{"id":"https://openalex.org/W4295117927","doi":"https://doi.org/10.3389/fimmu.2022.939829","title":"Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of social jet-lag and sleep debt","display_name":"Immune disruptions and night shift work in hospital healthcare professionals: The intricate effects of social jet-lag and sleep debt","publication_year":2022,"publication_date":"2022-09-09","ids":{"openalex":"https://openalex.org/W4295117927","doi":"https://doi.org/10.3389/fimmu.2022.939829","pmid":"https://pubmed.ncbi.nlm.nih.gov/36164341","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9509137"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.939829","doi":"https://doi.org/10.3389/fimmu.2022.939829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.939829","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2022.939829","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047791181","display_name":"Brice Faraut","orcid":"https://orcid.org/0000-0002-2317-8712","observed_orcids":["https://orcid.org/0000-0002-2317-8712"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Brice Faraut","raw_affiliation_strings":["APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4403386739"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080075251","display_name":"Emilie Cordina\u2010Duverger","orcid":"https://orcid.org/0000-0002-1146-3735","observed_orcids":["https://orcid.org/0000-0002-1146-3735"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Cordina-Duverger","raw_affiliation_strings":["Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4210103698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032529006","display_name":"Guillen Aristizabal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillen Aristizabal","raw_affiliation_strings":["Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4210103698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014789840","display_name":"Catherine Drogou","orcid":"https://orcid.org/0000-0002-9208-4437","observed_orcids":["https://orcid.org/0000-0002-9208-4437"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Drogou","raw_affiliation_strings":["Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), Unit\u00e9 Fatigue et Vigilance, Br\u00e9tigny sur Orge, France","Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), Unit\u00e9 Fatigue et Vigilance, Br\u00e9tigny sur Orge, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014089656","display_name":"Caroline Gauriau","orcid":"https://orcid.org/0000-0002-2998-028X","observed_orcids":["https://orcid.org/0000-0002-2998-028X"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Gauriau","raw_affiliation_strings":["APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4403386739"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034261775","display_name":"Fabien Sauvet","orcid":"https://orcid.org/0000-0002-4298-2319","observed_orcids":["https://orcid.org/0000-0002-4298-2319"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Sauvet","raw_affiliation_strings":["Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), Unit\u00e9 Fatigue et Vigilance, Br\u00e9tigny sur Orge, France","Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), Unit\u00e9 Fatigue et Vigilance, Br\u00e9tigny sur Orge, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078259466","display_name":"Fran\u00e7is L\u00e9vi","orcid":"https://orcid.org/0000-0003-1364-7463","observed_orcids":["https://orcid.org/0000-0003-1364-7463"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]},{"id":"https://openalex.org/I4210127762","display_name":"Coventry (United Kingdom)","ror":"https://ror.org/030nd5313","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210127762"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]},{"id":"https://openalex.org/I4405255658","display_name":"Chronoth\u00e9rapie, cancers et transplantation","ror":"https://ror.org/038x32w97","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I4405255658"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Francis L\u00e9vi","raw_affiliation_strings":["Cancer Chronotherapy Team, Cancer Research Centre, Division of Biomedical Sciences, Warwick Medical School, Coventry, United Kingdom","Hepato-Biliary Center, H\u00f4pital Paul Brousse, Villejuif, France","UPR \"Chronoth\u00e9rapie, Cancers, et Transplantation\", Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Saclay, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Chronotherapy Team, Cancer Research Centre, Division of Biomedical Sciences, Warwick Medical School, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362","https://openalex.org/I4210127762"]},{"raw_affiliation_string":"Hepato-Biliary Center, H\u00f4pital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"UPR \"Chronoth\u00e9rapie, Cancers, et Transplantation\", Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Saclay, Villejuif, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4405255658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016310387","display_name":"Damien L\u00e9ger","orcid":"https://orcid.org/0000-0003-1168-480X","observed_orcids":["https://orcid.org/0000-0003-1168-480X"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4403386739","display_name":"Sommeil, vigilance, fatigue et sant\u00e9 publique","ror":"https://ror.org/044dv9p07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Damien L\u00e9ger","raw_affiliation_strings":["APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APHP, APHP-Centre Universit\u00e9 de Paris, H\u00f4tel Dieu, Centre du Sommeil et de La Vigilance, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4403386739"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, VIFASOM (UPR 7330 Vigilance Fatigue, Sommeil et Sant\u00e9 Publique), Paris, France","institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4403386739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036750796","display_name":"Pascal