":[174],"(95%":[175,181,187,195,207,211,216,227,231,236],"confidence":[176],"interval":[177],"[CI])":[178],"9.4":[180],"CI,":[182,188,196,208,212,217,228,232,237,257],"6.4-13.4)":[183],"for":[184,190,198,203,222,342],"placebo,":[185],"6.7":[186],"4.2-10.1)":[189],"DMAb,":[192],"10.7":[194],"7.4-15)":[197],"Annualized":[201,220],"3.6":[206],"1.9-6.3),":[209],"2.9":[210],"1.4-5.4),":[213],"7.5":[215],"4.8-11.1),":[218],"respectively.":[219,239],"0.59":[226],"0.1-2.1),":[229,233],"0.57":[230],"3.34":[235],"1.7-6.0),":[238],"regression":[243],"model,":[244],"significantly":[248],"associated":[249],"(odds":[253],"ratio":[254],"3.0;":[255],"95%":[256],"1.4-6.5).":[258],"Of":[259],"15":[260],"VFs,":[264],"13":[265],"had":[266],"exposure":[268],"(mean":[269],"\u00b1":[270,275],"standard":[271],"deviation":[272],"[SD],":[273],"4.9":[274],"2.2":[276],"years).":[277],"increases":[285],"increased":[287],"Patients":[292],"transitioning":[293],"off":[294],"3":[297],"years":[298],"warrant":[300],"more":[301],"frequent":[302],"administration":[303],"zoledronic":[305],"acid":[306],"another":[308],"bisphosphonate":[309],"maintain":[311],"bone":[312,315],"turnover":[313],"mineral":[316],"density":[317],"(BMD)":[318],"prevent":[320],"\u00a9":[322],"2022":[323],"Authors.":[325],"Journal":[326],"Bone":[328,343],"Mineral":[330,345],"Research":[331,346],"published":[332],"Wiley":[334],"Periodicals":[335],"LLC":[336],"on":[337],"behalf":[338],"American":[340],"Society":[341],"(ASBMR).":[347]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":25}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}