{"id":"https://openalex.org/W4295093333","doi":"https://doi.org/10.3389/fphar.2022.946058","title":"Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis","display_name":"Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis","publication_year":2022,"publication_date":"2022-09-09","ids":{"openalex":"https://openalex.org/W4295093333","doi":"https://doi.org/10.3389/fphar.2022.946058","pmid":"https://pubmed.ncbi.nlm.nih.gov/36160387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500448"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2022.946058","doi":"https://doi.org/10.3389/fphar.2022.946058","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946058","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.946058/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.946058/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113577754","display_name":"Yuan Yuan","orcid":"https://orcid.org/0009-0002-9540-2100","observed_orcids":["https://orcid.org/0009-0002-9540-2100","https://orcid.org/0009-0006-5172-8570","https://orcid.org/0009-0008-8264-2205","https://orcid.org/0009-0009-1997-4343"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102898962","display_name":"Jinmeng Li","orcid":"https://orcid.org/0000-0001-6589-3610","observed_orcids":["https://orcid.org/0000-0001-6589-3610"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinmeng Li","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752510","display_name":"Yanhong Chen","orcid":"https://orcid.org/0000-0002-9965-5773","observed_orcids":["https://orcid.org/0000-0002-9965-5773"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhong Chen","raw_affiliation_strings":["Laboratory Animal Center of Zhejiang University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Center of Zhejiang University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103251536","display_name":"Qingshan Cai","orcid":"https://orcid.org/0000-0002-2611-7640","observed_orcids":["https://orcid.org/0000-0002-2611-7640"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingshan Cai","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081643835","display_name":"Yingying Xu","orcid":"https://orcid.org/0000-0003-4924-9379","observed_orcids":["https://orcid.org/0000-0003-4924-9379"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Xu","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073262731","display_name":"Luting Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luting Lin","raw_affiliation_strings":["College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074839968","display_name":"Yazhen Lang","orcid":"https://orcid.org/0000-0003-1878-2891","observed_orcids":["https://orcid.org/0000-0003-1878-2891"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yazhen Lang","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070121197","display_name":"Suhang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhang Guo","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017576758","display_name":"Ruoying Zhang","orcid":"https://orcid.org/0000-0003-1076-3805","observed_orcids":["https://orcid.org/0000-0003-1076-3805"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruoying Zhang","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101794598","display_name":"Xinjun Cai","orcid":"https://orcid.org/0000-0003-3606-8819","observed_orcids":["https://orcid.org/0000-0003-3606-8819"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinjun Cai","raw_affiliation_strings":["Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang University School of Medicine, Affiliated Hangzhou Chest Hospital, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017576758","https://openalex.org/A5101794598"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.1509,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79594279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"946058","last_page":"946058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0982000008225441,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.7760000228881836},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8019999861717224},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7239999771118164},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.7200000286102295},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.796999990940094},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.9168049097061157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.730635941028595},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6566913723945618},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6297844052314758},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5850217342376709},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5733420252799988},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5233749151229858},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5065187215805054},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3227577805519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11578533053398132},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.09578806161880493},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08971545100212097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08195176720619202},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.06487208604812622},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2022.946058","doi":"https://doi.org/10.3389/fphar.2022.946058","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946058","