{"id":"https://openalex.org/W4295136809","doi":"https://doi.org/10.1016/j.crmeth.2022.100292","title":"TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy","display_name":"TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4295136809","doi":"https://doi.org/10.1016/j.crmeth.2022.100292","pmid":"https://pubmed.ncbi.nlm.nih.gov/36160048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500001"},"language":"en","primary_location":{"id":"doi:10.1016/j.crmeth.2022.100292","doi":"https://doi.org/10.1016/j.crmeth.2022.100292","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2022.100292","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667237522001746/pdf","source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2667237522001746/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088686115","display_name":"Simon A. Levy","orcid":"https://orcid.org/0000-0002-4623-5716","observed_orcids":["https://orcid.org/0000-0002-4623-5716"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon A. Levy","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076411103","display_name":"Gabrielle Zuniga","orcid":"https://orcid.org/0000-0003-2118-1990","observed_orcids":["https://orcid.org/0000-0003-2118-1990"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Zuniga","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087732023","display_name":"Elias M. Gonzalez","orcid":"https://orcid.org/0000-0003-1783-5664","observed_orcids":["https://orcid.org/0000-0003-1783-5664"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias M. Gonzalez","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067778342","display_name":"David Butler","orcid":"https://orcid.org/0000-0002-0256-1595","observed_orcids":["https://orcid.org/0000-0002-0256-1595"]},"institutions":[{"id":"https://openalex.org/I4210105225","display_name":"Neural Stem Cell Institute","ror":"https://ror.org/00x6sm138","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Butler","raw_affiliation_strings":["Neural Stem Cell Institute, Rensselaer, NY 12144, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neural Stem Cell Institute, Rensselaer, NY 12144, USA","institution_ids":["https://openalex.org/I4210105225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084751732","display_name":"Sally Temple","orcid":"https://orcid.org/0000-0001-7301-783X","observed_orcids":["https://orcid.org/0000-0001-7301-783X"]},"institutions":[{"id":"https://openalex.org/I4210105225","display_name":"Neural Stem Cell Institute","ror":"https://ror.org/00x6sm138","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally Temple","raw_affiliation_strings":["Neural Stem Cell Institute, Rensselaer, NY 12144, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neural Stem Cell Institute, Rensselaer, NY 12144, USA","institution_ids":["https://openalex.org/I4210105225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044174930","display_name":"Bess E Frost","orcid":"https://orcid.org/0000-0002-1212-8138","observed_orcids":["https://orcid.org/0000-0002-1212-8138"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bess Frost","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":"https://orcid.org/0000-0002-1212-8138","affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044174930"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.6185,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6462335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"2","issue":"9","first_page":"100292","last_page":"100292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hsp90-inhibition","display_name":"HSP90 inhibition","score":0.9940000176429749},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.9223788976669312},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6852632761001587},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5950141549110413},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5947130918502808},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.587729811668396},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.5552265644073486},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5268644094467163},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5252073407173157},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5129784941673279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5004966259002686},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.46020573377609253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.433917760848999},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41979360580444336},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3550211787223816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2755822539329529},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2614904046058655},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.1955297291278839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09667301177978516},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09634089469909668},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.crmeth.2022.100292","doi":"https://doi.org/10.1016/j.crmeth.2022.100292","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2022.100292","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667237522001746/pdf","source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9500001","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500001","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep Methods","raw_type":"Text"},{"id":"pmid:36160048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36160048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports