{"id":"https://openalex.org/W4295129692","doi":"https://doi.org/10.2131/fts.9.117","title":"Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation","display_name":"Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4295129692","doi":"https://doi.org/10.2131/fts.9.117"},"language":"en","primary_location":{"id":"doi:10.2131/fts.9.117","doi":"https://doi.org/10.2131/fts.9.117","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.9.117","pdf_url":"https://www.jstage.jst.go.jp/article/fts/9/4/9_117/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/fts/9/4/9_117/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068593141","display_name":"Maori Kono","orcid":"https://orcid.org/0009-0004-9821-9656","observed_orcids":["https://orcid.org/0009-0004-9821-9656"]},"institutions":[{"id":"https://openalex.org/I4405265512","display_name":"Mandom Corp. (Japan)","ror":"https://ror.org/0517pdh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265512"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maori Kono","raw_affiliation_strings":["Laboratory of advanced cosmetic science, Graduate School of Pharmaceutical Sciences, Osaka University","Product Assurance Division, Mandom Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of advanced cosmetic science, Graduate School of Pharmaceutical Sciences, Osaka University","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Product Assurance Division, Mandom Corporation","institution_ids":["https://openalex.org/I4405265512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074916834","display_name":"Tomoaki Okuda","orcid":"https://orcid.org/0000-0002-5057-9044","observed_orcids":["https://orcid.org/0000-0002-5057-9044"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Okuda","raw_affiliation_strings":["Faculty of Science and Technology, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029195277","display_name":"Masayuki Takaishi","orcid":"https://orcid.org/0009-0000-3191-0603","observed_orcids":["https://orcid.org/0009-0000-3191-0603"]},"institutions":[{"id":"https://openalex.org/I4405265512","display_name":"Mandom Corp. (Japan)","ror":"https://ror.org/0517pdh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265512"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Takaishi","raw_affiliation_strings":["Laboratory of advanced cosmetic science, Graduate School of Pharmaceutical Sciences, Osaka University","Product Assurance Division, Mandom Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of advanced cosmetic science, Graduate School of Pharmaceutical Sciences, Osaka University","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Product Assurance Division, Mandom Corporation","institution_ids":["https://openalex.org/I4405265512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046600020","display_name":"Hidefumi Ikeda","orcid":"https://orcid.org/0009-0008-8506-9790","observed_orcids":["https://orcid.org/0009-0008-8506-9790"]},"institutions":[{"id":"https://openalex.org/I4405265512","display_name":"Mandom Corp. (Japan)","ror":"https://ror.org/0517pdh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265512"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidefumi Ikeda","raw_affiliation_strings":["Product Assurance Division, Mandom Corporation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Product Assurance Division, Mandom Corporation","institution_ids":["https://openalex.org/I4405265512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087613632","display_name":"Nami Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nami Ishihara","raw_affiliation_strings":["Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010566917","display_name":"Yasuhiro Ishihara","orcid":"https://orcid.org/0000-0001-9751-7660","observed_orcids":["https://orcid.org/0000-0001-9751-7660"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Ishihara","raw_affiliation_strings":["Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2386,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44007506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"4","first_page":"117","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.41850000619888306,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.41850000619888306,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.3472000062465668,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pm2-5","display_name":"PM2.5","score":0.8769999742507935},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.902999997138977},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.6990000009536743},{"id":"https://openalex.org/keywords/dermal-exposure","display_name":"dermal exposure","score":0.6010000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chemokine-secretion","display_name":"chemokine secretion","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/camellia-sinensis","display_name":"Camellia sinensis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/argania-spinosa","display_name":"Argania spinosa","score":0.9919999837875366},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.8880000114440918},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2992816389","wikidata":"https://www.wikidata.org/wiki/Q101815","display_name":"Camellia