Gu\u00e9nel","orcid":"https://orcid.org/0000-0002-8359-518X","observed_orcids":["https://orcid.org/0000-0002-8359-518X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210103698","display_name":"Centre de recherche en Epid\u00e9miologie et Sant\u00e9 des Populations","ror":"https://ror.org/01ed4t417","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4210097159","https://openalex.org/I4210103698","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Gu\u00e9nel","raw_affiliation_strings":["Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, CESP (Center for research in Epidemiology and Population Health), Team Exposome and Heredity, University Paris-Saclay, Gustave-Roussy, Villejuif, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I4210103698"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047791181"],"corresponding_institution_ids":["https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4403386739"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"EUR","value_usd":3181},"fwci":5.7396,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.96260939,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"13","issue":null,"first_page":"939829","last_page":"939829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/night-shift-work","display_name":"night shift work","score":0.9769999980926514},{"id":"https://openalex.org/keywords/rotating-shift-work","display_name":"rotating shifts","score":0.5899999737739563},{"id":"https://openalex.org/keywords/social-jetlag","display_name":"social jetlag","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sleep-debt","display_name":"sleep debt","score":0.9869999885559082},{"id":"https://openalex.org/keywords/circadian-misalignment","display_name":"circadian misalignment","score":0.9419999718666077},{"id":"https://openalex.org/keywords/immune-markers","display_name":"immunological markers","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nurses","display_name":"nurses","score":0.6919999718666077},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8349999785423279},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sleep-duration","display_name":"sleep duration","score":0.6039999723434448},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/occupational-health","display_name":"occupational health","score":0.531000018119812},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.4259999990463257},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.780811071395874},{"id":"https://openalex.org/C2776176791","wikidata":"https://www.wikidata.org/wiki/Q1068683","display_name":"Shift work","level":2,"score":0.7605716586112976},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.7423228025436401},{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.736899733543396},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5597707033157349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49788570404052734},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.4743439257144928},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.4379979372024536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40683943033218384},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3422464430332184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22366076707839966},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15354841947555542},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12778913974761963},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073577","descriptor_name":"Shift Work Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003695","descriptor_name":"Delivery of Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014940","descriptor_name":"Work Schedule Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020179","descriptor_name":"Jet Lag Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2022.939829","doi":"https://doi.org/10.3389/fimmu.2022.939829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.939829","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9509137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9509137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:36164341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36164341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:wrap.warwick.ac.uk:169559","doi":null,"is_oa":false,"landing_page_url":"https://wrap.warwick.ac.uk/169559/2/WRAP-Immune-disruptions-night-shift-work-hospital-healthcare-professionals-social-jet-lag-sleep-debt-22.pdf","pdf_url":"https://wrap.warwick.ac.uk/169559/2/WRAP-Immune-disruptions-night-shift-work-hospital-healthcare-professionals-social-jet-lag-sleep-debt-22.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4e7f204669e141c6ac95c5d1a93eaa84","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4e7f204669e141c6ac95c5d1a93eaa84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.939829","doi":"https://doi.org/10.3389/fimmu.2022.939829","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.939829","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320324529","display_name":"Agence Nationale de S\u00e9curit\u00e9 Sanitaire de l\u2019Alimentation, de l\u2019Environnement et du