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.946058/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9500448","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9500448","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:36160387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36160387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3ddf8fae6cd041a8ad1661eb317b6df7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3ddf8fae6cd041a8ad1661eb317b6df7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2022.946058","doi":"https://doi.org/10.3389/fphar.2022.946058","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2022.946058","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2022.946058/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3844275834","display_name":null,"funder_award_id":"82003669","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338199","display_name":"Medical Science and Technology Project of Zhejiang Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4295093333.pdf","grobid_xml":"https://content.openalex.org/works/W4295093333.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1784352764","https://openalex.org/W1990008022","https://openalex.org/W2066538679","https://openalex.org/W2098989644","https://openalex.org/W2114110528","https://openalex.org/W2130293503","https://openalex.org/W2134972630","https://openalex.org/W2138793764","https://openalex.org/W2151539341","https://openalex.org/W2156273977","https://openalex.org/W2171152889","https://openalex.org/W2746909161","https://openalex.org/W2794388557","https://openalex.org/W2898922831","https://openalex.org/W2899101800","https://openalex.org/W2901676159","https://openalex.org/W2903804211","https://openalex.org/W2904326384","https://openalex.org/W2947664464","https://openalex.org/W2948615623","https://openalex.org/W2991551920","https://openalex.org/W2998634777","https://openalex.org/W3009599329","https://openalex.org/W3010945518","https://openalex.org/W3038356802","https://openalex.org/W3041476499","https://openalex.org/W3045271288","https://openalex.org/W3108150642","https://openalex.org/W3111039366","https://openalex.org/W3151928973","https://openalex.org/W3158131484","https://openalex.org/W3187561692","https://openalex.org/W3212457907","https://openalex.org/W4200542594","https://openalex.org/W4200623771","https://openalex.org/W4211144518","https://openalex.org/W4220698480","https://openalex.org/W4221053065","https://openalex.org/W4282025469","https://openalex.org/W4283155986","https://openalex.org/W4283164733"],"related_works":["https://openalex.org/W7165695808","https://openalex.org/W4283360727","https://openalex.org/W4416353016","https://openalex.org/W7202264809","https://openalex.org/W4410046801","https://openalex.org/W4387981532","https://openalex.org/W4296100753","https://openalex.org/W1987864694","https://openalex.org/W4415538253","https://openalex.org/W4413104650"],"abstract_inverted_index":{"Multidrug-resistant":[0],"tuberculosis":[1],"(MDR-TB)":[2],"remains":[3],"a":[4,60,74,132],"main":[5],"global":[6],"health":[7],"concern":[8],"as":[9],"there":[10],"is":[11,103,209],"no":[12],"comprehensive":[13],"therapeutic":[14,23],"intervention":[15],"yet":[16],"and":[17,94,109,119,146,173,177],"numerous":[18],"adverse":[19],"effects":[20],"follow":[21],"the":[22,50,107,125,164,169,178,185,212],"process.":[24],"In":[25,81,201],"recent":[26],"years,":[27],"linezolid":[28,41,130,162],"has":[29,42],"been":[30],"frequently":[31],"used":[32,115],"for":[33],"treating":[34],"MDR-TB.":[35,57],"However,":[36],"peripheral":[37,54,64,79,207],"neuropathy":[38,55,208],"associated":[39,140,210],"with":[40,139,184,211],"reduced":[43],"patient":[44],"compliance.":[45],"The":[46,101],"current":[47],"study":[48],"explored":[49],"mechanism":[51],"underlying":[52],"linezolid-induced":[53,78,99,206],"in":[56,91,106,157],"Autophagy":[58],"plays":[59],"neuroprotective":[61,75],"role":[62,76],"against":[63,77],"nerve":[65,137],"injury.":[66],"We":[67,127],"hypothesized":[68],"that":[69,129,161,205],"autophagy":[70,192,215],"might":[71],"also":[72,154,194],"play":[73],"neuropathy.":[80],"this":[82],"study,":[83],"we":[84,114,203],"collected":[85],"12":[86],"questionnaires":[87],"from":[88],"MDR-TB":[89],"patients":[90],"our":[92],"hospital,":[93],"10":[95],"of":[96,135,142,148,166,171,180,214],"them":[97],"developed":[98],"pain.":[100],"pain":[102],"mainly":[104],"concentrated":[105],"feet":[108],"accompanied":[110],"by":[111,156],"numbness.":[112],"Subsequently,":[113],"Sprague-Dawley":[116],"(SD)":[117],"rats":[118],"Schwann":[120],"cells":[121],"(SCs)":[122],"to":[123,199],"explore":[124],"mechanism.":[126],"found":[128],"causes":[131],"sparse":[133],"arrangement":[134],"sciatic":[136],"tissue":[138],"loss":[141],"neurons,":[143],"myelin":[144],"sheaths,":[145],"down-regulation":[147],"LC3B":[149,181],"expression.":[150],"These":[151],"results":[152,197],"were":[153],"confirmed":[155],"vitro":[158],"experiments,":[159],"showing":[160],"inhibited":[163],"proliferation":[165],"SCs.":[167],"And":[168],"expression":[170,179],"P-AKT":[172],"P62":[174],"was":[175],"elevated,":[176],"declined":[182],"compared":[183],"control":[186],"group.":[187],"Moreover,":[188],"chloroquine":[189],"(CQ),":[190],"an":[191],"inhibitor,":[193],"exhibited":[195],"experimental":[196],"similar":[198],"linezolid.":[200],"summary,":[202],"conclude":[204],"inhibition":[213],"flux.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-09-10T00:00:00"}