sinensis","level":2,"score":0.8244829177856445},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6730053424835205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5888302326202393},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5333924889564514},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.472545862197876},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4543057084083557},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.36052244901657104},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.32528212666511536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30621474981307983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2774083614349365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.055723369121551514},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0555860698223114},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2131/fts.9.117","doi":"https://doi.org/10.2131/fts.9.117","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.9.117","pdf_url":"https://www.jstage.jst.go.jp/article/fts/9/4/9_117/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2131/fts.9.117","doi":"https://doi.org/10.2131/fts.9.117","is_oa":true,"landing_page_url":"https://doi.org/10.2131/fts.9.117","pdf_url":"https://www.jstage.jst.go.jp/article/fts/9/4/9_117/_pdf","source":{"id":"https://openalex.org/S2764788834","display_name":"Fundamental Toxicological Sciences","issn_l":"2189-115X","issn":["2189-115X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamental Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2865022124","display_name":"Disruption of brain chemokine networks and impaired neural circuit formation due to developmental exposure to chemicals","funder_award_id":"20H04341","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4765767118","display_name":null,"funder_award_id":"20H04341 to YI","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4950213239","display_name":null,"funder_award_id":"JPMEERF20205007","funder_id":"https://openalex.org/F4320315051","funder_display_name":"Environmental Restoration and Conservation Agency"},{"id":"https://openalex.org/G7692177386","display_name":null,"funder_award_id":"JPMEERF20205007","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8131333863","display_name":null,"funder_award_id":"JPMEERF20165051","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8889447256","display_name":null,"funder_award_id":"JPMEERF20165051","funder_id":"https://openalex.org/F4320315051","funder_display_name":"Environmental Restoration and Conservation Agency"}],"funders":[{"id":"https://openalex.org/F4320315051","display_name":"Environmental Restoration and Conservation Agency","ror":"https://ror.org/01c9agy38"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295129692.pdf","grobid_xml":"https://content.openalex.org/works/W4295129692.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1992744358","https://openalex.org/W1998743558","https://openalex.org/W2004194302","https://openalex.org/W2037113689","https://openalex.org/W2103893521","https://openalex.org/W2135116979","https://openalex.org/W2168400677","https://openalex.org/W2318698569","https://openalex.org/W2491160856","https://openalex.org/W2543722953","https://openalex.org/W2792025613","https://openalex.org/W2977594772","https://openalex.org/W2994794704","https://openalex.org/W3082641911","https://openalex.org/W3145878117","https://openalex.org/W3157177905","https://openalex.org/W3167823505","https://openalex.org/W3174852841","https://openalex.org/W3194081660","https://openalex.org/W3195959100","https://openalex.org/W4283216955","https://openalex.org/W4285170350","https://openalex.org/W4285386488"],"related_works":["https://openalex.org/W3149541811","https://openalex.org/W2806476502","https://openalex.org/W2998385027","https://openalex.org/W4386790021","https://openalex.org/W4410866798","https://openalex.org/W4415656719","https://openalex.org/W2912921529","https://openalex.org/W4309607998","https://openalex.org/W2971619769","https://openalex.org/W4285386488"],"abstract_inverted_index":{"Skin":[0],"is":[1],"the":[2,17,20,39,52,101,114],"primary":[3],"tissue":[4],"exposed":[5],"to":[6,128],"ambient":[7],"air":[8,136],"pollution":[9],"because":[10],"it":[11],"acts":[12],"as":[13,66],"an":[14],"interface":[15],"between":[16],"body":[18],"and":[19,34,58,70,81,121],"surrounding":[21],"atmosphere.":[22],"We":[23,46],"previously":[24],"reported":[25],"that":[26,51,132],"particulate":[27],"matter":[28],"2.5":[29],"(PM2.5)":[30],"induced":[31,76],"oxidative":[32],"stress":[33],"subsequent":[35],"chemokine":[36],"release":[37,80],"in":[38,48,84],"human":[40,85],"epidermis,":[41],"followed":[42],"by":[43,68,106],"neutrophil":[44,82],"chemotaxis.":[45],"identified":[47],"this":[49],"study":[50],"leaf":[53,91],"extracts":[54,92,111,124],"from":[55,93,116,135],"Camellia":[56,94,119],"sinensis":[57,95,120],"Argania":[59,97,122],"spinosa":[60,98,123],"showed":[61],"high":[62],"radical":[63],"scavenging":[64],"activity":[65],"evaluated":[67],"2,2-diphenyl-1-(2,4,6-trinitrophenyl)-hydrazinyl":[69],"2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic":[71],"acid":[72],"assays.":[73],"PM2.5":[74,117],"exposure":[75],"lipid":[77],"peroxidation,":[78],"IL-8":[79],"migration":[83],"3-dimensional":[86],"cultured":[87],"epidermis.":[88],"Pretreatment":[89],"with":[90],"or":[96],"significantly":[99],"suppressed":[100],"above":[102],"harmful":[103],"effects":[104],"elicited":[105],"PM2.5.":[107],"Taken":[108],"together,":[109],"both":[110],"can":[112],"protect":[113],"epidermis":[115],"exposure.":[118],"could":[125],"be":[126],"added":[127],"a":[129],"novel":[130],"cosmetic":[131],"protects":[133],"skin":[134],"pollution.":[137]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-09-11T00:00:00"}