Travail","ror":"https://ror.org/0471kz689"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W129279618","https://openalex.org/W1511275384","https://openalex.org/W1760402555","https://openalex.org/W1928049461","https://openalex.org/W1965011825","https://openalex.org/W1970138464","https://openalex.org/W1987150557","https://openalex.org/W1989351248","https://openalex.org/W2005810962","https://openalex.org/W2010226707","https://openalex.org/W2012435382","https://openalex.org/W2020885061","https://openalex.org/W2024021647","https://openalex.org/W2026050411","https://openalex.org/W2030197272","https://openalex.org/W2035535447","https://openalex.org/W2039956956","https://openalex.org/W2043698417","https://openalex.org/W2049329559","https://openalex.org/W2049777419","https://openalex.org/W2052866392","https://openalex.org/W2056229820","https://openalex.org/W2065479473","https://openalex.org/W2066703225","https://openalex.org/W2071400945","https://openalex.org/W2091912666","https://openalex.org/W2108860104","https://openalex.org/W2119434070","https://openalex.org/W2126846966","https://openalex.org/W2128485372","https://openalex.org/W2129221732","https://openalex.org/W2129670950","https://openalex.org/W2132211535","https://openalex.org/W2132471961","https://openalex.org/W2135303822","https://openalex.org/W2140832481","https://openalex.org/W2145656092","https://openalex.org/W2163553356","https://openalex.org/W2170718300","https://openalex.org/W2171647161","https://openalex.org/W2189028582","https://openalex.org/W2194186997","https://openalex.org/W2270148235","https://openalex.org/W2413978766","https://openalex.org/W2422798254","https://openalex.org/W2512516821","https://openalex.org/W2599544301","https://openalex.org/W2612132639","https://openalex.org/W2619017063","https://openalex.org/W2746269430","https://openalex.org/W2751780586","https://openalex.org/W2774609933","https://openalex.org/W2788454556","https://openalex.org/W2798049216","https://openalex.org/W2802571577","https://openalex.org/W2843902902","https://openalex.org/W2898559052","https://openalex.org/W2902803183","https://openalex.org/W2915822548","https://openalex.org/W2921419167","https://openalex.org/W2921990773","https://openalex.org/W2927147597","https://openalex.org/W2953383732","https://openalex.org/W2991982517","https://openalex.org/W2996301129","https://openalex.org/W3033347524","https://openalex.org/W3033741987","https://openalex.org/W3041598772","https://openalex.org/W3044949069","https://openalex.org/W3133775656","https://openalex.org/W3192675792","https://openalex.org/W4283575264"],"related_works":["https://openalex.org/W4322732528","https://openalex.org/W4294192104","https://openalex.org/W2157778907","https://openalex.org/W3208753592","https://openalex.org/W2120101711","https://openalex.org/W3086932486","https://openalex.org/W2270148235","https://openalex.org/W2991982517","https://openalex.org/W3134054323","https://openalex.org/W7204457790"],"abstract_inverted_index":{"Objectives:":[0],"We":[1],"aimed":[2],"to":[3,326,333,353],"examine":[4],"the":[5,68,73,77,201,212,216,221,247],"effects":[6],"of":[7,72,160,194,230,261,286,330,347],"circadian":[8,161,334],"and":[9,23,44,55,70,79,98,108,110,119,128,145,154,186,239,249,265,293,299,310,319,336,355],"sleep":[10,54,136,149,174,180,263,288,291,314,337],"rhythm":[11],"disruptions":[12],"on":[13,52,87,268],"immune":[14,125,195,269,331,348],"biomarkers":[15,196,270],"among":[16,205,272,277],"hospital":[17],"healthcare":[18],"professionals":[19],"working":[20,30,61],"night":[21,34,111,114,170,226,278,340,360],"shifts":[22,46],"rotating":[24,41],"day":[25,39,93,103,168,206,273],"shifts.":[26],"Methods:":[27],"Hospital":[28],"nurses":[29],"either":[31],"as":[32,38,132,134],"permanent":[33],"shifters":[35,40,94,104,115,171,207],"(n=95)":[36],"or":[37],"between":[42],"morning":[43,90],"afternoon":[45,100],"(n=96)":[47],"kept":[48],"a":[49,59,283,304,311],"daily":[50],"diary":[51],"their":[53],"work":[56,88,142],"schedules":[57],"over":[58],"full":[60],"week.":[62],"Blood":[63],"samples":[64],"were":[65,81,163,198,241],"collected":[66],"at":[67,96,106,117,243,253],"beginning":[69],"end":[71],"last":[74],"shift":[75,91,101,112],"during":[76,141,215,246],"week,":[78],"participants":[80],"categorized":[82],"into":[83],"three":[84],"groups":[85],"based":[86],"shift:":[89],"(39":[92],"sampled":[95,105,116],"7:00":[97],"14:00),":[99],"(57":[102],"14:00":[107],"21:00),":[109],"(95":[113],"21:00":[118],"7:00).":[120],"Circulating":[121],"blood":[122,228],"counts":[123],"in":[124,211,220,225,339,359],"cells,":[126,234],"interleukin-6":[127,240,309],"C-reactive":[129],"protein":[130],"concentrations":[131,197,229,271],"well":[133],"total":[135,231,287,297,313],"time":[137,289,315],"per":[138],"24":[139],"hours":[140],"days":[143,147],"(TST24w)":[144],"free":[146],"(TST24f),":[148],"debt":[150,181,292,338],"(TST24f":[151],"-":[152],"TST24w)":[153],"social":[155,187,266,294,305],"jet-lag":[156,188,267,295,306],"(a":[157],"behavioral":[158],"proxy":[159],"misalignment)":[162],"assessed.":[164],"Results:":[165],"Compared":[166],"with":[167,200],"shifters,":[169,227,279],"had":[172],"shorter":[173],"duration":[175],"(TST24w=5.4":[176],"\u00b1":[177,183,190],"1.4h),":[178],"greater":[179],"(3.2":[182],"1.4":[184],"h)":[185],"(6.7":[189],"2.4":[191],"h).":[192],"Variations":[193],"consistent":[199],"expected":[202],"diurnal":[203],"variations":[204],"(i.e.,":[208],"low":[209],"level":[210],"morning,":[213],"increase":[214,351],"day,":[217],"peak":[218],"value":[219],"evening).":[222],"By":[223],"contrast,":[224,276],"lymphocytes,":[232],"T-helper":[233,300],"cytotoxic":[235],"T-cells,":[236],"memory":[237],"B-cells":[238],"lower":[242],"21:00,":[244],"increased":[245],"night,":[248],"reached":[250],"higher":[251],"values":[252],"7:00.":[254],"Multivariate":[255],"analyses":[256,281],"ruled":[257],"out":[258],"significant":[259],"impact":[260],"TST24w,":[262],"debt,":[264],"shifters.":[274,341],"In":[275],"multivariate":[280],"indicated":[282],"combined":[284],"effect":[285,307,316],"(TST24w),":[290],"for":[296,308,317],"lymphocytes":[298],"cells":[301,349],"but":[302],"only":[303],"single":[312],"neutrophil":[318],"B-Cells.":[320],"Conclusions:":[321],"Altogether,":[322],"our":[323],"results":[324],"point":[325],"intricate":[327],"response":[328],"patterns":[329],"rhythms":[332],"misalignment":[335],"Specifically,":[342],"these":[343],"altered":[344],"pattern":[345],"expressions":[346],"may":[350],"vulnerability":[352],"infections":[354],"reduce":[356],"vaccination":[357],"efficiency":[358],"workers.":[361]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-10T00:00:00"}