methods","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f7d9edc9e434404193eb6b5988e2cd67","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f7d9edc9e434404193eb6b5988e2cd67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports: Methods, Vol 2, Iss 9, Pp 100292- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.crmeth.2022.100292","doi":"https://doi.org/10.1016/j.crmeth.2022.100292","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.crmeth.2022.100292","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2667237522001746/pdf","source":{"id":"https://openalex.org/S4210214705","display_name":"Cell Reports Methods","issn_l":"2667-2375","issn":["2667-2375"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports Methods","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2172993490","display_name":"South Texas Medical Scientist Training Program (STX-MSTP)","funder_award_id":"T32GM113896","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G330731456","display_name":null,"funder_award_id":"TR002647","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G5551878694","display_name":null,"funder_award_id":"NS082145","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G571033708","display_name":null,"funder_award_id":"GM113896","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6099097669","display_name":null,"funder_award_id":"IA 52242","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6437977765","display_name":"Cell Type and Regional Vulnerability in Frontotemporal Dementia","funder_award_id":"RF1NS123568","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6527784256","display_name":null,"funder_award_id":"AG021890","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6601323369","display_name":"NRSA Training Core (TL1)","funder_award_id":"TL1TR002647","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8659715656","display_name":"Training Grant on the Biology of Aging","funder_award_id":"T32AG021890","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000089312","display_name":null,"funder_award_id":"NIH P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000884549","display_name":"Integrated Graduate Training Program in Neuroscience, UTHSCSA","funder_award_id":"T32NS082145","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295136809.pdf","grobid_xml":"https://content.openalex.org/works/W4295136809.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1480786153","https://openalex.org/W1511517753","https://openalex.org/W1981127983","https://openalex.org/W1987549963","https://openalex.org/W1989208474","https://openalex.org/W1993023011","https://openalex.org/W1993050837","https://openalex.org/W2000437732","https://openalex.org/W2005755021","https://openalex.org/W2011637489","https://openalex.org/W2025394006","https://openalex.org/W2038120434","https://openalex.org/W2052742260","https://openalex.org/W2058519323","https://openalex.org/W2081966615","https://openalex.org/W2082429191","https://openalex.org/W2087063545","https://openalex.org/W2094676199","https://openalex.org/W2099340107","https://openalex.org/W2099540110","https://openalex.org/W2113485885","https://openalex.org/W2140631432","https://openalex.org/W2143997071","https://openalex.org/W2160034474","https://openalex.org/W2519516239","https://openalex.org/W2747080631","https://openalex.org/W2768415339","https://openalex.org/W2777639897","https://openalex.org/W2924714335","https://openalex.org/W2981351500","https://openalex.org/W3002977256","https://openalex.org/W3011666962","https://openalex.org/W3147722354","https://openalex.org/W6792925374","https://openalex.org/W6816066816"],"related_works":["https://openalex.org/W7169494748","https://openalex.org/W7127343443","https://openalex.org/W285827561","https://openalex.org/W2744780223","https://openalex.org/W2095379951","https://openalex.org/W2236899712","https://openalex.org/W7099514652","https://openalex.org/W7096378436","https://openalex.org/W4401412384","https://openalex.org/W2152841877"],"abstract_inverted_index":{"Tau":[0],"protein":[1],"aggregates":[2],"are":[3],"a":[4,10,25,56,118],"defining":[5],"neuropathological":[6],"feature":[7],"of":[8,12,29,81,88,102,128],"\u201ctauopathies,\u201d":[9],"group":[11],"neurodegenerative":[13],"disorders":[14],"that":[15,78,124],"include":[16],"Alzheimer\u2019s":[17],"disease.":[18],"In":[19],"the":[20,64,100,126,129],"current":[21],"study,":[22],"we":[23,35],"develop":[24],"Drosophila":[26,66,130],"split-luciferase-based":[27],"sensor":[28],"tau-tau":[30],"interaction.":[31],"This":[32],"model,":[33],"which":[34],"term":[36],"\u201ctauLUM,\u201d":[37],"allows":[38],"investigators":[39],"to":[40,70,133],"quantify":[41],"tau":[42,91,136],"multimerization":[43,92],"at":[44],"individual":[45],"time":[46],"points":[47],"or":[48,85],"longitudinally":[49],"in":[50,55,63,96,120],"adult,":[51],"living":[52],"animals":[53],"housed":[54],"96-well":[57],"plate.":[58],"TauLUM":[59],"causes":[60],"cell":[61,94],"death":[62,95],"adult":[65],"brain":[67],"and":[68,73,93,108],"responds":[69],"both":[71],"pharmacological":[72,86],"genetic":[74,109],"interventions.":[75],"We":[76],"find":[77],"transgenic":[79],"expression":[80],"an":[82],"anti-tau":[83],"intrabody":[84],"inhibition":[87],"HSP90":[89],"reduces":[90],"tauLUM":[97,116],"flies,":[98],"establishing":[99],"suitability":[101],"this":[103],"system":[104],"for":[105],"future":[106],"drug":[107],"modifier":[110],"screening.":[111],"Overall,":[112],"our":[113],"studies":[114],"position":[115],"as":[117],"powerful":[119],"vivo":[121],"discovery":[122],"platform":[123],"leverages":[125],"advantages":[127],"model":[131],"organism":[132],"better":[134],"understand":[135],"multimerization.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-11T00:00:00"}
